Chlorpheniramine

This page contains recent news articles, when available, and an overview of Chlorpheniramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Chlorpheniramine (when available)

Pharmacology and use:
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

Mechanism Of Action:
Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

News Articles on Chlorpheniramine

China Sky One Medical develops nasal spray for rheumatic disease  -  Aug 18, 2008
...recently completed R&D for the spray, which includes the active ingredients naphazoline hydrochloride chlorpheniramine maleate and benzalkonium bromide. Trading Markets (press release),

Older People in Danger from Common Drugs  -  Aug 28, 2008
Chlorpheniramine (Chlor-Trimeton) and diphenhydramine (Benedryl) can cause drowsiness, confusion, and urine retention. Consider cetirizine (Zyrtec) NewsMax.com,

中 류마티스 비강 스프레�?�제 개발  -  Aug 22, 2008
...�?� 스프레�?�제�?� 활성성분�?� '염산나파졸린'(naphazoline hydrochloride), '�?레�?�산�?�로르페니�?�민'(chlorpheniramine maleate), '벤잘코늄브로마�?�드'(benzalkonium 디지틀보사,

壯陽膠囊誇療效地下電�?�主�?人�?辦  -  Aug 26, 2008
...由於膠囊�?分被驗出�?�有Vardenafil�?Acetaminophen�?Chlorpheniramine 自由時報,

Nhiệt kế thủy ngân, ẩn h�?a khôn lư�?ng  -  07 Aug 2008
Nếu sơ ý để da tiếp xúc với thủy ngân, bị ban đ�?, ngứa ngáy thì phải uống thuốc chống dị ứng (như chlorpheniramine) và bôi thuốc ngoài da vào chỗ mẩn ngứa. Ti�?n Phong Online,

Ministry Warns Over Traditional Medicine  -  Jul 29, 2008
By Azlan Othman Bandar Seri Begawan - The Ministry of Health has detected an adulterant, Chlorpheniramine, in "Maajun Kuat Sakit Pinggang", Bru Direct,

Sales spikes, overdoses prompt drug restrictions  -  Jun 30, 2008
Chlorpheniramine maleate, also found in "Triple C," can cause bleeding from bodily orifices and possibly death. The Web site Wanser used actually warns Stars and Stripes,

Police say Westmoreland County fall victims impaired  -  Jun 5, 2008
Investigators believe Christopher Cardy, 25, of Ligonier, and Sara Kent Baum, 24, of Greensburg, both consumed large amounts of the drug chlorpheniramine, Pittsburgh Tribune-Review,

Ask The Mayo Clinic: Over-the-counter allergy medicine makes ...  -  Jun 29, 2008
Apart from that, many nonprescription allergy medications -- including those containing diphenhydramine (Benadryl, others), chlorpheniramine maleate Seattle Post Intelligencer

Pharmaceutical drug abuse increasing in India: UN0  -  Jun 23, 2008
Pharmaceuticals like buprenorphine, dextropropoxyphene, diazepam, nitrazapam, codeine based cough syrups, phenergan and chlorpheniramine are commonly abused Economic Times,

People With Dementia Should Avoid Certain Drugs  -  Jun 27, 2008
Antihistamines, single or combination products, such as Azatadine (Optimine), Brompheniramine (Dimetane), Carbinoxamine, Chlorpheniramine (Chlor-Trimeton), RedOrbit,

Ministry of Health recalls medicines, cosmetic products  -  Jun 12, 2008
Sdn Bhd in Malaysia and Ching Du Wan 300 mg capsules (containing Chloramphenicol and Chlorpheniramine), manufactured by Maxi Herbs Sdn Bhd, Malaysia. Borneo Bulletin,

Pharma drug shots tied to AIDS, says UN study  -  Jun 25, 2008
...as buprenorphine, dextropropoxyphene and pentazocine, often cocktailed with diazepham and antihistaminics (chlorpheniramine maleate and promethazine). Newindpress,

