Cefuroxime

This page contains recent news articles, when available, and an overview of Cefuroxime but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cefuroxime
(when available)

Pharmacology and use:
Cefuroxime, a second-generation cephalosporin, is used to treat severe upper and lower respiratory tract infections, skin infections, otitis media, and surgical prophylaxis. For the treatment of the following infections (respiratory, skin, soft tissue, urinary tract infections, ear, nose, throat infectsion) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph. Also used to treat acute bacterial bronchitis in patients with COPD

Mechanism Of Action:
Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.

News Articles on Cefuroxime

Orchid receives USFDA nod for Cefuroxime  -  Oct 17, 2008
Chennai-based Orchid Chemicals & Pharmaceuticals (Orchid) has got approval for 3 of its Abbreviated New Drug Application (ANDA) for Cefuroxime drug by US Stock Watch,

Orchid gets USFDA approval for Cefuroxime  -  Oct 16, 2008
Cefuroxime an antibiotic resistant to most betalactamases and active against a wide range of gram-positive and gram -negative organisms is used in treating Myiris.com,

Antimicrobial Resistance Patterns Of Urinary Tract Pathogens And ...  -  Sep 28, 2008
80% of those E. coli in that year were also susceptible to gentamicin, 90% to cefuroxime and amikacin and 60% to piperacillin. By 2006 those similar strands Medical News Today (press release),

Market Live  -  Oct 16, 2008
12:10 pm: Orchid Chemicals & Pharmaceuticals has received approvals from USFDA for three of its abbreviated new drug application's for Cefuroxime injection Economic Times,

Modified depth, incisions for LASIK flap increase strength ...  -  Oct 9, 2008
Peter Barry, FRCS, spoke about intracameral cefuroxime and endophthalmitis. Intracameral cefuroxime may not only protect patients against endophthalmitis, OSN SuperSite (subscription),

Ranbaxy’s Achilles heel  -  Sep 25, 2008
The blacklisted drugs included antibiotic Cefuroxime Axetil and anti-bacterial Ciprofloxacin — drugs that helped fuel growth in the US — besides flagship Hindu Business Line,

Learn about the World Antibiotics Market  -  Sep 24, 2008
USP II-23Advancis's Keflex Receives FDA Approval II-23Wockhardt Gains Marketing Approval for Cefuroxime axetil inthe US II-23Wyeth's Mylotarq Receives International Business Times,

Learn about the World Antibiotics Market  -  Sep 24, 2008
USP II-23 Advancis's Keflex Receives FDA Approval II-23 Wockhardt Gains Marketing Approval for Cefuroxime axetil in the US II-23 Wyeth's Mylotarq Earthtimes (press release),

Thuốc giả và kém chất lượng: Vẫn khó quản lý  -  Sep 27, 2008
Theralene viên nén, Direxiode, Postinor, Dogmatil, Levitral, Quinin sunfat và một số thuốc dạng tiêm Acetaphen, Neotil, Cefuroxime, Paracétamol dạng ống An ninh thủ đô,

Cefuroxime may protect vision in addition to preventing ...  -  15 Sep 2008
BERLIN — Intracameral cefuroxime may not only protect patients against endophthalmitis, but may also protect final visual acuity in the case of infection, OSN SuperSite (subscription),

Tick trouble  -  15 Sep 2008
...who don't have allergies to this medication), and cefuroxime or erythromycin (for people who are allergic or cannot tolerate the first two antibiotics). MyFox Atlanta,

My experiences with the brown recluse  -  Sep 9, 2008
The doctor gave me a shot of the antibiotic Rocephin and prescribed an oral antibiotic, cefuroxime. These antibiotics worked for me, and I continued to put Carroll County News,

Prophylactic antibiotics for joint arthroplasty: Which one and for ...  -  Sep 5, 2008
Second-generation cephalosporins such as cefuroxime have also been used as prophylactic agents because of their broader coverage which includes activity Ortho SuperSite,

Antimicrobial Resistance Patterns of Urinary Tract Pathogens and ...  -  Sep 10, 2008
...to Co-trimoxazole (SXT), more than 80% to gentamicin (GN), more than 90% to cefuroxime (CXM) and amikacin (AN), and more than 60% to piperacillin (PIP). UroToday,

