|
 |
CelebrexThis page contains recent news articles, when available, and an overview of Celebrex but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Celebrex (when available) Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Celecoxib is used to treat rheumatoid arthritis, osteoarthritis, and familial adenomatous polyposis (FAP). It is not known if there are any effects of Celecoxib on platelets. For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis Mechanism Of Action: The mechanism of action of Celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (COX-1 and COX-2), Celecoxib is a noncompetitive inhibitor of cyclooxygenase-2 (COX-2) enzyme. It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. News Articles on Celecoxib Five Ways To Reduce Inflammation Naturally - Aug 28, 2009 ...to get rid of and instead choose to medicate our pain, swelling, or stiffness with drugs like Advil or Celebrex in an attempt to relieve the discomfort. Huffington Post Real death panels - Aug 20, 2009 So my doctor prescribed a non-steroidal anti-inflammatory medicine (Celebrex). It is not a new or experimental medicine, but there is no generic. Salt Lake Tribune It seems the McGuinty Government just can't get it right - Aug 27, 2009 As well, pain relief medications Celebrex and Oxycontin patents will expire. That's the good tidings; the disturbing news is that the government will Northumberland Today Low sodium levels - Aug 9, 2009 The foot doctor said I had to be off Celebrex until the foot completely healed. I had been on it for several years. I have osteoporosis and rheumatoid Sarasota Herald-Tribune Ohio State Cancer Drug Begins Clinical Trials Testing - Aug 29, 2009 Chen and his colleagues used the anti-inflammatory drug, drug celecoxib ( Celebrex ), a nonsteroidal anti-inflammatory drug, or NSAID, as a starting point Media Newswire (press release) Gen-Y Physicians Take Ethical High Road with Pharma and Medical ... - Aug 17, 2009 Celebrex has been associated with an increased risk for heart attack and stroke. As the incident at Harvard Medical School demonstrates, at least for the DARKDaily.com - Laboratory News Turmeric Extract for Your Joints, Not Just Your Spice Rack - Aug 17, 2009 Turmeric has been shown in studies to inhibit the production of COX-2, in a way comparable to the pharmaceutical COX-2 inhibitors such as Celebrex, Christian Post Wellemeyer scratched for Tuesday - Aug 10, 2009 I'll take some time off and try some Celebrex and see what happens. It's pretty much the way the year has gone. But we'll get back on track. StlCardinals.com Child Abuse to Eating Disorders -- It Shows In Your Teeth - Aug 18, 2009 Decrease in saliva (dry mouth) – This often happens with certain medications (eg: Celebrex and asthma treatments). Saliva helps maintain alkalinity levels EmpowHer Price Gouging And Excess Profits - Aug 17, 2009 ...the active ingredients used in manufacturing them: Celebrex - 21712%; Claritin - 30306%; Lipitor -- 4696%; Prevacid -- 34136%; and Prilosec -- 69417 %. GOPUSA Pfizer Finalizes Another Lawsuit Over Their Products - Aug 5, 2009 Drugs like Bextra, Celebrex, and Vioxx have all been recalled for causing problems and even death in patients who've taken the drug. TestCountry.com Patients Are Reminded of Aspirin's Risks - Aug 12, 2009 A clinical trial of another COX-2 inhibitor, celecoxib, which has the brand name Celebrex, is in the planning stages and will be enrolling patients early New York Times BUYINS.NET: GE, RF, WFC, F, PFE, LVS With Highest Daily Short ... - Aug 28, 2009 It also provides Celebrex for arthritis pain, and inflammation and acute pain; Vfend for esophageal candidiasis and blood stream infections; Trading Markets (press release) In case you're puzzled, just question a doctor - Aug 26, 2009 ...→If a tree falls in the woods and no one is around, would Celebrex be right for the tree? →Do people ever see you for treatment of headaches, backaches, NewsOK.com Susan Dorey's Journey to Find Relief from Rheumatoid Arthritis ... - Aug 25, 2009 ..."My rheumatoid arthritis was so severe that I took antibiotics daily, Celebrex twice a day, weekly gold injections, Advil in the morning, and Tylenol for PR Web (press release) Sifma: "No Purpose Served" By Extending the Time Limit To Sue for ... - Aug 19, 2009 ...with Harvard University that found an increased risk of heart attack in patients taking Vioxx, compared to patients taking Celebrex or a placebo. Securities Industry News (subscription) Cephalon, Inc. Q2 2009 Earnings Call Transcript - Aug 4, 2009 As a result of the exchange of our note for the elimination of any financial obligations with respect to injectable CELEBREX, Acusphere will no longer be Seeking Alpha Patients', drug plans' costs drop as more drug patents expire - Aug 12, 2009 Patents on popular drugs such as heart medicines Lipitor Norvasc, Crestor, Plavix and