|
 |
ChlorprothixeneThis page contains recent news articles, when available, and an overview of Chlorprothixene but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Chlorprothixene (when available) Chlorprothixene is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine analgesic effects. An antiemetic effect, as with most antipsychotics, exists. It is used in the treatment of nervous, mental, and emotional conditions. Improvement in such conditions is thought to result from the effect of the medicine on nerve pathways in specific areas of the brain. Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side-effects. Chlorprothixene is structurally related to chlorpromazine, with which it shares in principal all side effects. Allergic side-effects and liver damage seem to appear with an appreciable lower frequency. For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. Mechanism Of Action: Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. News Articles on Chlorprothixene Atypical Antipsychotics in the Treatment of Schizophrenia During ... - Dec 6, 2006 Am J Psychiatry (subscription)...in behavior or cognition in 66 9-and 10-year-olds with in utero exposure, only after the 20th week of gestation, to chlorpromazine or chlorprothixene. ... Health Tip: Drugs to Avoid While Breast-Feeding Feb 16, 2006 Trazodone. Antipsychotic drugs: Chlorpromazine Galactorrhea, Chlorprothixene, Clozapine, Haloperidol, Mesoridazine, Trifluoperazine. ... - Forbes Brand Names/Synonyms: Chlorprothixene is also known by the following brand names and/or synonymsAlpha-Chlorprothixene; CPT; CPX; Chloroprothixene; Chlorprothixen; Chlorprothixene; Chlorprothixine; Chlorprotixen; Chlorprotixene; Chlorprotixine; Chlothixen; Cis-Chlorprothixene; Iaractan; MK 184; N 714; N 714C; N-714; Paxyl; Rentovet; Tactaran; Taractan; Tarasan; Tardan; Tranquilan; Traquilan; Trictal; Truxal; Truxaletten; Truxil; Vetacalm Drug Category: Chlorprothixene is categorized under the following by the FDA: Antipsychotics; Dopamine Antagonists; ATC:N05AF03 Dosage Forms: TABLET, SYRUP, CONCENTRATE Absorption: Not Available Interactions: Interactions for Chlorprothixene: Chlorprothixene may increase the plasma-level of concomitantly given lithium. In order to avoid lithium intoxication, lithium plasma levels should be monitored closely. If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively. Avoid the concomitant use of chlorprothixene and tramadol (Ultram). Massive seizures may be encountered with this combination. Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates. Choose particular low doses of these drugs. Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma. Chemical IUPAC Name: 3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethyl-propan-1-amine : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |