Arimidex

This page contains recent news articles, when available, and an overview of Arimidex but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Arimidex (when available)

Pharmacology and use:
Anastrozole is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of advanced breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In post-menopausal women, the principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol. Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. For treatment of advanced breast cancer.

Mechanism Of Action:
Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues. Therefore, aromatase inhibition leads to a decrease in circulatin estrogen, leading to a decreased tumor mass or delayed progression of tumor growth in some women.

News Articles on Anastrozole

Low-dose estrogen may help if breast cancer recurs  -  ‎Aug 18, 2009‎
They include Pfizer's Aromasin, Novartis's Femara, and AstraZeneca Plc's Arimidex. "The women in the study had all experienced a relapse while on Reuters

AstraZeneca Expands Market Presence  -  ‎Aug 26, 2009‎
The company's product range includes Arimidex, Crestor, Nexium, Seroquel and Symbicort. The company's subsidiary, Astra Tech is engaged in the research, Pharmaceutical Business Review

Antihormonal Cancer Therapies  -  ‎Aug 28, 2009‎
These will remain the top three brands through to 2018, even though Arimidex and Casodex will lose around 40% of their brand value due to generic PR-Inside.com (Pressemitteilung)

The Bald Woman's Blog: Part 48  -  ‎Aug 28, 2009‎
However, one thing has taken up residence in my life since I last wrote in here and that is the Arimidex tablet! Now, I read far too much sometimes about Dunstabke Today

A College Kid On Drugs: Development Platforms Will Unlock Your E ...  -  ‎Aug 13, 2009‎
Take a look at www.arimidex.com. This is a webpage that advertises a drug called Arimidex, a therapy for postmenopausal women in the early stages of breast Pharmaceutical Processing

Pharmacokinetics and Pharmacodynamics of Anastrozole in Pubertal ...  -  ‎Aug 5, 2009‎
Anastrozole (Arimidex) is a potent and selective reversible inhibitor of the aromatase enzyme in females. Objective: Our objective was to characterize the Journal of Clinical Endocrinology and Metabolism

Unpaid parking ticket leads to nightmare  -  ‎Aug 19, 2009‎
Arthur said that, when booked into the Holding Center, she told one deputy and then another that she would need her medicine — Arimidex, which helps shrink Buffalo News

Targeted Cancer Therapies – The Future of Cancer Treatment?  -  ‎Aug 25, 2009‎
Arimidex and Femara are two commonly used drugs of this type. Another form of breast cancer, called HER-2 (Human Epidermal Growth Receptor 2) Positive, EmpowHer

Fighting cancer with good deals  -  ‎Aug 19, 2009‎
She's now on Arimidex, a hormonal medicine she'll have to keep taking for the next five years in order to be declared cancer-free. Carlisle Sentinel

Going, going, gone Patents set to expire soon on many brand-name drugs  -  ‎Aug 7, 2009‎
8 Arimidex (anastrozole) — AstraZeneca's after-surgery treatment for postmenopausal women with early breast cancer was set to expire in December 2009, Modern Medicine

Collectively, the antihormonal therapy cancer brands generated ...  -  ‎Aug 24, 2009‎
Antihormonal cancer therapies are a class of drugs used predominantly in the treatment of breast cancer and prostate cancer. The high incidence of these PR-Inside.com (Pressemitteilung)

Dosis de estrógenos podría ayudar si reaparece cáncer de mama  -  ‎Aug 18, 2009‎
Los investigadores incluyeron Aromasin, de Pfizer, Femara, de Novartis y Arimidex, de AstraZeneca Plc. "Todas las mujeres del estudio habían experimentado Reuters América Latina

阿斯利康拓展中东市场伊朗设新办事处扩大业务  -  ‎Aug 28, 2009‎
...该公�?�主�?产�?包括：乳腺癌�?�Arimidex�?�?醇�?�Crestor�?溃疡�?�Nexium�?精神病�?�物Seroquel与哮喘�?�Symbicort。其�?公�?�AstraTech主�?从事用于泌尿科�?外科以�?�牙科的生物谷

