Chlorpheniramine

This page contains recent news articles, when available, and an overview of Chlorpheniramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Chlorpheniramine (when available)

Pharmacology and use:
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

Mechanism Of Action:
Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

News Articles on Chlorpheniramine

Common drugs can help allergic rhinitis  -  ‎Mar 29, 2009‎
Most of these products, while bearing different brand names, contain similar active ingredients such as Brompheniramine maleate (Dimetapp), Chlorpheniramine Daytona Beach News-Journal

Saving Lives through Quality Product  -  ‎Apr 13, 2009‎
...and solution contain three internationally proven active ingredients which are paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate. THISDAY

Watch out for these unapproved cough and cold meds  -  ‎Apr 14, 2009‎
New Allergy DM suspension, D-Tann CT tablets, B-Vex D suspension, Histex SR, and Chlorpheniramine Maleate 12 mg/Pseudoephedrine HCl 120 mg LA tablets. Modern Medicine

FDA Obtains Permanent Injunction Barring Two Companies from ...  -  ‎Apr 13, 2009‎
The unapproved drugs manufactured by Unigen and/or Advent include, but are not limited to: Chlorpheniramine Maleate 12 mg/Pseudoephedrine HCl 120 mg LA Pharmaceutical Processing

FDA stops two firms from manufacturing, selling 50 unapproved drug ...  -  ‎Apr 10, 2009‎
New Allergy DM Suspension, D-Tann CT Tablets, B-Vex D Suspension, Histex SR, and Chlorpheniramine Maleate 12 mg/Pseudoephedrine HCl 120 mg LA Tablets. RTT News

美FDA下令�?�售50�?咳嗽和感冒�?�  -  ‎Apr 12, 2009‎
Tann 20 mg/CP Tann 4 mg�?BP New Allergy DM�?B-Vex D，和�?�片D-Tann CT�?Chlorpheniramine Maleate 12 mg/Pseudoephedrine HCl 120 mg LA以�?�Histex SR胶囊。大纪元

50種咳嗽和感冒藥被美FDA明令�?售  -  ‎Apr 13, 2009‎
Tann 20 mg/CP Tann 4 mg�?BP New Allergy DM�?B-Vex D，和藥片D-Tann CT�?Chlorpheniramine Maleate 12 mg/Pseudoephedrine HCl 120 mg LA以�?�Histex SR膠囊。希望之聲電台

09年执业西�?�师�?�物化  -  ‎Apr 16, 2009‎
...例如氯苯那�?（Chlorpheniramine）等。此类�?�物的脂溶性大于乙二胺类和氨基醚类，因此抗组胺作用强，作用时间长。化学�??：N，N-二甲基-γ-（4-氯苯基）-2-�?�啶丙胺顺�? 青年人

Không nên quá lo lắng bệnh vẩy nến  -  ‎Apr 2, 2009‎
Có thể dùng thêm thuốc chống ngứa, chống dị ứng như Phenecgan hoặc Chlorpheniramine lúc đi ngủ. Không nên tiêm K-Cort hoặc uống Prednisolon vì dùng những An ninh thủ đô

Drixoral: Why the Allergy Medicine Isn't Available, and What to ...  -  ‎Mar 9, 2009‎
As an alternative to Drixoral, people can seek out medicines that combine one of two older antihistamines, chlorpheniramine or diphenhydramine, U.S. News & World Report

UCB warding off effects of patent expiries  -  ‎Mar 4, 2009‎
Sales reached 1.27 billion euros, an increase of 23%, while the anti-tussive Tussionex (hydrocodone and chlorpheniramine) grew 29% to 147 million euros, Pharma Times

UCB (BE) - UCB: Full Year 2008 Financial Results  -  ‎Mar 3, 2009‎
Net sales of the antitussive, Tussionex® (hydrocodone polistirex and chlorpheniramine polistirex), grew by 29% (+38% CER) to EUR 147 million benefiting from PharmaLive.com (press release)

Küçüklere ilaç verirken bir daha düşünün  -  ‎Mar 10, 2009‎
Aynı tarihler arasında soğuk algınlığı ilaçlarında bulunan anti-histaminik özellikli diphenhydramine, brompheniramine ya da chlorpheniramine maddelerine İhlas.Net

