Aminosalicylic Acid

This page contains recent news articles, when available, and an overview of Aminosalicylic Acid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Aminosalicylic Acid (when available)

Pharmacology and use:
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Zidovudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of Human immunovirus (HIV) infections

Mechanism Of Action:
Zidovudine, a structural analog of thymidine, inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.

News Articles on Zidovudine

Effectiveness Confirmed for Multi-Drug Treatment of XDR-TB  Aug 25, 2008
...but 80% or more of XDR-TB patients received capreomycin, ofloxacin, cycloserine, para-aminosalicylic acid, or ethionamide or prothionamide.MedPage Today,

Mild to Moderate Crohn's Disease in Children: High Dose Oral 4 ...  Sep 3, 2008
AP classes aren'ta part of NJ school landscape Want to dig deeper? SmartBrief brings you news, research, and other information related to this issue.SmartBrief,

Traitement des tuberculoses résistantes, les antibiotiques utilisés  Sep 8, 2008
Les antibiotiques les plus utilisés chez les 48 tuberculeux XDR ont été : la cyclosérine, l'éthionamide, le PAS ou para-aminosalicylic acid,Maroc Info Com,

Chronic Nonhealing Ulcer of the Right Thumb With Multiple ...  -  Jul 22, 2008
2-4 Special stains, such as para-aminosalicylic acid or Gomori-methenamine silver, can be used to visualize these cigar-shaped fungi on biopsy specimens. Ortho SuperSite,

Single-Dose MMX Mesalazine May Be Effective for Ulcerative Colitis  -  Jun 19, 2008
..."MMX mesalazine is a once-daily, high-strength (1.2 g/tablet) formulation of 5-aminosalicylic acid [5-ASA]. This study evaluated the safety and efficacy of Medscape (subscription)

Hepatotoxicity of Pyrazinamide: Cohort and Case-Control Analyses  -  Jun 17, 2008
...of pyrazinamide at a dosage of 3 g daily with isoniazid showed a high risk of hepatitis in comparison with isoniazid and para- aminosalicylic acid (12). RedOrbit,

Alaven Pharmaceutical Introduces Kit for UC Patients  -  Jun 9, 2008
5-aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology. 1987;92(6):1894-1898. RedOrbit,

Mesalamine Induces Mucosal Healing in Ulcerative Colitis in ...  -  May 28, 2008
...high-strength (1.2 g/tablet) formulation of 5-aminosalicylic acid/mesalamine (marketed as Lialda in the United States, Mezavant XL in the United Kingdom Medscape (subscription)

Anti-TNF Therapy for Crohn's Disease: Expert Interview With David ...  -  May 27, 2008
We know from studies done with 5-aminosalicylic acid in ulcerative colitis that adherence with prescribed treatment is important for maintaining remission. Medscape (subscription)

Ajinomoto to Obtain Rights for Colon Ulcer Drug from German Firm  -  Apr 7, 2008
The drug, 5-aminosalicylic acid, marketed as Salofalk and Granu-Stix by Dr. Falk Pharma in Europe, comes in a form of granulated powder, and only needs to Japan Corporate News (press release),

Guidelines for Ulcerative Colitis Management Reviewed  -  Nov 13, 2007
For isolated proctitis, rectal therapy with 5-aminosalicylic acid (5-ASA) compounds is recommended, but oral 5-ASA compounds and oral corticosteroids are Medscape (subscription)

Ulcerative colitis  -  Oct 30, 2007
...(5 ASA = 5-aminosalicylic acid.) Table 6. Common Medical Therapies for Patients with Ulcerative Colitis note: Listed in order of pharmacologic treatments AAFP News Now

Gut Feeling  -  Aug 13, 2007
One new drug to treat IBD is 5-aminosalicylic acid (5-ASA), which is also called mesalamine. Corticosteroids such as prednisone suppress the immune system New Haven Register (subscription),

TB Tests Show Promise, but Flaws Limit Progress  -  Jul 24, 2007
BlueRidgeNow.com,But it also said that resistance tests for second-line drugs like cycloserine and para-aminosalicylic acid should not be performed for lack of reliability.

TB-free, I remember the trials and stigma  -  Jun 5, 2007
Atlanta Journal Constitution (subscription),Fortunately, by the 1960s, as doctors there explained, two newer drugs — INH and PAS (isoniazid and para-aminosalicylic acid) — reinforced streptomycin in

DDW: A Bit of Good News for Rosiglitazone (Avandia), With ...  -  May 21, 2007
MedPage Today,The first line of treatment for the disease is drugs containing 5-aminosalicylic acid, but some patients either don't respond or can't take those

New Prevention, Treatment Methods For Patients With Painful Bowel ...  -  May 23, 2007
Medical News Today (press release),Currently, 5-aminosalicylic acid (5-ASA) is the most common treatment for ulcerative colitis (UC), a form of inflammatory bowel disease (IBD).

Ligand rosiglitazone for active ulcerative colitis  -  May 22, 2007
SpiritIndia,Currently, 5-aminosalicylic acid (5-ASA) is the most common treatment for ulcerative colitis (UC), a form of inflammatory bowel disease (IBD).

