Arestin

This page contains recent news articles, when available, and an overview of Arestin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Arestin
(when available)

Pharmacology and use:
Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Minocycline is used to treat nongonococcal urethritis, mucopurulent cervicitis, acne vulgaris, and rheumatoid arthritis and some othet infections. Because of its lipid solubility, minocycline is able to eradicate the meningococcal carrier state in tears and saliva. For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae, Upper respiratory tract infections caused by Streptococcus pneumoniee; For the treatment of asymptomatic carriers of Neisseria meningitidis

Mechanism Of Action:
Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30 S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.

News Articles on Minocycline

Advanced Gum Disease Treatment, Arestin, Offered by LA Dentist ...  -  ‎Aug 13, 2009‎
LA dentist : , City Dental, offers an Arestin procedure that can cure all of these issues along with other conditions that frequently accompany gum disease. PR-Inside.com (Pressemitteilung)

OraPharma renews ARESTIN Student Access Program  -  ‎Aug 13, 2009‎
The company has renewed its ARESTIN Student Access Program and created a new Professional Affairs Team to provide field support and instructor training for Dental Economics

Henry Schein Inc. Q3 2008 Earnings Call Transcript  -  Nov 5, 2008
We have solid relationships with our key suppliers such as Colgate for consumable dental merchandise, Johnson & Johnson for products such as Arestin Danaher Seeking Alpha,

Annual Report to shareholders  -  Oct 19, 2008
It is marketed under several trade names, including Minomycin, Minocin, Arestin, and Dynacin. Minocycline formulations are the largest selling tetracycline Sydney Morning Herald,

Build patient relationships  -  Oct 1, 2008
For other patients with periodontal abscesses, I clean out the pocket and place Arestin by OraPharma. In both cases if I say nothing to patients, Dental Economics,

Henry Schein, Inc. Q2 2008 Earnings Call Transcript  -  Aug 5, 2008
During the second quarter, we began distributing the ARESTIN in the United States. Under the exclusive agreement with Orapharma, J&J, a Johnson and Johnson Seeking Alpha,

“Escracheâ€? en el Colegio de Abogados y Tribunales  -  Jul 8, 2008
La Multisectorial Mar del Plata -que reúne diversas agrupaciones entre las que se encuentran Quebracho, Compañeros Independientes, MAS, MTR, Fogoneros, 0223 Vespertino Digital,

Good times in Chicago  -  Jun 4, 2008
I continued on through the meeting and ended up at the OraPharma booth, the makers of Arestin. Getting rid of bugs in the periodontal pocket is crucial to Dental Economics,

OraPharma renews ARESTIN Student Access Program; launches ...  -  May 28, 2008
The ARESTIN Student Access Program launched last year as the result of discussion and collaboration between OraPharma and the directors of leading dental Dental Economics,

Henry Schein Dental to be Sales Agent and Exclusive Distributor of ...  -  23 Apr 2008
...“Our goal is to provide ‘everything dental’ to our customers, and the addition of ARESTIN to our offering certainly furthers that mission. Business Wire (press release),

When you call for help, will cops understand you?  -  Apr 5, 2008
..."Nosotros sentimos que no estamos consiguiendo la protección adecuada — protección es lo que necesitamos," she says to Andres Arestin, one of nine bilingual Times Herald-Record,

Pharma Marketers Face DTC, DTP and CME Scrutiny, More at iiBIG ...  -  Mar 9, 2008
Regulatory Affairs, MedImmune -- Jan Malek, Director, IBSG-Life Sciences, Cisco Systems -- John S. Lenart, Senior Brand Director, Arestin®, OraPharma, PR-USA.net (press release),

OraPharma, Inc.'s ARESTIN receives accolades  -  Feb 13, 2008
ARESTIN was named as one of the "Products Dental Hygienists Cannot Live Without" by a leading independent, nonprofit dental education and product testing RDH,

Beyond DTC: Pharma Industry Faces New Challenges, Competition ...  -  Jan 15, 2008
Org -- Jan Malek, Director, IDSG-Life Sciences, Cisco Systems -- John S. Lenart, Senior Brand Director, Arestin(R), OraPharma, Inc. -- Ilyssa Levins, Earthtimes,

Lev Pharmaceuticals Expands Senior  -  Nov 14, 2007
Mr. Truitt built the sales management team at orapharma, Inc., and led the successful launch of the company's flagship product, Arestin®. Ad-Hoc-News (Pressemitteilung),

Lev Pharmaceuticals Expands Senior Management Team  -  Nov 14, 2007
Mr. Truitt built the sales management team at orapharma, Inc., and led the successful launch of the company's flagship product, Arestin®. Business Wire (press release),

Subscribe to this News Feed  -  Sep 25, 2007
Clinical studies have proven that ARESTIN® used as an adjunct to scaling and root planing (SRP) is more effective than SRP alone in eliminating periodontal Emediawire (press release),

Industry News  -  Sep 19, 2007
According to Arestin Product Director John Lenart, “We have been working closely with the directors of leading dental and hygiene schools for several years RDH,

Start Your Cosmetic Dentistry with Basic Oral Health and Hygiene  -  Sep 28, 2007
Although there are a few different topically applied antibiotics; we prefer “Arestin� a crystal/powder form of minocycline (cousin to tetracycline) that is The Open Press (press release)

New Periodontal Disease Study Shows SRP is Significantly More ...  -  Aug 27, 2007
Study results indicate clearly that when ARESTIN ® is placed at the time of initial SRP, clinical markers of disease are reduced, such as pocket depth, Business Wire (press release),

New Study Shows Standard Therapy For Gum Disease is Significantly ...  -  Aug 27, 2007
A new study published today in the Journal of Periodontology shows that a combination of the locally delivered antibiotic ARESTIN(R) (minocycline Genetic Engineering News (press release),

Emne: These patients to submit viral genome society.  -  Jul 12, 2007
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When discarding too much finding is disrupted.  -  Jul 9, 2007
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Lev Pharmaceuticals, Inc. Announces Completion of Marketing and ...  -  Jun 26, 2007
PR Newswire (press release),While at OraPharma, Ms. Heinzinger developed and implemented marketing programs for the company's flagship product, ARESTIN(R). Prior to Johnson & Johnson,

Controlling the Intraoral Environment Before and After Implant Therapy  -  Jun 19, 2007
RDH,Skaleric U, Schara R, Medvescek M, Hanlon A, Doherty F, Lessem J. Periodontal treatment by Arestin and its effects on glycemic control in type 1 diabetes

New Online Information Resource for Periodontal Disease Treatment  -  May 23, 2007
HealthNews-Stats (press release),As well, patients are educated about the risks and symptoms of periodontal disease, along with the importance of treatment with ARESTIN® plus SRP.�

Don’t Look Back  -  May 18, 2007
Dental Economics,Similar circumstances delayed use of the digital camera, patient education systems, and some clinical protocols such as the use of Arestin.

Dental representatives and how they affect your practice  -  Apr 13, 2007
Dental Economics,Some of the companies that offer lunch-and-learn programs are Philips Oral Health Care (Sonicare), OraPharma (ARESTIN), Procter and Gamble (Whitestrips and

Form follows Function  Aug 17, 2006
West Palm Beach, Fla.), doxycycline gel (Atridox; CollaGenex Pharmaceuticals Inc., Newtown, Pa.), and minocycline HCl 1 mg microspheres (ARESTIN(r); OraPharma ... -RDH

Lev Pharmaceuticals Appoints Vice President, Sales and Marketing ...  Aug 3, 2006
...& Johnson, Mr. Truitt built the sales management team at OraPharma, Inc., and led the successful launch of the company's flagship product, Arestin(R). At Lev ... -Business Wire

Brand Names/Synonyms:
Arestin is also known by the following brand names and/or synonymsAlti-Minocycline; Apo-Minocycline; Arestin; BRN 3077644; CL 59806; DYNACIN; Dynacin; Gen-Minocycline; HSDB 3130; Klinomycin; MINOCYCLINE; Minociclina [Inn-Spanish]; Minocin; Minocyclin; Minocycline; Minocycline Hcl; Minocycline [Usan:Ban:Inn]; Minocyclinum [Inn-Latin]; Minocyn; Minomycin; Novo-Minocycline; Vectrin

Drug Category:
Arestin is categorized under the following by the FDA: Anti-bacterial Agents; Tetracyclines; ATC:A01AB23; ATC:J01AA08

Dosage Forms:
Capsules; Subgingival (sustained-release); IV Injection;

Absorption:
rapidly absorbed from the gastrointestinal tract

Interactions:
Interactions for Minocycline:

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and iron-containing preparations.

The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.





Chemical IUPAC Name:
2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione

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