Ansaid

This page contains recent news articles, when available, and an overview of Ansaid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Ansaid (when available)

Pharmacology and use:
Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID) of the propionic acid class, is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis and for the inhibition of intraoperative miosis. Flurbiprofen exhibits antiinflammatory, analgesic, and antipyretic activities. Flurbiprofen tablets are indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteorarthritis.

Mechanism Of Action:
The antiinflammatory effect of flurbiprofen may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. Flurbiprofen also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

News Articles on Flurbiprofen

Sny Island Levee Preparedness  -  Jun 21, 2008
The levee is split into 4 reaches, that spreads across Pike, and part of Adams, ansaid Mike Reed Sny Island Levee Superintendentd Calhoun county. KHQA,

New Alzheimer Drug Candidate Promising  -  Jun 11, 2008
Tarenflurbil is somewhat similar to NSAID flurbiprofen (brand name Ansaid), but lacks anti-inflammatory activity. Researchers have come to an important eFluxMedia

Pharma companies  -  May 28, 2008
For pain and inflammation, Nemisulide ANSAID - widely prescribed by the medical fraternity - has also been made Hepetoprotective by adding Racemethiomine, Economic Times,

AAN: Investigational Amyloid Inhibitor Slows Early Alzheimer's ...  -  Apr 18, 2008
It's a chemical sibling (specifically, the R-enantiomer) of the nonsteroidal anti-inflammatory drug flurbiprofen (Ansaid). The 24-month phase II trial was MedPage Today,

Deoband denounces terrorism in all forms  -  Feb 26, 2008
The clerics denounced terrorism in one voice ansaid Islam did not preach violence. Instead it preaches the tenets of peace, harmony, brotherhood, Newstrack India,

37 Die As Car Bomb Hits Near Iraq Shrine  -  Apr 14, 2007
Guardian Unlimited,...``This bombing shows a security breach, ansaid. The Jadriyah bridge suffered little damage. On Thursday, a suicide truck bomb completely collapsed the

Brand Names/Synonyms:
Ansaid is also known by the following brand names and/or synonymsAdfeed; Ansaid; Antadys; Apo-Flurbiprofen; Cebutid; FLP; Flurbiprofen; Flurbiprofen Axetil; Flurbiprofen Sodium; Flurbiprofene [Inn-French]; Flurbiprofeno [Inn-Spanish]; Flurbiprofenum [Inn-Latin]; Flurofen; Froben; Froben Sr; Novo-Flurprofen; Nu-Flurbiprofen; Ocufen; Stayban; Zepolas

Drug Category:
Ansaid is categorized under the following by the FDA: Anti-inflammatory Agents; Analgesics; Nonsteroidal Antiinflammatory Agents (NSAIDs); Carbonic Anhydrase Inhibitors; Cyclooxygenase Inhibitors; ATC:M01AE09; ATC:M02AA19; ATC:S01BC04

Dosage Forms:
CAPSULE (SUSTAINED-RELEASE); LIQUID; TABLET

Absorption:
The mean oral bioavailability of flurbiprofen from tablets is 96% relative to an oral solution.

Interactions:
Interactions for Flurbiprofen:

Antacids: Administration of flurbiprofen to volunteers under fasting conditions, or with antacid suspension yielded similar serum flurbiprofen time profiles in young subjects (n=12). In geriatric subjects (n=7) there was a reduction in the rate but not the extent of flurbiprofen absorption.

Anticoagulants: Flurbiprofen like other nonsteroidal anti-inflammatory drugs, has been shown to affect bleeding parameters in patients receiving anti-coagulants, and serious clinical bleeding has been reported. The physician should be cautious when administering flurbiprofen to patients taking anticoagulants.

Aspirin: Concurrent administration of aspirin and flurbiprofen resulted in 50% lower serum flurbiprofen concentrations. This effect of aspirin (which also lowers serum concentrations of other nonsteroidal anti-inflammatory drugs given with it) has been demonstrated in patients with rheumatoid arthritis (n= 15) as well as normal volunteers (n= 16). Concurrent use of flurbiprofen and aspirin is therefore not recommended.

Beta-adrenergic Blocking Agents: The effect of flurbiprofen on blood pressure response to propranolol and atenolol was evaluated in men with mild uncomplicated hypertension (n = 10). Flurbiprofen pretreatment attenuated the hypotensive effect of a single dose of propranolol but not atenolol. Flurbiprofen did not appear to affect the beta-blocker-mediated reduction in heart rate. Flurbiprofen did not affect the pharmacokinetic profile of either drug, and the mechanism under lying the interference with propranolol's hypotensive effect is unknown. Patients taking both flurbiprofen and a beta-blocker should be monitored to ensure that a satisfactory hypotensive effect is achieved.

Cimetidine, Ranitidine: In normal volunteers (n=9), pretreatment with cimetidine or ranitidine did not affect flurbiprofen pharmacokinetics except that a small (13 %) but statistically significant increase in the area under the serum concentration curve of flurbiprofen resulted with cimetidine.

Digoxin: Studies of concomitant administration of flurbiprofen and digoxin to healthy men (n= 14) did not show a change in the steady state serum levels of either drug.

Diuretics: Studies in normal volunteers have shown that flurbiprofen like other nonsteroidal anti-inflammatory drugs, can interfere with the effects of furosemide. Although results have varied from study to study, effects have been shown on furosemide-stimulated diuresis, natriuresis, and kaliuresis. Other nonsteroidal anti-inflammatory drugs that inhibit prostaglandin synthesis have been shown to interfere with thiazide diuretics in some studies and with potassium-sparing diuretics. Patients receiving flurbiprofen and furosemide or other diuretics should be observed closely to determine if the desired effect is obtained.

Oral Hypoglycemic Agents: In one study, flurbiprofen was given to adult diabetics who were already receiving glyburide (n=4), metformin (n=2) chlorpropamide with phenformin (n= 3) or glyburide with phenformin (n=6). Although there was a slight reduction in blood sugar concentrations during concomitant administration of flurbiprofen and hypoglycemic agents, there were no signs or symptoms of hypoglycemia.

Chemical IUPAC Name:
2-(3-fluoro-4-phenyl-phenyl)propanoicacid

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