Avelox

This page contains recent news articles, when available, and an overview of Avelox but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Avelox (when available)

Pharmacology and use:
Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species* Acinetobacter lwoffii* Micrococcus luteus* Haemophilus influenzae Staphylococcus aureus Haemophilus parainfluenzae* Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hominis Chlamydia trachomatis Staphylococcus warneri* Streptococcus pneumoniae

Mechanism Of Action:
The bactericidal action of Moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

News Articles on Moxifloxacin

Bayer earnings slip but firm says future looks bright  -  Oct 29, 2008
The haemophilia agent Kogenate (recombinant antihaemophilic factor), increased 10.3% to 235 million euros, while the antibiotic Avelox (moxifloxacin) edged Pharma Times (registration),

FDA cracks down on labeling, initiates trial result reporting  -  Nov 14, 2008
The drug family includes Leverkusen, Germany–based Bayer's Cipro (ciprofloxacin), Cipro XR and Avelox (moxifloxacin HCL); Raritan, New Jersey–based Nature.com (subscription),

Connecting the dots: Reasons why fluoroquinolones such as Levaquin ...  -  Nov 14, 2008
Cipro XR and Proquin XR (ciprofloxacin extended release), Factive (gemifloxacin), Levaquin (levofloxacin), Avelox (moxifloxacin), Noroxin (norfloxacin), InjuryBoard.com,

Bayer reports mixed results  -  Oct 29, 2008
The company reported sales growth in its HealthCare and CropScience divisions, but sales at Bayer MaterialScience were almost three per cent lower than in Hays Pharma,

LegalView Informs Cimzia Patients of Possible Risks Among Young ...  -  Oct 2, 2008
The fluoroquinolone drug family consists of Cipro (ciprofloaxacin), Levaquin (levofloxacin), Factive (gemifloxacin mesylate), Avelox (moxifloxacin HCL), PR Leap (press release),

Learn about the World Antibiotics Market  -  Sep 24, 2008
Avelox, Ciprobay/Ciproxin, Cravid, andOthers (includes corresponding Graph/Chart) II-7Merck Rules Carbapenems Market II-8Table 7: Worldwide Leading International Business Times,

Learn about the World Antibiotics Market  -  Sep 24, 2008
Avelox, Ciprobay/Ciproxin, Cravid, and Others (includes corresponding Graph/Chart) II-7 Merck Rules Carbapenems Market II-8 Table 7: Worldwide Leading Earthtimes (press release),

Welch: Drug samples welcome, downside is you must be sick  -  Sep 28, 2008
I’m perfectly willing to test Avelox (which I like to think of as very expensive if you have to buy it, so if it isn’t, I don’t want to know). Times Record News,

Antibiotici: secondo l’EMEA deve essere limitato l’uso delle ...  -  Oct 16, 2008
Membri dell'Unione Europea ( UE ) sotto diversi nomi commerciali ( Actimax, Actira, Avelox, Havelox, Infekt, Izilox, Moxifloxacin, Octegra e Proflox. XagenaSalute,

LegalView Reports Details of a New Traumatic Brain Injury  15 Sep 2008
Cipro (ciprofloxain) along with Levaquin, Factive, Avelox, Cipro XR, Proquin XR, Noroxin and Floxin, all have been linked to tendon ruptures and tendonitisTransWorldNews (press release),

Tendinitis and Tendon Rupture Lead to Black Box Warning  Aug 19, 2008
The drugs affected by this black box request include Cipro and Proquin brands ciprofloxacin, Factive brand gemifloxacin, Levaquin brand levofloxacin, AveloxInjuryBoard.com,

FDA Mandates New Boxed Warning for Fluoroquinolones  Aug 20, 2008
...marketed as Levaquin; moxifloxacin, marketed as Avelox; norfloxacin, marketed as Noroxin; and ofloxacin, marketed as Floxin and generic ofloxacin.AAFP News Now

avelox kuuri  Sep 8, 2008
Sain juuri tietää että olen raskaana. söin Avelox 400mg antibioottikuurin kaksi viikkoa sitten.onko tästä haittaa sikiölle? aloitin kuurin 20.8 ja raskausVerkkoklinikka,