Au secours ! Mon chat s'arrache les poils !  -  ‎Feb 27, 2009‎
Certains chats souffrant de pelade psychogène peuvent répondre à la chlorpheniramine (un antihistaminique) ou à des glucocorticoïdes systémiques. Waliboo

L'épilepsie canine  -  ‎Feb 27, 2009‎
Réaction allergique à un médicament : Chlorpheniramine (antihistaminique, surdosage), ibuprofène, aspirine ou mitotane, un médicament utilisé dans le Waliboo

Research and Markets: Top Three Drugs by Sales in Kazakhstan were ...  -  Jan 27, 2009
Novartis' over-the-counter (OTC) flu treatment Theraflu (acetaminophen + chlorpheniramine + dextromethorphan + phenylephrine + pheniramine + MarketWatch (press release)

Failure to launch  -  Jan 20, 2009
About a third of men improve after treatment with medicines that close the bladder neck, such as pseudoephedrine, phenylephrine, chlorpheniramine, Malaysia Star,

Treating colds: What works, what doesn't  -  Jan 12, 2009
Take a sustained-release first generation antihistamine (the kind that can make you drowsy) like diphenhydramine (Benadryl), chlorpheniramine (Chlotrimeton Philippine Star,

Can’t cure cold but sure can fight one  -  Jan 16, 2009
My favorite is chlorpheniramine (Chlor-Trimeton), but diphenhydramine (Benadryl) and doxylamine (Unisom) work well. Ibuprofen (Advil) or acetaminophen Greenwood Commonwealth,

GSK introduces Panadol Cold & Catarrh  -  Dec 22, 2008
Paracetamol is for fever and pain relief, phenylephrine hydrochloride to decongest the nose and chlorpheniramine maleate to strongly prevent allergic body Vanguard,

WHEN TAKING CARE OF YOUR COUGH  -  Dec 18, 2008
TussiCaps® is the first and only FDA-approved hydrocodone/chlorpheniramine capsule for the relief of cold-related cough in adults and children 6 years of North American Press Syndicate,

Health warning issued under Section 98 of the Medicines Act 1981  -  Dec 9, 2008
Ankahuangmin Jiaonang (Paracetamol, Caffeine, Artificial Cow Bezoar and Chlorpheniramine Maleate Capsules). This product is presented as blister packs New Zealand Doctor Online,

UPI NewsTrack Health and Science News  -  Dec 18, 2008
The products affected are those containing any active ingredients that are given orally: --Antihistamines: brompheniramine maleate, chlorpheniramine maleate United Press International

Canada mandates relabeling of kids' drugs  -  Dec 18, 2008
The products affected are those containing any active ingredients that are given orally: --Antihistamines: brompheniramine maleate, chlorpheniramine maleate United Press International

China Sky One Medical, Inc. Obtains Production Rights for Two ...  -  Dec 16, 2008
Compound Naphazoline spray is for the treatment of rhinopathy; -- Naphazoline Hydrochloride Chlorpheniramine Maleate and Benzalkonium Bromide spray for SYS-CON Media,

The Promethazine and Codiene Syrup Appreciation...  -  Dec 2, 2008
...(Yellow Syrup: XR Hydrocodone and Atropine or Chlorpheniramine, Pink Syrup: Cheratussin AC brand Codeine and Guaifenesin). Cheratussin AC(and other brands), AllHipHop

Health Canada Releases Decision on the Labelling of Cough and Cold ...  -  Dec 18, 2008
...and brompheniramine maleatecold medicines chlorpheniramine maleate(used to treat sneezing, clemastine hydrogen fumeraterunny nose) dexbrompheniramine International Business Times,

懷孕�?�哺乳期的感冒治療  -  Dec 8, 2008
HCL�?Acetylcysteine；�?鼻水�?鼻塞�?�用傳統藥物如Chlorpheniramine uho優活�?�康網,

תרופות לל�? מרש�? למחלות חורף  -  Dec 10, 2008
...קלורפנרמין (CHLORPHENIRAMINE)- טיפול בתסמיני הצטננות, התעטשות, דמעת ונזלת. תופעת הלוו�?י השכיחה ביותר עקב השפעה על המח הי�? רצון לישון ועייפות. BeOK פורטל ברי�?ות ויופי,

