Atropine

This page contains recent news articles, when available, and an overview of Atropine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Atropine (when available)

Pharmacology and use:
L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent. Hyoscyamine is used to manage peptic ulcer disease, biliary tract disorders, cystitis, severe allergic rhinitis, hypermotility disorders of the lower urinary tract, infant colic, and to control salivation and excessive secretions before an operation. For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Hyoscyamine may also be used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis

Mechanism Of Action:
Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.

News Articles on Hyoscyamine

Dobutamine Stress Cardiovascular Magnetic Resonance at 3 Tesla  -  Oct 9, 2008
Images were acquired at rest and stress in accordance with a standardized high-dose dobutamine-atropine protocol during short breath-holds in three short 7thSpace Interactive (press release),

Symptomatic bradycardia 2: assessment and management  -  Sep 25, 2008
Atropine sulphate is the most popular choice for immediate intervention. Atropine has a role in the emergency management of symptomatic bradycardia (British Nursing Times,

Life-saving bag stolen from ambulance  -  Oct 2, 2008
They are in a variety of containers including bottles, ampoules and syringe cases and include adrenaline, atropine and amiodarone. Redditch Standard,

Medication Stolen ; CRIME  -  Sep 27, 2008
The drugs inside the bag are in a variety of containers including bottles and syringe cases, and include adrenaline, atropine and amiodarone. RedOrbit,

Procedure Guideline for Myocardial Perfusion Imaging 3.3*  -  Oct 6, 2008
In some patients, atropine may be required to increase the heart-rate response, although increasing the heart rate by atropine does not cause the same RedOrbit,

Landmark COPD Trial UPLIFT(R) Shows SPIRIVA(R) HandiHaler(R ...  -  Oct 5, 2008
Do not use SPIRIVA if you are allergic to atropine, ipratropium, tiotropium bromide, or lactose. A lactose allergy is not the same as lactose intolerance. MarketWatch

Teen girl poisoned by Devil's Seed; police issue warning  -  Oct 14, 2008
All parts of the Jimson weed contain the belladonna alkaloids atropine, but the highest concentration of belladonna alkaloids occurs in the seeds. LondonTopic.ca,

Specialist presents options for treating pediatric eye disorders  -  Oct 6, 2008
Also, atropine vs. patching produces similar results, which is a "useful but not primary therapy," he said. "It can be used once or twice a week. OSN SuperSite (subscription),

Vision tests early on in kids' lives pay off  -  Oct 1, 2008
Treatment for lazy eye includes glasses, eye patches, surgery and atropine drops, Suh said. The eyedrops blur the vision in the good eye so the patient is DesMoinesRegister.com,

Established Safety Profile Of Spiriva Confirmed By 30 Rigorously ...  -  Sep 27, 2008
Do not use Spiriva if you are allergic to atropine, ipratropium, tiotropium bromide, or lactose. A lactose allergy is not the same as lactose intolerance. Medical News Today (press release),

From Antibodies to Goats: Ensuring the Public Health  -  Sep 24, 2008
One of the strengths of Protexia not seen with the standard of care - atropine, pralidoxime chloride and diazepam - are the neurological deficits and loss BioWorld Online,

Study: Patching, atropine produce similar visual acuity ...  Aug 25, 2008
Michael X. Repka, MD, and colleagues randomly assigned 419 children with amblyopia to receive either patching or atropine eye drops for 6 months.OSN SuperSite (subscription),

Molecules Of Murder, by John Emsley  Aug 21, 2008
The active ingredient of deadly nightshade is a chemical called atropine, and a single berry of the plant contains enough to kill a young child.Independent,

'Burn Notice' recap: Enter Mike's doppleganger  Sep 12, 2008
Larry likes to give people heart attacks by spraying atropine on their silverware. Number two, last night's show featured Burn Notice's most heart-poundingEntertainment Weekly

Gel Helps Slow Progression Of Myopia In Kids  Sep 1, 2008
Previous studies have suggested that a drug called atropine can delay progression of myopia. The new results show that pirenzepine—a related drug with fewerOneindia,

Single case of Shigellosis has been found at Boynton Elementary School  Sep 9, 2008
...“Antidiarrheal agents such as loperamide (Imodium*) or diphenoxylate with atropine (Lomotil*) can make the illness worse and should be avoided.Catoosa County News,

