Anastrozole

This page contains recent news articles, when available, and an overview of Anastrozole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Anastrozole (when available)

Pharmacology and use:
Anastrozole is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of advanced breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In post-menopausal women, the principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol. Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. For treatment of advanced breast cancer.

Mechanism Of Action:
Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues. Therefore, aromatase inhibition leads to a decrease in circulatin estrogen, leading to a decreased tumor mass or delayed progression of tumor growth in some women.

News Articles on Anastrozole

New pediatric information available for 32 products from the Food ...  -  ‎Apr 1, 2009‎
...anastrozole in male pubertal patients with gynecomastia or in females with McCune-Albright syndrome, and bicalutamide in males with testotoxicosis. AAP News (subscription)

Breast Cancer: Preoperative Chemotherapy  -  ‎Mar 31, 2009‎
Abstract Phase III randomized study of neoadjuvant therapy comprising exemestane versus letrozole versus anastrozole in postmenopausal women with estrogen Medscape

Ostéoporose, traitements hormonaux et prévention  -  ‎Apr 15, 2009‎
Chez la femme ménopausée Chez la femme ménopausée, on utilise seuls les antiaromatases, soit le letrozole ou anastrozole, ou encore l’exemestane Vie Femme

혈압강하제 등 12개 품목 15�?�부터 20% �?�하  -  ‎Apr 5, 2009‎
...한국아스트�?�제네카�?� 항악성종양제 ‘아리미�?�스정(anastrozole)’, 삼아제약�?� 기타 화학요법제 스파�?�정(sparfloxacin)등�?� �?한금액�?� 내린다. 헬스코리아뉴스

Anastrazole Superior to Tamoxifen Preventing Disease Recurrence in ...  -  18 Mar 2009
At 9 years, the total number of all first events for anastrozole versus tamoxifen, with the Kaplan-Meier proportion estimate in parentheses, was 609 (25.8%) DG News

High-Dose Fulvestrant Has Greater Biological Activity Than Normal ...  -  ‎Mar 16, 2009‎
Analysis of the primary endpoint (clinical benefit rate) demonstrated that fulvestrant HD was at least as effective as anastrozole (72.5% vs 67.0%; DG News

Extended Adjuvant Therapy With Anastrozole Safe, Effective for Up ...  -  ‎Mar 14, 2009‎
GALLEN, Switzerland -- March 14, 2009 -- Extended adjuvant therapy with anastrozole offers a safe and efficacious treatment for as long as 3 years in cancer DG News

FDA Safety Changes: Arimidex, Coreg/Coreg CR, Myozyme  -  ‎Mar 11, 2009‎
March 11, 2009 — The US Food and Drug Administration (FDA) has approved safety labeling revisions to warn against use of anastrozole in pregnancy and advise Medscape

Arimidex offers women greater protection against HR+ early breast ...  -  ‎Mar 13, 2009‎
...“Anastrozole is the only aromatase inhibitor (AI) which has now been shown to prevent recurrences in women with hormone receptor positive early breast PharmaLive.com (press release)

Access widened for breast cancer medication  -  ‎Mar 11, 2009‎
Access to the frequently prescribed breast cancer medicine, Arimidex (anastrozole), has been widened through changes to funding as of 1 February 2009. New Zealand Doctor Online

Daily Briefs: Missouri Rep. Cynthia Davis justifies herself  -  ‎Feb 25, 2009‎
I'll tell you right now that all I have to do is switch from my alternating cycles of Anastrozole and deca-durabolin to a cocktail of Clenbuterol, Pitch Weekly

Daily Cancer News  -  ‎Mar 10, 2009‎
...hormone receptor–positive breast cancer and compared two different hormonal therapies: tamoxifen and Arimidex® (anastrozole, an aromatase inhibitor). Cancer Consultants

Endocrine therapy plus zoledronic acid in premenopausal breast cancer  -  ‎Mar 10, 2009‎
SC every 28 days) and either tamoxifen (20 mg/day po) or anastrozole (1 mg/day po) with or without zoledronic acid (4 mg IV every 6 months) for 3 years. American Journal of Hemotology and Oncology

Do Ferrets With Adrenal Gland Disease Need Lupron For Life?  -  ‎Mar 2, 2009‎
...on these medications and the relative costs. Some of those medications include implantable melatonin and oral medications, such as Arimidex (anastrozole). SmallAnimalChannel.com

