Cephalexin

This page contains recent news articles, when available, and an overview of Cephalexin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cephalexin
(when available)

Pharmacology and use:
Cephalexin is a first-generation cephalosporin antibiotic which is effective against most gram-positive bacteria. Cephalexin is used to treat otitis media and respiratory tract infections caused by susceptible staphylococci, Streptococcus pneumoniae, and group A beta-hemolytic streptococci. For the treatment of respiratory, skin, soft tissue, urintary tract infections caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Mechanism Of Action:
Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.

News Articles on Cephalexin

Pork Magazine and Pigs on Drugs  -  ‎Aug 25, 2009‎
The whole penicillian-pigs-and-cephalexin-cows-are-ruining-medicine thing is such powerful conventional wisdom that it's easy to accept ever-larger and more Reason Online

Six month investigation leads to arrest of three Waynoka residents  -  ‎Aug 27, 2009‎
One bottle contained Cephalexin 500 mg, pills used to treat infections, and another later identified by a pharmacy technician as Diclofenac Sodium, Alva Review-Courier

Help for Harry?  -  ‎Aug 19, 2009‎
Currently, he is on Benadryl, Doxicycline and Cephalexin to control his itching, treat what is possibly tick fever and his ear infections. Examiner.com

Mozart suffered from strep throat  -  ‎Aug 17, 2009‎
Antibiotics such as penicillin, cefdinir, cephalexin, and others are used to treat strep throat. Detecting strep throat can assist the doctor in providing eMaxHealth

MiddleBrook Pharmaceuticals Reports Second Quarter 2009 Results  -  ‎Aug 6, 2009‎
KEFLEX (cephalexin, USP) Capsules, is MiddleBrook's immediate-release first-generation cephalosporin antibiotic. KEFLEX has been shown to be active against PharmaLive.com (press release)

Case Study: Decontamination of Beta-Lactams in a Production ...  -  ‎Aug 18, 2009‎
From the Cephalosporin group, Cefadroxil, Cefazolin and Cephalexin were incorporated into the cocktail. Imipenem, of the Carbapenum group, was also inside Pharmaceutical Processing

HobNobMurfreesboro Raises Awareness to Free Prescriptions at ...  -  ‎Aug 13, 2009‎
These medicines include the following: Amoxicillin, Cephalexin, Sulfamethoxazole/Trimethoprim (SMZ-TMP), Ciprofloxacin (excluding ciprofloxacin XR), PR-USA.net (press release)

What is the best empiric therapy for community-acquired cellulitis?  -  13 Jul 2009
Meanwhile, culture of punch biopsy specimens yields a pathogen in only 20% to 30% of cases.3,17-19 Due to increased CA-MRSA incidence, cephalexin should not The Hospitalist Online

Antibiotic Resistance in Children with Recurrent or Complicated ...  -  ‎Jul 8, 2009‎
Empirical treatment with Trimethoprim-Sulfamethoxazole (TMP-SMX) or Cephalexin as the initial drug is ineffective. Nitrofurantoin and Nalidixic acid can be UroToday

best price on cialis  -  ‎Jul 10, 2009‎
Cephalexin And Photo Sun sept. Mrs. Gardiner was standing a few moments, he asked the scarecrow. ''the tin woodman were waiting on them. Glace Bay Gleaner

Pharyngitis: bacterial or viral?  -  ‎Jun 29, 2009‎
Streptococcus pyogenes can easily be treated with antibiotics such as penicillin, cephalexin, or amoxicillin. If you allergic to penicillin, erythromycin is Examiner.com

Man gets prison time for assault in Keene  -  ‎Jun 23, 2009‎
13. u Matthew M. Montgomery, 29, of Brattleboro pleaded guilty to possession of methadone, buprenorphine, oxycodone and cephalexin. The Keene Sentinel

Dilute bleach baths may ease eczema symptoms in children  -  ‎Jun 26, 2009‎
All were given oral cephalexin for 14 days to treat staph infections. Bacterial cultures and culture sensitivities were obtained from the nares and the most AAP News (subscription)