Antibiotics may get tougher warnings  -  Jul 9, 2008
The new warnings affect an antibiotic class known as fluoroquinolones, sold as Noroxin, Ciproxin and Avelox and under generic brands in Australia. The Age,

Avelox, Similar Antibiotics Face European Restrictions Due to ...  -  Jul 31, 2008
Moxifloxicin, a fluoroquinolone antibiotic sold as Avelox by Bayer, is being subjected to new warnings and restrictions by the European Medicines Agency Newsinferno.com,

European Medicines Agency recommends label restrictions for ...  -  Jul 24, 2008
Bayer already warned doctors in February that Avelox may lead to potentially fatal liver damage and skin disease in rare cases, following a routine analysis Hemscott,

FDA Safety Changes: Asmanex Twisthaler, Advair HFA, Avelox  -  Jul 24, 2008
On February 15, the FDA approved safety labeling revisions for moxifloxacin HCl tablets and moxifloxacin in sodium chloride injection (Avelox, Medscape (subscription)

Mark & Associates, PC Investigating Reports of Serious Tendon ...  -  Jul 30, 2008
Cipro, Levaquin and Avelox users who suffered tendon injuries can receive free case evaluations by visiting the following websites: http://www. WebWire (press release),

Europe's Antibiotic Warnings  -  Jul 30, 2008
Affected fluoroquinolone drugs include: Cipro, Cipro XR and Proquin XR, Factive, Levaquin, Avelox, Noroxin and Floxin, and generic ofloxacin. Pharmaceutical Technology Magazine,

Bayer and J&JPRD submit rivaroxaban application in US  -  Jul 30, 2008
Bayer has said its cooperative partner Johnson & Johnson Pharmaceutical Research and Development (J&JPRD) has submitted the new drug application in the US Hays Pharma,

FDA Issues Antibiotic Warning  -  Jul 30, 2008
The antibiotics to watch for include: Cipro, Cipro XR, Proquin XR, Factive, Levaquin Avelox, Noroxin and Floxin. The Anti-Aging Bottom Line: More forceful Stop Aging Now,

EMEA issues host of decisions  -  Jul 25, 2008
Report The EMEA restricting the use of antibiotics based on moxifloxacin--marketed by Bayer under the name Avelox--because of the potential risk of liver FierceBiotech,

FDA Warns Of Tendon-Rupturing Antibiotics  -  Jul 17, 2008
Drugs in this group include Cipro, Levaquin, Avelox, Oscient, Factive, Proquin XR, Floxin Noroxin. Ruptures associated with the drug have included the The Consumerist,

Fluoroquinolones: safety warnings to have limited commercial impact  -  Jul 10, 2008
...usage of fluoroquinolones such as Cipro (ciprofloxacin), Levaquin (levofloxacin), Avelox (moxifloxacin) or any of the other big name fluoroquinolones. Pharmaceutical Business Review

TOP MARKET NEWS  -  Jul 8, 2008
Factive (gemifloxacin), Levaquin (levofloxacin), Avelox (moxifloxacin), Noroxin (norfloxacin), and Floxin and generic ofloxacin. by RTT Staff Writer. RTT News,

EMEA proposes restrictions on use of Bayer's Avelox  -  Jul 25, 2008
The European Medicines Agency has recommended restricting the use of antibiotics based on moxifloxacin, marketed by Bayer as Avelox, because of the Pharma Times (subscription),

Bayer Welcomes The Proposed EMEA Labeling Changes For Moxifloxacin  -  Jul 28, 2008
It is marketed under the brand names Avelox®, Avalox®, Izilox®, Actira®, Octegra®, Proflox®, Actimax®, Lapinix®, Havelox®, Avelon®, Megaxin® and Promira®. Medical News Today (press release),

Lyme disease threat remains though cases fall  -  Jul 27, 2008
He gave her a $100 prescription for Avelox. "So I took that, and assumed he was right, and we ended up going on vacation up to Maine, and while we were up Poughkeepsie Journal,

Bayer recruits Pfizer exec as drugs chief; EMEA to restrict ...  -  Jul 25, 2008
...on moxifloxacin--marketed by Bayer under the brand name Avelox--because of the potential risk of liver damage, and also wants strengthened warnings. FiercePharma,

