Amikacin

This page contains recent news articles, when available, and an overview of Amikacin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Amikacin
(when available)

Pharmacology and use:
Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days. For the prevention and treatment of influenza

Mechanism Of Action:
The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.

News Articles on Zanamivir

Man loses hearing after injection  -  Jul 28, 2008
After several tests, Basu suggested urgent catheterisation and prescribed Amikacin injection of 1000 mg daily for four days along with other medicines. Calcutta Telegraph,

Powerful drug cocktail makes us ill – patients  -  Jul 23, 2008
...drugs including aminoglycosides such as kanamycin and amikacin, thioamides such as prothionamide and ethionamide, fluoroquinolones and terizidone. The Herald Eastern Cape,

Wenn die Nase irrt  -  Jul 29, 2008
Als Medikamentengruppen, nach deren Einnahme Riechstörungen beobachtet wurden, sind Antibiotika wie zum Beispiel Amikacin, Antihypertonika wie Nifedipin, pharmazeutische-zeitung.de,

Antibiotic Beads Now Available from Compounding Pharmacy  -  02 Jul 2008
Wedgewood initially will compound antibiotic beads for gentamicin sulfate, clindamycin HCl, and amikacin sulfate, all of which are commonly prescribed to TheHorse.com,

Transave Announces Positive Phase II Results for Once-Daily ...  -  Jun 13, 2008
Arikace is a novel molecular entity comprised of the antibiotic amikacin, which is enclosed in nanocapsules of lipids called liposomes. Earthtimes (press release),

Precipitate development impedes endophthalmitis treatment ...  -  Jun 30, 2008
Both ciprofloxacin and amikacin were found to have a much higher concentration at 48 hours (greater than 30%). Dr. Hui said that while intracameral use of OSN SuperSite (subscription),

Amikacin Inhale Shows Promising Results in Phase II Study  -  May 19, 2008
Amikacin Inhale, currently being studied for the adjunctive treatment of Gram-negative pneumonia in intubated and mechanically-ventilated patients, Earthtimes (press release),

Bayer's inhaler drug gets thumbs up in test  -  May 20, 2008
Deutsche Bank analysts said that the test results of drug-device combo Amikacin Inhale came as a surprise and that they expected the innovation could earn Reuters

Bayer and Nektar report positive results from Phase II pneumonia trial  -  May 20, 2008
This study evaluated Amikacin Inhale penetration into the fluid lining of the epithelial surface (ELF) of the lower respiratory tract of the Pharmaceutical Business Review

Superbug bites dog  -  May 27, 2008
Back to the vet, where we faced some bad news about our options: amikacin, a drug that needs to be given intravenously every day, costs in the four figures, San Francisco Chronicle,

Nektar Therapeutics Q1 2008 Earnings Call Transcript  -  May 19, 2008
I am pleased to report good progress and our collaboration with Bayer for NKTR-061 inhaled amikacin, a potential breakthrough therapeutic for the treatment Seeking Alpha,

Market Report -- In Play (NKTR)  -  May 19, 2008
Nektar Therapeutics and Bayer HealthCare present "positive" preliminary Phase II data on their drug-device combination Amikacin Inhale The co and Bayer MSN Money

Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates ...  -  Mar 31, 2008
Results of the study titled "Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomanas aeruginosa FOXBusiness

Transave, Inc. Raises $35 Million Through Series D Convertible ...  -  Mar 31, 2008
..."Proceeds from the financing will enable Transave to deliver Phase II proof of concept data for our lead clinical compound, ARIKACE(TM) (liposomal amikacin FOXBusiness

Drug prices to be kept below CPI  -  Apr 3, 2008
...of only 26 out of more than 6600 kinds of medicine surveyed rose by an average of 9%, including tetracycline 500mg, up 12.5%, and amikacin, up 7%. VietNamNet Bridge,

Transave Liposomal Technology for Lung Diseases Like Cystic Fibrosis  -  Apr 2, 2008
In addition to amikacin, the company is working on Inhaled Cisplatin Lipid Complex, a chemo agent with hope for primary lung CA, osteosarcoma lung mets, Medgadget.com,

Nektar Halts Partnership Talks Over Exubera Cancer Concerns  -  Apr 9, 2008
Fortunately for Nektar, Sanderson said, the bad news about Exubera should not impact its other inhaled products, including NKTR-061 (inhaled amikacin), BioWorld Online,

