Cardizem

This page contains recent news articles, when available, and an overview of Cardizem but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Cardizem (when available)

Pharmacology and use:
Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. For the treatment of Hypertension

Mechanism Of Action:
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, dilitiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

News Articles on Diltiazem

Biovail Turns To Profit In Q2 - Update  -  ‎Aug 6, 2009‎
...agreement with the US Attorney's Office for the District of Massachusetts related to their investigation into the 2003 commercial launch of Cardizem LA. RTT News

Judge Dismisses Biovail's Suit Against Hedge Fund  -  ‎Aug 20, 2009‎
...a subsidiary conspired against the American government by paying doctors to prescribe Cardizem LA, a blood pressure drug critical to Biovail's business. New York Times

COMMENTARY: Where Are the Smith Brothers When We Need Them?  -  ‎Jun 26, 2009‎
Cardizem? A pickpocket who deflates the tires on minivans. Coreg? A mutation of one of Queen Elizabeth's dogs. Let's take a name-recognition test. HNN Huntingtonnews.net

USA: Judge Jails Cameroonian Woman Until Baby is Born  -  ‎Jun 19, 2009‎
...hypothermiawolf haldenstein announces viagra different nations singing At peak the morning and nighttime doses of Cardizem R LA demonstrated comparable Ici Cemac

Paramedic's Corner: Atrial fibrillation, Part II  -  20 Apr 2009
...common treatment in the pre-hospital phase by the paramedics would most likely be a calcium channel blocker such as the medication diltiazem (Cardizem). Pulaski County Daily News

OSC Alleges Melnyk "Seized Upon" Truck Accident >BVF  -  ‎Apr 7, 2009‎
He said management could be blamed for the Cardizem CD problem, but the other two problems were out of its control. It was the second day of testimony by Wall Street Journal

Sewage plant upgrade won't filter medications  -  ‎Apr 7, 2009‎
Diltiazem (Cardizem), a medication that helps control high blood pressure, and carbamazepine (Tegretol), a drug used for epilepsy and bipolar disorder, The Canberra Times

Five US Rivers Tainted with Pharmaceutical and Chemical Residues  -  ‎Apr 4, 2009‎
Other substances that tested positive in the study included diphenhydramine (a common antihistamine and sedative), diltiazem (Cardizem, a blood pressure Natural News.com

米国�?�河�?魚�?�薬剤�?�汚染�?�れ�?��?�る  -  ‎Apr 1, 2009‎
...�?�れ�?��?��?�野生�?�魚�?�ら検出�?�れ�?��?��?��?��?��?��?��?��?��?��?�。高血圧治療�?�用�?�られるカルシウム拮抗薬ジル�?アゼム（Cardizem�?日本�?��?�商�?�??：ヘルベッサー�?��?�）。日本経済新聞

Biovail Reports Fourth Quarter, Year-End 2008 Financial Results  -  ‎Feb 26, 2009‎
Partially offsetting factors include increases in revenues from Cardizem(R) LA, Legacy products and the Company's generic products portfolio; MarketWatch (press release)

Biovail Investor Suit Against SAC Thrown Out by Judge  -  ‎Feb 20, 2009‎
A truck carrying a shipment of its Wellbutrin XL antidepressant crashed and a shipment of Cardizem was delivered late. A shareholder suit, first filed in Bloomberg

Biovail posts 4th-quarter profit on tax gain  -  ‎Feb 26, 2009‎
Sales of legacy products rose 9 percent to $38.7 million from $35.7 million, and revenue from the long-acting blood pressure drug Cardizem LA climbed 71 MSNBC

Benefits From Private Antitrust Enforcement: An Analysis of Forty ...  -  ‎Mar 11, 2009‎
42 Table 3: Private Litigation Not Preceded by Government Action Case Recovery ($ millions) Augmentin 91 Buspirone 220 Cardizem 110 Taxol 66 Caldera 275 Linex Legal

