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CardizemThis page contains recent news articles, when available, and an overview of Cardizem but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Cardizem (when available) Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. For the treatment of Hypertension Mechanism Of Action: Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, dilitiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue. News Articles on Diltiazem FDNY paramedics sound alarm - Sep 24, 2008 They're also running low on nitroglycerin, which is used to treat angina and heart failure, and Cardizem, a medication used to stabilize a dangerously fast Staten Island Advance - SILive.com, www.companiesandmarkets.com: Biovail Corporation - Corporate and ... - Sep 26, 2008 Its products include Cardizem CD, Ativan, Vaseretic, Vasotec, and Isordil. Biovail derives its revenues primarily from the sales of pharmaceutical products Trading Markets (press release), Biovail Corporation Q2 2008 Earnings Call Transcript - Sep 24, 2008 And lastly, in May we reached an agreement with the US Department of Justice related to their investigation into the 2003 commercial launch of Cardizem LA. Seeking Alpha, EMT Rep Says Life-Saving Drugs In Short Supply On SI - Sep 25, 2008 They include cardizem, nitroglyercin, sodium bicarbonate and other drugs to treat patients with obstructed breathing. Ungar says the problem falls on poor NY1, United States: Reverse Payment Patent Settlements: the Interplay ... - Oct 3, 2008 ...held that the pertinent settlement agreements were not anticompetitive, the court in In re Cardizem CD Antitrust Litig., 332 F.3d 896 (6th Cir. Mondaq News Alerts (subscription), UPDATE 1-Biovail faces suit that it misled investors - Oct 9, 2008 Earlier this year the company agreed to pay $24.6 million to settle a case that was launched in connection with the commercial launch of its Cardizem LA Trading Markets (press release), Dr. Gott: Allergy pills refuse to digest properly - Aug 28, 2008 Dear Reader: Cardizem (diltiazem) is a calcium channel blocker used to treat hypertension and certain other cardiac disorders. Northwest Herald, Patent suits against 3 drug majors in Aug - Aug 18, 2008 Sun Pharma was sued by Biovail for infringing the latter’s US patents for Cardizem, used to treat hypertension, with Sun’s proposed generic version of Financial Express, Understanding hypertension - Aug 18, 2008 We can reduce arterial muscle strength (Norvasc and Cardizem), reduce the nerve stimulation of the muscle (Atenalol and Metoprolol) and reduce the brain Staten Island Advance - SILive.com, Vaincu, Eugene Melnyk vend des actions de Biovail - Aug 18, 2008 Elle commercialise une foule de médicaments dont le Cardizem, qui traite certains problèmes cardiovasculaires, et le Zyban, utilisé par ceux qui veulent Cyberpresse, Biovail's Melnyk Drops Board Challenge and Will Start New Firm - Jul 28, 2008 ...strategies to combat flagging sales of Biovail's two biggest-selling drugs, the antidepressant Wellbutrin XL and blood-pressure medicine Cardizem LA. Bloomberg Biovail Judge to Rule by July 14 on Board Election (Update1) - Jul 8, 2008 After Melnyk's departure last year, Biovail also settled a criminal probe and investor class-action lawsuit over Cardizem marketing. Bloomberg 2008-07-17 12:51:18 - Biovail Corporation - Corporate and ... - Jul 17, 2008 Its products include Cardizem CD, Ativan, Vaseretic, Vasotec, and Isordil. The company´s total revenues increased at a CAGR of 7.9% during 2002-2006, PR-Inside.com (Pressemitteilung), Biovail Founder Melnyk Wins Board Vote Challenge (Update3) - Jul 16, 2008 ...touted competing strategies to combat flagging sales of Biovail's two biggest-selling drugs, Wellbutrin XL and blood-pressure medicine Cardizem LA. Bloomberg AHA Releases Guidelines for Hypertension Management in Adults With ... - Jul 16, 2008 Several drugs are contraindicated in patients with heart failure, including verapamil (Calan), diltiazem (Cardizem), clonidine (Catapres), and moxonidine RedOrbit, Take control of your blood pressure - Jul 9, 2008 Calcium channel blockers, such as diltiazem (Cardizem), work by dilating the arteries, he said. ACE inhibitors, such as quinapril (Accupril), LubbockOnline.com, Biovail Founder Melnyk Seeks Change at `Broken' Firm (Update3) - Jun 3, 2008 Biovail's first-quarter profit dropped 40 percent on lower sales of drugs including the antidepressant Wellbutrin XL and blood pressure medicine Cardizem LA Bloomberg Biovail Founder Melnyk Vows Court Fight Over Proxy (Update1) - Jun 25, 2008 Biovail, which makes the antidepressant Wellbutrin XL and blood pressure medicine Cardizem LA, fell 8 cents to $10.68 at 12:58 pm in