Amnesteem

This page contains recent news articles, when available, and an overview of Amnesteem but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Amnesteem (when available)

Pharmacology and use:
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Mechanism Of Action:
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

News Articles on Tretinoin

Decrease chance of birth defects  -  Jan 21, 2008
The acne drug isotretinoin (sold under the brand names Accutane, Amnesteem, Claravis and Sotret) poses a high risk of serious birth defects. Jackson Clarion Ledger,

Letters - Cerasee cured my eczema (part 2)  -  Jun 26, 2007
Jamaica Gleaner,I will definitely look into cerasee but currently I am taking Accutane (the generic form, Amnesteem) and have tolerated it well (this is not my first

Purchasing isotretinoin online is risky, FDA warns  -  Apr 4, 2007
AAP News (subscription)...www.fda.gov/buyonline/accutane, will appear in online search results for Accutane (isotretinoin) or one of the generic-name versions, Amnesteem,

FDA CAPSULES  -  Apr 3, 2007
Newsday,Isotretinoin is sold as Accutane, Amnesteem, Claravis and Sotret. VOLUNTARY RECALL OF RHINO MAX SUPPLEMENT. Cosmos Trading Inc. is recalling its supplement

Web Page By FDA Warns Of Online Purchase And Use Of Generic Form ...  -  Apr 2, 2007
All Headline NewsThe drug isotretinoin is sold under the brand name Accutane and three generic names: Amnesteem, Claravis and Sotret. The web page from the FDA also guides

FDA Launches Web Page Warning Against Buying Accutane And Its Generic  -  Apr 2, 2007
WebWire (press release),...under any one of its four names (Isotretinoin is sold under the brand name of Accutane and in generic versions called Amnesteem, Claravis, and Sotret.

Web Page Launched for Accutane  -  Mar 30, 2007
Facts and Comparisons,The page will appear in online search results for Accutane (isotretinoin) or one of its generic versions (Amnesteem, Claravis, or Sotret) and stresses this

Online Roaccutane warning  -  Mar 29, 2007
Health24.com,...someone searches for Accutane (the American version of Roaccutane), or any other generic form of isotretinoin, such as Amnesteem, Claravis or Sotret.

FDA discourages consumers from purchasing Accutane online  -  Apr 2, 2007
News-Medical.net,The Web page is designed to open when people conduct online searches for Accutane, as well as its three generic versions -- Amnesteem from Mylan

Roche's Accutane Isn't Safe to Buy Online, US Warns (Update1)  -  Mar 28, 2007
BloombergInternet users who search for information on Accutane or its generic equivalents, called Amnesteem, Claravis, and Sotret, will see a link to the new FDA Web

Junk food ads dominate children's television.  -  Mar 29, 2007
Hellenic News of America,The new Web page also will pop up for "other generic forms of isotretinoin, such as Amnesteem, Claravis or Sotret." The Wall Street Journal (3/29) and

Debate again shadows Accutane  24 Sep 2006
Accutane and Amnesteem, Sotret and Claravis – the three generics approved in the past four years – are the only effective treatment for severe recalcitrant ... -Fort Wayne Journal Gazette

FDA Needs To Ban Accutane  Sep 23, 2006
...in patients. Isotretinoin is also sold under the brand names of Accutane, Roaccutane, Amnesteem, Claravis and Sotret. The purpose ... -Media Monitors Network

Popular Acne Drug, Isotretinoin, Linked To Depression In Animal ...  Sep 19, 2006
Isotretinoin is also sold under the brand names: Accytane, Roaccutane, Amnesteem, Claravis and Sotret. The drug is usually used for teenagers with severe acne. ... -Medical News Today

Accutane Restrictions Creating Problems  Aug 29, 2006
...or take isotretinoin. Isotretinoin is sold as Accutane and in three generic versions: Amnesteem, Claravis and Sotret. Doctors and ... -Sci-Tech Today

Accutane restrictions creating problems  Aug 28, 2006
...or take isotretinoin. Isotretinoin is sold as Accutane and in three generic versions: Amnesteem, Claravis and Sotret. "Every time ... -Sky Valley Journal

Complaints abound for acne drug program  Sep 14, 2006
Accutane, along with Amnesteem, Sotret and Claravis - the trio of generics approved in the past four years - are the only effective treatment for severe ... -Myrtle Beach Sun News

Restrictions curb use of powerful acne drug  Sep 12, 2006
Isotretinoin is sold as Accutane, from Roche Holding AG, and in three generic versions: Amnesteem from Mylan Laboratories Inc., Claravis from Barr ... -Pittsburgh Post Gazette

Health Highlights: Aug. 29, 2006  Aug 29, 2006
...the Associated Press reported. The drug is also sold in three generic versions -- Amnesteem, Claravis and Sotret. Nine out of 10 ... -Forbes

Accutane rules create problems  Aug 28, 2006
...or take isotretinoin. Isotretinoin is sold as Accutane and as three generics: Amnesteem, Claravis and Sotret. The registry program ... -DetNews.com

