Carbinoxamine Maleate

This page contains recent news articles, when available, and an overview of Carbinoxamine Maleate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Carbinoxamine Maleate (when available)

Pharmacology and use:
Carbinoxamine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, carbinoxamine competes with free histamine for binding at HA-receptor sites. Carbinoxamine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of carbinoxamine. For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis

Mechanism Of Action:
Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

News Articles on Carbinoxamine

FDA Approves Carbinoxamine Maleate Tablet  -  Jun 5, 2008
Carbinoxamine Maleate 4mg Tablet is indicated to treat seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant eMaxHealth.com,

Boca Pharmacal Receives FDA Approval for Carbinoxamine Maleate 4 ...  -  02 Jun 2008
Carbinoxamine Maleate 4mg Tablet is indicated to treat seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant Earthtimes (press release),

Boca Pharmacal Receives FDA Approval for Carbinoxamine Oral Solution  -  Feb 28, 2008
Carbinoxamine Maleate Oral Solution 4mg/5mL is indicated to treat seasonal and perennial allergic rhinitis. "This approval is another example of our FOXBusiness

Brand Names/Synonyms:
Carbinoxamine Maleate is also known by the following brand names and/or synonymsAllergefon; Carbinoxamine; Carbinoxamine Maleate; Clistin; Paracarbinoxamine; Paracarinoxamine; Rotoxamine; Twiston

Drug Category:
Carbinoxamine Maleate is categorized under the following by the FDA: Antihistamines; ATC:R06AA08

Dosage Forms:
Oral Drops; Syrup; Tablet

Absorption:
Not Available

Interactions:
Interactions for Carbinoxamine:

Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS depressants. MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Sympathomimetic amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine. Effects of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers.

Chemical IUPAC Name:
2-sulfanylethanesulfonicacid

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