Avapro

This page contains recent news articles, when available, and an overview of Avapro but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Avapro (when available)

Pharmacology and use:
Irbesartan, an angiotensin II receptor antagonist similar to losartan and valsartan, is used alone or with hydrochlorothiazide to treat hypertension For the treatment of hypertension.

Mechanism Of Action:
Irbesartan antagonizes angiotensin II, the primary vasoactive hormone of the renin-angiotensin system, at the AT₁ receptor subtype. As angiotensin II is vasoconstrictor which stimulates aldosterone secretion by the adrenal gland, blockage of its effects results in a decrease in systemic vascular resistance.

News Articles on Irbesartan

Fitch reaffirms Bristol-Myers Squibb ratings  -  ‎Aug 27, 2009‎
The company will likely see sales of its high blood pressure drug Avapro and blood-thinner Plavix fall after 2011 as patents expire. Forbes

The Transformation Of Sanofi-Aventis US  -  ‎Aug 26, 2009‎
Products like Actonel, Avapro, and Plavix, are founded on partnerships. We're committed to the best science, whether generated through in-house innovation Life Science Leader Magazine

Onglyza Approved for Treatment of Type 2 Diabetes  -  ‎Aug 10, 2009‎
Their top 3 selling products include PLAVIX® (clopidogrel bisulfate), ABILIFY® (aripiprazole), and AVAPRO®/AVALIDE® (irbesartan and MediNEWS.Direct!

Fitch Affirms Bristol-Myers Squibb Co.'s IDR at 'A+'; Outlook Stable  -  ‎Aug 27, 2009‎
The Rating Outlook is Stable. taken significant steps to mitigate the effects of the looming patent expiries of Avapro and Plavix in 2011, PR-Inside.com (Pressemitteilung)

Bristol-Myers Squibb: Fitch Ratings réaffirme ses notes.  -  ‎Aug 27, 2009‎
...par le fait que le laboratoire a entrepris les mesures nécessaires afin de compenser l'impact des pertes de brevets sur Avapro et Plavix à horizon 2011. BFM radio

沙�?�类�?�物销售�?少70亿美元 �?�临被仿之痛  -  ‎Aug 4, 2009‎
...之�?�，ATIIRa类�?�诞生了诸如诺�?�公�?�的代文（缬沙�?��?Diovan）�?默沙东公�?�的科素亚（氯沙�?��?Cozaar）和赛诺�?�-安万特公�?�的厄�?沙�?�（Irbesartan�?Avapro）等销售中国食品商务网

沙�?�类�?�物研�?��?�滞专利到期�?70亿美元  -  ‎Aug 3, 2009‎
...之�?�，ATIIRa类�?�诞生了诸如诺�?�公�?�的代文（缬沙�?��?Diovan）�?默沙东公�?�的科素亚（氯沙�?��?Cozaar）和赛诺�?�-安万特公�?�的厄�?沙�?�（Irbesartan�?Avapro）等销售慧聪网

Bristol-Myers Squibb Picks MediaVest  -  ‎Jun 30, 2009‎
It identifies its top selling brands as Plavix ($5.6 billion), Abilify ($2.2 billion), Avapro/Avalide ($1.3 billion), Reyataz ($1.3 billion) and Sustiva Brandweek Magazine

Sanofi-Aventis: Strong Pipeline, Possible Mid-Sized Acquisition in ...  -  ‎Jun 26, 2009‎
For 2009 we expect revenue growth to return, as generic erosion is more than offset by strong growth of Taxotere, Lantus, Avapro and the vaccines business. Seeking Alpha

BMY -10 Companies With Ironclad Balance Sheets  -  ‎Jun 28, 2009‎
The Pharmaceuticals segment offers cardiovascular products, including PLAVIX, AVAPRO/AVALIDE, and PRAVACHOL; virology products comprising REYATAZ, SUSTIVA, TransWorldNews (press release)

