Cetirizine

This page contains recent news articles, when available, and an overview of Cetirizine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Cetirizine (when available)

Pharmacology and use:
Cetirizine, the active metabolite of the piperazine H₁-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis. For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria

Mechanism Of Action:
Cetirizine competes with histamine for binding at H₁-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.

News Articles on Cetirizine

Private-label OTC Drugs Post Solid Gains in 2008, According to Kline  -  ‎Apr 8, 2009‎
...as well as its equivalent private-label cetirizine; feminine products was the other area that grew 7.3% in 2008 as a result of strong sales growth of PR Newswire (press release)

Abington man faces drug charges  -  ‎Apr 6, 2009‎
He was charged with possession of Class E Loratadine, Detrol LA, Cetirizine Hydrochloride, Zoloft, and Class C Diazepam. Dyer also was charged with driving Enterprise News

Spring Allergy Survival Guide: When Do You Need To See The Doctor?  -  ‎Apr 18, 2009‎
Longer-lasting alternatives are loratidine (Claritin) or cetirizine (Zyrtec), which typically don't cause drowsiness and come in once-a-day formulas. Medical News Today (press release)

PBMs Are Taking New Steps to Influence Consumer Behavior, Push ...  -  ‎Apr 8, 2009‎
He points, as an example, to the brand allergy medicine Zyrtec (cetirizine), which costs $91 as a brand, $25 as an OTC brand, and $16 as the CVS generic OTC Atlantic Information Services, Inc.

Too busy to see your GP? Then ask me  -  ‎Apr 4, 2009‎
Avoid antihistimines with a sedating side-effect, such as chlorphenamine (Piriton), in favour of “non-drowsy�? treatments such as cetirizine (Zyrtec). Times Online

Allergic rhinitis: market evolution  -  ‎Apr 3, 2009‎
In the United States, loratadine (Claritin and Alavert) and cetirizine (Zyrtec) have been the major antihistamine entrants into the OTC market. Nature.com (subscription)

De l'intérêt du Dossier Pharmaceutique…  -  ‎Apr 9, 2009‎
Il suggère un autre médicament, comme le Cetirizine®. Environ 10 à 20 % des interactions nécessitent une intervention de la part du pharmacien. Senior Actu

09年执业西�?�师�?�物化  -  ‎Apr 16, 2009‎
...将乙二胺类�?�物的两个氮原�?�?用一个乙基环�?��?�演�?�出哌嗪类�?�物，也具有抗过�?作用，这类�?�物最终�?�展出西替利嗪（Cetirizine）等，作用强而�?久，且无镇�?�作用。青年人

Achoo! Mulberry woes in Valley nothing to sneeze at  -  18 Mar 2009
Cetirizine, commonly known as Zyrtec, is somewhat sedating but not as much as other over-the-counter drugs. Seggev says some over-the-counter allergy drugs Las Vegas Review - Journal

Orchid Pharma gets USFDA nod for Cetirizine Hydrochloride tablet  -  ‎Feb 22, 2009‎
...received ANDA (Abbreviated New Drug Application) approved from US Food and Drug Administration (US FDA) for its drug Cetirizine Hydrochloride tablet. Myiris.com

Ash, elm trees pollen starts the allergy season  -  ‎Mar 4, 2009‎
We now have Zyrtec over-the-counter or Cetirizine (generic Zyrtec). These are good antihistamines, they are safe." Shubert said his waiting room is full of KTAR.com

Synthon announces European approvals for Levocetirizine  -  ‎Mar 4, 2009‎
The product contains the active ingredient levocetirizine, which is the enantiopure form of cetirizine, the active ingredient in UCB’s product Zyrtec®. PharmaLive.com (press release)

Drixoral: Why the Allergy Medicine Isn't Available, and What to ...  -  ‎Mar 9, 2009‎
Newer over-the-counter antihistamines, such as Claritin (loratadine) and Zyrtec (cetirizine), can be purchased in formulations that also contain a U.S. News & World Report

Video: Experts Unite to Help People Manage Spring Nasal Allergy ...  -  ‎Mar 2, 2009‎
The use of XYZAL(R) is contraindicated in: patients with a known hypersensitivity to levocetirizine or any of the ingredients of XYZAL(R) or to cetirizine PharmaLive.com (press release)