composite trading. Bloomberg Biovail says Melnyk just out for control - Jun 5, 2008 The company currently relies heavily on its antidepressant Wellbutrin and its Cardizem heart drugs. However, Wells said the generic path has "run out of Reuters Blood Pressure Medications Can Multi-Task - Jun 30, 2008 Popular ones include amlodipine (Norvasc), verapamil (Calan), nifedipine (Procardia) and diltiazem (Cardizem). ACE inhibitors: ACE (angiotensin converting Best of Times, Biovail stock falls after analyst cuts rating - Jun 20, 2008 Adding to that, a generic version of Biovail's blood pressure drug Cardizem LA could be launched as soon as April 2009 by Watson Pharmaceuticals (nyse: WPI Forbes, Owner Woes, Europe on Bettman's Summer List - Jun 19, 2008 ...with the Department of Justice in regard to criminal allegations related to activities surrounding the 2003 commercial launch of the drug Cardizem LA. New York Sun, Melnyk's proposed CEO challenges Biovail CEO Bill Wells to debate - Jun 16, 2008 The company, plagued by legal problems from the launch of its Cardizem LA blood-pressure drug in 2003, has urged shareholders to spurn any slate of CFTKTV, Biovail unit to plead guilty in US Cardizem case - May 16, 2008 The settlement will not affect the continued marketing of Cardizem, said Biovail, which has been plagued with lawsuits and regulatory issues for several Reuters Five Dumbest Things on Wall Street: May 23 - May 23, 2008 The time the charges stemmed from the Department of Justice and were related to the way Biovail handled the release of its heart drug Cardizem LA. TheStreet.com Biovail hubris exposed - May 20, 2008 The marketing program in question - Proving Cardizem LA through Clinical Experience, or PLACE - aimed to build physician awareness of Biovail's 2003 launch CNNMoney.com STOCKS TO WATCH: Stocks In Focus For Monday - May 18, 2008 Biovail Pharmaceuticals will also plead guilty to charges relating to making payments to induce purchasing or ordering of Cardizem. E-Trade Financial Corp. CNNMoney.com Business Digest - May 17, 2008 TORONTO -- A subsidiary of Biovail Corp. has agreed to pay US$24.6 million to settle US criminal allegations related to the launch of Cardizem LA heart drug London Free Press, Biovail Pleads Out DOJ Charges of Paying Doctors to Write ... - May 19, 2008 The DOJ alleges that prior management’s actions in 2002 and 2003 in respect of the Cardizem LA clinical experience program, titled PLACE (Proving LA through Patent Baristas, Biovail to Pay $24.6 Million to Settle Charges, Keep Federal Business - May 21, 2008 It will not affect current or future Biovail medicines approved for use in the US, including the continued marketing of Cardizem LA, according to the FDA news (subscription), The Early Edge: Amazon.com, Biovail, ConocoPhillips, and Lehman ... - May 19, 2008 The pharmaceutical firm will also plead guilty to charges that it offered payments to induce Cardizem purchases. In return, criminal liability against BVF Schaeffers Research, UPDATE 3-Biovail to shift focus, shut plants as profit dips - May 8, 2008 But he said the company would still maintain a focus on its key Wellbutrin and Cardizem drugs, noting that these products provide the cash flow to invest in Reuters Biovail Reports 40% Drop in Net Income, Closes Plants (Update2) - May 8, 2008 Lower sales for generic drugs along with Cardizem LA and Ultram ER led the revenue decline. Biovail will shift its focus to developing treatments for Bloomberg Business browser - May 17, 2008 TORONTO - A subsidiary of Biovail Corp. will plead guilty to US charges it made payments to induce purchasing or ordering of the Cardizem LA heart drug. Edmonton Journal, AGS: A Little Anticholinergic Burden Can Be Disabling - May 6, 2008 ...such as furosemide (Lasix) and diltiazem (Cardizem) -- could lead to functional impairment when taken in combination, researchers reported here. MedPage Today, Biovail Reports First-Quarter 2008 Financial Results - May 8, 2008 In the first quarter of 2008, Cardizem® LA generated revenues of $10.2 million, compared with $23.9 million for the corresponding period in 2007. Business Wire (press release), High-Yield Stocks You've Never Heard Of - May 21, 2008 ...including Wellbutrin XL for depression; Ultram ER for chronic pain; Zovirax Ointment for genital herpes; Cardizem LA for high blood pressure; Tiazac, TheStreet.com TSX index posts record close - May 17, 2008 Biovail Corp., which announced its US subsidiary had pleaded guilty to paying doctors to use the drug Cardizem, was up six cents to $12.79. Calgary Herald, Proxy Briefs - May 21, 2008 ...has reached an agreement with the US Department of Justice settling criminal allegations related to the 2003 commercial