BUYINS.NET: BLUD, NVO, RBN, ROS, SNY, CPII. Abnormal Price ...  -  ‎Jun 26, 2009‎
Its primary medicines include Lovenox/Clexane, Plavix/Iscover, Aprovel/Avapro/Karvea, Tritace/Triatec/Delix/Altace, Lantus, Amaryl/Amarel/Solosa, Acomplia, Trading Markets (press release)

Dennis Hopper  -  ‎Jul 2, 2009‎
Cialis Versus viagra is better viagra cialis and avapro. Guaranteed lowest prices on our new online pharmacy online. Cialis injury lawyer cleveland. Tiscali.cz

Zacks Analyst Blog Highlights: Sanofi-Aventis, Biogen-Idec ...  -  ‎Jun 26, 2009‎
For 2009 we expect revenue growth to return, as generic erosion is more than offset by strong growth of Taxotere, Lantus, Avapro and the vaccines business. Earthtimes (press release)

最具潜力�??大新�?�  -  ‎Jun 17, 2009‎
...其主打产�?氯�?�格雷(波立维,Plavix)和�?�?沙�?�（阿瓦普， Avapro）届时将在美国失去专利�?护，阿立哌唑（Abilify）的销售许�?�也将到期（最新消�?�：4月6日施贵�?与大冢生物通

Bristol-Myers Squibb: An Attractive Value  -  ‎Apr 9, 2009‎
The US patent covering Plavix expires in November 2011, and Avapro's patent expires in March 2012. We currently model companywide revenue to fall 9.5% in Seeking Alpha

Sanofi-Aventis Rated Hold  -  ‎Apr 14, 2009‎
For 2009 we expect revenue growth to return as generic erosion is more than offset by strong growth of Taxotere, Lantus, Avapro and the vaccines business. Zacks.com

Zacks Analyst Blog Highlights: Smith Micro Software, Inc., Johnson ...  -  ‎Apr 15, 2009‎
For 2009 we expect revenue growth to return as generic erosion is more than offset by strong growth of Taxotere, Lantus, Avapro and the vaccines business. Zacks.com

Bristol to Sell Mood-Stabilizing Abilify Until 2015  -  ‎Apr 6, 2009‎
Sanofi-Aventis SA share profits of the anti-clotting drug Plavix, the world’s second- biggest-selling drug, and of the hypertension treatment Avapro. Bloomberg

Bristol-Myers намерен �?овершить р�?д покупок на $9 млрд.  -  ‎Apr 10, 2009‎
производимых Bristol-Myers, можно отметить противо�?вертывающий препарат Plavix, лекар�?тво дл�? больных гипертонией Avapro, препарат дл�? лечени�? раковых K2Kapital

Bristol-Myers out in the cold? Big mergers surround drug giant  -  ‎Mar 15, 2009‎
The Manhattan-based company's patents for Plavix and Avapro, used to treat high blood pressure, are expected to expire in 2012, the same year it is Crain's New York Business

Is Bristol-Myers the next pharma target?  -  ‎Mar 12, 2009‎
...target of Sanofi-Aventis SA (PINK:SNYNF) mostly because the two share profits of the anti-clotting drug Plavix and on the hypertension treatment Avapro. The Daily Deal (subscription)

Merck Deal Puts Pressure on AstraZeneca, Sanofi, J&J  -  ‎Mar 10, 2009‎
Paris-based Sanofi may target Bristol-Myers Squibb Co., of New York, which sells the French company’s Plavix blood thinner and Avapro hypertension treatment Bloomberg

Drug majors put on bid alert  -  ‎Mar 13, 2009‎
The two firms already have a partnership for the antithrombotic Plavix (clopidogrel) and the antihypertensive Avapro (irbesartan). "Overall, the most likely CITY A.M.