Driver, victim likely not high: Inquest  Sep 5, 2008
Heather Dinn, a toxicologist with the RCMP, testified that Tait, a Surrey teenager, had no alcohol and no drugs of any kind in his body save for atropine,Surrey Leader,

Murder charge filed in bar death Posted on: Friday, September 05 ...  Sep 5, 2008
Blood tests showed Alexis had marijuana, PCP and atropine in his system, but no alcohol. Patrol officers responded to a fight at 11:12 pm May 24.Killeen Daily Herald,

World traditional medicines day  Aug 30, 2008
Atropine — a very important agent in surgery and eye investigations — is derived from the poisonous fruit of a very poisonous plant, the deadly nightshade.The Herald,

Boy makes amazing recovery from lightning strike injuries  Aug 29, 2008
In a last ditch effort they injected him with a shot of atropine, a drug commonly used to speed the heart rate. The shot worked, and David regained a pulse.News-Herald,

Pot debate lingers on  Aug 19, 2008
Morphine, atropine, scopolamine, digoxin, vinblastin, taxol are some examples. As per the route of administration, inhaling drugs causes a very fast entryTerrace Standard,

Thử nghiệm thuốc tra mắt làm chậm tốc độ cận thị  Aug 31, 2008
Những nghiên cứu v�? đi�?u trị mắt trước đây cũng chỉ ra rằng atropine (chất thư�?ng xuyên được sử dụng trong nhãn khoa) cũng có công dụng đi�?u trị mắt.Khanh Hoa,

Un traitement contre la myopie ?  Aug 26, 2008
Des études antérieures ont prouvé que l’atropine (fréquemment employé en ophtalmologie) avait la même acion mais avec des effets secondaires bien tropnouvelobs.com,

La feuille de coca : millénaire et sacrée  Aug 31, 2008
Entre autres composantes de la coca, on trouve l’atropine, la papaïne, la globuline, la pectine, la coléïne, l’inuline, on peut en extraire 14 alcaloïdes,Bellaciao,

Drôle de signature : du pétrole dans la cocaïne  Aug 22, 2008
Il ya deux ans, le labo de Lyon a découvert de l’atropine dans un échantillon de cocaïne, de l’anti-inflamatoire dans un autre.Le Progrès,

Using various treatments together is best method for strabismus ...  -  Jul 29, 2008
BUENOS AIRES — The combination of occlusion and atropine is the best method for treating pediatric strabismus, a surgeon said here. OSN SuperSite (subscription),

Blast from the past  -  Jul 21, 2008
According to statements by the two officials who followed him round the course, the tiny Italian had been taking atropine and strychnine capsules during the Hindustan Times,

Emotional moments from past Olympics  -  Jul 20, 2008
According to statements by the two officials who followed him round the course, the tiny Italian had been taking atropine and strychnine capsules during the Daily Times,

Generation Kill: Our Interview With Author Evan Wright And First ...  -  Jul 27, 2008
Those surrendering Iraqis [at the end of Episode 1] were carrying atropine injectors [and] gas masks, and when they were debriefed, some of them said were Huffington Post,

Completion of VX neutralization means many things to Valley  -  Jul 19, 2008
In addition, depot personnel responsible for handling VX carry pharmaceutical antidote kits, with Atropine and 2-PAM Chloride, which in combination Terre Haute Tribune Star,

Officials: Weed turned potato stew into poison  -  Jul 15, 2008
Jimsonweed contains belladonna alkaloids atropine and scopolamine, ingredients that may cause symptoms such as: mental confusion, agitation, Business Gazette,

Weer honden in Bestse wijk vergiftigd  -  Jul 26, 2008
Dierenartsen in Best hebben de getroffen dieren de anti-stof atropine toegediend, waarna de klachten afnamen. Voor in ieder geval twee honden en een kat Eindhovens Dagblad,

헬기 �?�용한 �?�급환�?�?� 후송  -  Jul 24, 2008
...같�?� 온 �?�급구조사가 ambu bagging�?� 하였고, 간호사가 IV line�?� 다시 잡았으며, 그 사�?��? epinephrine, atropine�?� �?�소보다 2.5배 용량으로 T-tube로 넣었다. 디지틀보사,

"Urgences", quatorze saisons à l’hôpital  -  Jul 16, 2008
Donne-moi 2 de morphine, 2 d'atropine, 4 culots de O nég !" Il ya encore 12 ans, à moins d'être médecin ou carabin, il était difficile de comprendre ces Pèlerin.info,