Orbus Pharma Inc.: Orbus Pharma Inc. Announces Additional Financing  -  Sep 8, 2008
...(v) the Corporations to pursue their interest in selling the Corporation's Cefuroxime Axetil business with net proceeds applied to reduce the related Trading Markets (press release),

Surgical Wound Mucormycosis Necessitating Hand Amputation  -  Sep 3, 2008
...distress syndrome and was treated with hydrocortisone (100 mg twice a day) for 2 weeks and intravenous cefuroxime (750 mg 3 times a day) for 10 days. RedOrbit,

Ä?ình chỉ hai loại thuốc không đạt chất lượng  -  Sep 8, 2008
SÄ?K: VD-1577-06 do cÆ¡ sở Công ty TNHH Dược phẩm NIC-PHARMA sản xuất và thuốc viên bao phim REETAC-500 (Cefuroxime Acetyl 500 mg), Lô SX: EHT06/B-02, Khanh Hoa,

Sagent Pharmaceuticals Launches Ceftriaxone, USP, and Cefuroxime ...  -  Jul 16, 2008
Cefuroxime for injection, USP, is a semisynthetic broad spectrum antibiotic agent for parenteral administration used to treat a variety of infections and is Earthtimes (press release),

Effectiveness and Safety of Short-Course Vs Long-Course Antibiotic ...  -  Aug 5, 2008
Short course therapy with cefuroxime axetil for group A streptococcal tonsillopharyngitis in children. Pediatr Infect Dis J. 1998;17(6):452-457. 25. RedOrbit,

Personal Health A Threat in a Grassy Stroll: Lyme Disease  -  Jul 15, 2008
Other options include cefuroxime axetil (Ceftin) and erythromycin. But these guidelines are controversial. They have been challenged by a nonprofit medical New York Times,

LIOs com antibiótico apresentam eficácia contra bactérias resistentes  -  Aug 4, 2008
No entanto, questões têm sido levantadas pelo uso “off-label� de cefuroxime, ea resistência à droga pode aumentar com o tempo. Além disso, como o tempo de OSN SuperSite (subscription),

Q&A: DISEASE'S CAUSE, CURES  -  03 Jul 2008
Most people can be cured with a few weeks of oral antibiotics such as doxycycline, amoxicillin, or cefuroxime axetil. Those diagnosed with later stages of Newsday,

Intracameral cefuroxime is best option for endophthalmitis ...  -  Jun 30, 2008
Peter Barry, FRCS, made his case for why intracameral cefuroxime, and not topical fluoroquinolones, should be the standard of care for surgical prophylaxis OSN SuperSite (subscription),

Your physician knows best  -  Jun 5, 2008
I would like to cite an instant where my late mother who was 85 years old at the time, almost passed away, when a generic cefuroxime (bought from a SPC Daily Mirror,

Tick trouble  -  Jun 27, 2008
...who don't have allergies to this medication), and cefuroxime or erythromycin (for people who are allergic or cannot tolerate the first two antibiotics). MyFox WGHP,

Rosiglitazone may Slow Progression of Diabetic Retinopathy  -  Jun 26, 2008
Some of their products include Albenza (albendazole), Ceftin (cefuroxime axetil), Flonase (fluticasone proprionate), and Paxil (paroxetine hydrochloride). Medi News Direct,

Beware of Bug Bites and Stings  -  Jun 19, 2008
Antibiotics commonly used for oral treatment include doxycycline, amoxicillin, or cefuroxime axetil (Ceftin). People with certain illnesses related to the Food Consumer,

Is DRA responsible for cheap ineffective brand drugs?  -  Jun 16, 2008
SPC amoxicillin cefuroxime or will they prescribe a more effective amoxicillin such as amoxil or oral Zinnat or Zinacef IV or any other effective brand? Daily Mirror,

When Are Antibiotics For Lyme Disease Medically Necessary?  -  Jun 7, 2008
Most doctors prescribe doxycycline, (for adults and children over eight years old) or amoxicillin or cefuroxime (for adults and children under eight). eMaxHealth.com,

Orchid Chemicals gains on strong FY 2008 numbers  -  May 29, 2008
...received approval from the US Food & Drug Administration (US FDA) for its abbreviated new drug application for cefuroxime axetil tablets. NDTV.com,