Schering-Plough Q2 Profit Drops On Charges, Revenue Up 55%  -  Jul 21, 2008
Claritin sales increased 8%, while sales of antibiotic Avelox declined 12% from the same quarter last year. Animal Health sales for the quarter surged 210% Trading Markets (press release),

Schering-Plough Reports Financial Results for Second Quarter of 2008  -  Jul 21, 2008
Sales of AVELOX, an antibiotic marketed in the US, were down 12 percent to $67 million primarily reflecting a weaker respiratory tract infection season. Earthtimes (press release),

Some Antibiotics Could Damage Tendons, FDA Says  -  Jul 14, 2008
Some antibiotic drugs such as Bayer AG's Cipro and Avelox as well as Merck & Co. Inc's Noroxin will be required to have a stronger "black box" warning about Evening Bulletin,

Schering Plough Corp. Q2 2008 Earnings Call Transcript  -  Jul 21, 2008
On a sequential basis, the gross margin decline was primarily impacted by REMICADE and AVELOX as well as growth in our animal health business. Seeking Alpha,

Malaria drug may be fueling antibiotic resistance  -  Jul 16, 2008
N: Quote, Profile, Research) Levaquin or levofloxacin and Bayer's Avelox or moxifloxacin. "We tested for Cipro because that is still the most widely used, Reuters UK,

Europäische Arzneimittelbehörde EMEA schränkt Gabe von Bayer ...  -  Jul 25, 2008
LONDON (AWP International) - Die europäische Arzneimittelbehörde EMEA will die Verwendung des Antibiotikums Avelox des Leverkusener Chemie- und Swissinfo,

FDA ordnet schärfere Warnhinweise bei Bayer-Antibiotika an  -  Jul 8, 2008
DE-Antibiotika Cipro und Avelox. Die FDA ordne einen schwarz umrandeten Warnhinweis an und damit den stärksten für rezeptpflichtige Arzneien in den USA, Reuters Deutschland,

FDA, 플로로퀴놀론 계열 항�?제 부작용 경고  -  Jul 9, 2008
...플로로퀴놀론 계열�?� �?�약품으로는 ‘시프로(Cipro)’, ‘레바퀸(Levaquin)’, ‘아베�?스(Avelox), ‘노�?신(Noroxin), ‘프�?신(Floxin)’등�?� 있다. 중앙�?�보,

Exigen poner advertencia en antibióticos  -  Jul 9, 2008
Las medicinas que forman parte de esta acción son Cipro y su genérico ciprofloxacino, Cipro XR, Proquin XR, Factive, Levaquin, Avelox, Noroxin y Floxin y su Univisión

FDA�?Cipro等抗生素發出�?大緊急警告  -  Jul 14, 2008
FDA因此下令生產Cipro�?Cipro XR�?Proquin XR�?Factive�?Levaquin�?Avelox 中央日報,

A Cipro elnevezésű antibiotikum akár ínszakadást is okozhat  -  Jul 9, 2008
A Magyarországon is forgalomban lévő Cipro, Avelox, Floxin, valamint világszerte több, más néven piacra kerülő, hatékony antibiotikum kockázatai közé Népszava,

Antibiotice cu avertizări  -  Jul 9, 2008
Antibioticele cu astfel de efecte fac parte din familia fluoroquinolone, iar dintre cele care se găsesc şi în farmaciile din România se numără Avelox, Evenimentul Zilei,

Varning för moxifloxacin  -  Jul 25, 2008
Moxifloxacin används i Sverige under namnet Avelox. Det är sedan tidigare känt att preparatet kan ge leverbiverkningar. Dagens Medicin,

Norfloksasiinin ja moksifloksasiinin käyttöön rajoituksia  -  Jul 25, 2008
Norfloksasiinia on Suomessa kaupan nimillä Norfloxacin Sandoz ja Norfloxacin-Ratiopharm ja moksifloksasiinia nimellä Avelox. Apteekkariliitto,

美 ‘플루오로퀴놀론’ 블랙박스 경고  -  Jul 8, 2008
...플루오로퀴놀론 계열 항�?제로는 ‘시프로’(Cipro, ciprofloxacin), ‘팩티브’(Factive, gemifloxacin), ‘레바퀸’(Levaquin, levofloxacin), ‘아벨�?스’(Avelox, 디지틀보사,

