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BumetanideThis page contains recent news articles, when available, and an overview of Bumetanide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Bumetanide (when available) Bumetanide, a sulfonamide-type loop diuretic structurally related to furosemide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Bumetanide inhibits sodium reabsorption in the ascending limb of the loop of Henle. For the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome Mechanism Of Action: Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, leads to diuresis. News Articles on Bumetanide Saints DE Smith expected to bounce back after rough season - Apr 18, 2009 Smith and Grant were suspended after testing positive for StarCaps, a water pill that contains bumetanide, which is banned by the NFL. Pro Football Weekly Vikings excited about their defense, if everyone stays healthy - Apr 5, 2009 The Williamses, who are not related, were suspended after testing positive for Bumetanide, a diuretic contained in a weight-loss supplement called StarCaps. Pioneer Press Dr. Bill Elliott: Some 'natural' products can be anything but healthy - Apr 5, 2009 StarCaps, which has been widely promoted, was found to contain bumetanide (Bumex - a powerful diuretic). Some of the other undeclared pharmaceutical Marin Independent-Journal Too Good to Be True - Apr 1, 2009 ...and the diuretic bumetanide. No prescription drug—even a diet aid like an appetite suppressant—should be taken without medical supervision. Newsweek Study: Diuretic may put women at risk - Apr 5, 2009 The group of prescription medications, which includes furosemide, torsemide, bumetanide and ethacrynic, work by easing the heart's workload, Memphis Commercial Appeal 10-K: CHINA MEDICINE CORP - Mar 31, 2009 ...the distribution of pharmaceutical products from suppliers, the distribution of self-developed pharmaceutical products (including Bumetanide injection, MarketWatch (press release) Geneesmiddelenfabriek dicht door buitenlandse concurrentie - Apr 12, 2009 Onder andere de door nier- en transplantatiepatiënten gebruikte medicijnen captopril, prednison, azathioprine en bumetanide horen tot het assortiment van NierNieuws.nl 10-K: CHINA PHARMA HOLDINGS, INC. - 18 Mar 2009 In 2008, we launched a new diuretic product: Bumetanide; in November 2008, we were granted approval for our new formulation antibiotic to enter clinical MarketWatch (press release) Trial date set for Kevin, Pat Williams - Feb 25, 2009 Kevin and Pat Williams, who are not related, along with three New Orleans Saints players, were suspended after testing positive for bumetanide, ESPN Authorities drop charges against Vilma - Feb 25, 2009 The five players tested positive for Bumetanide, a banned substance under the NFL’s steroids and related substance policy. All five players claimed the SunHerald.com (subscription) Sports briefs - Feb 26, 2009 The players' union has said the league didn't properly inform the players that a supplement called StarCaps contained the banned diuretic bumetanide. Dubuque Telegraph Herald NFL Notes: Jets' Coles a free agent - Feb 25, 2009 The players' union has said the league didn't properly inform the players that a supplement called StarCaps contained the banned diuretic bumetanide. Asbury Park Press FDA Releases Names of Drugs Now Available as Money-Saving Generics - Feb 24, 2009 ...(Feb 24, 2009)-- Each year, the Food and Drug Administration (FDA) approves scores of generic drugs that treat a wide variety of conditions and help Compliance Home Diet Pills: Are They Natural or Not? - Mar 4, 2009 Unfortunately for supporters like Kathie Lee Gifford, the popular supplement, StarCaps, was found to contain bumetanide, a diuretic that can cause Pierce Mattie Public Relations Lions sign free-agent DT Jackson, CB Buchanon - Mar 4, 2009 Some players said the banned substance Bumetanide was not listed as an ingredient in StarCaps, an over-the-counter weight-loss pill. The Associated Press Tackle Grady Jackson expected to sign with Lions - Mar 3, 2009 The still-pending suspensions resulted from the use of a weight-loss supplement -- called StarCaps -- that contained Bumetanide, a banned diuretic. DetNews.com Magic pill, herb do not exist; - Feb 25, 2009 ...an anti-seizure medication, phenolphthalein, a solution used in chemical experiments and a suspected cancer causing agent and bumetanide, a diuretic. Benson News Sun China Biotech in Review: Investments Continue - Feb 22, 2009 Bumetanide; a hepatitis B treatment, Tiopronin Enteric-Coated Capsules; and Pusen OK, a generic version of cold medication Aleve-D. Sinobiomed (SOBM. Seeking Alpha Your “Natural� Weight-Loss Supplement May Be a Health Hazard - Feb 19, 2009 ...