国际制�?�业或迎�?�并购潮  -  ‎Mar 10, 2009‎
...百时美是赛诺�?�血液稀释剂波立维（Plavix）�?�抗高血压�?�伊�?沙�?�（Avapro）在美国的销售商。 Moskowitz表示，其它�?�能对百时美有�?的�?�商包括阿斯利康和强生（Johnson 财讯

Adquisición de Merck presiona a competidores  -  ‎Mar 11, 2009‎
...de Nueva York, que vende el anticoagulante Plavix y el tratamiento contra la hipertensión Avapro de la compañía francesa en Estados Unidos. Periódico La República (Costa Rica)

Acordo da Merck pressiona empresas farmacêuticas  -  ‎Mar 10, 2009‎
A Sanofi, com sede em Paris, pode focar na Bristol-Myers Squibb, de Nova York, que comercializa os medicamentos Plavix (anticoagulante) e Avapro (para o Gazeta Mercantil

Handicapping Continues In The Drug Sector  -  Feb 3, 2009
The two companies collaborated on blood thinner Plavix and blood pressure drug Avapro. Plavix is the world’s second-largest selling drug behind Pfizer’s Barron's Blogs

Ligand drug reduces hypertension in midstage study  -  Feb 2, 2009
400-milligram, or 800-milligram doses and compared with placebo or 300-milligram doses of irbesartan, which is the medical name for Avapro, Forbes,

Will Bristol Plug Its Plavix Hole or Become Another Drugmaker’s Plug?  -  Jan 28, 2009
Combine sales of Plavix with those of blood-pressure drug Avapro and antipsychotic Abilify and you’ve accounted for around half of the company’s business, Wall Street Journal Blogs,

Zacks Bull & Bear of the Day Highlights: InterDigital, Overstock ...  -  Feb 3, 2009
The duo collaborated on blood thinner Plavix and blood pressure drug Avapro through 50/50 joint ventures. Plavix is the world?s second largest selling drug Ad-Hoc-News (Pressemitteilung),

For Pfizer, a Big Buy Could Be a Big Mistake  -  Jan 15, 2009
The hypertension drug Avapro and its cousin Avalide contributed $974 million, but the Avapro patent expires in 2012. All three are licensed from Motley Fool

Earnings Preview: Bristol-Myers Squibb  -  Jan 23, 2009
...a three-year "patent cliff," as top seller Plavix is expected to face generic competition that year, followed by Abilify and blood pressure drug Avapro. Forbes,

AP Business NewsBrief at 8:15 am EST  -  Jan 27, 2009
The New York-based maker of Abilify for bipolar disorder and Avapro for high blood pressure reported net income of $1.24 billion, or 63 cents per share, TMCnet

Pharma Earnings In Q4 - Healthy Or Ailing?  -  Jan 25, 2009
Bristol Myers' key products include blood thinner drug Plavix, anti-hypertension drugs Avapro/Avalide, HIV drugs Reyataz and Sustiva, antipsychotic drug Trading Markets (press release),

Business News  -  Jan 27, 2009
The New York-based maker of Abilify for bipolar disorder and Avapro for high blood pressure reported net income of US$1.24 billion, or 63 cents per share, AOL Canada,

Beta-blocker benefit questioned in heart failure with preserved ...  -  Jan 9, 2009
The I-PRESERVE trial, as recently reported by heartwire, found no effect on mortality or CV events from the angiotensin-receptor blocker irbesartan (Avapro, TheHeart.Org,

Avery Dennison reports sales drop, will cut 3600 jobs  -  Jan 27, 2009
The New York-based maker of Abilify, for treatment of bipolar disorder, and Avapro, for high blood pressure, reported net income of $1.24 billion, Los Angeles Times,

Blood pressure medicine can cause hacking cough  -  Dec 22, 2008
Angiotensin receptor blockers such as Avapro, Benicar, Cozaar and Diovan are less likely to cause a chronic cough. My doctors were mystified by my anemia. Los Angeles Times,

Bristol-Myers to cut 10 percent of workforce  -  Dec 16, 2008
...bipolar disorder treatment Abilify and blood pressure drug Avapro are expected to face low-cost generic competition, which will likely lead to falling The Associated Press

Can Bristol-Myers Squibb Co. Break Through Resistance?  -  Dec 10, 2008
Some of the firm's cardiovascular drugs include heart disease drug Plavix, as well as Pravachol (which lowers cholesterol) and Avapro (for hypertension). Schaeffers Research,