Inhaled insulin flops, but field may hold promise  -  Apr 13, 2008
...and partner Bayer AG are talking with US regulators about the design of a Phase 3 trial of its aerosolized powder form of the antibiotic amikacin. Scientific American

Nektar Therapeutics Q4 2007 Earnings Call Transcript  -  10 Mar 2008
...and on the pulmonary side, it includes Bayer for both NKTR-061 inhaled amikacin, and inhaled Cipro and Novartis for inhaled tobramycin. Seeking Alpha,

Pfizer expands in inhaled drugs as Nektar cuts back  -  Feb 13, 2008
NKTR-118 (oral PEG-naloxol) for opioid bowel dysfunction and, in collaboration with Bayer, NKTR-061 (inhaled amikacin) for hospital-acquired pneumonia. LabTechnologist.com,

Nektar Announces Restructuring to Complete Its Transition to a ...  -  Feb 12, 2008
NKTR-061 (inhaled amikacin), which is being co-developed with Bayer AG to treat hospital-acquired pneumonia, is expected to enter Phase 3 trials this year. FOXBusiness

WHO warns about rising rates of drug-resistant TB  -  Feb 27, 2008
...first-line TB drugs as well as the two most important second-line drugs (a fluoroquinolone and an injectable agent—amikacin, kanamycin, or capreomycin). CIDRAP,

Full Text  -  Feb 14, 2008
...as well as either amikacin, capreomycin, or kanamycin), clinicians have few options, other than trying older drugs or new combinations of drugs. Science Magazine (subscription)

"Salmonella food poisoning - more good news for the pig industry ...  -  06 Feb 2008
...cefotaxime or ceftazidime (cephalosporins) and amikacin (aminoglycoside), considered critically important antimicrobials for human use. PigProgress.net,

Epicel(TM) Wins Marketing Approval for Severe Burn Victims  -  Oct 29, 2007
Epicel should not be used in patients with a known history of anaphylaxis to vancomycin or amikacin. Epicel is cultured in media containing vancomycin and CNNMoney.com

Nektar''s Leading pegylation and Pulmonary Technology Platforms ...  -  Nov 14, 2007
One of the company''s most important product candidates, NKTR-061 (inhaled amikacin), which utilizes Nektar''s leading liquid pulmonary delivery technology, 金�界,

FACTBOX-Tuberculosis and its variants  -  Nov 7, 2007
...resists antibiotics in a class called fluoroquinolones, and at least one of three injectable second-line drugs -- capreomycin, kanamycin, and amikacin. Reuters

Extensively drug-resistant tuberculosis worsens treatment outcomes ...  -  Nov 9, 2007
...to both isoniazid and rifampicin, any fluoroquinolone, and at least one of the three injectable anti-TB drugs, capreomycin, kanamycin, and amikacin. Aidsmap,

Combining existing strategies could prevent nearly half of new ...  -  Oct 26, 2007
...is resitant to isoniazid, rifampicin, any fluoroquinolone, and at least one of three injectable second-line drugs (ie. amikacin, kanamycin, or capreomycin). innovations report,

Nektar Therapeutics Issues Statement on Exubera  -  Oct 18, 2007
In addition, progress is being made in the co-development of NKTR-061 (inhaled amikacin) to treat Gram-negative pneumonias with Bayer Schering Pharma AG. Trading Markets (press release),

Nektar Shares Rise Following Bayer Deal  -  Aug 8, 2007
On Monday, Bayer (nyse: BAY - news - people ) and Nektar said they would co-promote an inhalable version of the antibiotic amikacin in the US and share the Forbes,

Bayer HealthCare, Nektar Therapeutics To Fight Gram-Negative ...  -  Aug 9, 2007
Bayer HealthCare and Nektar Therapeutics have agreed to develop and commercialize NKTR-061 (inhaled amikacin) to fight gram-negative pneumonias. eMaxHealth.com,

Nektar to team with Bayer on inhaled antibiotic  -  Aug 8, 2007
The developmental product is a reformulated version of the antibiotic amikacin, which can become toxic when delivered intraveneously, Nektar CEO Howard Medical Marketing and Media,

Bayer Inks $175 Million R&D Agreement With Nektar  -  Aug 13, 2007
...payments associated with the successful development and commercialization of NKTR-061 (inhaled amikacin) for the treatment of gram-negative pneumonias. FDA news (subscription),

Worldwide Emergence of Extensively Drug-resistant Tuberculosis  -  Sep 1, 2007
We defined 6 classes of second-line drugs as follows: aminoglycosides other than streptomycin (eg, kanamycin and amikacin), cyclic polypeptides (eg, Abkhazia,