Warning over medicines sold by Chinese supermarket  -  Dec 7, 2008
The Ministry of Health is warning people not to take six medicines that have been on sale at a supermarket selling mainly Chinese goods in South Auckland. Radio New Zealand,

UCB on track  -  Oct 30, 2008
Key products contributing to growth were Keppra(R) (levetiracetam), Xyzal(R) (levocetirizine) and Tussionex(R) (hydrocodone polistirex and chlorpheniramine MarketWatch

Pharmacist weighs in on cold remedies  -  Nov 3, 2008
Antihistamines: Antihistamines are designed to treat allergies; however, some older antihistamines, such as brompheniramine, chlorpheniramine and News-Leader.com,

Safety of Kids Cough and Cold Medicines Questioned  -  Oct 27, 2008
Other deaths occurred because of the association with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. Natural News.com,

Küçüklere İlaç İçirmeyin  -  21 Oct 2008
Aynı tarihler arasında soğuk algınlığı ilaçlarında bulunan anti-histaminik özellikli diphenhydramine, brompheniramine ya da chlorpheniramine maddelerine Yeni Bursa,

FDA Hears Testimony On Children's Cold Medicine  -  Oct 2, 2008
A review of records between 1969 and 2006 shows 69 deaths associated with antihistamines, diphenhydramine, brompheniramine, and chlorpheniramine -- active KDKA,

CONSUMER REPORTS: Back to Basics For Safer Childbirth  -  Oct 8, 2008
3rd None trimester: Do not take -- unacceptable risk Chlorpheniramine Chlor- 1st, 2nd trimester: Claritin Trimeton; Use with caution (Loratadine); MarketWatch

First Aid for Bug Bites - Mosquitos, Ticks, Spiders, Bedbugs ...  -  Oct 4, 2008
For stronger bug bite reactions, Dr. Fox recommends taking an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy), chlorpheniramine PR Web (press release),

Một trẻ dị ứng thuốc nặng do ngư�?i nhà tự đi�?u trị  -  Oct 1, 2008
...bớt tổn thương Trước khi nhập viện khoảng 1 tuần, M. bị sốt, ho và sổ mũi, ngư�?i nhà tự mua thuốc cho bé uống gồm bactrim, toplexil, chlorpheniramine. Ngư�?i Lao �?ộng,

China Sky One Medical develops nasal spray for rheumatic disease  -  Aug 18, 2008
...recently completed R&D for the spray, which includes the active ingredients naphazoline hydrochloride chlorpheniramine maleate and benzalkonium bromide. Trading Markets (press release),

Older People in Danger from Common Drugs  -  Aug 28, 2008
Chlorpheniramine (Chlor-Trimeton) and diphenhydramine (Benedryl) can cause drowsiness, confusion, and urine retention. Consider cetirizine (Zyrtec) NewsMax.com,

中 류마티스 비강 스프레�?�제 개발  -  Aug 22, 2008
...�?� 스프레�?�제�?� 활성성분�?� '염산나파졸린'(naphazoline hydrochloride), '�?레�?�산�?�로르페니�?�민'(chlorpheniramine maleate), '벤잘코늄브로마�?�드'(benzalkonium 디지틀보사,

壯陽膠囊誇療效地下電�?�主�?人�?辦  -  Aug 26, 2008
...由於膠囊�?分被驗出�?�有Vardenafil�?Acetaminophen�?Chlorpheniramine 自由時報,

Nhiệt kế thủy ngân, ẩn h�?a khôn lư�?ng  -  07 Aug 2008
Nếu sơ ý để da tiếp xúc với thủy ngân, bị ban đ�?, ngứa ngáy thì phải uống thuốc chống dị ứng (như chlorpheniramine) và bôi thuốc ngoài da vào chỗ mẩn ngứa. Ti�?n Phong Online,

Ministry Warns Over Traditional Medicine  -  Jul 29, 2008
By Azlan Othman Bandar Seri Begawan - The Ministry of Health has detected an adulterant, Chlorpheniramine, in "Maajun Kuat Sakit Pinggang", Bru Direct,