MiddleBrook Pharmaceuticals Secures $10 Million Revolving Line of ...  -  ‎Jul 1, 2009‎
MiddleBrook currently markets KEFLEX(R), the immediate-release brand of cephalexin, and MOXATAG - the first and only FDA-approved once-daily amoxicillin. FOXBusiness

调查显示:澳洲医è?¯è¡¥è´´è®¡åˆ’作用紊乱  -  ‎Jun 17, 2009‎
...消费者使用补贴计划购买抗生素Cephalexin需è¦?支付15.76元,而ç§?人处方å?ªéœ€6.99元。 领å?–救济金的人在PBS下æ¯?个处方å?ªéœ€ä»˜5.30元,而用ç§?人处方购买有些è?¯ç”šè‡³æ›´ä¾¿å®œã€‚ 大纪元

Father charged in child's death  -  ‎Apr 1, 2009‎
...a glass smoking pipe, Clonazepam, Fluoxetine, Cephalexin, Levaquin, Loestrin and several unknown pills in the bedroom that Kohn and his son shared. Phoenixville News

MiddleBrook Pharmaceuticals Schedules Conference Call and Webcast ...  -  ‎Apr 6, 2009‎
MiddleBrook currently markets KEFLEX, the immediate-release brand of cephalexin, and MOXATAG – the first and only FDA-approved once-daily amoxicillin. Business Wire (press release)

S. aureus cultured from nares did not match wound isolates in many ...  -  ‎Mar 30, 2009‎
...with skin and soft tissue infections participating in a trial conducted to compare cephalexin and clindamycin as outpatient treatments. Pediatric SuperSite

Endocarditis Prophylaxis: Who and When?  -  ‎Apr 6, 2009‎
If the adult patent is intolerant to penicillins or ampicillin, cephalexin 2 g orally or 50 mg/kg in children, clindamycin 600 mg or 20 mg/kg in children ADVANCE for Physician Assistants

LWSN, CERS, MBRK  -  ‎Apr 8, 2009‎
MiddleBrook currently markets KEFLEX, the immediate-release brand of cephalexin, and MOXATAG - the first and only FDA-approved once-daily amoxicillin. TMC Net

Acute Exercise-induced Bilateral Thigh Compartment Syndrome  -  18 Mar 2009
A 10-day course of oral cephalexin resulted in resolution of infectious signs. Three and a half months later, the right thigh wound developed a draining Ortho SuperSite

Local Pharmacy Makes Mistake With Child’s Prescription  -  ‎Mar 16, 2009‎
One bottle read amoxicillin and the other read cephalexin. “She had been taking the cephalexin. She took three doses of it, which are two teaspoons each,“ NBC4i.com

10-K: MIDDLEBROOK PHARMACEUTICALS, INC.  -  ‎Mar 13, 2009‎
Initially we are focused on developing PULSYS product candidates utilizing approved and marketed drugs such as amoxicillin and cephalexin. MarketWatch (press release)

Company Profile for MiddleBrook Pharmaceuticals, Inc.  -  ‎Mar 13, 2009‎
MiddleBrook currently markets KEFLEX, the immediate-release brand of cephalexin, and MOXATAG – the first and only FDA-approved once-daily amoxicillin. Business Wire (press release)

Free prescription antibiotics?  -  ‎Mar 2, 2009‎
The list of eight includes: Amoxicillin, Ampicillin, Cephalexin, Ciprofloxacin, Doxycycline, Erythromycin, Penicillin, Trimeth/Sulfa. ConnectAmarillo.com powered by KVII

MiddleBrook Pharmaceuticals Reports 2008 Fourth Quarter and Full ...  -  ‎Mar 5, 2009‎
MiddleBrook currently markets KEFLEX, the immediate-release brand of cephalexin, and MOXATAG – the first and only FDA-approved once-daily amoxicillin. Business Wire (press release)

