Chloroprocaine

This page contains recent news articles, when available, and an overview of Chloroprocaine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Chloroprocaine (when available)

Pharmacology and use:
Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic. For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.

Mechanism Of Action:
Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Chloroprocaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

News Articles on Chloroprocaine

Direct control of paralysed muscles by cortical neurons  -  Oct 15, 2008
Wrist muscles were then paralysed by injecting anaesthetic (3% chloroprocaine or 2% lidocaine, each with 1:100000 adrenaline) into catheters or cuffs Nature.com (subscription),

Paul McCartney Probably Doing It With That Rich American Lass Now  -  Apr 1, 2008
But give her an injection of Chloroprocaine, a blindfold and a piece of wood to bite down on and she won't even feel a thing. hecklerspray,

The SCPI Stem Cell Implant The Protocol  -  Jul 26, 2007
TransWorldNews (press release),...after disinfecting the skin with an iodine solution, 10 cc of the local anesthetic procaine HCL 2% or analogs (chloroprocaine, bupivacaine) is used,

Ser polymorphism healthcare workers and vehemently outbreak.  -  Jun 12, 2007
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Ser polymorphism overall population havoc that premises.  -  Jun 12, 2007
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Abraxis BioScience Completes Acquisition of the AstraZeneca US ...  Jun 28, 2006
EMLA(R) Cream (Eutectic Mixture of Lidocaine and Prilocaine), Xylocaine(R) (lidocaine), Polocaine(R) (mepivacaine), Nesacaine(R) (chloroprocaine HCl Injection ... -Genetic Engineering News

Abraxis BioScience Announces Co-Promotion Agreement with ...  Apr 26, 2006
...including EMLA(R) (Eutectic Mixture of Lidocaineand Prilocaine), Xylocaine(R) (lidocaine), Polocaine(R) (mepivacaine),Nesacaine(R) (chloroprocaine HCl Injection ... - Finanzen.net

Abraxis BioScience Announces Co-Promotion Agreement with ...  Apr 27, 2006
EMLA(R) (Eutectic Mixture of Lidocaine and Prilocaine), Xylocaine(R) (lidocaine), Polocaine(R) (mepivacaine), Nesacaine(R) (chloroprocaine HCl Injection, USP ... - PharmaLive.com

Brand Names/Synonyms:
Chloroprocaine is also known by the following brand names and/or synonymsAstracaine 4%; Astracaine 4% Forte; CHLOROPROCAINE; Carbocaine; Carbocaine with Neo-Cobefrin; Chirocaine; Chlor-Procaine; Chloroprocain; Chloroprocaine; Chloroprocaine Hcl; Chloroprocainum [Inn-Latin]; Chlorprocaine; Chlorprocainum; Citanest Forte; Citanest Plain; Cloroprocaina [Inn-Spanish]; Dalcaine; Dilocaine; Duranest; Duranest-Mpf; HSDB 3301; Halestyn; Isocaine; Isocaine 2%; Isocaine 3%; L-Caine; Lidoject-1; Lidoject-2; Marcaine; Marcaine Spinal; Nesacaine; Nesacaine-Ce; Nesacaine-Mpf; Novocain; Octocaine; Octocaine-100; Octocaine-50; Piocaine; Polocaine; Polocaine-Mpf; Pontocaine; Sensorcaine; Sensorcaine Forte; Sensorcaine-Mpf; Sensorcaine-Mpf Spinal; Septocaine; Ultracaine D-S; Ultracaine D-S Forte; Xylocaine; Xylocaine 5% Spinal; Xylocaine Test Dose; Xylocaine-Mpf; Xylocaine-Mpf with Glucose

Drug Category:
Chloroprocaine is categorized under the following by the FDA: Anesthetics; Local Anesthetics; ATC:N01BA04

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Interactions for Chloroprocaine:

The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. Concurrent use of these agents should generally be avoided. In situations when concurrent therapy is necessary, careful patient monitoring is essential.

Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

The para-aminobenzoic acid metabolite of chloroprocaine inhibits the action of sulfonamides. Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed.

Chemical IUPAC Name:
2-diethylaminoethyl4-amino-2-chloro-benzoate

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