Sales spikes, overdoses prompt drug restrictions  -  Jun 30, 2008
Chlorpheniramine maleate, also found in "Triple C," can cause bleeding from bodily orifices and possibly death. The Web site Wanser used actually warns Stars and Stripes,

Police say Westmoreland County fall victims impaired  -  Jun 5, 2008
Investigators believe Christopher Cardy, 25, of Ligonier, and Sara Kent Baum, 24, of Greensburg, both consumed large amounts of the drug chlorpheniramine, Pittsburgh Tribune-Review,

Ask The Mayo Clinic: Over-the-counter allergy medicine makes ...  -  Jun 29, 2008
Apart from that, many nonprescription allergy medications -- including those containing diphenhydramine (Benadryl, others), chlorpheniramine maleate Seattle Post Intelligencer

Pharmaceutical drug abuse increasing in India: UN0  -  Jun 23, 2008
Pharmaceuticals like buprenorphine, dextropropoxyphene, diazepam, nitrazapam, codeine based cough syrups, phenergan and chlorpheniramine are commonly abused Economic Times,

People With Dementia Should Avoid Certain Drugs  -  Jun 27, 2008
Antihistamines, single or combination products, such as Azatadine (Optimine), Brompheniramine (Dimetane), Carbinoxamine, Chlorpheniramine (Chlor-Trimeton), RedOrbit,

Ministry of Health recalls medicines, cosmetic products  -  Jun 12, 2008
Sdn Bhd in Malaysia and Ching Du Wan 300 mg capsules (containing Chloramphenicol and Chlorpheniramine), manufactured by Maxi Herbs Sdn Bhd, Malaysia. Borneo Bulletin,

Pharma drug shots tied to AIDS, says UN study  -  Jun 25, 2008
...as buprenorphine, dextropropoxyphene and pentazocine, often cocktailed with diazepham and antihistaminics (chlorpheniramine maleate and promethazine). Newindpress,

Attorney general set to take legal action against Rite Aid  -  Jun 20, 2008
Theraflu is a product that contains a number of medications for symptoms associated with colds and flu, including acetaminophen, chlorpheniramine, Fulton Valley News (subscription),

OTC Firm Used Wrong Identity Test, Warning Letter Follows  -  Jun 13, 2008
...test for incoming APIs dextromethorphan tannate, pseudoephedrine tannate and chlorpheniramine tannate, which was inappropriate, the letter said. FDA news (subscription),

Don't Let Allergies And Asthma Ruin Your Summer  -  Jun 5, 2008
Other antihistamines available over-the-counter including diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton) are effective alternatives for Boston Channel.com,

Act fast with  -  Jun 3, 2008
Take an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy) or chlorpheniramine maleate (Chlor-Trimeton, Actifed). Myrtle Beach Sun News,

NTSB: Pilot caused fatal plane crash in Mesilla  -  Jun 4, 2008
Tests on Steinmetz's blood and urine found chlorpheniramine - an antihistamine that may cause drowsiness, the agency said. The crash was caused by "the El Paso Times,

Interim Report: UCB off to a good  -  May 14, 2008
...percentages innet sales growth as did Xyzal® (levocetirizine) revenues as well asTussionex® (hydrocodone polistirex and chlorpheniramine polistirex). Ad-Hoc-News (Pressemitteilung),

Interim Report: UCB off to a good start in 2008  -  May 14, 2008
...percentages in net sales growth as did Xyzal® (levocetirizine) revenues as well as Tussionex® (hydrocodone polistirex and chlorpheniramine polistirex). Euronext (persbericht),

Ministry Recalls Three Traditional Medicines  -  May 8, 2008
...found to contain Sildenafil and its analogues; and Edoly Capsules manufactured by Shen Loon She Enterprise Sdn Bhd, Malaysia contained Chlorpheniramine. Bru Direct,

Cough medicines still OTC  -  Apr 21, 2008
Products containing brompheniramine, chlorpheniramine or diphenhydramine that are not re-labelled will become prescription only. The TGA says these products 6minutes,