Sheriff ramps up prescription drug battle  -  May 31, 2008
Cefuroxime axetil is an antibiotic. Pravastatin is a cholesterol medication. Diclofenac sodium is an anti-inflammatory drug. Cymbalta treats depression. Princeton Times Leader,

Summer Safety  -  May 12, 2008
...who don't have allergies to this medication), and cefuroxime or erythromycin (for people who are allergic or cannot tolerate the first two antibiotics). FOX 11 Online,

Aurobindo Pharma receives nine product approval from MCC - South ...  -  May 12, 2008
Product Name : Zinoxime Active ingredient : Cefuroxime Axetil Dosage Form : Tablet Strength: 125mg, 250mg,500mg Category : Anti-infective 5. Equity Bulls,

Orbus Pharma Inc. Reports First Quarter 2008 Results  -  May 6, 2008
...with Nobelpharma to market Metoprolol Succinate XR in Turkey and through an agent, Helm Portugal, to market Cefuroxime to another licensee in Portugal. Filing Services Canada (press release),

Antibiotic-soaked IOLs show efficacy against bacteria  -  May 6, 2008
However, issues have been raised by the off-label use of cefuroxime, and resistance to the drug may increase over time. In addition, because the average OSN SuperSite (subscription),

Prophylactic Antibiotics Effective Immediately Following Knee ...  -  Apr 11, 2008
They randomized the subjects to 1.5 g cefuroxime 10 to 30 minutes before tourniquet inflation and placebo 10 minutes before tourniquet deflation (the Medscape (subscription)

Dragon Pharma Announces Strategic Realignment of its Business ...  -  Apr 22, 2008
The formulation products include injectable powder for ceftriaxone, cefazolin, cefotaxime, cefoperazone, ceftazidime and cefuroxime. Dragon plans to expand CNNMoney.com

Sensitivity Profiling of Solid Oral Doses  -  Apr 22, 2008
The following results show the effect of different climatic conditions on the hygroscopicity of a cefuroxime formulation.?As can be seen in Figure 4, Pharmaceutical Processing,

Ranbaxy's net profit at USD 39mn (Rs 1530 mn), + 19%  -  Apr 22, 2008
During the quarter, Ranbaxy received approval from the US FDA to manufacture and market Cefuroxime Axetil Oral Suspension USP, 125 mg/5mL and 250 mg/5mL. Moneycontrol.com (press release),

Information about Lyme Disease Treatment  -  Mar 27, 2008
Oral antibiotics — usually doxycycline for adults and children older than 8, or amoxicillin or cefuroxime axetil for adults, younger children and pregnant Los Angeles Chronicle,

Injectable Antibiotic Protects Against Lyme Disease in Mice  -  Apr 4, 2008
As for treatment, the CDC suggests that two to four weeks of repeated oral antibiotics -- such as doxycyline, amoxicillin, and cefuroxime axetil -- can U.S. News & World Report,

Polyurethane cuffed endotracheal tubes to prevent early ...  -  Mar 28, 2008
...or ventilator-associated pneumonia without previous antibiotic exposure consists of cefuroxime or amoxicillin (INN amoxicilline) and clavulanate, The Journal of Thoracic and Cardiovascular Surgery

Emerging Antimicrobial Resistance in Neisseria gonorrhoeae: Urgent ...  -  Apr 14, 2008
Cefuroxime axetil, 1 g, also meets the less stringent efficacy criteria, but it has poor pharmacodynamic characteristics that may select for stepwise Annals of Internal Medicine

Treatment of Acute and Chronical Bacterial Prostatitis Caused by ...  -  Apr 8, 2008
Cephalothin (4 %),Cefuroxime (31%), Cefotaxime (20%), Imipenem (46%) , Gentamicin (46 %) , Tobramycin (57%) , Netilmicin (16 %), Ciprofloxacin(23 %) ScienceBlog.com,

Green tea shows superbug-battling potential  -  Apr 1, 2008
Green tea also demonstrated an ability to break down the resistance of one out of the five tested isolates to the antibiotic cefuroxime. NutraIngredients.com,