launch of Cardizem LA. Hedgeworld (subscription), Decisions, decisions - May 20, 2008 ...and penalties as part of a settlement of charges related to improper payments to doctors to promote Biovail’s Cardizem LA blood pressure medication. CanadianBusiness.com, Medication not always the answer when it comes to high blood pressure - May 20, 2008 Cardizem? Or will she suggest you put into action a do-it-yourself lifestyle program? In some cases, the do-it-yourself path might be the right one, Daily News Transcript, ALSO NOTED: Salix gets approvable letter; Intermune drug hits the ... - May 19, 2008 ...drugmaker agreed to pay almost $25 million to settle claims that it paid docs and their office managers to get patients onto its Cardizem heart drug. FierceBiotech, Market Report -- In Play (BVF) - May 16, 2008 In particular, the allegations relate to prior management's actions in 2002 and 2003 in respect of the Cardizem LA clinical experience program, titled PLACE MSN Money Business News - May 17, 2008 ...(TSX:BVF) has agreed to pay US$24.6 million to settle US criminal allegatons related to the launch of Cardizem LA blood-pressure drug in 2003, AOL Canada, Biovail settles another legal battle - 23 Apr 2008 ...$85 million after the resolution of insurance claims, centered on claims Biovail made regarding its two key products, Cardizem LA and Wellbutrin XL. Reuters Canada, phentermine prescription no consultation herbal - 23 Apr 2008 ...without prescription | phentermine online order | non perscription phentermine | pravachol cardizem cd phentermine aceon Fee and close to consult a. dBTechno, Biovail gets new chief - Apr 22, 2008 ...maker of antidepressant Wellbutrin XL and hypertension drug Cardizem LA -- to spend "extraordinary" amounts on legal fees, the new chief executive said. Vancouver Sun, cardizem cd actos phentermine norvasc - Apr 13, 2008 Preparing well-educated and specialists in. Association in the american pharmacist can. Important item reviewed by the area of medication through ZDNet cardizem cd phentermine claritin - Apr 13, 2008 Introduction to develop mentoring relationships. Spinler,., bcps, bcop, one of contemporary pharmacy score for patients. By physicians and summers growing ZDNet CHRONOLOGY: Drug company Biovail's legal woes - Mar 24, 2008 February 1, 2008 - Biovail faces US grand jury probe over marketing of Cardizem heart drug. December 11, 2007 - Biovail settles US shareholder lawsuit that Reuters Research Oracle: Biovail Corporation; BVF - BUY, BVF.TO – BUY - Apr 10, 2008 We believe the company may continue to experience pressure on its top-line due to greater generic threat to Wellbutrin XL and Cardizem LA (expected generic Research Oracle (subscription), online phentermine detailed information about phentermine - Apr 13, 2008 Enter the industry sites, regulatory affairs describe the crozer health professionals to. herbal phentermine review best diet pills | cardizem cd ZDNet Pharmacy technician for CVS insists he's sportscaster for CBS - Apr 12, 2008 ...character who speaks mostly in the third person and really goes over the top when Mrs. (Bertha) Jenkins picks up her monthly supply of Cardizem. CBSSports.com The SEC vs. Biovail - Mar 25, 2008 The company is still the subject of a US grand jury investigation in Boston over allegations surrounding its marketing of its Cardizem LA heart drug. CanadianBusiness.com, Biovail founder Melnyk refuses to go quietly - Mar 24, 2008 ...drug Cardizem LA, and class-action settlements with shareholders totalling US$138-million -- the founder launches salvos from the sidelines. National Post, Biovail Settles SEC Accounting Investigation; Charges Laid Against ... - Mar 24, 2008 ...and four other ex-executives of making misleading statements about the launch of Cardizem to boost the company's stock price between 2002 and 2003. RTT News, Drug company Biovail's legal woes - Feb 28, 2008 Biovail Corp. said earlier this month that it is being investigated by a US Federal grand jury concerning the 2003 commercial launch of its Cardizem LA Financial Post, Analysts skeptical of Melnyk's privatization plans - Feb 29, 2008 More recently, Biovail said this month that a US federal grand jury is investigating activities surrounding the 2003 launch of heart drug Cardizem LA, Toronto Star, Melnyk urges change at Biovail, warns action - Mar 6, 2008 More recently, Biovail said that a US federal grand jury is investigating activities surrounding the 2003 launch of Cardizem LA, a major initiative while Business Edge, Biovail Founder Melnyk Unhappy With Company Direction (Update1) - Feb 28, 2008 ...the company's officers and directors lied about the effectiveness of its Cardizem LA drug for high blood pressure when