Medicine triggers hallucinations  -  Dec 22, 2008
Angiotensin receptor blockers such as Avapro, Benicar, Cozaar and Diovan are less likely to cause a chronic cough. For more information about pros and cons Online Athens,

Ellen McDonald Joins Regado Biosciences as Senior Vice President ...  -  Dec 2, 2008
She was responsible for leading the growth in sales of Plavix(R), the second-largest-selling drug in the world last year, Pravachol(R) and Avapro(R). MarketWatch

Insurers Push To Use Cheaper Drugs  -  Dec 12, 2008
Co-pays for her two longtime drugs, Lipitor and Avapro, for blood pressure, will jump from $40 a month to about $200 next year. She can avoid the increase Tampa Tribune,

Irbesartan Fails to Improve Diastolic Heart Failure  -  Dec 4, 2008
One group received irbesartan (Avapro) 300 mg and the other group was given a placebo. Patients were tracked for 5 years. Treatment with irbesartan did not DG News

Sanofi-Aventis : un nouveau site à Floirac  -  Dec 15, 2008
Lantus, Copaxone, Aprovel, Avapro, Karvea, Tritace, Triatec, Delix, Altace, Allegra, Telfast, Amaryl, Amarel, Solosa, Xatral, Actonel, Dépakine. Échos Judiciaires Girondins,

Avapro Blood pressure drug fails heart failure trial  -  Nov 11, 2008
By Bill Berkrot and Ransdell Pierson NEW ORLEANS (Reuters) - The blood pressure medicine Avapro, sold by Bristol-Myers Squibb Co and Sanofi-Aventis, Reuters

Is Bristol Ripe for a Buyout?  -  Oct 30, 2008
Sanofi also helps promote Bristol's Avapro, a drug used against hypertension and congestive heart failure. Pfizer, Bristol's partner in developing Apixaban, BusinessWeek

Bristol-Myers plans to boost cash flow up to $1B  -  Nov 13, 2008
...competition for three blockbusters: its top-seller, blood thinner Plavix, along with Abilify for bipolar disorder and blood pressure drug Avapro. CNNMoney.com

PDI Appoints Pharma Industry Veteran Nancy Lurker as Chief ...  -  Nov 17, 2008
During this time she directed or developed strategy in many of the Company's major business units and successfully launched Plavix(R) and Avapro(R). MarketWatch

Avapro provides no benefit for heart-failure patients in study  -  Nov 12, 2008
Avapro was no better than placebo in lowering deaths or hospitalizations because of cardiovascular events in people with a hard-to-treat type of heart SmartBrief,

Care plans are just more paperwork  -  Nov 16, 2008
For example, Avapro frequently causes hyperkalaemia, and haloperidol should be used for behavioural disturbance in dementia rather than risperidone because 6minutes,

I-PRESERVE: Strike three for RAAS inhibition in preserved-LVEF ...  -  Nov 12, 2008
New Orleans, LA - About four years of treatment with the angiotensin-receptor blocker (ARB) irbesartan (Avapro, Bristol-Myers Squibb/Sanofi-Synthelabo) TheHeart.Org,

Sanofi-aventis Q3 2008 Adjusted EPS Excluding Selected Items(1):  -  Oct 31, 2008
The share of after-tax profits from territories managed by BMS under the Plavix(R) and Avapro(R) alliance was up 9.9% at EUR 155 million . Earthtimes (press release),

Reality Check on the Big Pharma Rumor Mill  -  Oct 31, 2008
The two companies collaborate on the development and promotion of two blockbuster products; blood-thinning agent Plavix and hypertension drug Avapro. Seeking Alpha,

Sanofi profits up as French firm rides out generic storm  -  Oct 31, 2008
Sales of the antihypertensive Aprovel/Avapro/Karvea (irbesartan) increased 14.6% to 298 million euros. The anti-obesity drug Acomplia (rimonabant), Pharma Times (registration),