Current and Emerging Strategies in Biologic Therapy for IBD  -  Dec 4, 2006
Medscape (subscription)...progresses from the use of 5-aminosalicylic acid, antibiotics, and steroids on through immunomodulators and culminates with anti-TNF-alpha therapy.

Prevention of colorectal cancer in inflammatory bowel disease  Sep 19, 2006
This article evaluates prevention strategies for colorectal cancer such as surveillance colonoscopy and drug treatment with 5'-aminosalicylic acid in patients ... -innovations report

para-AminoSalicylic Acid may cure Parkinson's-like illness  Aug 12, 2006
The researchers learned that an Aspirin-like drug called sodium para-AminoSalicylic Acid, or PAS, dramatically reduces symptoms on a long-term basis. ... -Xagena.it

Tuberculosis drug may offer cure for Parkinson's  Jun 27, 2006
The aspirin-like drug, sodium para-aminosalicylic acid or PAS, that has previously been used for tuberculosis may be the solution. ... -The Exponent

Drug cures disease similar to Parkinson's  Jun 22, 2006
...in China, however, assisted by a professor at Purdue University, have discovered that a tuberculosis drug called sodium para-aminosalicylic acid cures the ... -South Bend Tribune

Advances in the Use of Nonbiologic Agents to Treat Inflammatory ...  Jun 22, 2006
As highlighted during this year's meeting, although 5-aminosalicylic acid (5-ASA) therapy has been available for many decades, a new formulation that allows ... -Medscape (subscription)

International Approvals: Invirase and Remicade  May 15, 2006
6-MP/AZA; the second study, ACT 2, involved patients refractory to at least 1 standard therapy of immunosuppressants, corticosteroids, or 5-aminosalicylic acid ... - Medscape (subscription)

Drug-resistant strain emerges  Apr 17, 2006
...the six classes of drugs used for second-tier therapy -- aminoglycosides, polypeptides, fluoroquinolones, thioamides, cycloserine and para-aminosalicylic acid. ... - Deccan Herald

New ‘Super’ Antibiotic-Resistant Strain of Tuberculosis Poses ...  Mar 28, 2006
...least three of the six main classes of second-line drugs (aminoglycosides, polypeptides, fluoroquinolones, thioamides, cycloserine, and para aminosalicylic acid ... - Newsinferno.com

Virulent Drug-Resistant TB Strain Emerges  Mar 24, 2006
...the six classes of drugs used for second-tier therapy — aminoglycosides, polypeptides, fluoroquinolones, thioamides, cycloserine and para-aminosalicylic acid ... - Los Angeles Times

Antibe Therapeutics Receives $500,000 Commercialization Award from ... Feb 7, 2006
...presently on the market. The Company's lead drug is a derivative of mesalamine (5-aminosalicylic acid). Mr. Daniel Legault, President ... - CCNMatthews,

Shire seeks approval for its ulcerative colitis drug in Europe  Feb 10, 2006
Although mesalanine (5-aminosalicylic acid) is an existing and well-known treatment for the condition, if approved SPD476 would offer a once-daily oral ... - In-PharmaTechnologist.com,

Shire Announces European Filings of SPD476 (Mesalazine) for ... Feb 3, 2006
SPD476 is a novel, high-dose 5-aminosalicylic acid (5-ASA; mesalazine) in a delayed and extended release formulation (MMX) being studied for the induction and ... - PR Newswire UK,

Shire Announces European Filings of SPD476 (Mesalazine) for ...  Feb 3, 2006
MMX was developed by Cosmo SpA Notes to editors SPD476 SPD476 is a novel, high-dose 5-aminosalicylic acid (5-ASA; mesalazine) in a delayed and extended release ... - PR Newswire,

Brand Names/Synonyms:
Aminosalicylic Acid is also known by the following brand names and/or synonymsA 1909; Amino-Pas; Aminopar; Aminosalicylic Acid; Aminox; Apacil; Apas; Deapasil; Entepas; Ferrosan; Gabbropas; Hellipidyl; Kyselina P-Aminosalicylova; NIH 2939; NSC 2083; Neopasalate; Osacyl; P-Aminosalicylic Acid; PAS; PAS-C; PASK; Pamacyl; Pamisyl; Para-Amino Salicylic Acid; Para-Pas; Paramycin; Parasal; Parasalicil; Parasalindon; Pasa; Pasalon; Pasara; Pascorbic; Pasdium; Pasem; Paser; Pasmed; Pasnodia; Pasolac; Propasa; Rezipas; Sanipirol-4; Sanipriol-4

Drug Category:
Aminosalicylic Acid is categorized under the following by the FDA: Antituberculosis Agents; ATC:J04AA01

Dosage Forms:
Packet of coated granules

Absorption:
Not Available

Interactions:
Drug Interactions for Aminosalicylic Acid:
Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body. In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed. Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency. Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.

Chemical IUPAC Name:
4-amino-2-hydroxy-benzoic acid

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