MiddleBrook Pharmaceuticals' Nationwide Field Sales Force Hired  -  ‎Feb 25, 2009‎
KEFLEX, immediate-release (cephalexin USP) capsules, is a first-generation cephalosporin antibiotic shown to be active against strains of both gram- Business Wire (press release)

MiddleBrook Pharmaceuticals to Webcast Management Presentation at ...  -  ‎Mar 2, 2009‎
MiddleBrook currently markets KEFLEX ® , the immediate-release brand of cephalexin, and MOXATAG – the first and only FDA-approved once-daily amoxicillin. American Digital Networks (press release)

Community-Acquired MRSA in Children  -  ‎Feb 20, 2009‎
We can't just send people home on cephalexin anymore, because MRSA is resistant to that antibiotic. So we give them a prescription for rifampin, ADVANCE for LPNs

Understanding Antibiotic Resistance: Finland and Why We Need a ...  -  ‎Mar 2, 2009‎
Cephalexin (cefalexin) or cefadroxil, trimethoprim-sulfamethoxazole, and amoxicillin (amoxicilline) are recommended for use as second-line drugs. ScienceBlogs

Efficacy of Amitraz plus Metaflumizone for the treatment of canine ...  -  ‎Mar 5, 2009‎
The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot-on formulation at two weeks intervals until two consecutive skin 7thSpace Interactive (press release)

StandoutStocks.com: "Stocks that Standout" picks for today are ...  -  ‎Feb 20, 2009‎
MiddleBrook currently markets KEFLEX(R), the immediate-release brand of cephalexin, and will begin promoting MOXATAG(TM) - the first and only FDA-approved Trading Markets (press release)

India's drug industry remains strong  -  ‎Mar 6, 2009‎
Ranbaxy's top five brands - amoxicillin antibiotic Mox, with sales of rupees (Rs) 1.093bn ($20.8m), multivitamin Revital (Rs880m), cephalexin antibiotic ICIS (subscription)

MiddleBrook Pharmaceuticals Schedules Conference Call and Webcast ...  -  ‎Feb 19, 2009‎
MiddleBrook currently markets KEFLEX ® , the immediate-release brand of cephalexin, and will begin promoting MOXATAG™ – the first and only FDA-approved PharmaLive.com (press release)

MiddleBrook Pharmaceuticals Retains Almac Pharma Services(r) to ...  -  04 Feb 2009
The Company currently markets the Keflex brand of cephalexin and has received regulatory approval for MOXATAG -- the first and only once-daily amoxicillin GlobeNewsWire (press release),

Grocer to Offer Free Antibiotics  -  Feb 2, 2009
The drugs are: Amoxicillin, Cephalexin: Sulfamethoxazole/Trimethoprim, Ciprofloxacin, Penicillin VK, Ampicillin, Doxycycline and Erythromycin. WHSV,

Treatment options for respiratory infections  -  Jan 27, 2009
In practice, however, such first-generation cephalosporins as cephalexin (Keflex) are often used. This is because cephalexin has repeatedly led to higher Clinical Advisor,

More Mid-Atlantic Chains Offer Free Antibiotics  -  Jan 14, 2009
The drugs in the ShopRite program include: amoxicillin, ampicillin, bacitracin, cephalexin, ciprofloxacin, doxycycline, erythromycin, penicillin VK, Supermarket News,

What treatments work for cellulitis and erysipelas?  -  Jan 21, 2009
Kiani R. Double-blind, double-dummy comparison of azithromycin and cephalexin in the treatment of skin and skin structure infections. guardian.co.uk,

Health Connection: News Briefs  -  Jan 28, 2009
Antibiotics included in ShopRite's program include: Amoxicillin, Ampicillin, Bacitracin, Cephalexin, Ciprofloxacin, Doxycycline, Erythromycin, Penicillin VK Vineland Daily Journal,

Local Business Report: News agent reports NJ Lottery winnings  -  Jan 16, 2009
Antibiotics included in ShopRite's program are: Amoxicillin, Ampicillin, Bacitracin, Cephalexin, Ciprofloxacin, Doxycycline, Erythromycin, Penicillin VK and Vineland Daily Journal,