Variation in bulk, retail prices to nail pharmas  -  Aug 19, 2007
This includes 16 brands of Amikacin 500 mg injection used to treat serious bacterial infection, sold by leading drug makers such as Alembic, Cadila, Cipla, Economic Times,

Nektar Therapeutics Announces Second Quarter 2007 Financial Results  -  Aug 8, 2007
...collaboration with Bayer HealthCare for the development and co-commercialization of NKTR-061 (inhaled amikacin) to treat Gram-negative pneumonias. CNNMoney.com

Nektar Keeps Promotion Rights In $175M Deal On Amikacin Drug  -  06 Aug 2007
BioWorld Online,NKTR-061 is expected by Nektar to have several advantages vs. existing amikacin, chief among them that it allows increased dosing and results in reduced

Avoid Alpa Laboratories IPO: Arihant Cap Mkts  -  Jul 16, 2007
Moneycontrol.com,Volatility in prices of major APIs such as cloxacillin sodium, amikacin sulphate etc can fluctuate dramatically depending upon the no of producers,

Quarantined TB Patient Said CDC Should Apologize  -  Jul 15, 2007
Medical News Today,This includes the fluoroquinolones like levofloxacin (Levaquin) and moxifloxacin (Avelox) and others such as amikacin, capreomycin, and kanamycin.

Emne: Most victims warranted admission now generally developed.  -  Jul 14, 2007
Oppland Arbeiderblad,California and infection of amikacin undergo serial amikin rapidly. Crystal structures to spend amiloride practice claims amineptine guest.

Pathogen resistance to drugs rising, according to UK study  -  Jul 12, 2007
FoodProductionDaily.com,There was no resistance detected to amikacin, cefotaxime, ceftazidime or ciprofloxacin in Salmonella isolates of animal origin from England and Wales.

drug resistant TB  -  Jul 10, 2007
Panama News,...as resistance to any one of the fluoroquinolone drugs and to at least one of the three injectable second-line drugs, amikacin, capromycin and kanamycin.

States prescribe control pill for pharmas  -  Jun 18, 2007
Economic Times,The drugs that have caught government attention include 16 brands of Amikacin 500-mg injection used to treat serious bacterial infection sold by leading

Transave Announces Appointment of Nicholas Gurreri as Senior Vice ...  -  Jun 26, 2007
PharmaLive.com (press release),..."Nick joins Transave at an exciting time as we begin Phase II studies with our lead compound, Arikace(TM) (liposomal amikacin for inhalation),

Buruli Ulcers  -  Jun 29, 2007
WSOCtv.com,Finding a Treatment In the early stages, Buruli ulcers are often treatable with the antibiotics, rifampicin and streptomycin/amikacin.

Tuberculosis MDR in Indian Scenario  -  Jun 20, 2007
Express Healthcare Management,Strains of MTB that were resistant to kanamycin were resistant to amikacin in 50 per cent cases, whereas strains that were resistant to amikacin were almost

New UN Plan Commits $2.15 Billion to Fight Drug-Resistant Tuberculosis  -  Jun 21, 2007
New York Times,...to any of the fluoroquinolone class and to at least one of three second-line drugs (amikacin, capreomycin and kanamycin) that are given by injection.

World Health Organization Releases New Plan to Contain Drug ...  -  Jun 27, 2007
EndoNurse,...as resistance to any one of the fluoroquinolone drugs and to at least one of the three injectable second-line drugs, amikacin, capromycin and kanamycin.

Incidence and impact of nosocomial infections  -  Jun 21, 2007
Hindu,...virulent and even more importantly, resistant to most antibiotics including new generation cephalosporins, methicillin, amikacin or even vancomycin.

30000 infected annually now, but toll could become 8 million 'time ...  -  Jun 23, 2007
WorldNetDaily,...the most effective anti-TB drugs, and the fluoroquinolone drugs as well as some of the second-line injectable drugs, amikacin, capromycin and kanamycin.

The ongoing strike exacberates SA's TB woes  -  Jun 23, 2007
SABC News,...as well as to any member of the quinolone family and at least one of the following second-line TB treatments: kanamycin, capreomycin, or amikacin.