医�?�商Biovail上季盈利1.204亿美元  -  ‎Feb 26, 2009‎
...其他常规�?�物销售�?较一年�?的3570万美元�??高9%，至3870万美元，�?压�?�物Cardizem LA销售�?增至1410万美元，较一年�?的820万美元�??高71%。Biovail生产的仿制�?��?�收也由东方财富网

醫藥公�?�Biovail上季度盈利1.204億美元  -  ‎Feb 26, 2009‎
...其他常�?藥物銷售�?較一年�?的3570�?�美元�??高9%，至3870�?�美元，�?壓藥物Cardizem LA銷售�?增至1410�?�美元，較一年�?的820�?�美元�??高71%。Biovail生產的仿製藥營收也由新浪網

Buy cardizem  -  Jan 17, 2009
Therapeutics a klonopin be purity buy cardizem lacrosse gabor zolpidem from slipping buy cardizem Wireless atenolol please reader buy cardizem controversy Griggs County Courier,

Biovail to pay record $5M fine to Ontario Securities Commission  -  Jan 9, 2009
Last May, Biovail's chief US subsidiary agreed to pay $24.6 million US to settle US criminal allegations related to the launch of the Cardizem LA CBC.ca,

Judges: Schall, Prost (author), Ward (District Judge sitting by ...  -  Jan 22, 2009
The Court distinguished the Sixth Circuit's decision in In re Cardizem CD Antitrust Litigation, 332 F.3d 896 (6th Cir. 2003), wherein the Sixth Circuit Mondaq News Alerts (registration),

Study Unveils Newest Front in Doping Fight  -  Jan 15, 2009
And an existing benzothiazepine, like Cardizem for instance, likely wouldn’t trigger a positive even if it has the same nucleus, because the chemical Bicycling

Modern-day Santa tale makes fable more realistic  -  Dec 22, 2008
Did you take your Cardizem and Lipitor this morning?�? Just then, the tremendous sound of a deafening crack filled the air. Santa looked out the window and Loudoun Times,

Using Medicare's Plan Finder, or Beware Hidden Costs!  -  Dec 13, 2008
In my scenario, there is a footnote number 8 next to the cost of Cardizem under both Health Net Orange's and SilverScript's plans. The Oregonian - OregonLive.com,

Cortria Appoints Dennis H. Giesing, Ph.D., Former Worldwide Head ...  -  Dec 9, 2008
...instrumental in the development and approval of multiple new pharmaceutical products including Allegra, Ketek, Adipra, Anzemet, Cardizem, and Pentassa. MarketWatch

5 Stocks That Are Debt-Free and Paying Big  -  Dec 9, 2008
Demand for Zovirax, a herpes cream, and Cardizem LA, a pill for high blood pressure, is cooling, too. Companywide sales are on pace to shrink to $748 Smartmoney.com

Generic Drugs are as Good as Brand Names for Heart Problems  -  Dec 2, 2008
For example, the brand-name drug Cardizem, a calcium channel blocker, was no more effective than its generic version, diltiazem. A long-acting beta-blocker HealthNewsDigest.com,

Jay L. Himes, Former Antitrust Bureau Chief for the New York ...  -  Dec 2, 2008
...partial settlement; case on-going), In re Cardizem Litigation ($80 million settlement), and In re Compact Disc Litigation ($67 million settlement). Business Wire (press release),

Biovail Corporation - Corporate and Strategic Assessment Report ...  -  Nov 19, 2008
Its products include Cardizem CD, Ativan, Vaseretic, Vasotec, and Isordil. The company´s total revenues increased at a CAGR of 7.9% during 2002-2006, Live-PR.com (Pressemitteilung),

Biovail Reports Third-Quarter 2008 Financial Results  -  Nov 6, 2008
In the third quarter of 2008, Cardizem(R) LA generated revenues of $13.2 million, compared with $14.4 million for the corresponding period in 2007. Centre Daily Times,

Fitch Affirms Watson Pharmaceuticals' IDR at 'BBB-'; Outlook Stable  -  Oct 27, 2008
...on regulatory hold, including generic Toprol XL, Concerta and Cardizem LA as well as the Actos plus metformin extended release branded pharmaceutical. MarketWatch