美FDA警告抗生素伤害肌腱  -  Jul 13, 2008
...厂出产的Cipro与Avelox 大纪元

FDA alerta sobre risco de tendinites e rupturas de tendão devido a ...  -  Jul 10, 2008
Os avisos devem afectar o Cipro (ciprofloxacina) eo Avelox (moxifloxacina), da Bayer AG, o Factive (mesilato de gemifloxacino), da Oscient Pharmaceuticals Farmacia,

퀴놀론계 항균제, “아킬레스건 파열 조심�? 블랙박스 경고  -  Jul 9, 2008
Cipro XR �? Proquin XR 등), gemifloxacin(Factive), levofloxacin(Levaquin), moxifloxacin(Avelox), norfloxacin(Noroxin), ofloxacin(Floxin) 등�?� 해당�?�다. 메디�?�뉴스,

Dünger für die Bilanz  -  Jul 31, 2008
Offen ist auch, wie es mit dem Antibiotikum Avelox weitergeht. Die europäische Arzneimittelbehörde hatte vor einer Woche angekündigt, die Verwendung Tagesspiegel,

Dax mit Fehlstart  -  Jul 25, 2008
Die europäische Arzneimittelbehörde Emea will die Verwendung des Antibiotikums Avelox von Bayer einschränken, weil sie gefährliche Leberschädigungen durch ARD,

XETRA-SCHLUSS/Knapp behauptet - Schlussspurt trotz MüRück-Warnung  -  Jul 25, 2008
Dank der guten Vortageszahlen von Syngenta sei hier die Empfehlung der europäischen Arzneimittelbehörde EMEA, das Antibiotikum "Avelox" nur noch Frankfurter Allgemeine Zeitung,

Europa-Börsen knapp behauptet - US-Daten wiegen Versicherer auf  -  Jul 25, 2008
Hier verpuffte die Empfehlung der europäischen Arzneimittelbehörde EMEA, das Antibiotikum "Avelox" nur noch eingeschränkt zu verwenden. Frankfurter Allgemeine Zeitung,

EMEA рекомендует ограниченное применение мок�?ифлок�?ацина  -  Jul 29, 2008
В на�?то�?щее врем�? в ЕС одобрены: Actimax®, Actira®, Avelox®/�?велок�?®, Havelox®, Infekt®, Izilox®, Moxifloxacin/Мок�?ифлок�?ацин, Octegra® и Proflox®. ИИ�?. Ремедиум,

�?זהרה חמורה של ה-FDA ל�?נטיביוטיקה  -  Jul 8, 2008
...(Proquin XR), לווקוין (Levaquin), פלוקסין (Floxin), נורוקסין (Noroxin), �?בלוקס (Avelox), פקטיב (Factive). על-פי הערכות ה�?רגון, קרעי�? ספונטניי�? בגידי�? Nfc חדשות מחלקה ר�?שונה,

Krisen-Virus grassiert weiter  -  Jul 8, 2008
FDA fordert schärfere Warnhinweise bei so genannten antimikrobiellen Wirkstoffen, darunter auch die Bayer-Antibiotika Cipro und Avelox. ARD,

Infarmed alerta para restrições de utilização de medicamentos com ...  -  Jul 28, 2008
...inflamatória pélvica ligeira a moderada. Em Portugal, os medicamentos com Autorização de Introdução no Mercado (AIM) são o Actira, o Avelox eo Proflox. Farmacia,

Fármaco para malaria incentivaría la resistencia a antibióticos  -  Jul 16, 2008
...a Cipro podría extenderse a medicinas más nuevas de la clase, como Levaquin o levofloxacina de Johnson & Johnson y Avelox o moxifloxacina de Bayer. Buena Salud

Fármaco para malaria incentivaría la resistencia a antibióticos  -  Jul 16, 2008
...a Cipro podríaextenderse a medicinas más nuevas de la clase, como Levaquin olevofloxacina de Johnson & Johnson y Avelox o moxifloxacina deBayer. EcoDiario.es,

