Antithymocyte globulin

This page contains recent news articles, when available, and an overview of Antithymocyte globulin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Antithymocyte globulin (when available)

Pharmacology and use:
This immunosuppressive product, obtained by immunization of rabbits with human thymocytes, contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. This reduces the host immune response against tissue transplants or organ allografts. For prevention of renal transplant rejection

Mechanism Of Action:
Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.

News Articles on Antithymocyte globulin

Antibody-Mediated Rejection of the Kidney After Simultaneous ...  Aug 21, 2008
Treatments varied but included corticosteroids, rabbit-derived antithymocyte globulin (13 cases), intravenous immune globulin (IVIG, 12 cases),Medscape (subscription)

Single-Dose Rituximab Safe and Effective in Desensitising Highly ...  -  Jun 3, 2008
...induction therapy with alemtuzumab while patients in group 2 received alemtuzumab (n = 33), daclizumab (n = 19), or antithymocyte globulin (n = 3). DG News

Transplantation: It may take two to tango and to treat  -  Mar 28, 2008
The authors show that adding B-cell depletion (anti-CD20—rituximab) to a standard-of-care T-cell immunotherapy (antithymocyte globulin—ATG and maintenance Nature.com (subscription),

Successful Organ Transplantation May be Possible Without Long-Term ...  -  Feb 15, 2008
The immune system was altered by subjecting it to total lymphoid irradiation and antithymocyte globulin treatment, creating a persistent ‘hybrid’ immune Medi News Direct,

Tolerance and Chimerism after Renal and Hematopoietic-Cell ...  -  Jan 23, 2008
A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. New England Journal of Medicine (subscription),

Nurses Conduct Research from the Bedside  -  Jan 14, 2008
A phase 2 trial is assessing the mechanism and response of antithymocyte globulin (Thymoglobulin) in patients with myelodysplastic syndrome, a rare, Nurse.com,

Treatment of ANCA-Associated Vasculitis  -  Dec 18, 2007
...in some of these patients prior to monoclonal antibody therapy also included plasma exchange, intravenous immunoglobulin, or antithymocyte globulin. Journal of American Medical Association (subscription),

Therapies for Myelodysplastic Syndrome Only Improve Survival in ...  -  May 23, 2007
DG News...and evaluated antithymocyte globulin (ATG), thalidomide, valproic acid, low-dose arabinoside C (AraC), induction chemotherapy, and allogeneic stem cell

Insight: Questions follow reports of stem cell diabetes cure  -  Apr 24, 2007
New Scientist (subscription),Also the drugs used in the trial included antithymocyte globulin, which selectively damps down immune reactions. This alone might explain any benefits,

It's Not Too Late  -  Apr 20, 2007
Kommersant,Treatment with antithymocyte globulin “produced no hematological result,�? Machan explained. The only thing that can save him is a transplant of healthy bone

Insight: Questions follow reports of stem cell diabetes cure  -  Apr 18, 2007
New Scientist (subscription),Also the drugs used in the trial included antithymocyte globulin, which selectively damps down immune reactions. This alone might explain any benefits,

Stem Cells Tame Type 1 Diabetes in Pilot Study  -  Apr 10, 2007
MedPage Today,The cells were injected intravenously back into the patients after further conditioning with cyclophosphamide (200 mg/kg) and rabbit antithymocyte globulin

Autologous Nonmyeloablative Hematopoietic Stem Cell ...  -  Apr 10, 2007
Journal of American Medical Association (subscription),The cells were injected intravenously after conditioning with cyclophosphamide (200 mg/kg) and rabbit antithymocyte globulin (4.5 mg/kg).

Study in Today's New England Journal of Medicine Shows Benefits of ...  09 Nov 2006
Results of the study, Rabbit Antithymocyte Globulin versus Basiliximab for Induction in Renal Transplantation, showed that treatment with Thymoglobulin ... -Yahoo! News (press release) Drug Reduces Kidney-Transplant Rejection Rates  09 Nov 2006
A new study found that one drug, rabbit antithymocyte globulin (brand name Thymoglobulin) was better at reducing the risk of acute rejection than a commonly ... -CBC News, Something Human  Oct 13, 2006
For the antithymocyte globulin. The state provides children with antithymocyte globulin. But it is horse antithymocyte globulin. ... -Kommersant, Alemtuzumab Induction Therapy  Sep 1, 2006
...acute rejection by 1 year when compared with other antibody preparations, including interleukin-2 receptor antagonists and rabbit antithymocyte globulin (rATG ... -Medscape (subscription)

Early Reduced-Intensity Stem Cell Transplantation Promising for ...  Jul 26, 2006
...fludarabine, cytarabine and amsacrine followed after 4 days of rest by the RIC regimen of total body irradiation, cyclophosphamide and antithymocyte globulin. ... -Cancer Consultants

Early Reduced-intensity Stem Cell Transplantation Promising for ...  Jul 26, 2006
...with Fludara®, Cytarabine, and amsacrine followed by four days of rest, followed by total-body irradiation, cyclophosphamide, and antithymocyte globulin. -Cancer Consultants

Bone marow disease at core Feb 16, 2006
In Robin’s case, her brother’s bone marrow wasn’ta match. “We opted for a treatment called ATG, short for antithymocyte globulin,�? she said laughing ... - Cape Gazette,

Brand Names/Synonyms:
Antithymocyte globulin is also known by the following brand names and/or synonymsThymoglobulin; Thymoglobulin (SangStat Medical; Genzyme)

Drug Category:
Antithymocyte globulin is categorized under the following by the FDA: Immunomodulatory Agents; unclassified therapeutic agents (92:00.00)

Dosage Forms:
POWDER FOR SOLUTION

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
Rabbit anti-thymocyte globulin

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