Attorney general set to take legal action against Rite Aid  -  Jun 20, 2008
Theraflu is a product that contains a number of medications for symptoms associated with colds and flu, including acetaminophen, chlorpheniramine, Fulton Valley News (subscription),

OTC Firm Used Wrong Identity Test, Warning Letter Follows  -  Jun 13, 2008
...test for incoming APIs dextromethorphan tannate, pseudoephedrine tannate and chlorpheniramine tannate, which was inappropriate, the letter said. FDA news (subscription),

Don't Let Allergies And Asthma Ruin Your Summer  -  Jun 5, 2008
Other antihistamines available over-the-counter including diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton) are effective alternatives for Boston Channel.com,

Act fast with  -  Jun 3, 2008
Take an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy) or chlorpheniramine maleate (Chlor-Trimeton, Actifed). Myrtle Beach Sun News,

NTSB: Pilot caused fatal plane crash in Mesilla  -  Jun 4, 2008
Tests on Steinmetz's blood and urine found chlorpheniramine - an antihistamine that may cause drowsiness, the agency said. The crash was caused by "the El Paso Times,

Interim Report: UCB off to a good  -  May 14, 2008
...percentages innet sales growth as did Xyzal® (levocetirizine) revenues as well asTussionex® (hydrocodone polistirex and chlorpheniramine polistirex). Ad-Hoc-News (Pressemitteilung),

Interim Report: UCB off to a good start in 2008  -  May 14, 2008
...percentages in net sales growth as did Xyzal® (levocetirizine) revenues as well as Tussionex® (hydrocodone polistirex and chlorpheniramine polistirex). Euronext (persbericht),

Ministry Recalls Three Traditional Medicines  -  May 8, 2008
...found to contain Sildenafil and its analogues; and Edoly Capsules manufactured by Shen Loon She Enterprise Sdn Bhd, Malaysia contained Chlorpheniramine. Bru Direct,

Cough medicines still OTC  -  Apr 21, 2008
Products containing brompheniramine, chlorpheniramine or diphenhydramine that are not re-labelled will become prescription only. The TGA says these products 6minutes,

• FDA ADVISORY  -  Apr 8, 2008
Tussionex is a prescription cough medicine containing hydrocodone, a narcotic ingredient, and the antihistamine chlorpheniramine. The Plain Dealer - cleveland.com,

The Safe Use of Tussionex Pennkinetic Extended-Release Suspension  -  Apr 6, 2008
Tussionex is a prescription cough medicine containing hydrocodone and the antihistamine, chlorpheniramine that is made to be given every 12 hours Food Consumer,

Treating drug allergies  -  Apr 2, 2008
Mild allergy symptoms (rash, itching and mild hives) may be relieved with antihistamines such as diphenhydramine or chlorpheniramine maleate, MyFox Kansas City,

Kids and Colds: Health Life 4/1/08  -  Apr 1, 2008
...or ephedrine and 69 reported deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. KCRG,

Guilty plea in child abuse, DUI case  -  Mar 27, 2008
Pastorek was under the influence of chlorpheniramine and dextromethorphan, both key ingredients in some cold medications. At the time of the crash, Grand Forks Herald,

Autopsy Finds That Death of Gotbaum Was Accident  -  Mar 26, 2008
...an anti-inflammatory; dextromethorphan, a cough suppressant; and two antihistamines, diphenhydramine and chlorpheniramine. A flight attendant on Ms. New York Times Blogs,

Ways to clear your mind  -  Feb 25, 2008
Even over-the-counter drugs, notably older antihistamines such as chlorpheniramine (Chlor-Trimeton and generic) and diphenhydramine (Benadryl Allergy and Indianapolis Star,

It's allergy season for your cats, dogs  -  Mar 9, 2008
In cats, chlorpheniramine is often used. Use of newer antihistamines like Claritin, Zyrtec and Allegra is beginning, but data is not yet available that Tri-Valley Herald,

Conventional Medical Treatment for Hives  -  Feb 17, 2008
Many antihistamines are available without prescription, such as diphenhydramine (Benadryl), taken in doses of 25 milligrams and chlorpheniramine American Chronicle,