乳癌藥物Femara與Tamoxifen的比較  -  ‎Aug 26, 2009‎
Femara屬於芳香酶抑制劑的一種，這類藥物還包括Arimidex與Aromasin，其作用是抑制aromatase enzyme的活性。這項新的研究顯示，大約經�?�六年，�?��?用Femara或是先臺灣新浪網

�?и�?ки дози е�?троген полезни при повторен рак на гърдата  -  ‎Aug 18, 2009‎
Това �?а "Aromasin" на "Пфайзер", "Femara" на "�?оварти�?" или "Arimidex" на "�?�?траЗенека". "Жените в из�?ледването в�?ички �?а изпитали повторение на БГНЕС

阿斯利康五大产�?�?然畅销  -  ‎Aug 14, 2009‎
...该公�?�的五项主�?产�?（Crestor�?Nexium�?Seroquel�?Symbicort 和Arimidex）�?�了该公�?�上�?�年总销售�?的一�?�以上，其中胆固醇类�?�Crestor和心血管类�?�Toprol XL销售新浪网

여성호르몬 �?스트로�?, 유방암 치료�? �?�움  -  ‎Aug 18, 2009‎
ATAC (Arimidex, Tamoxifen, Alone or in Combination) 임�? 등�? 따르면 아로마타제 억제제는 유방암�?� 재발�?� 보다 효과�?으로 예방할 수 있�?� �? 아니�?� 타목시펜 헬스코리아뉴스

Dosis Rendah Estrogen Cegah Kambuhnya Kanker Payudara  -  ‎Aug 19, 2009‎
Semua itu meliputi Aromasin, produksi Pfizer, Femara dari Novartis dan Arimidex dari AstraZeneza Plc. "Semua perempuan di dalam studi tersebut telah Berita8

AstraZeneca plc  -  13 Jul 2009
The company has developed a broad product range, including many world leaders such as breast cancer therapy Arimidex, cholesterol reducer Crestor, Fresh Business Thinking

Ipsen Afflicted by Too Many Drugs, Bucks Trend Infecting Others  -  ‎Jul 5, 2009‎
Arimidex had sales of $1.86 billion last year. Belingard, 60, says the company has other cancer compounds in development that are “even more promising. Bloomberg

arimidex compared to tamoxifen, arimidex smoking and arimidex ...  -  ‎Jun 30, 2009‎
Your Granny Santa much through in call medical tiredness now arimidex compared to tamoxifen In job at pharma some arimidex compared to tamoxifen arrimidex На плувка и дъно

AstraZeneca's Pipeline Must Deliver  -  ‎Jun 29, 2009‎
Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Seeking Alpha

Analysis: Getting drug stocks flowing  -  ‎Jun 19, 2009‎
Out of stocks lists at some pharmacies have extended to three pages, with Arimidex, Zyprexa, Cellcept, Neoral and Keppra being difficult, if not impossible, Chemist+Druggist

Cancer patients especially vulnerable  -  ‎Jun 30, 2009‎
Breast cancer patients on tamoxifen or aromatase inhibitors like Femara or Arimidex should not use red clover, dong quai or licorice because of Times Herald-Record

Broken toilet convinced Sapp to start dropping weight  -  ‎Jun 24, 2009‎
...and the rest of the bludgers... and some arimidex to mitigate all the ugly side effects.. you dont get those puffy, red cheeks for nothing... mma/ufc Yahoo! Sports

A survivor's story  -  ‎Jun 25, 2009‎
I chose not to have chemotherapy or radiation, but I do take Arimidex daily. The chance of my breast cancer recurring was not much different with or without Atlantic News Telegraph

One in three breast cancers 'harmless  -  ‎Jul 9, 2009‎
Mrs Milton had to take the drug Tamoxifen for three years after her operation, followed by two years of Arimidex. She said: "I am always shouting at people Scotsman

Zacks Analyst Blog Highlights: AstraZeneca, Darden Restaurants ...  -  ‎Jun 29, 2009‎
Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Earthtimes (press release)

乳腺癌新�?�  -  ‎Jun 24, 2009‎
...蒽环类抗肿瘤�?��?环磷酰胺和紫�?�烷类抗肿瘤�?�物被广泛应用于肿瘤的辅助治疗，乳腺癌新�?�包括了和激素治疗�?�物他莫昔芬�?瑞�?得（Arimidex）�?弗隆（Femara）�?�用；和阿医盟网健康资讯

最具潜力�??大新�?�  -  ‎Jun 22, 2009‎
...该公�?�也�?�临�?�一些�?磅炸弹级�?�物的专利�?�将到期，如比�?��?胺(康士得，Casodex)�?阿那曲唑(瑞�?得，Arimidex)和埃索美拉唑(�?信，Nexium)分别在2009年�?2910年珠海新闻网

AstraZeneca a Hold for Now  -  ‎Apr 13, 2009‎
Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Zacks.com

Pfizer selects Ogilvy to revive Viagra in Indonesia  -  ‎Apr 15, 2009‎
Iressa (a lung cancer treatment), and Arimidex (a post-menopausal hormonal balancing drug). Meanwhile in Australia, the Lance Armstrong Foundation is to Media

Study sheds light on breast cancer drug failure  -  ‎Apr 2, 2009‎
The lab results could also lead to a clinical test to pinpoint women who should be given so-called aromatase inhibitors such as AstraZeneca Plc's Arimidex Canada.com

BUYINS.NET: Market Maker Surveillance Report. Top 6 Winning Stocks ...  -  ‎Mar 31, 2009‎
Its primary products include Arimidex for hormonal breast cancer; Crestor that provides treatment for managing cholesterol levels; Nexium for acid-related Trading Markets (press release)

Zacks Analyst Blog Highlights: Lattice Semiconductor, Moog Inc ...  -  ‎Apr 14, 2009‎
Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Business Wire (press release)

Zacks Analyst Blog Highlights: Lattice Semiconductor, Moog Inc ...  -  ‎Apr 14, 2009‎
Atacand and Arimidex will both be subject to generic competition in 2010, then Seroquel and Symbicort lose US patent protection in 2011 and 2012, Trading Markets (press release)

Ostéoporose, traitements hormonaux et prévention  -  ‎Apr 15, 2009‎
...non ménopausées, et recevant pendant trois ans après le traitement chirurgical du Zoladex®, associé soit au tamoxifène soit à l'Arimidex®. Vie Femme

Prevención es importante en la vida de las mujeres  -  ‎Apr 3, 2009‎
Un estudio ATAC (ARIMIDEX), uno de los más extensos y de mayor duración en mujeres posmenopáusicas con cáncer de mama temprano, fue diseñado para investigar El Siglo de Torreón

Karin fick fel medicin  -  ‎Apr 3, 2009‎
Istället för värktabletterna Ardinex fick kunden Arimidex när hon köpte ut sin medicin på apoteket. – Min hustru blev helt förtvivlad. Blekinge Läns Tidning

Cancro al seno: il trattamento con Anastrozolo è associato a ...  -  ‎Mar 31, 2009‎
Martedì 31 Marzo 2009 - Lo studio ATAC (Arimidex, Tamoxifen, Alone or in Combination ), con un follow-up mediano di 68 mesi, ha mostrato che l’Anastrozolo XagenaSalute

AstraZeneca loses its fizz as expiry of patents looms  -  18 Mar 2009
30 per cent cut in revenue by 2014 from the expiry of patents on its top-selling Seroquell antidepression drug and its Arimidex breast cancer treatment, Times Online

Anastrazole Superior to Tamoxifen Preventing Disease Recurrence in ...  -  18 Mar 2009
...[Presentation title: Initial Adjuvant Therapy With Anastrozole - Early- and Late-Event Data From the Arimidex, Tamoxifen, Alone or in Combination (ATAC) DG News

"AstraZeneca" baut 120 Stellen ab  -  18 Mar 2009
Große Umsatzbringer wie das Krebsmittel Casodex fallen im laufenden Jahr aus dem Patentschutz, im kommenden Jahr das Brustkrebspräparat "Arimidex". Hamburger Abendblatt

FDA Safety Changes: Arimidex, Coreg/Coreg CR, Myozyme  -  ‎Mar 11, 2009‎
On December 10, 2008, the FDA approved safety labeling revisions for anastrozole (Arimidex tablets; AstraZeneca) to warn against its use in pregnancy and of Medscape

Poor Compliance with Adjuvant Arimidex® in Women with Breast Cancer  -  ‎Mar 11, 2009‎
Researchers from Germany have reported that postmenopausal women with localized breast cancer taking adjuvant Arimidex® (anastrozole) for localized hormone Cancer Consultants

Arimidex offers women greater protection against HR+ early breast ...  -  ‎Mar 13, 2009‎
Professor Tony Howell, Christie Hospital, UK MACCLESFIELD, England, Friday 13 March 2009 -- A new analysis of the ATAC (ARIMIDEX, Tamoxifen, PharmaLive.com (press release)

Daily Cancer News  -  ‎Mar 10, 2009‎
To evaluate the use of Oncotype DX in a broader group of patients, researchers assessed 1231 women who participated in the Arimidex, Tamoxifen Alone or in Cancer Consultants

Zometa® Decreases Relapses in Premenopausal Women with Breast Cancer  -  ‎Feb 19, 2009‎
There were no differences in disease-free survival between women receiving Arimidex or Nolvadex; disease-free survivals were 92.0% and 92.8%, respectively. Cancer Consultants

Do Ferrets With Adrenal Gland Disease Need Lupron For Life?  -  ‎Mar 2, 2009‎
...on these medications and the relative costs. Some of those medications include implantable melatonin and oral medications, such as Arimidex (anastrozole). SmallAnimalChannel.com

Supplements of DIM Stop Many Cancers in Their Tracks  -  ‎Mar 9, 2009‎
...drugs as Arimidex or Tamoxifen, because they would know that their own natural estrogen is not their enemy when it is properly balanced and metabolized. Natural News.com

New drug may target hard-to-treat breast tumours  -  ‎Feb 23, 2009‎
The treatment is not an alternative for a new class of drugs called aromatase inhibitors such as AstraZeneca's (AZN.L) Arimidex, Ford said. Continued Reuters

Breast removal - the anguish of Sophie's choice  -  ‎Feb 22, 2009‎
And/or women can ask about joining a clinical trial that is testing preventative measures, such as the drugs Tamoxifen and Arimidex in breast cancer. Times Online

Neuer Wirkstoff von AstraZeneca gegen Brustkrebs zeigt Erfolg  -  ‎Mar 13, 2009‎
In den ersten zwei Jahren nach einer Operation sei das Risiko einer Rückkehr von Brustkrebs bei Frauen nach den Wechseljahren bei Einsatz von "Arimidex" Frankfurter Allgemeine Zeitung

Nuevo fármaco apuntaría a tumores mamarios difíciles de tratar  -  ‎Feb 23, 2009‎
El tratamiento no es una alternativa a la nueva clase de medicinas llamadas inhibidores de la aromatasa, como Arimidex de AstraZeneca, indicó Ford. Terra.com

�?��?乳癌》轉移性乳癌的治療  -  04 Feb 2009
...至於�?�經後的乳癌病患則�?��?�擇芳香環轉化酶抑制劑(如:Arimidex 中時電�?報,

Meta-analyses of aromatase inhibitors versus tamoxifen  -  Feb 3, 2009
...were used to conduct separate meta-analyses of the cohort 1 trials: Arimidex, Tamoxifen, Alone or in Combination (ATAC) and Breast International Group American Journal of Hemotology and Oncology,

Risk Assessment and Individualized Therapy: A Report from the 2008 ...  -  Jan 29, 2009
However, poor metabolizers who were randomized to switch to Arimidex after two years of tamoxifen did not experience an increased recurrence risk at years Cancer Consultants,