Orchid receives US FDA approval for Cefuroxime Axetil ANDA  -  Feb 20, 2008
2008 has announced that it has received approval from the US FDA for its ANDA (Abbreviated New Drug Application) for Cefuroxime Axetil Tablets. Equity Bulls,

Orchid gets US FDA approval for Cefuroxime Axetil ANDA  -  Feb 19, 2008
Orchid Chemicals & Pharmaceuticals has got US FDA approval for its ANDA (Abbreviated New Drug Application) for cefuroxime axetil tablets. Myiris.com,

Intracameral fluoroquinolone safe for endophtalmitis prevention  -  Mar 6, 2008
...“It is easy to administer and, as compared with intracameral cefuroxime, needs no dilution or mixing,� Samuel Masket, MD, said at the meeting of the OSN SuperSite (subscription),

Orchid receives two US FDA approvals  -  Mar 9, 2008
Apart from granisetron hydrochloride tablets, Orchid also got approval for its Abbreviated New Drug Application (ANDA) cefuroxime axetil tablets. Express Pharma,

Glaxo's fatal jab  -  Feb 22, 2008
He said the manufacturing equipment at the site is suitable only for the cephelasporin family of antibiotics; cefuroxime, which is used to treat hospital NW Evening Mail,

Orchid Chemicals cleared by FDA to make, market generic version of ...  -  Feb 19, 2008
Cefuroxime Axetil is an orally administered antibiotic used to treat mild-to-moderate infections. The current market size of the tablets is around 40 mln Euro2day,

Orchid gets US FDA approval for its drug  -  Feb 20, 2008
...and Pharmaceuticals Ltd Wednesday said it has received an approval from US Food and Drug Administration (US FDA) for its Cefuroxime Axetil tablets. Thaindian.com,

FDA Approves Ranbaxy’s Generic Ceftin  -  Feb 13, 2008
The FDA’s Office of Generic Drugs has approved Indian drugmaker Ranbaxy Laboratories’ generic pediatric formulation of the antibiotic cefuroxime axetil, FDA news (subscription),

Homeopathy does have a place  -  Feb 26, 2008
On returning 10 minutes later to set up a drip and administer his IV cefuroxime and metronidazole, I was somewhat surprised to find him sipping water. Pulse,

GlaxoSmithKline Q3 Net Up 19%  -  Feb 25, 2008
The Company’s principal activity is to manufacture and market pharmaceutical and healthcare products such as betamethasone, cefuroxime and ranitidine. Stock Watch,

Ranbaxy Labs receives USFDA for Cefuroxime Axetil  -  06 Feb 2008
MUMBAI: Ranbaxy Laboratories has received approval from the US Food and Drug Administration to manufacture and market Cefuroxime Axetil for Oral Suspension Economic Times,

Antibiotic resistance: A global phenomenon  -  06 Feb 2008
...from human settlements on the tundra had resistance to cefadroxil, cefuroxime, and cefpodoxime, a resistance pattern commonly seen in clinical isolates, LabnewsOnline,

Sinusitis and Allergy Suffers Now Have a New Effective Form of ...  -  Jan 25, 2008
She states that “After three months of Cefuroxime nebulizing treatment my symptoms were gone for four solid months. This is when I realized what healthy PR-USA.net (press release),

Prophylactic cefuroxime cuts postop endophthalmitis risk  -  Nov 11, 2007
NEW ORLEANS — A postoperative cefuroxime injection effectively reduced the incidence of endophthalmitis after cataract surgery, according to a recent study. OSN SuperSite (subscription),

Use of intracameral cefuroxime growing rapidly in Ireland  -  Sep 19, 2007
..."More than 50% of the surgeons have altered their practice to date, and about 36% are waiting for intracameral cefuroxime to become commercially available," OSN SuperSite (subscription),

Intracameral cefuroxime proves effective against endophthalmitis ...  -  Sep 18, 2007
STOCKHOLM, Sweden — The introduction of intracameral cefuroxime and povidone iodine wash at the end of surgery, as indicated by the ESCRS endophthalmitis OSN SuperSite (subscription),