COURT: Mother of dead infant sues Altru  -  Feb 13, 2008
At the time, the complaint said, he was under the influence of chlorpheniramine and dextromethorphan, both key ingredients in some cold medications. Grand Forks Herald (subscription),

Are Cold Remedies Enough to Raise Blood Pressure?  -  Feb 12, 2008
Besides the normal mantra of plenty of bed rest and lots of fluids, try medications with acetaminophen and chlorpheniramine and/or dextromethorphan, TamilStar.com,

Hold that tissue!  -  Feb 3, 2008
The first-generation antihistamines like doxylamine and chlorpheniramine have a sedating effect, so they're often ingredients in the medicines that brag Chicago Daily Herald,

FDA Says No To OTC Cold Medications for Young Children  -  Jan 17, 2008
13, 2006, the agency had 69 deaths reported with a link to antihistamines and ingredients diphenhydramine, brompheniramine and chlorpheniramine. InjuryBoard.com,

Don’t over use cough suppressants to fight common cold  -  Jan 31, 2008
...other medications such as acetaminophen, guaifenesin, ephedrine, and chlorpheniramine maleate which can also be harmful if taken in large amounts. Journal Review,

The 'cold war' continues  -  Jan 23, 2008
Antihistamines such as chlorpheniramine and dyphenhydramine (warning, these may cause drowsiness) and decongestants such as pseudoephedrine can remove the Jamaica Gleaner,

Cold Meds Not Safe for Kids Under 2, FDA Warns  -  Jan 17, 2008
It also found 69 reports of deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. U.S. News & World Report,

Some cold medications not recommended for children  -  Jan 25, 2008
...or ephedrine and 69 reported deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. News 8 Austin,

Cough Medicines Dogged by Efficacy Concerns for Adults, Too  -  Jan 23, 2008
Clemastine and chlorpheniramine showed no benefit in one trial. Diphenhydramine was no more effective than dextromethorphan or placebo against children's MedPage Today,

FDA Repeats Warning on Cold Medicines in Infants  -  Jan 17, 2008
13, 2006, and 69 reports of deaths linked to antihistamines with the ingredients diphenhydramine, brompheniramine and chlorpheniramine. eFluxMedia

UPDATE: FDA Panel Studying Children's Cold Medicine Safety  -  Oct 18, 2007
13, 2006 , and 69 reports of deaths linked to antihistamines with ingredients diphenhydramine, brompheniramine and chlorpheniramine when it reviewed reports CNNMoney.com

Autopsy Finds That Death of Gotbaum Was Accident  -  Nov 9, 2007
...an anti-inflammatory; dextromethorphan, a cough suppressant; and two antihistamines, diphenhydramine and chlorpheniramine. A flight attendant on Ms. New York Times,

Over-the-counter medicine safety questioned  -  Nov 13, 2007
It also found 69 reports of deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine, according to an Naples Sun Times,

Thumbs down for cough mixture  -  Oct 24, 2007
...decongestants like pseudoephedrine and phenylephrine; expectorants like guaifenesin; and antihistamines like brompheniramine, chlorpheniramine maleate, ABC Online,

Professionals Unsurprised by Panel’s Vote Against Pediatric Drugs  -  Oct 22, 2007
Antihistamines, including brompheniramine and chlorpheniramine, do not relieve cold symptoms. The federal panel, outside experts and even the manufacturers New York Times,

Wrong Dosage Measures Draws Wyeth Children's Medicines Recall  -  Oct 31, 2007
...like: pseudoephedrine, phenylephrine or ephedrine, and antihistamines, like: diphenhydramine, brompheniramine or chlorpheniramine. eFluxMedia

Latest Cold Medicine Recalls: Children's Cold Medicine  -  Oct 30, 2007
Likewise is true for cold medicines containing the antihistamines: diphenhydramine, Brompheniramine or chlorpheniramine. Since this is likely a dosage issue About.com - Drugs,

Left out in the cold: Why kids' drugs were recalled  -  Oct 29, 2007
...antihistamines including diphenhydramine, brompheniramine and chlorpheniramine; and cough syrups including dextromethoraphan. Kankakee Daily Journal,

Cold medicines might be dangerous  -  Oct 28, 2007
...phenylephrine or ephedrine), and another 69 deaths were associated with antihistamines (including diphenhydramine, brompheniramine or chlorpheniramine). Akron Beacon Journal,

Kids & Cold Drugs: Questions, Answers  -  Oct 22, 2007
Third is the expectorant, guaifenesin. And fourth are the antihistamines: brompheniramine, chlorpheniramine maleate, diphenhydramine -- Benadryl -- and others. WebMD

Cold comfort: What medicine is safe for your kid?  -  Oct 21, 2007
Antihistamines to avoid in small children include diphenhydramine, brompheniramine and chlorpheniramine. Most brands warn parents about giving the Portsmouth Herald News,

Recall on Children's Cold Medicine: Advisory Committee Urges Ban  -  Oct 19, 2007
There were 69 reports of deaths associated with antihistamines that contain diphenhydramine, brompheniramine or chlorpheniramine. Most of the deaths were in About.com - Drugs,

FDA Officials: Cold Meds Not for Kids  -  Sep 28, 2007
It also found 69 reports of deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. The Associated Press

Parents have options when treating babies with colds  -  Oct 12, 2007
Antihistamines to avoid in small children include diphenhydramine, brompheniramine and chlorpheniramine. Most brands warn parents about giving the Atlanta Journal Constitution,

Drug Makers to Curb Sales Of Medicine for Kids Under 2  -  Oct 11, 2007
13, 2006, and 69 reports of deaths linked to antihistamines with the ingredients diphenhydramine, brompheniramine and chlorpheniramine. Wall Street Journal

Cold formulas too risky for kids  -  Oct 2, 2007
Another 69 died after taking antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine. Mortality was highest among children Atlanta Journal Constitution,

Rethinking Remedies for Colds and Coughs  -  Oct 1, 2007
...the active ingredient in Benadryl; dexbrompheniramine, an active ingredient in Drixoral; and chlorpheniramine, the active ingredient in Chlor-Trimeton. New York Times,

Plans for Greenacres Starbucks on track  -  Oct 7, 2007
13, it had 69 reports linked to antihistamines with the ingredients diphenhydramine, brompheniramine and chlorpheniramine and 54 reports of deaths in Palm Beach Post,

Medicine fears  -  Oct 2, 2007
...containing pseudoephedrine, phenylephrine or ephedrine, and antihistamine medications containing dyphenhydramine, brompheniramine or chlorpheniramine. El Paso Times,

FDA Says Stop Giving Your Child Over-The-Counter Drugs  -  Oct 1, 2007
...including phenylephrine, diphenhydramine, and chlorpheniramine--ingredients, which in certain doses, can be dangerous to kids, sometimes causing death. KLTV,

FDA Gives Oct 31 Deadline To Manufacturers Of Unapproved Children ...  -  Sep 28, 2007
Nearly 69 reports of deaths associated with antihistamine medicines containing diphenhydramine, brompheniramine or chlorpheniramine were also found on AHN

Symposium: Freud's legacy – does medication = healing?  -  Sep 21, 2007
...including clonidine, valproic acid, depakote, dextromethorphan and chlorpheniramine. As if the death of their only child wasn't enough to endure, WorldNetDaily,

Kids' cold drugs pulled from shelves  -  Oct 12, 2007
The FDA also found that 69 deaths of children were linked to antihistamines that contained diphenhydramine, brompheniramine and chlorpheniramine. Sauk Valley Newspapers,

Its Time To Sue Doctors Who Prescribe Drugs Off-Label Part II  -  Aug 17, 2007
..."In this case," Dr Jackson says, "the primary culprits were dextromethorphan and chlorpheniramine, an antihistamine which also boosts serotonin levels. Lawyers and Settlements,