SCRS et médias (4 de 5) Ces menaces d’attentats vous sont offertes ...  -  Jul 8, 2008
...vague planification à long terme » lorsque la discussion porta sur l’acquisition de 5000 doses d’Atropine pour traiter la contamination au gaz sarin. Cent Papiers,

Bioniche Pharma Acquires Baxter's ENLON(R) and ENLON-PLUS(R)  -  02 Jul 2008
ENLON-PLUS(R) (edrophonium chloride, USP and atropine sulfate, USP) Injection is recommended as a reversal agent or antagonist of nondepolarizing Earthtimes (press release),

Other News To Note  -  02 Jul 2008
Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection 5 mL ampule; and Enlon-Plus (edrophonium chloride, USP and atropine sulfate, TMCnet

SwRI awarded grant to develop nerve agent antidote  -  Jun 24, 2008
We now have to overcome issues that would normally restrict absorption of both of the atropine and MMB4." Based in San Antonio, SwRI is an independent, Bizjournals.com,

The diagnostic accuracy of pharmacological stress echocardiography ...  -  Jun 19, 2008
...dipyridamole stress echo performed with state-of-the art protocols (either 0.84 mg/kg in 10' plus atropine, or 0.84 mg/kg in 6' without atropine). 7thSpace Interactive (press release),

Chemical warfare antidote grant awarded  -  Jun 25, 2008
...that will not hinder atropine, which is used in combination to effectively treat the effects of a chemical nerve agent," Joe McDonough, SwRI's Chemistry United Press International

Stolen drugs plea  -  Jun 21, 2008
In the bag are 10 smaller packs, each including two "pens" containing the drugs pralidoxime chloride and atropine linked by a plastic cap. Lakeland Today,

Bag stolen from ambulance  -  Jun 18, 2008
In the bag are 10 smaller packs, each containing two "pens" containing the drugs Pralidoxime Chloride and Atropine which are linked by a plastic cap. Lakeland Today,

People With Dementia Should Avoid Certain Drugs  -  Jun 27, 2008
Gastrointestinal/urinary antispasmodics, single or combination products, such as Belladonna alkaloids, Atropine, Hyoscyamine (Levsin), Scopolamin, RedOrbit,

Endotoxin Augments Myeloid Dendritic Cell Influx into the Airways ...  -  Jun 17, 2008
Bronchoscopy After premedication (inhalation of 200 mg salbutamol, atropine 0.5 mg subcutaneously, and midazolam 0.05-0.1 mg/kg intravenously) and local RedOrbit,

Ocular compression a century on: time for a thumbs-off approach?  -  Jun 6, 2008
Although the OCR is best known as a vagal-mediated cardio-inhibitory reflex, sympathetic withdrawal is also involved, as atropine does not abolish the OCR John Libbey Eurotext,

Low-dose dobutamine cardiac magnetic resonance imaging with ...  -  Jun 16, 2008
Oral β-blockers were not withheld before stress testing, and atropine infusion was not used to augment heart rate during testing. The imaging technique has The Journal of Thoracic and Cardiovascular Surgery

Jimson Weed Is In Bloom  -  Jun 15, 2008
However, two chemicals, atropine and scopolamine, toxins found in Jimson weed, were found in his brain tissue. One way or the other, the use of Jimson weed Officer.com

Emotional moments from past Olympics  -  Jun 9, 2008
According to statements by the two officials who followed him round the course, the tiny Italian had been taking atropine and strychnine capsules during the Lanka Business Online,

Neuromuscular Junction Disorders and Peripheral Neuropathies  -  Jun 7, 2008
However, if one elects to perform this test, atropine should be ready at the bedside to reverse the effects if they become too severe or life-threatening. TMCnet

Pınar Aylin, 'Türk Yürüyüşü'nde  -  Jun 1, 2008
Pharmacology has developed from herbalism and many drugs are still derived from plants (atropine, ephedrine, warfarin, aspirin, digoxin, vinca alkaloids, Güncel Haber,

Legislature honors county’s paramedics  -  May 31, 2008
...including electrocardiogram interpretation, establishing an IV, and administration of epinephrine and atropine, two drugs given to restart the heart. Catskill Daily Mail,

Ischemic Preconditioning During the Use of the Percusurge ...  -  May 22, 2008
Prophylactic atropine (0.5–1.0 mg) was administered prior to simulation of the carotid baroreceptor by angioplasty balloon inflation. Abkhazia,

Battlefield: Bad Company  -  May 13, 2008
After feeling the satisfying thump of the hypodermic adrenaline or atropine or whatever crazy drug these guys are juicing in order to keep from dying (they Gamespy.com,

Recommendations for Primary Care of the Patient With Cancer  -  May 16, 2008
Otherwise, an antimotility agent such as loperamide or diphenoxylate/atropine may be helpful. Alopecia may also begin 7 to 10 days after initiating Abkhazia,

Dartmouth-Hitchcock Medical Center Evaluation Findings Demonstrate ...  -  May 28, 2008
...poor heart rate control, acute bradycardia needing atropine, new onset A-fib, unrecognized obstructive patterns of respiration like sleep apnea, Earthtimes (press release),

Effect of Preemptive Epidural Analgesia on Cytokine Response and ...  -  May 9, 2008
Patients were premedicated with atropine 0.5 mg and midazolam 3 mg intramuscularly, 1 hour before surgery. Fifteen minutes before the induction of RedOrbit,

PharmaDerm enters 20 billion dollar global market with its newly ...  -  May 21, 2008
..."The company is focusing its efforts on equipping military and emergency personnel with a convenient, accurate, multiple-dose and needle-free atropine. PR Newswire (press release),

Early Vision Screening in Children with Amblyopia Aids in Better ...  -  May 8, 2008
...acuity tests and cyclopegic drops, with treatment modalities including patching of the unaffected eye, instilling atropine drops and vision therapy. Medi News Direct,

Medicines Running Out in City  -  Apr 21, 2008
Stocks of adrenaline and atropine in some clinics will run out within less than a month, City Hall’s Health Committee said on Monday. St.Petersburg Times.ru,

Russia facing anaesthetics crisis: report  -  Apr 16, 2008
Hospitals are facing drastic shortages of several types of anaesthetics such as adrenaline and atropine as bureaucratic backlogs keep out foreign firms and AFP

ISRAEL: Revisiting the gas masks  -  Apr 1, 2008
Those cardboard boxes containing gas masks, atropine syringes and other protective equipment in case of a non-conventional attack. Los Angeles Times,

Human Foods, Products Can Kill Pets  -  Mar 26, 2008
Tomatoes contain atropine, a product sometimes used to treat eye problems in animals. But too much atropine can cause dilated pupils, tremors and heart Local6.com,

Chronic inflammation presents after uncomplicated cataract surgery  -  Apr 17, 2008
He was started on Pred Forte (prednisolone acetate 1%, Allergan) and Vigamox (moxifloxacin 0.5%, Alcon) four times per day and atropine once daily in the OSN SuperSite (subscription),

Recognition and Treatment of Right Ventricular Myocardial Infarction  -  Mar 28, 2008
20 Symptomatic bradycardias can be treated with atropine up to 3 mg, and AV blocks may require external pacing. Transport to the proper cardiac center is of EMS Magazine,

Pulmonary vein isolation and the Cox maze procedure only partially ...  -  Mar 28, 2008
Nadolol (n = 6) and atropine (n = 6) were administered to block sympathetic and parasympathetic responses, respectively. Changes in heart rate and The Journal of Thoracic and Cardiovascular Surgery

Brand Names/Synonyms:
Atropine is also known by the following brand names and/or synonymsATROPINE; Anaspaz; Cystospaz; Daturine; Duboisine; Duretter; Egacene; Egazil; Gastrosed; Hyocyamine; Hyoscyamine; Hyoscyamine, L-; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Hyoscyamine Free Base; L-Tropine Tropate; Levbid; Levsin; Levsinex; OIN; Peptard; Scopolia Extract

Drug Category:
Atropine is categorized under the following by the FDA: Mydriatics; Bronchodilator Agents; Antiarrhythmic Agents; Adjuvants; Antimuscarinics; Antispasmodics; ATC:A03BA03

Dosage Forms:
Oral tablets, oral drops, elixir, injection

Absorption:
absorbed totally and completely by sublingual administration as well as oral administration

Interactions:
Interactions for Hyoscyamine:

Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines. Antacids may interfere with the absorption of LEVSIN. Administer LEVSIN before meals; antacids after meals.

Chemical IUPAC Name:
(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)3-hydroxy-2-phenyl-propanoate

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