Accutane Restrictions Creating Problems  29 Aug 2006
...take isotretinoin. Isotretinoin is sold as Accutane and in three generic versions: Amnesteem, Claravis and Sotret. The registry ... -Washington Post

Acne drug registry irritates patients  Aug 21, 2006
...with iPledge, which is jointly administered by companies that sell the drug as generic isotretinoin or under the brand names Accutane, Amnesteem, Claravis and ... -Chicago Sun-Times

Accutane: Kills Acne, But Can It Kill You Too?  Apr 18, 2006
Other names for accutane include Amnesteem, Claravis, Isotretinoin and Sotret. But wait, there is always some sort of "bad" that comes with the "good". ... - MediaSyndicate

Accutane - Another Case of Too Little Too Late  Apr 16, 2006
The drug is manufactured by Roche Pharmaceuticals and is also marketed under the generic names Amnesteem, Claravis, Isotretinoin, and Sotret. ... - Scoop.co.nz

Pregnant Women Not Using Acne Drug Properly: Study  Mar 20, 2006
...study, used by 73 percent. The next most commonly prescribed version was Amnesteem, used by 12 percent of the women. In follow-ups of ... - Fashion Monitor Toronto

New warnings, risks, or restrictions for three skin drugs  Mar 13, 2006
People using isotretinoin (Accutane, Amnesteem, Claravis, Sotret) to treat acne or other skin disorders literally need to get with the program--the iPLEDGE ... - Consumer Reports (subscription)

FDA refuses to delay March 1 debut of Accutane registry in US Feb 24, 2006
The drug, known formally as isotretinoin, is best known as Accutane but also is sold generically as Amnesteem, Claravis and Sotret. ... - Canada.com,

Birth defects prompt limits on acne drug  Mar 1, 2006
...online with iPledge, a new risk management program sponsored by the four companies that market isotretinoin, sold as Accutane, Claravis, Sotret and Amnesteem. ... - San Jose Mercury News,

FDA Considers Extending Accutane Deadline Feb 10, 2006
...drug isotretinoin. Isotretinoin is sold as Accutane and in three generic versions: Amnesteem, Claravis and Sotret. But glitches ... - Forbes

FDA might extend acne-drug deadline  Feb 11, 2006
...acne drug isotretinoin. Isotretinoin is sold as Accutane and in generic versions: Amnesteem, Claravis and Sotret. But glitches in ... - Orlando Sentinel,

American Academy of Dermatology Looks to Delay Start of Accutane ... Feb 11, 2006
March 1. Isotretinoin is sold in the Accutane brand as well as in three generic versions: Amnesteem, Claravis and Sotret. However ... - All Headline News

Accutane registry to begin next week  Feb 21, 2006
The program focuses on the drug isotretinoin, best known as Accutane but also sold generically as Amnesteem, Claravis and Sotret. ... - Seattle Post Intelligencer

Accutane program to prevent pregnancies among users to begin March ... Feb 26, 2006
...get medication,�? she said. Accutane is also sold under the brand names of Amnesteem, Claravis and Sotret. Even though the drug ... - Earthtimes.org

Accutane Safety Program Improved Before Start Date  Feb 24, 2006
Accutane is marketed in the United States by Hoffman-LaRoche Inc and is also available generically as Amnesteem (made by Genpharm Inc), Claravis (made by Barr ... - Medscape (subscription)

Mylan Reports Third Quarter Adjusted Diluted EPS of $0.25 Feb 2, 2006
Continued competition on certain products, primarily omeprazole, carbidopa/levodopa and Amnesteem(TM), was responsible for the overall unfavorable pricing and ... - PR Newswire,

March of Dimes Applauds FDA Monitoring Program  Feb 9, 2006
...tests. Other brands of isotretinoin include Amnesteem, Claravis and Sotret. Other retinoids include Targretin and Vesanoid. The ... - PR Newswire,

March of Dimes Applauds FDA Monitoring Program  09 Feb 2006
...tests. Other brands of isotretinoin include Amnesteem, Claravis and Sotret. Other retinoids include Targretin and Vesanoid. The ... - PR Newswire

Mylan Reports Third Quarter Adjusted Diluted EPS of $0.25  Feb 2, 2006
Continued competition on certain products, primarily omeprazole, carbidopa/levodopa and Amnesteem(TM), was responsible for the overall unfavorable pricing and ... - MSN Money

Acne medication can cause depression  Jan 10, 2006
Roche, openly shares this information. Other brand names include Amnesteem, Claravis and Sotret. These drugs, synthetic derivatives ... - Newsday

Doctors fear acne drug rules go too far  Jan 30, 2006
These precautions were part of a program organized by the makers of Accutane and other brands of isotretinoin (Amnesteem, Claravis and Sotret) meant to prevent ... - Atlanta Journal Constitution (subscription)

Brand Names/Synonyms:
Amnesteem is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid

Drug Category:
Amnesteem is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22

Dosage Forms:
CAPSULE; CREAM; GEL; LIQUID

Absorption:
1-31% (topical);

Interactions:
Interactions for Tretinoin:

Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA.

RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity.

Chemical IUPAC Name:
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid

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