NICE publishes recommendations for the care of patients with ...  -  ‎Feb 26, 2009‎
For example, the aromatase inhibitors anastrozole or letrozole are recommended for treatment of post-menopausal women with ER-positive early breast cancer Pharma Times

英 유방암 치료 가�?�드�?��?� 발표  -  ‎Mar 2, 2009‎
...�?국국립보건연구소(NICE)는 초기 침습�? 유방암�? 대해서 �?스트로�? 수용체 양성�?� �??경기 환�?�?� 경우 수술�?� 첫 보조요법으로 ‘아나스트로졸’(anastrozole)�?�나 디지틀보사

프레미나정 등 5품목 병용금기약�? 추가 등�?  -  ‎Mar 2, 2009‎
...�?, 다림바�?�오�? 프레미나정0.3mg·0.625mg�?� ‘anastrozole'성분�?� 한국아스트�?�제네카 아리미�?�스정과, 중외제약 트루페넴주0.5g는 ‘divalproex sodium'성분�?� 한국 메디파나뉴스

美国ASCO评出08年12项癌症防治�?大进展  -  04 Feb 2009
...接�?�他莫昔芬或者阿那曲唑（anastrozole 和讯网,

What's the evidence for aromatase inhibitors for early breast cancer?  -  Jan 21, 2009
One large study of 10000 women (a randomised controlled trial) found that anastrozole worked better than tamoxifen for women with early breast cancer and guardian.co.uk,

Meta-analyses of aromatase inhibitors versus tamoxifen  -  Feb 3, 2009
Intergroup Exemestane Study (IES)/ BIG 2-97, Italian Tamoxifen Anastrozole (ITA). Study end points included breast cancer recurrence (all, local only, American Journal of Hemotology and Oncology,

Risk Assessment and Individualized Therapy: A Report from the 2008 ...  -  Jan 29, 2009
...women with hormone-positive breast cancers who are treated with Arimidex® (anastrozole).7 The recent trial included 1308 hormone receptor-positive tumor Cancer Consultants,

Breast Cancer Update from the 2008 Meeting of the American Society ...  -  Jan 27, 2009
At a median follow-up of 60 months, there was no difference in DFS between patients who received tamoxifen and those who received anastrozole, nor was there Cancer Consultants,

Mr. Kennedy Caught In Another Lie, '09 Firings So Far, RAW  -  Jan 19, 2009
Between October 2006 and February 2007, according to documents, Anderson had received shipments of anastrozole, somatropin and testosterone. Wrestling-Edge.com,

New breast-cancer drug gives hope to Cyprus industry  -  Jan 29, 2009
The new drug, developed in cooperation with Pharmaceutical Oriented Services (PharOS) of Greece, contains anastrozole that claims a 13% longer survival Financial Mirror,

BREAKING NEWS: Sales rise but more job cuts at AstraZeneca  -  Jan 29, 2009
Sales of the breast cancer drug Arimidex (anastrozole) slipped 1% to $451, while generic competition in Europe to the oncology agent Casodex (bicalutamide) Pharma Times,

Illnesses and drugs that can cause osteoporosis  -  Jan 21, 2009
A drug called anastrozole, which is used to treat breast cancer. Scottish Intercollegiate Guidelines Network. Management of osteoporosis: a national guardian.co.uk,

Randy Orton's Storyline Disorder Linked To Steroid Use - Details  -  Jan 28, 2009
The article mentioned several current and former WWE wrestlers, including Orton, who was alleged to have obtained clomiphene citrate, anastrozole and the PWMania,

Randy Orton's 'Disorder', WWE Encyclopedia, Santino, & More  -  Jan 28, 2009
The article mentioned several current and former WWE wrestlers, including Orton, who was alleged to have obtained clomiphene citrate, anastrozole and the Wrestling-Edge.com,

SABCS: Anastrozole Shows Mixed Results in Breast Cancer Second ...  -  Dec 15, 2008
15 (HealthDay News) -- After breast cancer patients undergo surgery and receive tamoxifen, switching to anastrozole may increase the likelihood of Drug Topics Magazine,

Breast Cancer: Research On Tamoxifen Leads To Recommendation For ...  -  Dec 13, 2008
One group was randomized to five years of tamoxifen therapy, and the other randomized to tamoxifen for two years followed by three years of anastrozole, Science Daily (press release)

Ongoing Adjuvant Tamoxifen in Breast Cancer Offers Better Quality ...  -  Dec 13, 2008
Dr. Ohsumi pointed out that these new findings on quality of life suggest that if a switch to anastrozole causes unacceptable side effects, a patient can DG News

