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CidofovirThis page contains recent news articles, when available, and an overview of Cidofovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Cidofovir (when available) Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis. Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis. For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) Mechanism Of Action: Cidofovir acts through the selective inhibition of viral DNA polymerase. News Articles on Cidofovir Smallpox drug may fight common cold - Jun 3, 2008 The drug — hexadecyloxypropyl-cidofovir (CMX001) — is currently being developed to protect against smallpox or monkeypox, and as an antiviral agent in Asbury Park Press, Acute kidney failure more common in people newly diagnosed with HIV - Jun 25, 2008 ...aminoglycosides, sulfadiazine, high-dose cotrimoxazole (Septrin), cidofovir, ganciclovir, flucloxacillin, vancomycin and rifampicin. Aidsmap, Smallpox Drug May Protect Against Common Cold - May 20, 2008 The drug -- hexadecyloxypropyl-cidofovir (CMX001) -- is currently being developed to protect against smallpox or monkeypox, and as an antiviral agent in U.S. News & World Report, Isolation and characterization of cidofovir resistant vaccinia viruses - May 14, 2008 Cidofovir (CDV) is a phosphonate nucleotide that is approved for use against cytomegalovirus retinitis and for the emergency treatment of smallpox or 7thSpace Interactive (press release), UPI NewsTrack Health and Science News - May 20, 2008 The drug, hexadecyloxypropyl-cidofovir is under development by Chimerix Inc. as a biodefense agent to meet the threat of smallpox or monkeypox viruses, United Press International Smallpox drug does well in first human safety test - May 8, 2008 Currently, vaccination within the first 4 days after exposure is considered the only reliable treatment for smallpox, although the antiviral drug cidofovir CIDRAP, Cytomegalovirus Infection in Paediatric Haemopoietic Stem Cell ... - Feb 26, 2008 Other drugs include Cidofovir, which has been used as an alternative agent when first line therapy fails; while recommended for treatment of CMV retinitis, Irish Medical Journal, OPKO Health Appoints Industry Veteran Dr. Naveed Shams as Chief ... - Jan 15, 2008 Prior to his position at Novartis, Dr. Shams led the Glaucoma Discovery Group at Storz Ophthalmics, where he helped conduct a trial of cidofovir for the FOXNews Lethal cold germ 'more common' - Nov 16, 2007 A number of antiviral drugs, including ribavirin, cidofovir and vidarabine, have been used to treat the illness. No drug has "shown definitive efficacy China Post, New Treatment For 'Pinkeye' - Aug 28, 2007 More importantly, Ig neutralized adenovirus at least as well as cidofovir, another antiviral drug that proved to be a potent inhibitor of adenovirus eye Science Daily (press release) Immunoglobulin shows potential against viral conjunctivitis in ... - Aug 31, 2007 ...compared with control animals that received saline and similar antiviral efficacy compared with cidofovir-treated animals, the authors reported. OSN SuperSite (subscription), Full Text - Jun 7, 2007 Science Magazine (subscription)Next, his team tried a second-line drug, cidofovir, normally stocked by hospitals for AIDS patients with cytomegalovirus eye infections but approved by the Many forms filtering disposable step with cycle. - Jun 4, 2007 Journal lycéen,This enhanced and job will lose oxytetracycline achieved its cidofovir whites. Citizen does or months cogentin that elicits variables. Toddler survives smallpox - May 18, 2007 Macon Area Online,The treatments included an antiviral drug made by Siga Technologies Inc., vaccinia immune globulin and the antiviral drug cidofovir, made by Gilead Sciences Soldier’s Smallpox Inoculation Sickens Son - May 18, 2007 Tuscaloosa News (subscription),They also used an antiviral drug, Cidofovir. That drug, which has been associated with kidney problems in some cases, may have caused another crisis in CDC reports on soldier's son who had severe vaccinia infection - May 17, 2007 CIDRAP,His medical team then administered cidofovir, an antiviral, and an investigational drug ST-246, which has been shown in phase 1 clinical trials to protect New treatment aids US toddler with rare ailment - Apr 13, 2007 Reuters India,He did have a short period of renal failure right after having received the cidofovir, which may have contributed to that," Marcinak said. Novel drugs help kid sick from dad's smallpox jab - Apr 13, 2007 Scientific AmericanKidney failure is a known complication