“That product contained an active pharmaceutical ingredient that was, again, not declared, called bumetanide—a diuretic.� The FDA recently asked all the Health.com NFL Free Agency Capsules: Giants sign Houston Texans safety CC Brown - Mar 4, 2009 Some players said the banned substance Bumetanide was not listed as an ingredient in StarCaps, an over-the-counter weight-loss pill. Brownsville Herald FDA Warns Consumers About Tainted Weight Loss Products - Jan 30, 2009 ...(an anti-seizure medication), phenolphthalein (a solution used in chemical experiments and a suspected cancer causing agent) and bumetanide (a diuretic). InjuryBoard.com, FDA expands list of tainted weight-loss products - Jan 15, 2009 The FDA analysis found that these products contained sibutramine, phenytoin, phenolphthalein, and bumetanide. One product, known as Phyto Shape, TheHeart.Org, FDA Warns About Diet Pills - Jan 23, 2009 The FDA's Consumer Information website lists the weight-loss products that contain Sibutramine, Rimonabant, Phenytoin, Phenolphthalein, and Bumetanide, InjuryBoard.com, Study looks at side effects of blood pressure medicine - Jan 21, 2009 Other loop diuretics include bumetanide (Burinex) and torasemide (Torem). They work well, but they do have side effects. One of the side effects is to guardian.co.uk, China Pharma Wins Approval of Hepatitis Drug - Jan 13, 2009 Buflomedil, a treatment for peripheral blood vessel diseases; Roxithromycin dispersible tablet, a macrolide antibiotic; and Bumetanide, a newly approved Seeking Alpha, FDA Publishes More Weight Loss Supplement Warnings - Jan 10, 2009 50 products which contain either rimonabant, phenolphthalein, phenytoin, bumetanide or sibutramine and which make no mention of them on the labeling. UKMedix Health News, Brand Names/Synonyms: Bumetanide is also known by the following brand names and/or synonymsB3023; Bumetanida [Inn-Spanish]; Bumetanide; Bumetanide [Usan:Ban:Inn:Jan]; Bumetanidum [Inn-Latin]; Bumex; Burine; Burinex; CHEMBANK404; EI-168; Fontego; Fordiuran; Lixil; Lunetoron; PF 1593; Segurex; [Inn-Spanish] Drug Category: Bumetanide is categorized under the following by the FDA: Diuretics; ATC:C03CA02 Dosage Forms: TABLET Absorption: Not Available Interactions: Interactions for Bumetanide: 1. Drugs with ototoxic potential: Especially in the presence of impaired renal function, the use of parenterally administered bumetanide in patients to whom aminoglycoside antibiotics are also being given should be avoided, except in life-threatening conditions. 2. Drugs with nephrotoxic potential: There has been no experience on the concurrent use of bumetanide with drugs known to have a nephrotoxic potential. Therefore, the simultaneous administration of these drugs should be avoided. 3. Lithium: Lithium should generally not be given with diuretics (such as bumetanide) because they reduce its renal clearance and add a high risk of lithium toxicity. 4. Probenecid: Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by bumetanide. This antagonistic effect of probenecid on bu-metanide natriuresis is not due to a direct action on sodium excretion but is probably secondary to its inhibitory effect on renal tubular secretion of bumetanide. Thus, probenecid should not be administered concurrently with bumetanide. 5. Indomethacin: Indomethacin blunts the increases in urine volume and sodium excretion seen during bumetanide treatment and inhibits the bumetanide-induced increase in plasma renin activity. Concurrent therapy with bumetanide is thus not recommended. 6. Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs. 7. Digoxin: Interaction studies in humans have shown no effect on digoxin blood levels. 8. Anticoagulants: Interaction studies in humans have shown bumetanide to have no effect on warfarin metabolism or on plasma prothrombin activity. Chemical IUPAC Name: 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid : |
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