Oncotype DX® Predicts Recurrence Risk in Node-negative and Node ...  -  Dec 18, 2008
Among women with early, hormone receptor-positive breast cancer treated with either tamoxifen (Nolvadex®) or Arimidex® (anastrozole), the Oncotype DX test Cancer Consultants,

No shortage of cancer drugs  -  Dec 15, 2008
He said the two drugs - Anastrozole (1mg) and Letrozole (2.5) - are given to cancer patients and these two drugs are freely available at all hospitals where Ceylon Daily News,

Fighting Breast Cancer One Day At A Time  -  Dec 3, 2008
She now takes Arimidex (anastrozole). "It's the one medicine I never forget to take." She also now volunteers her time to Living Beyond Breast Cancer, North American Press Syndicate,

Oncotype DX™ Predicts Risk of Distant Recurrences Among Women with ...  -  Dec 19, 2008
Risk of distant recurrence using Oncotype DX in postmenopausal primary breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study. Cancer Consultants,

Aromatase Inhibitors Improve Outcomes in Early Breast Cancer  -  Dec 17, 2008
The aromatase inhibitors that were evaluated were Femara® (letrozole), Arimidex® (anastrozole), and Aromasin® (exemestane). Over the course of five years, Cancer Consultants,

Cancer hospital looks to public for funds to purchase drugs  -  Dec 10, 2008
Sources said the hospital was facing a crisis in providing breast cancer patients with two types of drugs namely; Anastrozole and Letorozole which should be Lanka Times,

Tamoxifen research paves the way for a CYP2D6 gene test recommendation  -  Dec 15, 2008
The results of the ABCSG-8 study revealed that the women who had switched to anastrozole, had a 40 percent reduced risk of breast cancer re-growth. HealthJockey.com,

Agendia Presents Data Supporting Predictive Claim For Breast Cancer Dx  -  Dec 17, 2008
...of distant recurrence using Oncotype DX in postmenopausal primary breast cancer patients treated with anastrozole or tamoxifen in the TransATAC study. Pharmacogenomics Reporter,

Jury Is In  -  Dec 12, 2008
Aromatase inhibitors used to treat breast cancer include Arimidex (anastrozole), Aromasin (exemestane), and Femara (letrozole). Results were presented on Curetoday.com (press release),

Holiday Messages from WWE Divas, Charlie Haas on His Past Steroid Use  -  Nov 29, 2008
Haas was allegedly prescribed anastrozole (used to ward off breast tissue following a steroid cycle), somatropin (Growth hormone), stanozolol (anabolic Impact Wrestling News

CON ANASTROZOLO MENO RECIDIVE DI TUMORE AL SENO  -  Dec 5, 2008
ATAC: 100 month median follow-up shows continued superior efficacy and no excess fracture risk for anastrozole compared with tamoxifen after treatment Italiasalute.it,

Hot Flashes, Night Sweats a Good Sign for Breast Cancer Patients  -  Oct 29, 2008
The differences in cancer recurrence rates were seen with both tamoxifen and anastrozole. Overall, patients with and without these symptoms who received Washington Post,

Natco Pharma obtains tentative nod from USFDA for Anastrozole  -  Nov 10, 2008
Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. Natco Pharma is engaged in manufacturing and marketing Myiris.com,

Science and Technology Awareness about breast cancer still low in RP  -  Nov 12, 2008
...manufacturers of breakthrough drugs against breast cancer, including tamoxifen and the new-generation targeted therapy, aromatase inhibitor anastrozole. Philippine Star,

The 2008 Annual American Society of Clinical Oncology Breast ...  -  Nov 18, 2008
...[8] These researchers conducted a clinical trial evaluating the effectiveness of Nexavar® (sorafenib) in addition to Arimidex® (anastrozole) among women Cancer Consultants,

Genomic Health Announces Third Quarter 2008 Financial Results and ...  -  Nov 5, 2008
...using Oncotype DX in postmenopausal primary breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study" -- "GRB7-dependent pathways Earthtimes (press release),

Health news: Bad side effects that are a blessing, a bacteria to ...  -  Nov 17, 2008
Now Cancer Research UK scientists have found that women who take tamoxifen or the AI drug anastrozole and suffer side effects within three months are 10 per Daily Mail,

Research boosts survival  -  Nov 1, 2008
There are three drugs in this class: anastrozole, letrozole and exemestane. They are used only in post menopausal women. Finally, we have fulvestrant, Malaysia Star,

Breast Cancer Patients Suffering Side Effects from Hormone Therapy ...  -  Nov 6, 2008
...outcomes among women treated with either tamoxifen (Nolvadex®) or Arimidex® (anastrozole) who experience side effects associated with these therapies. Cancer Consultants,

Why Antiestrogen Side Effects May Predict Decreased Risk of Breast ...  -  Nov 5, 2008
...women who developed hot flashes or night sweats within three months of starting either tamoxifen or anastrozole had a recurrence rate of 18 per cent CTV.ca,

Emerging markets push up AstraZeneca's earnings  -  Oct 31, 2008
Sales of Seroquel (quetiapine) for schizophrenia increased 41% to $1.13 billion, while the breast cancer drug Arimidex (anastrozole) was up 9% to $486 Pharma Times (registration),

研究：新�?��?�预测乳腺癌�?�?�?�?�  -  Nov 13, 2008
...研究人员观察了约四�?��??�?��?妇女�?用Arimidex（�?�俗称的Anastrozole 大纪元

Los sofocos y los sudores nocturnos podrían ser una buena señal ...  -  Nov 1, 2008
Las diferencias en la recurrencia del cáncer se observaron tanto con tamoxifén como con anastrozole. En general, las pacientes con presencia o ausencia de Info7,

�?약청, 한미약품 ‘암로디핀’ 등 10건 임�?승�?�  -  Nov 13, 2008
...아스트�?�제네카는 비-스테로�?�드성 아로마타제 억제제 치료 시 진행�?� �?�후, 국소�?으로 진행�?�/전�?�성 유방암�?� 있는 ER+ve �??경 후 여성�?� 대�?으로 Anastrozole 헬스코리아뉴스,

抗肿瘤�?�物�?�?�治疗领域�?�物总销售冠军  -  Nov 5, 2008
...赛诺�?�-安万特的多西他赛（Docetaxel，泰索�?，Taxotere）和奥沙利铂（Oxaliplatin，�?沙定，Eloxatin）�?阿斯利康的阿那曲唑（Anastrozole 生物通,

Β�?αδινές εξάψεις και ιδ�?ώτας ένδειξη επιτυχημένης θε�?απείας για ...  -  Oct 30, 2008
Οι επιστήμονες εξέτασαν 4.000 γυναίκες που έχουν πε�?άσει εμμηνόπαυση και οι οποίες έπαι�?ναν το φά�?μακο Arimidex, γνωστό και ως αναστ�?οζόλη (anastrozole) ή Newsnow,

Traitement ciblé des sarcomes  -  Nov 14, 2008
...une population de patientes porteuses de sarcome stromal endométrial traitées par des inhibiteurs de l’aromatase (anastrozole et letrosole). Bulletin du Cancer,

Brand Names/Synonyms:
Anastrozole is also known by the following brand names and/or synonymsAnastrole; Anastrozol; Anastrozole; Anastrozole [Usan:Ban:Inn]; Arimidex; CHEMBANK1630; ICI-D 1033; ZD 1033

Drug Category:
Anastrozole is categorized under the following by the FDA: Antineoplastic Agents; ATC:L02BG03

Dosage Forms:
tablets containing 1mg anastrozole

Absorption:
Absorbed into the systemic cirulation, and food does not affect the extent of absorption.

Interactions:
-->Interactions for Anastrozole:

Anastrozole inhibited in vitro metabolic reactions catalyzed by cytochromes P450 1A2, 2C8/9, and 3A4 but only at relatively high concentrations. Anastrozole did not inhibit P450 2A6 or the polymorphic P450 2D6 in human liver microsomes. Anastrozole did not alter the pharmacokinetics of antipyrine. Although there have been no formal interaction studies other than with antipyrine, based on these in vivo and in vitro studies, it is unlikely that co-administration of a 1 mg dose of ARIMIDEX with other drugs will result in clinically significant drug inhibition of cytochrome P450-mediated metabolism of the other drugs.

An interaction study with warfarin showed no clinically significant effect of anastrozole on warfarin pharmacokinetics or anticoagulant activity.

At a median follow-up of 33 months, the combination of ARIMIDEX and tamoxifen did not demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY ñ Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.

Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.

Drug/Laboratory Test Interactions

No clinically significant changes in the results of clinical laboratory tests have been observed.

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Chemical IUPAC Name:
2-[3-(1-cyano-1-methyl-ethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methyl-propanenitrile

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