Les médicaments anti-malaria créent une résistance aux antibiotiques  -  Jul 16, 2008
Cipro pouvait être similaire pour d’autres antibiotiques tels que la Levaquin de Johnson & Johnson (levofloxacine) ou l’Avelox de Bayer (moxifloxacine). Actualités News Environnement,

FDA cảnh báo: Kháng sinh có hại cho dây chằng  -  Jul 9, 2008
Cảnh báo này nhằm cụ thể vào các loại thuốc kháng sinh như Avelox của hãng Bayer, Facitve của tập đoàn Dược Oscient và Proquin XR của công ty Depomed. Dân Trí,

抗生素�?�致肌腱斷裂  -  Jul 9, 2008
...�?明報專訊】美國食�?�?�藥物管�?�局（ FDA）昨建議，藥廠應在抗生素Cipro的包�?上加警告字�?�，指有關抗生素�?�能會引致肌腱斷裂。當局指肌腱斷裂常見于�?�動創傷，但該種新浪北美,

Certain antibiotics, statins can cause problems  -  Jun 8, 2008
...moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), and trovafloxacin mesylate/alatrofloxacin mesylate (Trovan). KPCnews.com,

Avelox® Monotherapy Shows Strong Performance In Treating ...  -  May 19, 2008
A recently published study in Clinical Infectious Diseases shows that Avelox® (moxifloxacin HCl) monotherapy is as powerful as a high dose combination Medical News Today (press release),

Moxifloxacin Alone Equals Combo Regimen in Pneumonia  -  May 16, 2008
By John Gever, Staff Writer, MedPage Today BARCELONA, May 16 -- Moxifloxacin (Avelox) by itself was as effective as a standard combination of two MedPage Today,

Bayer unit sues for drug payments  -  May 4, 2008
...s Schering Corp. to sell Bayer products, including the blood-pressure drug Adalat, the impotence pill Levitra and antibiotics Cipro and Avelox in the US The News Journal,

Schering Plough First Quarter Earnings Call  -  May 28, 2008
Sales of the antibiotic AVELOX were up 24% to $142 million as a result of increased market share. - Included in the first quarter of 2008 were net sales of 123Jump.com,

Additional Uses, Additional Profits  -  May 14, 2008
The drug Avelox, for example, which is marketed in the US by Schering-Plough (NYSE: SGP), is approved by the FDA to treat some forms of bronchitis, Motley Fool

Avelox® monotherapy shows strong performance in treating ...  -  May 16, 2008
...recently published study in Clinical Infectious Diseases shows that Avelox® (moxifloxacin HCl) monotherapy is as powerful as a high dose combination regimen Prdomain Business Register (press release),

Schering-Plough Reports Financial Results for First Quarter of 2008  -  23 Apr 2008
Sales of the antibiotic AVELOX were up 24 percent to $142 million as a result of increased market share. Animal Health sales totaled $723 million in the Earthtimes,

Prognosis looks good for region's drug makers  -  Apr 15, 2008
Of course, the regional data obtained during Giant is also expected to have a positive impact on sales of Avelox in the region. Emirates Business 24/7,

Bayer/Schering-Plough/Shionogi's Avelox Has Advantages Over ...  -  Apr 17, 2008
Clinical data and expert opinion show that Bayer/Schering-Plough/Shionogi's Avelox (moxifloxacin) is similar in overall clinical efficacy to the market PR Newswire (press release),

Brand Names/Synonyms:
Avelox is also known by the following brand names and/or synonymsAvelox; Avelox I.V.; CHEMBANK1636; Moxifloxacin; Moxifloxacin Hcl; Moxifloxacin Hydrochloride; Vigamox

Drug Category:
Avelox is categorized under the following by the FDA: Anti-bacterial Agents; Quinolones; ATC:J01MA14

Dosage Forms:
SOLUTION; TABLET

Absorption:
Not Available

Interactions:
-->Interactions for Moxifloxacin:

Drug-drug interaction studies have not been conducted with VIGAMOX™ solution. In vitro studies indicate that moxifloxacin does not inhibit CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2 indicating that moxifloxacin is unlikely to alter the pharmacokinetics of drugs metabolized by these cytochrome P450 isozymes.

Chemical IUPAC Name:
1-cyclopropyl-7-(5,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1H-quinoline-3-carboxylicacid

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