Diovan; pain medications Celebrex and Oxycontin and Alzheimer's London Free Press McKinney global spam ringleader pleads guilty - Aug 11, 2009 ...pharmacy that dispenses FDA-approved generic versions of drugs such as Levitra, Avodart, Cialis, Propecia, Viagra, Lipitor, Celebrex and Zoloft. Star Community Newspapers Imaging the Future - Aug 5, 2009 He began his career doing, among other things, MRI studies of the effects of Celebrex (an anti-inflammatory drug) on breast cancer. Tucson Weekly Rheumatoid arthritis likely cause of aching feet - Aug 10, 2009 I take methotrexate and Celebrex for my arthritis. It has helped my feet but just slightly. (Before I could barely get out of bed and walk to the bathroom. Greenwich Time New MyPhield Device Offers Relief for Arthritis Pain – Without ... - Aug 8, 2009 After receiving BioResonance treatments and while waiting for her replacements, she was able to decrease the dosage of Celebrex, continue to be active and Advertiser Talk Online Pharmacy Medications Enthusiast Starts Blog Network - Aug 14, 2009 The study looked prices of five commonly prescribed substances, including Celebrex, Metoprolol, Lipitor, Albuterol and Metformin. More and more individuals Free press releases (press release) Denuncian el servicio del IMSS - Aug 18, 2009 ...“Padezco de dolor en el hueso de la pierna, acudí al Seguro para que me recetaran el medicamento llamado Celebrex, el cual es el único que me hace efecto A.M. Brand Names/Synonyms: Celebrex is also known by the following brand names and/or synonymsCelebra; Celebrex; Celecoxib; Celocoxib; HSDB 7038; YM 177 Drug Category: Celebrex is categorized under the following by the FDA: Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:L01XX33; ATC:M01AH01 Dosage Forms: CELEBREX oral capsules contain 100 mg and 200 mg of celecoxib. Absorption: When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Coadministration of CELEBREX with an aluminum-and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in A.C. CELEBREX capsules can be administered without regard to the timing of meals. Interactions: General: Significant interactions may occur when celecoxib is administered together with drugs that inhibit P450 2C9. Celecoxib metabolism is predominantly mediated via cytochrome P450 2C9 in the liver. Co-administration of celecoxib with drugs that are known to inhibit 2C9 should be done with caution. In vitro studies indicate that celecoxib is not an inhibitor of cytochrome P450 2C9, 2C19 or 3A4. In vitro studies also indicate that celecoxib, although not a substrate, is an inhibitor of cytochrome P450 2D6. Therefore, there is a potential for an in vivo drug interaction with drugs that are metabolized by P450 2D6. Clinical studies with celecoxib have identified potentially significant interactions with fluconazole and lithium. Experience with nonsteroidal anti-inflammatory drugs (NSAIDs) suggests the potential for interactions with furosemide and ACE inhibitors. The effects celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburide, ketoconazole, methotrexate, phenytoin, tolbutamide, and warfarin have been studied in vivo and clinically important interactions have not been found. ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors. This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors. Furosemide: Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. Aspirin: CELEBREX can be used with low dose aspirin. However, concomitant administration of aspirin with CELEBREX may result in an increased rate of GI ulceration or other complications, compared to use of CELEBREX alone. Because of its lack of platelet effects, CELEBREX is not a substitute for aspirin for cardiovascular prophylaxis. Fluconazole: Concomitant administration of fluconazole at 200 mg QD resulted in a two-fold increase in celecoxib plasma concentration. This increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazole (see CLINICAL PHARMACOLOGY - Pharmacokinetics: Metabolism). CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole. Lithium: In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with CELEBREX 200 mg BID as compared to subjects receiving lithium alone. Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn. Methotrexate: In an interaction study of rheumatoid arthritis patients taking methotrexate, CELEBREX did not have a significant effect on the pharmacokinetics of methotrexate. Warfarin: The effect of celecoxib on the anti-coagulant effect of warfarin was studied in a group of healthy subjects receiving daily doses of 2-5 mg of warfarin. In these subjects, celecoxib did not alter the anticoagulant effect of warfarin as determined by prothrombin time. However, caution should be used when administering CELEBREX with warfarin since these patients are at increased risk of bleeding complications. Chemical IUPAC Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |