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AvaproThis page contains recent news articles, when available, and an overview of Avapro but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Avapro (when available) Irbesartan, an angiotensin II receptor antagonist similar to losartan and valsartan, is used alone or with hydrochlorothiazide to treat hypertension For the treatment of hypertension. Mechanism Of Action: Irbesartan antagonizes angiotensin II, the primary vasoactive hormone of the renin-angiotensin system, at the AT1 receptor subtype. As angiotensin II is vasoconstrictor which stimulates aldosterone secretion by the adrenal gland, blockage of its effects results in a decrease in systemic vascular resistance. News Articles on Irbesartan Fitch Expects Bristol-Myers Squibb's Ratings to be Unaffected by ... - Jul 31, 2008 Revenue growth will be led by Bristol-Myers Squibb's five top-selling products: Plavix, Avapro/Avalide, Abilify, Reyataz and Sustiva, offset by loss of PR-Inside.com (Pressemitteilung), ARBs might prevent, treat Alzheimer's - Jul 28, 2008 Merck has Cozaar, Boehringer Ingelheim has Micardis, Bristol-Myers Squibb and Sanofi-Aventis have Avapro, Kos has Teveten, and AstraZeneca has Atacand. FiercePharma, Medical Watch: Top 7 Most Dangerous Drugs - Jul 24, 2008 You may know it by many different names including Caduet, Avapro or Zestil to name a few. According to the pharmacist, taking allergy or cold medicine with News Channel 7, Sanofi-aventis News - Jul 31, 2008 Worldwide presence of Aprovel(R)/ Avapro(R)/ Karvea(R) Change on a Change on a comparable comparable euro million Q2 2008 basis H1 2008 basis Europe 255 PR Newswire (press release), Sanofi-aventis News - Jul 31, 2008 The share of after-tax profits from territories managed by BMS under the Plavix(R) and Avapro(R) alliance amounted to euro 145 million, compared with euro PharmaLive.com (press release), Gaining Stunning Health Improvements Because Of Low-Carb Living - Aug 2, 2008 He said the Avapro( blood pressure medication ) does more for you than just lower your blood pressure, it also protects your kidneys. What? The Common Voice, 2nd UPDATE:Lilly, Bristol 2Q Profits Up On Higher Drug Sales - Jul 24, 2008 Combined sales of anti-hypertension medications Avapro and Avalide rose 13% to $335 million . HIV medication Reyataz posted a 28% increase to $324 million CNNMoney.com Bristol-Myers, Eli Lilly post strong 2Q results - Jul 24, 2008 Among the company's other key drugs, sales rose 13 percent to $335 million for blood-pressure drug Avapro, jumped 28 percent to $529 million for bipolar The Associated Press Sector Snap: Major pharma declines - Jul 18, 2008 Bristol-Myers will lose patent protection on its anticlotting drug Plavix and high blood pressure drug Avapro. Lilly shares declined 70 cents to $47.68, Forbes, Nem zörög a haraszt: eladás elÅ‘tt a gyógyszeripari óriás? - Jul 30, 2008 A szakmában sokat úgy vélik, a cég óriási teherpróba elÅ‘tt áll, 2012-ben ugyanis két termékének szabadalmi oltalma is lejár: az egyik az Avapro Weborvos, 施贵å®?第二å£åº¦ç›ˆåˆ©å?Œæ¯”攀å?‡8.2% - Jul 24, 2008 ...å·²ç»?上市销售多年的抗高血压è?¯ç‰©Avapro 新浪网, Ð?мериканÑ?кие фармацевты не Ñ?ошлиÑ?ÑŒ в цене - Aug 4, 2008 Ð’ портфолио компании входÑ?Ñ‚ такие препараты, как Avapro, Enfamil, Plavix, Sustiva и другие. Отметим, Bristol-Myers Squibb длительное времÑ? Ñ?влÑ?лаÑ?ÑŒ Комп&ньон.online (преÑ?Ñ?-релиз), Sanofi-Aventis : détails des comptes du second trimestre 2008 - Jul 31, 2008 La quote-part de profit après impôt, qui provient des territoires gérés par BMS dans le cadre de l'alliance sur Plavix et Avapro atteint 145 ME contre 136 Le Revenu, 制è?¯å…巨头第二财å£ç›ˆåˆ©å››å?‡ä¸¤é™? - Jul 24, 2008 ...å·²ç»?上市销售多年的抗高血压è?¯ç‰©Avapro æ…§è?ªç½‘, 百時美-施貴寶第二å£åº¦ç›ˆåˆ©å?Œæ¯”攀å?‡8.2% - Jul 24, 2008 ...已經上市銷售多年的抗高血壓藥物Avapro 新浪網, Notice of Launching of Anti-Hypertension Drug 'Avapro' - Jun 23, 2008 AVAPRO® is a long-acting ARB (angiotensin II receptor antagonist) with a long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, PharmaLive.com (press release), Rumor mill: BMS positioning itself for sale - Jun 30, 2008 Two key patents expire in 2012, for Avapro and Plavix, and the same year, BMS loses US rights to Abilify. But its pipeline is promising, and it has the FiercePharma, Losartan slows rate of enlargement of aorta in Marfan syndrome - Jun 25, 2008 Cozaar (losartan) was given to 17 of the children and Avapro (irbesartan) was given to one child. The researchers found that in this study, the medications About - News & Issues, Antihypertensive Drugs Prevent Aortic Dissection in Marfan's - Jun 25, 2008 ...of the angiotensin-receptor blockers losartan (Cozaar) or irbesartan (Avapro) compared with standard beta-blocker therapy (0.46 versus 3.54 mm per year, MedPage Today, Popular Drugs, Side-Effects and Feeling Ill - Jul 1, 2008 ...as well as the Designer Drugs; angiotensin II receptor blockers (ARBs); Olmesartan (Benicar ) including candesartan (Atacand) and irbesartan (Avapro), Rocklin and Roseville Today, Blood Pressure Medications Can Multi-Task - Jun 30, 2008 A newer group of drugs –but similar in action- came out and these “ARBsâ€? are known as Cozaar, Diovan, Avapro, Atacand and Micardis and Benicar. Best of Times, Vessel rescue - Jun 25, 2008 The other patient got a similar drug called irbesartan, sold as Avapro by Bristol-Myers-Squibb. The researchers report in the June 26 New England Journal of Science News POR AGENCIAS: Agencia IBNW - May 15, 2008 ...includes antiplatelet and antithrombotic agents with Plavix(R) and Clexane(R)/Lovenox(R), as well the antihypertensive agent Aprovel(R)/Avapro(R). InfoBolsa, Pharmacopeia's First-in-Class Investigational Therapy PS433540 ... - May 16, 2008 ...(1) Prescribing Information for Coreg CR(R), Lotensin(R), Avapro(R), Benicar(R) and Norvasc(R) (2) American Heart Association news release. PR Newswire (press release), Many Possible Routes to the Goal of 120/80 - Apr 21, 2008 They include Diovan, Benicar and Avapro. Calcium channel blockers. Drugs like Norvasc, Procardia XL and DynaCirc CR help dilate blood vessels by preventing New York Times, Japan Approves Dainippon Antihypertensive Drug Avapro - Apr 17, 2008 Avapro® is a long-acting ARB (angiotensin II receptor antagonist) with a long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, PharmaLive.com (press release), Sanofi-aventis Announces 2007 Earnings Ahead of Guidance Sharp ... - Feb 12, 2008 The share of after-tax profits from territories managed by BMS (primarily the United States) under the Plavix(R) and Avapro(R) alliance was euro 149 million PR Newswire (press release), Ahead of the Bell: Bristol-Myers Squibb - Jan 24, 2008 ..."Valuation now better reflects the company's growth challenges beyond Plavix, Avapro, and Abilify," Kelly wrote in a client note. Houston Chronicle, Bristol-Myers Squibb Company Reports Financial Results for the ... - Jan 31, 2008 2006 Twelve Months Ended December 31, Pharmaceuticals Cardiovascular Plavix $4755 $3257 46 % 4060 2655 53 % 34 % Avapro/Avalide 1204 1097 10 % 692 647 7 CNNMoney.com Bristol-Myers Posts Quarterly Loss on Investments (Update4) - Jan 31, 2008 Orencia, a rheumatoid arthritis medication approved in 2006, also more than doubled to $75 million. The blood-pressure medicines Avapro and Avalide rose 7 Bloomberg Bristol-Myers reports narrowed loss amid charges - Jan 31, 2008 Another big-seller, the hypertension medication Avapro, saw sales climbed 7% to $328 million. That product, whose key patent expires in 2012, MarketWatch B-MS posts loss and counts cost of subprime investments - Feb 1, 2008 As for B-MS’ other products, sales of the antipsychotic Abilify (aripiprazole) were up 28% to $462 million, while the antihypertensive Avapro/Avalide Pharma Times (subscription), BMS and Sanofi-Aventis Hypertension Drug Approved for Additional Use - Nov 28, 2007 After five weeks, the patients on Avalide had greater mean blood pressure reductions than those on Avapro alone. Avalide is approved for patients whose FDA news (subscription), FDA approves Sanofi-Aventis's Avalide for additional use - Nov 20, 2007 Now with Avapro (irbesartan) and Avalide physicians have more therapeutic options to treat mild, moderate and severe hypertension." Pharmaceutical Business Review Sector Snap: Pharma Shares Trade Mixed - Dec 6, 2007 ..."The patent cliff in 2012, which includes Plavix, (hypertension treatment) Avapro and returning (bipolar drug) Abilify to Otsuka create a significant hurdle Houston Chronicle, Bristol May Be Poised To Get Much Smaller - Nov 30, 2007 The analyst also suggested Bristol might even want to get out of its co-marketing arrangement with Sanofi-Aventis for the anti-hypertension drug Avapro. Wall Street Journal BMS Not Interested In Merger With Sanofi-Aventis - Source - Nov 28, 2007 ...has substantial research capability and the two groups have been historic partners in the marketing of Plavix and blood pressure treatment Avapro. CNNMoney.com UPDATE 2-Bristol profit jumps as Plavix continues rebound - Oct 25, 2007 Sales of blood pressure treatment Avapro rose 12 percent to $309 million, while sales of colon cancer drug Erbitux grew 6 percent to $185 million. Reuters Sanofi-aventis Announces a Good Third Quarter Performance ... - Oct 31, 2007 The share of after-tax profits from territories managed by BMS (primarily the United States) under the Plavix(R) and Avapro(R) alliance was euro 141 million CNNMoney.com Bristol-Myers Squibb Company Reports Financial Results for the ... - Oct 25, 2007 Sales of AVAPRO(R)/AVALIDE(R), an angiotensin II receptor blocker for the treatment of hypertension, also part of the sanofi-aventis alliance, increased 12% CNNMoney.com Business FYI: Organi Studios offers varied design services - Nov 11, 2007 A five-minute animation to market Bristol Myers Squibb's drug Avapro. While Gramblin loves animation, he said he simply wants to design, no matter what form Tulsa World, 3rd UPDATE: Bristol 3Q Net More Than Doubles On Gain, Plavix - Oct 25, 2007 Hypertension drugs Avapro and Avalide posted a combined 12% increase to $309 million . Bristol expects 2007 earnings excluding items of $1.42 to $1.47 CNNMoney.com UPDATE: Plavix Sales Stoke Bristol-Myers Earnings - Oct 25, 2007 Avapro, another product co-marketed with Sanofi, saw sales rise 12% to $309 million . Sales of the oncology drug Erbitux, which is co-marketed with imclone CNNMoney.com Bristol-Myers's Net More Than Doubles - Oct 25, 2007 Hypertension drugs Avapro and Avalide posted a combined 12% increase to $309 million. Looking ahead, Bristol, which has been the target of takeover Wall Street Journal Common Medications Provide Equal Blood Pressure Control - Nov 1, 2007 The arbs included were candesartan cilexetil (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan medoxomil (Benicar), Earthtimes, Return to form for Plavix propels profits at Bristol-Myers Squibb - Oct 26, 2007 As for B-MS’ other products, sales of the antipsychotic Abilify (aripiprazole) were up 34% to $420 million, while the antihypertensive Avapro/Avalide Pharma Times (subscription), Search By Symbol - Oct 25, 2007 Sales of Avapro/Avalide for the quarter climbed 12% to $309 million from $277 million in the same period of last year and include a 3% favorable foreign RTT News, Pharmacopeia Shares Rise on CIBC View - Oct 11, 2007 ...s Avapro. Even though DARA could require a warning for teratogenicity, or birth defects, he doesn't expect it to be a significant problem for sales if CNNMoney.com BERICHT: Buy Drugs Without Prescription. No Prior Prescription ... - Oct 7, 2007 ...avandia rosiglitazone maleate, transcripts avandia curt rosebrau fda, avapro face swelling, avapro taking effects blood, avapro chest pressure, Ermelo.org, FOCUS Sanofi-Aventis surges on Pfizer interest rumour; analysts ... - Oct 9, 2007 ..."If you look at 2010 and beyond, Pfizer loses a number of their major products and with Sanofi losing Taxotere, Eloxatine, Plavix and Avapro in exactly that Euro2day, Whistleblowers Responsible for Half-Billion Dollar Fraud Recovery ... - Oct 1, 2007 45 drugs made or marketed by Bristol Myers, including Tequin, Pravachol, Glucovance, Avapro, Plavix Abilify, Monopril, Metaglip, Taxol and Coumadin. Common Dreams (press release), Pharmacopeia advances dual cardiovascular drug into Phase II - Sep 17, 2007 The molecule is based on two drugs that share a common structural feature: Avapro (irbesartan), a AII receptor blocker that is jointly marketed by DrugResearcher.com, Ahead of the Bell: Forest Labs - Sep 4, 2007 ...the company faces a patent "black hole" in 2012, when its blood thinner Plavix and blood pressure drug Avapro/Avilide will face generic competition. Forbes, BIOTECH STOCKS Drug stocks climb; Forest gains on upgrade - Sep 4, 2007 The analysts cut Bristol-Myers to sell, citing the upcoming patent expirations for its blockbuster drugs Plavix and Avapro and high valuation due in part to MarketWatch Behind the Headlines: Bristol-Myers Squibb (BMY) Slips Sideways on ... - Sep 4, 2007 ...to "sell," citing inflated valuation of the shares and the upcoming loss of patent protection on its 2 top-selling drugs, Plavix and Avapro, in 2012. Schaeffers Research, Bristol-Myers Squibb's IDR affirmed at 'A+'; off watch negative ... - Aug 3, 2007 Forbes,...of 2006 will reverse this year bolstered by growth of Bristol-Myers' five leading drug products, Plavix, Abilify, Avapro/Avalide, Reyataz and Sustiva. Sanofi-aventis First Half 2007: Solid Results in a Difficult Context; - Aug 1, 2007 CNNMoney.comThe share of after-tax profits from territories managed by BMS (primarily the United States) under the Plavix(R) and Avapro(R) alliance was flat (euro136 2nd UPDATE: Bristol-Myers 2Q Net Up, Co Plans Job Cuts - Jul 26, 2007 CNNMoney.comHypertension drugs Avapro and Avalide posted a combined 6% increase to $297 million . Cancer drug Erbitux, for which Bristol-Myers pays royalties to ImClone Generics take a toll on Bristol-Myers earnings - Jul 26, 2007 MarketWatchSales of hypertension medication Avapro, also co-marketed with Sanofi-Aventis (SNY : According to a recent note by analysts at AG Edwards, Plavix sales were Bristol-Myers Net Gains on Schizophrenia, AIDS Drugs (Update1) - Jul 26, 2007 BloombergThe blood-pressure medicines Avapro and Avalide rose 6 percent to $297 million. Six experimental treatments for diabetes, cancer and blood clot prevention BMS raises earnings guidance but cuts jobs - Jul 27, 2007 Pharma Times (subscription),Meanwhile other strongly performing drugs included: the hypertension medicine Avapro/Avalide (irbesartan), which rose 6% to $297 million; the schizophrenia Rebound of Plavix bolsters Bristol - Jul 26, 2007 Newark Star Ledger,...antipsy chotic agent Abilify, up 27 percent; blood pressure pill Avapro, up 6 percent; and new rheumatoid arthritis drug Orencia, up 205 percent. Bristol-Myers Squibb reports slight increase in second-quarter sales - Jul 26, 2007 Medical Marketing and Media,Hypertension drugs Avapro and Avalide posted a combined 6.1% increase to $297 million. Meanwhile, sales of oncology drug Erbitux dropped 5.8% to $162 from Brand Names/Synonyms: Avapro is also known by the following brand names and/or synonymsAvalide; Avapro; CHEMBANK1635; Irbesarran; Irbesartan; Irbesartan [Usan:Inn]; Lrbesartan Drug Category: Avapro is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA04 Dosage Forms: Oral tablets Absorption: 60-80% Interactions: -->Interactions for Irbesartan: No significant drug-drug pharmacokinetic (or pharmacodynamic) interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, and nifedipine. In vitro studies show significant inhibition of the formation of oxidized irbesartan metabolites with the known cytochrome CYP 2C9 substrates/inhibitors sulphenazole, tolbutamide and nifedipine. However, in clinical studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin were negligible. Based on in vitro data, no interaction would be expected with drugs whose metabolism is dependent upon cytochrome P450 isozymes 1A1, 1A2,2A6,2B6,2D6,2E1,or 3A4. In separate studies of patients receiving maintenance doses of warfarin, hydrochlorothiazide, or digoxin, irbesartan administration for 7 days had no effect on the pharmacodynamics of warfarin (prothrombin time) or pharmacokinetics of digoxin. The pharmacokinetics of irbesartan were not affected by coadministration of nifedipine or hydrochlorothiazide.
Chemical IUPAC Name: 3-butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one : |
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