Simple Steps Can Make A Big Difference In Managing Nasal Allergies  -  ‎Feb 25, 2009‎
Note: Do not take XYZAL if you are allergic to XYZAL, cetirizine or ZYRTEC®. Be sure to tell your doctor if you have kidney disease. North American Press Syndicate

UCB warding off effects of patent expiries  -  ‎Mar 4, 2009‎
The results were particularly impressive given that sales of Zyrtec (cetirizine) sank 49% to 249 million euros. Its follow-up Xyzal (levocetirizine) brought Pharma Times

Full Year 2008 Financial Results: UCB continues on track  -  ‎Mar 3, 2009‎
Absorbing the expected loss of the Zyrtec® (cetirizine) patent and exclusivity for Keppra® (levetiracetam) in the US, total revenue reached EUR 3 601 PipelineReview.com (press release)

UCB : résultats 2008 miné par des éléments non-récurrents.  -  ‎Mar 3, 2009‎
Le chiffre d'affaires de 3 601 millions d'euros reste stable (-1% réel, +4% CCC), reflétant l'impact prévu de la perte d'exclusivité de Zyrtec (cetirizine) Boursorama

Major pharma contamination in India reported  -  Jan 26, 2009
According to one of Larsson’s studies, ciprofloxacin and the antihistamine cetirizine were found in the wells of six villages tested, but at measures “far Water Technology Online,

Antihistamines and decongestants  -  Jan 21, 2009
Some common antihistamine medicines for children include (with their brand names): cetirizine (Benadryl Allergy), loratidine (Clarityn Allergy Syrup) and guardian.co.uk,

The flowing  -  Jan 31, 2009
Ciprofloxacin, the antibiotic, and the popular antihistamine cetirizine had the highest levels in the wells of six villages tested. New Straits Times,

Pfizer's acquisition of Wyeth brings scale but will fail to ...  -  Feb 1, 2009
The hypertension therapy Norvasc (amlodipine) lost patent exclusivity in 2007, as did the Zyrtec (cetirizine) franchise, indicated for allergic rhinitis. PipelineReview.com (press release),

Govt plans to set up generic stores across the country  -  Feb 3, 2009
Under the initiative, anti-allergic drug Cetirizine would be offered at Rs 2.50 per strip, which is sold at Rs 27 in the market. Hindu,

India to probe drugs in water supplies discovered by Swedish ...  -  Jan 28, 2009
Larsson's data, presented at a US scientific conference in November, found ciprofloxacin, an antibiotic, and the popular antihistamine cetirizine in the The Canadian Press,

Pfizer net income falls 90% and confirms more job cuts  -  Jan 27, 2009
Generic competition battered sales of the antihistamine Zyrtec (cetirizine), down 99% to $4 million, the colorectal cancer drug Camptosar (irinotecan), Pharma Times,

What treatments work for sinusitis?  -  Jan 21, 2009
Some examples are acrivastine (brand name Benadryl Allergy Relief), cetirizine (Zirtek) and chlorphenamine (Piriton). Some antihistamines can make you guardian.co.uk,

What treatments work for hay fever?  -  Jan 21, 2009
Some of the most common antihistamines (with brand names) are loratadine (Clarityn, Boots Hayfever and Allergy Relief All Day), cetirizine (Zirtek) and guardian.co.uk,

The pollen season is here, and that means hay fever  -  Jan 21, 2009
Antihistamines you can buy over the counter include acrivastine (Benadryl Allergy Relief), cetirizine (Zirtek Allergy Relief) and loratadine (Clarityn). guardian.co.uk,

GSK buys UCB products in emerging countries for £483 million  -  Jan 26, 2009
...in certain countries, including the epilepsy blockbuster Keppra (levetiracetam), allergy drugs Xyzal (levocetirizine) and Zyrtec (cetirizine). Pharma Times,

Les médicaments pas chers empoisonnent les eaux en Inde  -  Jan 28, 2009
Joakim Larsson a révélé il ya quelques semaines que l’antibiotique mais aussi l’antihistaminique Cetirizine sont présents à haute dose dans les puits de six Tribune de Genève,