Junta Warns against Some Imported Medicine, Toothpaste  -  Aug 24, 2007
Ltd; and Tiffy Syrup (N-Acetyl-Paminophenol 120mg, Phenylephrine HCL 5mg Chlorpheniramine Maleate 1mg/5ml), produced by Thai Nakorn Patana Co., The Irrawaddy News Magazine,

Oahu pilot killed in '04 crash was on cold medications  -  Aug 8, 2007
A toxicological analysis of the pilot found that he had taken a number of common cold medications: chlorpheniramine, an antihistamine; dextrorphan and Honolulu Advertiser,

Prompt action has been taken: Naveen  -  Jul 31, 2007
Newindpress (subscription),Only one chlorpheniramine maleate strip was found to be empty. The company explained that the empty strip was due to technical problem and offered to

Pleasantville man enters not guilty plea in Yonkers cough-syrup ...  -  Jul 31, 2007
White Plains Journal News,According to the District Attorney's Office, Shreiqein had high levels of dextromethorphan and chlorpheniramine - chemical components of cough medicine - in

Some drugs that can cause memory loss  -  Jun 28, 2007
Owings Mills Times,A sampling: Antihistamines, including diphenhydramine (Benadryl, Excedrin PM and Tylenol PM), promethazine (Phenergan), chlorpheniramine (Chlor-Trimeton)

SHEA BUTTER, LIME: Effective natural therapy for dry cough ...  -  Jun 28, 2007
Nigerian Tribune,...are those that contains paracetamol, dextromethorphan hydrobromide, caffeine anhydrous and chlorpheniramine maleate, popularly refers to as piriton.

Hay fever drugs ‘cost students an exam grade’  -  Jun 13, 2007
Times Online,Dr Walker said that the sedating treatments, containing the drug chlorpheniramine and most usually sold under the name Piriton, adversely affected exam

First aid for insect bites, stings is easy  -  Jun 25, 2007
Lansing State Journal,Take an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy) or chlorpheniramine maleate (Chlor-Trimeton, Teldrin).

Pharma's best kept secret  -  Jun 8, 2007
Express Pharma,Resinates of propanolol, chlorpheniramine maleate and phenyl propanolamine have been described to show sustained release. Manek and Kamat evaluated Indion

BCP Veterinary Pharmacy's Transdermal Gels are Easy Way to ...  -  Jun 6, 2007
PR Newswire (press release),...prednisolone, methimazole, enrofloxacin, clomipramine, diltiazem, chlorpheniramine, diphenhyrdamine, metronidazole, amlodipine and phenylpropanolamine.

Brand Names/Synonyms:
Chlorpheniramine is also known by the following brand names and/or synonymsAller-Chlor; Allergican; Allergisan; Antagonate; Chlo-Amine; Chlor-Trimeton; Chlor-Trimeton Allergy; Chlor-Trimeton Repetabs; Chlor-Tripolon; Chlorate; Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloropiril; Chloroprophenpyridamine; Chlorphenamine; Chlorpheniramine; Chlorpheniramine Maleate; Chlorprophenpyridamine; Clorfeniramina; Cloropiril; Dexchlorpheniramine; Dexchlorpheniramine Maleate; Efidac 24 Chlorpheniramine Maleate; Gen-Allerate; Haynon; Histadur; Kloromin; Mylaramine; Novo-Pheniram; Pediacare Allergy Formula; Phenetron; Piriton; Polaramine; Polaronil; Pyridamal 100; Telachlor; Teldrin

Drug Category:
Chlorpheniramine is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Antihistamines; ATC:R06AB02

Dosage Forms:
Tablet (chlorpheniramine maleate)

Absorption:
Well absorbed by gastrointestinal tract

Interactions:
Interactions for Chlorpheniramine:

Substrate of CYP2D6 (minor), 3A4 (major); Inhibits CYP2D6 (weak).

Increased toxicity (CNS depression): CNS depressants, MAO inhibitors, tricyclic antidepressants, phenothiazines.

CYP3A4 inhibitors: May increase the levels/effects of chlorpheniramine. Example inhibitors include azole antifungals, ciprofloxacin, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, and verapamil.

Chemical IUPAC Name:
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine

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