it was introduced in 2003. Bloomberg Where are the Smith Brothers when we need them? - Feb 28, 2008 Cardizem? A pickpocket who deflates the tires on minivans. Coreg? A mutation of one of Queen Elizabeth’s dogs. Let’s take a name-recognition test. Evening Sun (subscription), Ask Dr. H: 'Nutcracker esophagus' tough to treat - Feb 25, 2008 Blood pressure medications in the class known as calcium channel blockers (Verapamil, Norvasc, Cardizem) help modestly by relaxing esophageal muscle tone. Philadelphia Inquirer, Watson rises as FDA starts inspection - Feb 14, 2008 ...attention deficit drug Concerta, antacid Prilosec and blood pressure medicine Cardizem, as well as branded combination diabetes drug Actos/metformin. BusinessWeek Registered Nurse - RN - Feb 29, 2008 Monitors special drugs (ie, Dopamine, Lidocaine, Dobutrex, and Cardizem) and other cardiac drugs, as per protocol. E7. Assesses patients in an on going ADVANCE, Stocks extend gains on M&A activity despite unsettling US ... - Feb 27, 2008 ...to $13.25 after the company said it is the target of US federal grand jury investigation into the 2003 commercial launch of its Cardizem heart drug. AOL Canada, United States: FTC Takes 4-in-1 Shot At Reverse Payment ... - Feb 28, 2008 2003)); see also In re Cardizem CD Antitrust Litig., 332 F.3d 896 (6th Cir. 2003) (agreement to delay entry that extended to non-infringing products per se Mondaq News Alerts (subscription), FDA starts inspecting stalled Watson facility - Feb 18, 2008 ...hyperactivity disorder, and of the antihypertensives Cardizem LA (extended-release diltiazem) and Toprol XL (extended-release metoprolol succinate). OutSourcing-Pharma.com, Brand Names/Synonyms: Cardizem is also known by the following brand names and/or synonymsAcalix; Anoheal; Adizem; Altiazem; Anginyl; Angizem; Apo-Diltiaz; Britiazim; Bruzem; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Cardizen LA; Cartia XT; Citizem; Cormax; Deltazen; Dilacor; Dilacor-XR; Diladel; Dilcontin; Dilpral; Dilrene; Dilt-cd; Dilta-Hexal; Diltia; Dilticard; Dilzem; Dilzen; Endrydil; Herbesser; Incoril AP; Masdil; Novo-Diltazem; Nu-Diltiaz; Syn-Diltiazem; Tiazac Tildiem; d-cis-Diltiazem Drug Category: Cardizem is categorized under the following by the FDA: Vasodilator Agents; Cardiovascular Agents; Antihypertensive Agents; Calcium-channel blocking agents; ATC:C08DB01 Dosage Forms: SOLUTION Absorption: Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect. Interactions: Interactions for Diltiazem: Due to the potential for additive effects, caution and careful titration are warranted in patients receiving diltiazem hydrochloride concomitantly with other agents known to affect cardiac contractility and/or conduction. Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac. As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem is both a substrate and an inhibitor of the cytochrome P-450 3A4 enzyme system. Other drugs that are specific substrates, inhibitors, or inducers of the enzyme system may have a significant impact on the efficacy and side effect profile of diltiazem. Patients taking other drugs that are substrates of CYP450 3A4, especially patients with renal and/or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels. Beta Blockers Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted. Cimetidine A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg. Ranitidine produced smaller, nonsignificant increases. The effect may be mediated by cimetidine's known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem. Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine. An adjustment in the diltiazem dose may be warranted. Digitalis Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization. Anesthetics The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers. When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully. Cyclosporine A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued. The effect of cyclosporine on diltiazem plasma concentrations has not been evaluated. Carbamazepine Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases. Patients receiving these drugs concurrently should be monitored for a potential drug interaction. Benzodiazepines Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo. The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam. Lovastatin In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone; no change in pravastatin AUC and Cmax was observed during diltiazem coadministration. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin. Rifampin Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered. Chemical IUPAC Name: [2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate : |
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