Sun Pharma Reports Continuing Growth in Q3  -  Jan 30, 2009
Sun Pharma site at Karkhadi (erstwhile Phlox Pharma) near Vadodara in India received a USFDA approval for manufacturing of generic cephalexin capsules. ITNews,

Wegmans will offer free generic antibiotics  -  Jan 9, 2009
The program will cover a 14-day supply of generic oral antibiotics Amoxicillin, Cephalexin, Sulfamethoxazole/Trimethoprim, Ciprofloxacin (excluding Citizens Voice,

Business Digest  -  Jan 18, 2009
The program includes the medications: amoxicillin, ampicillin; bacitracin ophthalmic ointment; cephalexin; ciprofloxacin, excluding ciprofloxacin XR; Annapolis Capital,

MiddleBrook Pharmaceuticals To Launch Moxatag March 2009  -  Jan 12, 2009
The Company currently markets the Keflex brand of cephalexin and has received regulatory approval for Moxatag - the first and only once-daily amoxicillin Logistics Online (press release),

Police Reports  -  Dec 17, 2008
The assistant principal told deputies the boy had a prescription drug bottle containing Cephalexin — an antibiotic — that did not have his name on it. Arizona Daily Star,

The Importance of Compliance  -  Nov 30, 2008
Right after you take a drug like cephalexin or amoxicillin, the concentration is very high. Over the next 8 hours, the concentration falls. seattlepi.com Mariners blog

DSM NV (AMS:DSM) DSM To Divest DSM Deretil In Management Buy-out  -  Nov 27, 2008
DSM Anti-Infectives DSM Anti-Infectives is the world's leading supplier of active pharmaceutical ingredients such as amoxicillin, ampicillin, cephalexin and ABN Newswire (press release),

Middlebrook Pharmaceuticals Opens Administrative and Sales Office ...  -  Dec 4, 2008
The Company currently markets the Keflex brand of cephalexin and has received regulatory approval for Moxatag -- the first and only once-daily amoxicillin PR Newswire (press release),

CORRECTED - UPDATE 3-Targanta drug seen similar to rivals-FDA  -  Nov 18, 2008
Cephalexin is also sold in various forms, including Keflex by Middlebrook Pharmaceuticals Inc (MBRK.O: Quote, Profile, Research, Stock Buzz), Reuters

High Growth Reported for the World Pharmaceuticals Market Brief  -  Nov 18, 2008
Cephalexin, and Warfarin 8 Table 6: Leading Generic Drugs Worldwide by Total Units Dispensed (2005): Annual Estimates in Millions for Hydrocodone/APAP, MarketWatch

MiddleBrook Pharmaceuticals Reports Third Quarter 2008 Financial ...  -  Nov 13, 2008
The decline is due primarily to the third quarter 2007 write-off of obsolete immediate-release Keflex (cephalexin USP) capsules inventory. CNNMoney.com (press release)

DSM to divest DSM Deretil in management buy-out  -  Nov 18, 2008
DSM Anti-Infectives is the world's leading supplier of active pharmaceutical ingredients such as amoxicillin, ampicillin, cephalexin and cefadroxil, MarketWatch

Targanta Presents Efficacy and Safety Data for Oritavancin for the ...  -  Oct 26, 2008
This study assessed the frequency and nature of HLIRs in two randomized, double-blind phase 3 studies comparing oritavancin with vancomycin/cephalexin in MarketWatch

DSM to divest DSM Deretil in management buy-out  -  Nov 18, 2008
DSM Anti-Infectives is the world's leading supplier of activepharmaceutical ingredients such as amoxicillin, ampicillin,cephalexin and cefadroxil, International Business Times,

Polypharmacy raises risks of side effects, skipped pills  -  Nov 16, 2008
...partner prescribed hydrochlorothiazide for mild lower extremity edema and a one-week course of cephalexin to treat an area of cellulitis in his forearm. American Medical News (subscription)