SANOFI-AVENTIS : Sanofi, Bristol : résultats décevants d'une étude ...  -  Nov 11, 2008
L'Avapro est un médicament de la classe des bloqueurs des récepteurs de l'angiotensine, ou ARB. L'étude, qui portait sur 4.128 patients suivis pendant une Zonebourse.com,

BMS prépare la perte de deux brevets  -  Nov 13, 2008
Le laboratoire américain va perdre entre 2011 et 2013 l'exclusivité sur le Plavix (anticoagulant) et l'Avapro (hypertension), forts contributeurs à son E24,

RESULTATS DU TROISIEME TRIMESTRE 2008  -  Oct 31, 2008
Présence mondiale1 d'Aprovel®/ Avapro®/ Karvea® Evolution à Evolution à Millions d'euros T3 2008 données 9 mois 2008 données comparables comparables Europe Fininfo (Communiqué de presse),

Ten Highest Yielding Pharma Stocks  -  20 Oct 2008
...(BMY) - Its drugs include PLAVIX, AVAPRO/AVALIDE, PRAVACHOL, COUMADIN, REYATAZ, SUSTIVA, BARACLUDE, ERBITUX, TAXOL, SPRYCEL, IXEMPRA, ABILIFY, ORENCIA, Seeking Alpha,

Mix of drugs may factor in dizziness, forgetfulness  -  Sep 29, 2008
Both blood-pressure medicines (Avapro and Norvasc) can cause dizziness. So can the pain reliever Lortab. If dizziness caused a fall, it could be devastating Los Angeles Times,

Sanofi: Long-Term Generic Impact  -  Oct 3, 2008
We see risk to Avapro, Allegra, Lovenox, Eloxatin, Delix, Plavix and Ambien all keeping a lid on shares over the next several quarters. Zacks.com,

Bristol-Myers Seen Moving To Next Target After ImClone Loss  -  Oct 6, 2008
...faces the loss of market exclusivity for current blockbuster Plavix, an anti-clotting drug; Abilify, an antipyschotic; and hypertension drug Avapro. CNNMoney.com

Senior Dimensions Lowers Prescription Drug Co-Payments on Many ...  -  Sep 24, 2008
The more widely used maintenance drugs with reduced co-pays include: Avapro and Benicar, both used to treat hypertension; Actos and Lantus, used to treat MarketWatch

BIPAI Opens New Children's AIDS Center In Uganda  -  Oct 4, 2008
...associate of Merck KGaA of Darmstadt, Germany. Avapro, Avalide and Plavix are trademarks of sanofi-aventis. Sinemet CR is a trademark of Merck & Co., Inc. Medical News Today (press release),

Brand Names/Synonyms:
Avapro is also known by the following brand names and/or synonymsAvalide; Avapro; CHEMBANK1635; Irbesarran; Irbesartan; Irbesartan [Usan:Inn]; Lrbesartan

Drug Category:
Avapro is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA04

Dosage Forms:
Oral tablets

Absorption:
60-80%

Interactions:
-->Interactions for Irbesartan:

No significant drug-drug pharmacokinetic (or pharmacodynamic) interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, and nifedipine.

In vitro studies show significant inhibition of the formation of oxidized irbesartan metabolites with the known cytochrome CYP 2C9 substrates/inhibitors sulphenazole, tolbutamide and nifedipine. However, in clinical studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin were negligible. Based on in vitro data, no interaction would be expected with drugs whose metabolism is dependent upon cytochrome P450 isozymes 1A1, 1A2,2A6,2B6,2D6,2E1,or 3A4.

In separate studies of patients receiving maintenance doses of warfarin, hydrochlorothiazide, or digoxin, irbesartan administration for 7 days had no effect on the pharmacodynamics of warfarin (prothrombin time) or pharmacokinetics of digoxin. The pharmacokinetics of irbesartan were not affected by coadministration of nifedipine or hydrochlorothiazide.

Chemical IUPAC Name:
3-butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one

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