FDNY paramedics sound alarm  -  Sep 24, 2008
They're also running low on nitroglycerin, which is used to treat angina and heart failure, and Cardizem, a medication used to stabilize a dangerously fast Staten Island Advance - SILive.com,

www.companiesandmarkets.com: Biovail Corporation - Corporate and ...  -  Sep 26, 2008
Its products include Cardizem CD, Ativan, Vaseretic, Vasotec, and Isordil. Biovail derives its revenues primarily from the sales of pharmaceutical products Trading Markets (press release),

Biovail Corporation Q2 2008 Earnings Call Transcript  -  Sep 24, 2008
And lastly, in May we reached an agreement with the US Department of Justice related to their investigation into the 2003 commercial launch of Cardizem LA. Seeking Alpha,

EMT Rep Says Life-Saving Drugs In Short Supply On SI  -  Sep 25, 2008
They include cardizem, nitroglyercin, sodium bicarbonate and other drugs to treat patients with obstructed breathing. Ungar says the problem falls on poor NY1,

United States: Reverse Payment Patent Settlements: the Interplay ...  -  Oct 3, 2008
...held that the pertinent settlement agreements were not anticompetitive, the court in In re Cardizem CD Antitrust Litig., 332 F.3d 896 (6th Cir. Mondaq News Alerts (subscription),

UPDATE 1-Biovail faces suit that it misled investors  -  Oct 9, 2008
Earlier this year the company agreed to pay $24.6 million to settle a case that was launched in connection with the commercial launch of its Cardizem LA Trading Markets (press release),

Dr. Gott: Allergy pills refuse to digest properly  -  Aug 28, 2008
Dear Reader: Cardizem (diltiazem) is a calcium channel blocker used to treat hypertension and certain other cardiac disorders. Northwest Herald,

Patent suits against 3 drug majors in Aug  -  Aug 18, 2008
Sun Pharma was sued by Biovail for infringing the latter’s US patents for Cardizem, used to treat hypertension, with Sun’s proposed generic version of Financial Express,

Understanding hypertension  -  Aug 18, 2008
We can reduce arterial muscle strength (Norvasc and Cardizem), reduce the nerve stimulation of the muscle (Atenalol and Metoprolol) and reduce the brain Staten Island Advance - SILive.com,

Vaincu, Eugene Melnyk vend des actions de Biovail  -  Aug 18, 2008
Elle commercialise une foule de médicaments dont le Cardizem, qui traite certains problèmes cardiovasculaires, et le Zyban, utilisé par ceux qui veulent Cyberpresse,

Biovail's Melnyk Drops Board Challenge and Will Start New Firm  -  Jul 28, 2008
...strategies to combat flagging sales of Biovail's two biggest-selling drugs, the antidepressant Wellbutrin XL and blood-pressure medicine Cardizem LA. Bloomberg

Biovail Judge to Rule by July 14 on Board Election (Update1)  -  Jul 8, 2008
After Melnyk's departure last year, Biovail also settled a criminal probe and investor class-action lawsuit over Cardizem marketing. Bloomberg

2008-07-17 12:51:18 - Biovail Corporation - Corporate and ...  -  Jul 17, 2008
Its products include Cardizem CD, Ativan, Vaseretic, Vasotec, and Isordil. The company´s total revenues increased at a CAGR of 7.9% during 2002-2006, PR-Inside.com (Pressemitteilung),

Biovail Founder Melnyk Wins Board Vote Challenge (Update3)  -  Jul 16, 2008
...touted competing strategies to combat flagging sales of Biovail's two biggest-selling drugs, Wellbutrin XL and blood-pressure medicine Cardizem LA. Bloomberg

AHA Releases Guidelines for Hypertension Management in Adults With ...  -  Jul 16, 2008
Several drugs are contraindicated in patients with heart failure, including verapamil (Calan), diltiazem (Cardizem), clonidine (Catapres), and moxonidine RedOrbit,

Take control of your blood pressure  -  Jul 9, 2008
Calcium channel blockers, such as diltiazem (Cardizem), work by dilating the arteries, he said. ACE inhibitors, such as quinapril (Accupril), LubbockOnline.com,