Jan Aushadhi to distribute essential medicines  -  Dec 19, 2008
These generic stores would provide most common unbranded drugs sold with the name of salts like paracetamol (for fever), cetirizine (anti-allergic), Newstrack India,

December 2008 Mayo Clinic Health Letter Highlights: Colorectal ...  -  Dec 9, 2008
...legs syndrome -- Toprol-XL (metoprolol succinate) for blood pressure, heart failure and angina -- Zyrtec-D (cetirizine/pseudoephedrine) for allergies. MarketWatch

Management of HIV/AIDS in older adults  -  Dec 15, 2008
Drugs discussed: abacavir, alendronate, atazanavir, atorvastatin, cetirizine, cimetidine, darunavir, didanosine, efavirenz, ezetimibe, fluconazole, Drug Topics Magazine,

懷孕�?�哺乳期的感冒治療  -  Dec 8, 2008
...�?��?授乳)�?Diphenhydramine (�?��?授乳)�?或新一代長效抗組織胺藥物如Cetirizine uho優活�?�康網,

Perrigo Co. F1Q09 (Qtr. End 09/30/08) Earnings Call Transcript  -  Nov 6, 2008
The overall OTC plus cold market in the quarter is up 7% from last year primarily due to the launch of Zyrtec and store brand Cetirizine. Seeking Alpha,

Ranbaxy hopeful of an early resolution to USFDA ban  -  Nov 17, 2008
The drugs include Simvastatin, Lorazepam, Acyclovir, Minocycline, Clindamycin, Loratadine-D, Cetirizine, Acetaminophen Extended tablets, Lisinopril and Economic Times,

UCB's Cimzia shows promise in rheumatoid arthritis trials  -  Nov 18, 2008
...resulting from the loss of patent protection on its biggest earners – the allergy drug Zyrtec (cetirizine) and the antiepileptic Keppra (levetiracetam). Pharma Times (registration),

Perrigo Reports Record First Quarter Sales and Income  -  Nov 6, 2008
The sales increase resulted from $66.8 million in revenue from new product sales led by Omeprazole, several Cetirizine products and the newly launched SYS-CON Media,

UCB on track  -  Oct 31, 2008
...by a mid-single digit percentage rate compared to the same period in 2007, due to the loss of Zyrtec® (cetirizine) patent in the US in December 2007. istockAnalyst.com (press release),

McNeil Consumer Healthcare Supports Voluntary Initiatives to Help ...  -  Oct 30, 2008
...and also do not apply to single-ingredient allergy medicines such as CHILDREN'S ZYRTEC(R) (cetirizine) and CHILDREN'S BENADRYL(R) (diphenhydramine). HispanicBusiness.com (press release),

UCB boosted by US approval for epilepsy drug Vimpat  -  Oct 30, 2008
...from the loss of patent protection on the allergy drug Zyrtec (cetirizine) last year and the antiepileptic Keppra (levetiracetam) in the near future. Pharma Times (registration),

UCB bevestigt vooruitzichten  -  Oct 31, 2008
Het Belgische farmabedrijf UCB heeft in het derde kwartaal in lijn met de verwachtingen gepresteerd. UCB bevestigt eveneens de vooruitzichten voor het De Tijd,

Perennial Allergic Rhinitis And Chronic Urticaria In Children ...  -  Oct 16, 2008
Cypress' Cetirizine HCl Oral Solution is the AA-rated generic equivalent to McNeil Consumer Healthcare's Zyrtec® Oral Solution. The prescription version of Medical News Today (press release),

Cypress wins FDA approval for generic allergy drug  -  Oct 16, 2008
By Staff Writer Cypress's Cetirizine HCl oral solution is the AA-rated generic equivalent to McNeil Consumer Healthcare's Zyrtec oral solution. Pharmaceutical Business Review

McNeil Consumer Healthcare Supports Voluntary Initiatives to Help ...  -  Oct 7, 2008
...and also do not apply to single- ingredient allergy medicines such as CHILDREN'S ZYRTEC(R) (cetirizine) and CHILDREN'S BENADRYL(R) (diphenhydramine). 1. istockAnalyst.com (press release),

Cooler weather about all that brings relief to some allergy sufferers  -  Oct 6, 2008
Cetirizine is the generic form of Zyrtec. When buying over-the-counter drugs, Scott tells his patients to avoid medications with pseudoephedrine. Grand Junction Sentinel,

USP database details look-alike, sound-alike drugs  -  Oct 5, 2008
For example, a search found that the blood pressure medication clonidine was confused with the gout drug colchicine, the antihistamine cetirizine and the American Medical News (subscription)

US FDA BLOCKS IMPORT OF 30 DRUGS MADE BY INDIAN PHARMA RANBAXY  -  Oct 3, 2008
These drugs include Simvastatin, Acyclovir, Minocycline, Clindamycin, Lorazepam, Loratadine-D, Cetirizine, Acetaminophen Extended tablets, Lisinopril and Trading Markets (press release),

Seven medicines suspended  -  Oct 2, 2008
Serariben-F lô 050308, the batch 050308 by the Ho Chi Minh City Central Vidipha Pharmaceutical Joint Stock Company; Cetirizine, the batch EV801 by Nhan Dan,

UCB withdraws application for Vimpat, Takeda pulls ramelteon file  -  Sep 26, 2008
These three drugs need to plug the gap in sales resulting from the loss of patent protection on the allergy drug Zyrtec (cetirizine) last year and the Pharma Times (subscription),

사�?�프레스사 알레르기 복제약 ‘세티리진’경구용액 허가  -  Oct 19, 2008
...김윤�? 기�? 사�?�프레스 제약(Cypress Pharmaceutical)�?� FDA가 Cetirizine Hcl 경구용액 1mg/lml�?� 처방 �? 비 처방약으로 간�?� 신약 허가 신청�?� 접수 최종 허가 메디�?�뉴스,

�?ình chỉ lưu hành 7 loại thuốc kém chất lượng  -  Sep 27, 2008
Ngoài ra, viên nén bao phim Cetirizine, lô SX: EV801, ngày SX: 3-2008, S�?K: VN-2786-07 do Công ty Kausikh Therapeutics (P) Ltd, Ấn �?ộ SX bị đình chỉ lưu Tuổi Trẻ,

Thế nào là dị ứng thuốc? Vì sao bị dị ứng thuốc?  -  Oct 8, 2008
Cetirizine: Dạng viên 10mg dùng 1 viên/ngày. Thuốc không dùng cho phụ nữ mang thai, cho con bú và trẻ em dưới 12 tuổi. - Terfenadine: Dạng viên 60mg và VN Media,

�?ình chỉ lưu hành 7 loại thuốc kém chất lượng  -  Oct 5, 2008
Ngoài ra, Cục Quản lý dược VN cũng đình chỉ lưu hành viên nén bao phim cetirizine, lô SX: EV801, ngày SX: 3-2008, S�?K: VN-2786-07 do Công ty Kausikh Ngư�?i Lao �?ộng,

7 loại thuốc bị đình chỉ lưu hành  -  Sep 29, 2008
Và 2 loại thuốc không đạt tiêu chuẩn v�? độ hòa tan là viên nén bao phim cetirizine, lô EV801do Công ty Kausikh Therapeutics (P) Ltd, Ấn �?ộ sản xuất. Dân Trí,

Veel mensen met huidallergie door stoffen in consumentenproducten  -  Oct 11, 2008
Bij allergische huidreacties zijn anti-allergische middelen in tabletvorm het meest effectief, zoals bv. loratidine (Claritine®) of cetirizine (Zyrtec®). Medical facts,

Brand Names/Synonyms:
Cetirizine is also known by the following brand names and/or synonymsAlerlisin; CHEMBANK1856; Cetirizina [Spanish]; Cetirizine; Cetirizinum [Latin]; Cetrizine Hcl; Cetryn; Formistin; Hitrizin Film Tablet; Reactine; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Zyrtec

Drug Category:
Cetirizine is categorized under the following by the FDA: Anti-allergic Agents; Antihistamines; ATC:R06AE07; ATC:R06AE09

Dosage Forms:
tablets

Absorption:
mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine

Interactions:
Interactions for Cetirizine:

Pharmacokinetic interaction studies with cetirizine in adults were conducted with pseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were observed. In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. The disposition of theophylline was not altered by concomitant cetirizine administration.

Drug-Drug Interactions: No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses could have a greater effect.

Chemical IUPAC Name:
2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticacid

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