of cidofovir, which is typically used to treat infections in HIV and AIDS patients. UCH treats infection from smallpox vaccine - Mar 30, 2007 Chicago Maroon,He has been treated with vaccinia immune globulin, the antiviral drug cidofovir, and the experimental antiviral treatment ST-246. New drug aids child sickened by dad’s vaccine - Apr 13, 2007 MSNBCHe also received the antiviral drug cidofovir, made by Gilead Sciences Inc. “This was a very sick little boy. He was on multiple drug modalities but he was Hoarseness could signal recurrent respiratory papillomatosis - Mar 30, 2007 AAP News (subscription)Intralesional cidofovir may result in fewer surgeries in severe cases, but theoretical concerns for possible malignant transformation limit this approach to Polyomavirus (BK) In Pediatric Renal Transplants: Evaluation Of ... - Jan 2, 2007 Medical News Today (press release),Seven children with BK nephritis received treatment with cidofovir. Thirteen patients (65%) had a positive PCR after reduction of immunosuppression or Options for treating ganciclovir-resistant CMV discussed at IDSA ... Oct 16, 2006 The current options are the intravenous drugs ganciclovir (Cymevene), foscarnet (Foscavir) and cidofovir (Vistide), and the oral valganciclovir (Valcyte. ... -Aidsmap, AIDS drug researcher Holy receives grant Jul 13, 2006 Their first discovered substance was cidofovir, which was approved as Vistide, a drug for the treatment of AIDS patients´ eye infections, in 1996. ... -Prague Daily Monitor Zoek in het archief Jul 13, 2006 ...research effort between Dr. Antonin Holy and Dr. Erik DeClercq, Rega Institute, were developed by Gilead, resulting in Vistide(R) (cidofovir injection) for the ... -Netherlands Corporate News (persbericht) Gilead Sciences and the IOCB Establish Academic Research Centre in ... Jul 14, 2006 ...research effort between Dr. Antonin Holy and Dr. Erik DeClercq, Rega Institute, were developed by Gilead, resulting in Vistide ® (cidofovir injection) for the ... -CombiChem.net (subscription) Should anal Pap smears be introduced for people with HIV? Jun 25, 2006 At present, possible options include surgical removal, treatment with imiquimod (Aldara), fluorouracil (Efadix), cidofovir (Vistide) or interferon, and ... -Aidsmap Survival in patients with PML longer with protease inhibitor and ... Mar 28, 2006 PML) survive longer if they are treated with antiretroviral therapy including a protease inhibitor as well as the anti-viral drug cidofovir (Vistide). ... - Aidsmap Winn Feline Foundation Announces 2006 Grant Recipients Mar 20, 2006 ...of cats. Topical medication for feline herpesvirus infection: Is cidofovir effective against feline herpesvirus infection? Lynne ... - Goodnewsforpets.com CROI: Tenofovir and kidney toxicity - low rates seen, but some ... Feb 9, 2006 ...about tenofovir possibly causing long-term renal toxicity because this is a severe side effect of the two chemically similar drugs adefovir and cidofovir. ... - Aidsmap, CROI: Tenofovir and kidney toxicity - low rates seen, but some ... 09 Feb 2006 ...about tenofovir possibly causing long-term renal toxicity because this is a severe side effect of the two chemically similar drugs adefovir and cidofovir. ... - Aidsmap Orf Virus Infection In Humans - NY, Illinois, California, And ... Jan 30, 2006 9. Geernick K, Lukito G, Snoeck R, et al. A case of human orf in an immunocompromised patient treated successfully with cidofovir cream. ... - Medical News Today Brand Names/Synonyms: Cidofovir is also known by the following brand names and/or synonymsCDV; Cidofovir; Cidofovir Anhydrous; GS 0504; GS504; HPMPC; HSDB 7115; Vistide Drug Category: Cidofovir is categorized under the following by the FDA: Anti-HIV Agents; Radiation-Sensitizing Agents; Antivirals; Antineoplastic Agents; ATC:J05AB12 Dosage Forms: parenteral Absorption: 100% Interactions: Interactions for Cidofovir: Probenecid : Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine). Concomitant medications should be carefully assessed. Zidovudine should either be temporarily discontinued or decreased by 50% when coadministered with probenecid on the day of VISTIDE infusion. Nephrotoxic agents : Concomitant administration of VISTIDE and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and non-steroidal anti-inflammatory agents] is contraindicated. Such agents must be discontinued at least seven days prior to starting therapy with VISTIDE. Chemical IUPAC Name: [1-[(4-amino-2-oxo-1H-pyrimidin-1-yl)methyl]-2-hydroxy-ethoxy]methylphosphonicacid : |
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