Biovail Founder Melnyk Seeks Change at `Broken' Firm (Update3)  -  Jun 3, 2008
Biovail's first-quarter profit dropped 40 percent on lower sales of drugs including the antidepressant Wellbutrin XL and blood pressure medicine Cardizem LA Bloomberg

Biovail Founder Melnyk Vows Court Fight Over Proxy (Update1)  -  Jun 25, 2008
Biovail, which makes the antidepressant Wellbutrin XL and blood pressure medicine Cardizem LA, fell 8 cents to $10.68 at 12:58 pm in composite trading. Bloomberg

Biovail says Melnyk just out for control  -  Jun 5, 2008
The company currently relies heavily on its antidepressant Wellbutrin and its Cardizem heart drugs. However, Wells said the generic path has "run out of Reuters

Blood Pressure Medications Can Multi-Task  -  Jun 30, 2008
Popular ones include amlodipine (Norvasc), verapamil (Calan), nifedipine (Procardia) and diltiazem (Cardizem). ACE inhibitors: ACE (angiotensin converting Best of Times,

Biovail stock falls after analyst cuts rating  -  Jun 20, 2008
Adding to that, a generic version of Biovail's blood pressure drug Cardizem LA could be launched as soon as April 2009 by Watson Pharmaceuticals (nyse: WPI Forbes,

Owner Woes, Europe on Bettman's Summer List  -  Jun 19, 2008
...with the Department of Justice in regard to criminal allegations related to activities surrounding the 2003 commercial launch of the drug Cardizem LA. New York Sun,

Melnyk's proposed CEO challenges Biovail CEO Bill Wells to debate  -  Jun 16, 2008
The company, plagued by legal problems from the launch of its Cardizem LA blood-pressure drug in 2003, has urged shareholders to spurn any slate of CFTKTV,

Brand Names/Synonyms:
Cardizem is also known by the following brand names and/or synonymsAcalix; Anoheal; Adizem; Altiazem; Anginyl; Angizem; Apo-Diltiaz; Britiazim; Bruzem; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Cardizen LA; Cartia XT; Citizem; Cormax; Deltazen; Dilacor; Dilacor-XR; Diladel; Dilcontin; Dilpral; Dilrene; Dilt-cd; Dilta-Hexal; Diltia; Dilticard; Dilzem; Dilzen; Endrydil; Herbesser; Incoril AP; Masdil; Novo-Diltazem; Nu-Diltiaz; Syn-Diltiazem; Tiazac Tildiem; d-cis-Diltiazem

Drug Category:
Cardizem is categorized under the following by the FDA: Vasodilator Agents; Cardiovascular Agents; Antihypertensive Agents; Calcium-channel blocking agents; ATC:C08DB01

Dosage Forms:
SOLUTION

Absorption:
Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Interactions:
Interactions for Diltiazem: Due to the potential for additive effects, caution and careful titration are warranted in patients receiving diltiazem hydrochloride concomitantly with other agents known to affect cardiac contractility and/or conduction. Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac. As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem is both a substrate and an inhibitor of the cytochrome P-450 3A4 enzyme system. Other drugs that are specific substrates, inhibitors, or inducers of the enzyme system may have a significant impact on the efficacy and side effect profile of diltiazem. Patients taking other drugs that are substrates of CYP450 3A4, especially patients with renal and/or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels. Beta Blockers Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted. Cimetidine A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg. Ranitidine produced smaller, nonsignificant increases. The effect may be mediated by cimetidine's known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem. Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine. An adjustment in the diltiazem dose may be warranted. Digitalis Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization. Anesthetics The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers. When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully. Cyclosporine A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued. The effect of cyclosporine on diltiazem plasma concentrations has not been evaluated. Carbamazepine Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases. Patients receiving these drugs concurrently should be monitored for a potential drug interaction. Benzodiazepines Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo. The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam. Lovastatin In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone; no change in pravastatin AUC and Cmax was observed during diltiazem coadministration. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin. Rifampin Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered.

Chemical IUPAC Name:
[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate

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