Rite Aid Expands List of Generic Medications Available at ...  -  Nov 13, 2008
...drugs such as the common antibiotics amoxicillin and cephalexin, amlodipine or simvastatin to treat cardiovascular conditions, loratadine for allergies, WELT ONLINE,

Antibiotic Use Is a Flashing Indicator for Cancer Risk  -  Nov 11, 2008
...not only the class of fluoroquinolones, known to be carcinogenic, but also such antibiotics as tetracycline, erythromycin, penicillin VK and cephalexin. Natural News.com,

MiddleBrook Pharmaceuticals Announces Orange Book Listing of ...  -  Nov 6, 2008
MiddleBrook currently markets the Keflex brand of cephalexin and has received regulatory approval for Moxatag -- the first and only once-daily amoxicillin SYS-CON Brasil,

Best Practices to Treat Urinary Tract Infections Reviewed  -  Oct 31, 2008
For recurrent UTI, continuous prophylaxis is recommended for 6 months, with nightly dosing of nitrofurantoin 100 mg, cephalexin 250 mg, Medscape (registration)

MiddleBrook Pharmaceuticals Schedules Conference Call and Webcast ...  -  Oct 30, 2008
The Company currently markets the KEFLEX(R) brand of cephalexin and has received regulatory approval for MOXATAG(TM) - the first and only once-daily PR Newswire (press release),

Journal of the American Podiatric Medical Association  -  Nov 18, 2008
A pyrazinone allergenic degradation product of cefaclor and cephalexin was identified. 10 , 23 Also, cephalothin was shown to be cross-reactive Journal of the American Podiatric Medical Association (subscription)

MiddleBrook Pharmaceuticals Hires Key Commercial Team Members  -  Nov 19, 2008
The Company currently markets the Keflex brand of cephalexin and has received regulatory approval for Moxatag - the first and only once-daily amoxicillin PR Newswire (press release),

Free antiobiotics  -  Nov 6, 2008
Included in the promotion are Amoxicillin, Cephalexin, Ampicillin, Sulfamethoxazole/Trimethoprim (SMZ-TMP) , Ciprofloxacin (excluding Ciprofloxacin XR), Canton Repository (subscription),

Brand Names/Synonyms:
Cephalexin is also known by the following brand names and/or synonymsAlcephin; Alexin; Alsporin; Biocef; CEX; Carnosporin; Cefa-Iskia; Cefablan; Cefadal; Cefadin; Cefadina; Cefaleksin; Cefalessina [Dcit]; Cefalexin; Cefalexin Sodium; Cefalexina [Inn-Spanish]; Cefalexine [Inn-French]; Cefalexinum [Inn-Latin]; Cefalin; Cefaloto; Cefaseptin; Cefax; Ceforal; Cefovit; Celexin; Cepastar; Cepexin; Cephacillin; Cephalexin; Cephalexin Hydrate; Cephalexin Monohydrate; Cephalexine; Cephalexinum; Cephanasten; Cephaxin; Cephin; Cepol; Ceporex; Ceporex Forte; Ceporexin; Ceporexin-E; Ceporexine; Check; Cophalexin; Durantel; Durantel Ds; Ed a-Ceph; Erocetin; Factagard; Felexin; Fexin; HSDB

Drug Category:
Cephalexin is categorized under the following by the FDA: Anti-bacterial Agents; Cephalosporins; ATC:J01DB01

Dosage Forms:
SUSPENSION; TABLET

Absorption:
It is rapidly absorbed after oral administration by the gastrointestinal tract

Interactions:
-->Interactions for Cephalexin:

Metformin ó In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.

Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.

Probenecid ó As with other b -lactams, the renal excretion of cephalexin is inhibited by probenecid.

Drug / Laboratory Test Interactions

As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions and also with Clinitest® tablets.

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Chemical IUPAC Name:
8-(2-amino-2-phenyl-acetyl)amino-4-methyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

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