• FDA ADVISORY  -  Apr 8, 2008
Tussionex is a prescription cough medicine containing hydrocodone, a narcotic ingredient, and the antihistamine chlorpheniramine. The Plain Dealer - cleveland.com,

The Safe Use of Tussionex Pennkinetic Extended-Release Suspension  -  Apr 6, 2008
Tussionex is a prescription cough medicine containing hydrocodone and the antihistamine, chlorpheniramine that is made to be given every 12 hours Food Consumer,

Treating drug allergies  -  Apr 2, 2008
Mild allergy symptoms (rash, itching and mild hives) may be relieved with antihistamines such as diphenhydramine or chlorpheniramine maleate, MyFox Kansas City,

Kids and Colds: Health Life 4/1/08  -  Apr 1, 2008
...or ephedrine and 69 reported deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. KCRG,

Guilty plea in child abuse, DUI case  -  Mar 27, 2008
Pastorek was under the influence of chlorpheniramine and dextromethorphan, both key ingredients in some cold medications. At the time of the crash, Grand Forks Herald,

Autopsy Finds That Death of Gotbaum Was Accident  -  Mar 26, 2008
...an anti-inflammatory; dextromethorphan, a cough suppressant; and two antihistamines, diphenhydramine and chlorpheniramine. A flight attendant on Ms. New York Times Blogs,

Ways to clear your mind  -  Feb 25, 2008
Even over-the-counter drugs, notably older antihistamines such as chlorpheniramine (Chlor-Trimeton and generic) and diphenhydramine (Benadryl Allergy and Indianapolis Star,

It's allergy season for your cats, dogs  -  Mar 9, 2008
In cats, chlorpheniramine is often used. Use of newer antihistamines like Claritin, Zyrtec and Allegra is beginning, but data is not yet available that Tri-Valley Herald,

Conventional Medical Treatment for Hives  -  Feb 17, 2008
Many antihistamines are available without prescription, such as diphenhydramine (Benadryl), taken in doses of 25 milligrams and chlorpheniramine American Chronicle,

COURT: Mother of dead infant sues Altru  -  Feb 13, 2008
At the time, the complaint said, he was under the influence of chlorpheniramine and dextromethorphan, both key ingredients in some cold medications. Grand Forks Herald (subscription),

Are Cold Remedies Enough to Raise Blood Pressure?  -  Feb 12, 2008
Besides the normal mantra of plenty of bed rest and lots of fluids, try medications with acetaminophen and chlorpheniramine and/or dextromethorphan, TamilStar.com,

Brand Names/Synonyms:
Chlorpheniramine is also known by the following brand names and/or synonymsAller-Chlor; Allergican; Allergisan; Antagonate; Chlo-Amine; Chlor-Trimeton; Chlor-Trimeton Allergy; Chlor-Trimeton Repetabs; Chlor-Tripolon; Chlorate; Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloropiril; Chloroprophenpyridamine; Chlorphenamine; Chlorpheniramine; Chlorpheniramine Maleate; Chlorprophenpyridamine; Clorfeniramina; Cloropiril; Dexchlorpheniramine; Dexchlorpheniramine Maleate; Efidac 24 Chlorpheniramine Maleate; Gen-Allerate; Haynon; Histadur; Kloromin; Mylaramine; Novo-Pheniram; Pediacare Allergy Formula; Phenetron; Piriton; Polaramine; Polaronil; Pyridamal 100; Telachlor; Teldrin

Drug Category:
Chlorpheniramine is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Antihistamines; ATC:R06AB02

Dosage Forms:
Tablet (chlorpheniramine maleate)

Absorption:
Well absorbed by gastrointestinal tract

Interactions:
Interactions for Chlorpheniramine:

Substrate of CYP2D6 (minor), 3A4 (major); Inhibits CYP2D6 (weak).

Increased toxicity (CNS depression): CNS depressants, MAO inhibitors, tricyclic antidepressants, phenothiazines.

CYP3A4 inhibitors: May increase the levels/effects of chlorpheniramine. Example inhibitors include azole antifungals, ciprofloxacin, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, and verapamil.

Chemical IUPAC Name:
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine

:

Web health.mongabay.com/health

Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com/health lead to other sites. health.mongabay.com/health does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com/health responsible for dead or misdirected links.