Replidyne Pipeline Featured at 47th Annual Interscience Conference ...  -  Sep 17, 2007
...titled "Comparison of the Bactericidal Activities of Faropenem, Ertapenem, Amoxicillin, Cefixime, Cefuroxime and Moxifloxacin against Streptococcus CNNMoney.com

Symptoms by treatment, Part 1  -  Sep 18, 2007
Antibiotics, such as cephalexin, clarithromycin, cefuroxime axetil, cefixime and a host of other generic names, may cause inflammation of the intestinal Sun.Star,

8 ospital ng gobyerno iniimbestigahan ng COA  -  Aug 27, 2007
Kinabibilangan ito ng 1820,00 capsules ng Cotrimoxazole 400mg; 91000 tabletas ng Enalapril 5mg; at 4550 vials ng Cefuroxime 250 mg. GMA news.tv,

COA probes 8 gov't hospitals for alleged abuse of poor patients  -  Aug 27, 2007
The drugs are composed of 1820,00 capsules of Cotrimoxazole 400mg; 91000 tablets of Enalapril 5mg; and 4550 vials of Cefuroxime 250 mg. GMA news.tv,

Ultraviolet Lighting During Orthopaedic Surgery and the Rate of ...  -  Sep 3, 2007
McQueen MM, Hughes SP, May P, Verity L. Cefuroxime in total joint arthroplasty. Intravenous or in bone cement.J Arthroplasty . 1990;5:169 -72. Journal of Bone and Joint Surgery (subscription)

DUPLEX For Use with Cefotetan Approved by US Food and Drug ...  -  Aug 20, 2007
...broad spectrum of intravenous cephalosporin antibiotic therapies for the hospital setting: Cefoxitin, CefTRIaxONE, Cefazolin, CefUROXime and Cefotetan. American Digital Networks (press release),

Ranbaxy Wins Right to Sell Glaxo Drug; Shares Rise (Update2)  -  Jul 26, 2007
BloombergIn 2002, the company won similar rights to sell 125 milligram, 250 milligram and 500 milligram tablets of cefuroxime axetil that's used to treat infections

ViroPharma Announces Key Additions to European Management  -  Jul 10, 2007
CNNMoney.comDr. Bax has been instrumental in the development and approval of numerous anti-infectives, including meropenem, moxalactam, cefotetan, and cefuroxime.

Reminders on Lyme disease  -  Jul 11, 2007
NorthJersey.com,One of three different oral antibiotics: doxycycline, amoxicillin, cefuroxime. The drugs will kill the bacteria in 97 percent of people infected.

Brand Names/Synonyms:
Cefuroxime is also known by the following brand names and/or synonymsAncef; Biofuroksym; Ceclor; Ceclor Cd; Cedax; Cefditoren; Cefizox; Cefotan; Ceftin; Ceftizoxime Sodium; Cefurax; Cefuril; Cefuroxim; Cefuroxime; Cefuroxime Axetil; Cefuroxime Free Acid; Cefuroxime Sodium; Cefuroxime Sodium Salt; Cefuroxime [Usan:Ban:Inn]; Cefuroxime and Dextrose in Duplex Container; Cefuroximo [Inn-Spanish]; Cefuroximum [Inn-Latin]; Cefzil; Cephuroxime; Ceptaz; Duricef; Elobact; Fortaz; Keflex; Keftab; Kefurox; Kefurox in Plastic Container; Kerurox; Mandol; Maxipime; Mefoxin; Monocid; Omnicef; Oraxim; Rocephin; Sharox; Tazicef; Vantin; Velosef; Zinacef; Zinacef Danmark; Zinacef in Plastic Container; Zinat; Zinnat

Drug Category:
Cefuroxime is categorized under the following by the FDA: Anti-bacterial Agents; Cephalosporins; ATC:J01DC02

Dosage Forms:
POWDER; POWDER FOR SOLUTION; TABLET

Absorption:
Well absorbed from the GI tract (bioavailability is 37-52%)

Interactions:
-->Interactions for Cefuroxime:

Drug/Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedictís or Fehlingís solution or with ClinitestÒ tablets) but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood plasma glucose levels in patients receiving cefuroxime.

Cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.





Chemical IUPAC Name:
4-(carbamoyloxymethyl)-8-[2-(2-furyl)-2-methoxyimino-acetyl]amino-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid

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