Health: Radical Step For Breast Cancer Survivors  -  Jan 26, 2009
..."Tamoxifen or Arimidex, those two drugs, not only treat the cancer that a patient had, but also decreased the risk of developing a future cancer," said Dr. CBS 3,

What's the evidence for aromatase inhibitors for early breast cancer?  -  Jan 21, 2009
Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet. guardian.co.uk,

BREAKING NEWS: Sales rise but more job cuts at AstraZeneca  -  Jan 29, 2009
Sales of the breast cancer drug Arimidex (anastrozole) slipped 1% to $451, while generic competition in Europe to the oncology agent Casodex (bicalutamide) Pharma Times,

Nontraditional Modalities Help Oncology Patients— Acupuncture and ...  -  Jan 30, 2009
...in breast cancer patients (Stages 0-III) who had been receiving either tamoxifen or Arimidex and who had been having at least 14 hot flashes per week. Oncology Nursing News,

Hormones Part I: Hormonal Balance is the Key to Vibrant Health for ...  -  Jan 16, 2009
...typically placed on Tamoxifin or other aromatase inhibitors such as arimidex, femara and aromasin, drugs that often produce debilitating side effects. Natural News.com,

Pharma Earnings In Q4 - Healthy Or Ailing?  -  Jan 25, 2009
AstraZeneca's other key products include breast cancer drug Arimidex, heartburn medication Nexium, anti-psychotic drug Seroquel and asthma drug Symbicort. Trading Markets (press release),

Cancers et problèmes hormonaux chez le furet  -  Jan 28, 2009
En injection et associée à l'Arimidex, elle soigne l'anémie provoquée par l'aplasie médullaire. Une fois que le taux d'œstrogènes a été abaissé, Waliboo,

Cancro al seno, un problema non solo femminile  -  Jan 15, 2009
...principali farmaci utilizzati nella cura del cancro al seno - Tamoxifen e Arimidex -- non avevo la minima idea che anche gli uomini potessero contrarlo. Tifeoweb,

ASTRAZENECA:ANALYTIKER SPÅR CORE V/A 1:24 USD 4 KV - SME (OMS)  -  Jan 28, 2009
2008 2007 ============================================================== Nettoomsättning Grupp 8.367 8.170 31.775 29.559 Arimidex 499 474 1.905 1.730 Dagens Nyheter,

Brand Names/Synonyms:
Arimidex is also known by the following brand names and/or synonymsAnastrole; Anastrozol; Anastrozole; Anastrozole [Usan:Ban:Inn]; Arimidex; CHEMBANK1630; ICI-D 1033; ZD 1033

Drug Category:
Arimidex is categorized under the following by the FDA: Antineoplastic Agents; ATC:L02BG03

Dosage Forms:
tablets containing 1mg anastrozole

Absorption:
Absorbed into the systemic cirulation, and food does not affect the extent of absorption.

Interactions:
-->Interactions for Anastrozole:

Anastrozole inhibited in vitro metabolic reactions catalyzed by cytochromes P450 1A2, 2C8/9, and 3A4 but only at relatively high concentrations. Anastrozole did not inhibit P450 2A6 or the polymorphic P450 2D6 in human liver microsomes. Anastrozole did not alter the pharmacokinetics of antipyrine. Although there have been no formal interaction studies other than with antipyrine, based on these in vivo and in vitro studies, it is unlikely that co-administration of a 1 mg dose of ARIMIDEX with other drugs will result in clinically significant drug inhibition of cytochrome P450-mediated metabolism of the other drugs.

An interaction study with warfarin showed no clinically significant effect of anastrozole on warfarin pharmacokinetics or anticoagulant activity.

At a median follow-up of 33 months, the combination of ARIMIDEX and tamoxifen did not demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY ñ Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.

Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.

Drug/Laboratory Test Interactions

No clinically significant changes in the results of clinical laboratory tests have been observed.

-->

Chemical IUPAC Name:
2-[3-(1-cyano-1-methyl-ethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methyl-propanenitrile

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