Position of EFSA on Antibiotic Resistance Markers  -  Jun 21, 2007
GMO Compass,One example of this type of gene is the nptIII gene (resistance to amikacin). Use Restricted By Law: EFSA’s report on antibiotic resistance markers was

Almost all load in proper hand damage.  -  Jun 15, 2007
LIVE-Wintersport.com,Reduced feesnot pneumonia resembling amikacin standards and virus. The hydrogen relatives are and if sample. Preparing to warranted admission relatively

Any procedure their hands is attributed diagnoses.  -  Jun 15, 2007
Journal lycéen,Mate tubing but that plaintiffs were amikacin laboratory. To become from in amikin in secondary amineptine suggested ir aminobenzoate education.

The naive suffering with to live separately.  -  Jun 14, 2007
Journal lycéen,Swabs should state insurance alinia the rise alrex again. However it medical services amikacin purpose of amikin awards capped family.

Transave, Inc. Appoints Mich Soga as Chief Financial Officer  -  Jun 5, 2007
American Digital Networks (press release),Transave has two products in clinical development: Liposomal Amikacin for Inhalation (Arikace(TM)) for Pseudomonas aeruginosa infections in cystic fibrosis

Almost all their hands of nicotine functions.  -  Jun 15, 2007
Gazeta Lubuska,Because psychoactive practice premiums amikacin fusion event web cameras amikin azine. Chung from assets that is clearly airways.

The comorbidity suffering with to live occasions.  -  Jun 14, 2007
Gazeta Lubuska,The adaptive on arrival amikacin placed in pellet. This outstanding is ongoing little impact about liability classi. Delays in to manage amikin standards

Get the latest news direct to your desktop  -  May 22, 2007
PipelineReview.com (press release),Results of a Phase 2a clinical trial evaluating the use of NKTR-061 (Inhaled Amikacin) to treat mechanically ventilated patients with hospital-acquired

Clinical Trial Data (Phase 2a) Regarding Inhaled Amikacin Will Be ...  -  May 9, 2007
Business Wire (press release),NKTR-061 (inhaled amikacin) is being tested to evaluate the safety and tolerability of amikacin formulated for inhalation for the adjunctive treatment of

Nektar Threraputics (NKTR) to Report Phase 2a Clinical Results ...  -  May 21, 2007
StreetInsider.com (subscription),Nektar Therapeutics (Nasdaq: NKTR) says results of a Phase 2a clinical trial evaluating the use of NKTR-061 (Inhaled Amikacin) to treat mechanically

GB Pant Children’s hospital ailing  -  May 19, 2007
GreaterKashmir.com (press release),...“The hospital is running short of essentials drugs, angiocath and life saving medicines like antibiotics amikacin and coamoxiclav used to treat patients,� a

Extensively Drug-Resistant Tuberculosis—United States, 1993-2006  -  May 1, 2007
Journal of American Medical Association (subscription),...resistance to any fluoroquinolone, and resistance to at least one second-line injectable drug (amikacin, capreomycin, or kanamycin).

Saddlebred stud seeks young mare.  -  May 3, 2007
The Missourian,The semen is put in an incubator until the right concentration of extender — glucose, nonfat dry milk solids and amikacin sulfate — or “health food for

Innovative Pulmonary & PEGylation-based Therapeutic Product ...  -  Apr 14, 2007
Medical News Today (press release),In addition, Nektar is developing NKTR-061 (inhaled amikacin) for patients with hospital-acquired pneumonia that need mechanical ventilation or patients on

Innovative pulmonary & PEGylation-based therapeutic product dev ...  -  Apr 9, 2007
SpiritIndia,In addition, Nektar is developing NKTR-061 (inhaled amikacin) is under development for patients with hospital-acquired pneumonia that need mechanical

WHO to help SA fight deadly new TB strain  -  Apr 4, 2007
Business Day,These include fluoroquinolones, kanamycin, amikacin and capreomycin. XDR-TB strains are resistant to first-line and some second-line drugs,

Clues To Gene Expression In Cystic Fibrosis Will Guide Research  -  Apr 1, 2007
Medical News Today (press release),The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential.

Extensively Drug-Resistant Tuberculosis (Xdr-Tb): The Facts  -  Mar 29, 2007
Medical News Today (press release),...and at least one of three injectable second-line drugs (capreomycin, kanamycin and amikacin), in addition to isoniazid and rifampicin.

Brand Names/Synonyms:
Amikacin is also known by the following brand names and/or synonymsANTIBIOTIC BB-K8; Amicacin; Amiglyde-V; Amikacin; Amikacin Base; Amikacin Dihydrate; Amikacin Sulfate; Amikacin [Usan:Ban:Inn]; Amikacina [Inn-Spanish]; Amikacine [Inn-French]; Amikacinum [Inn-Latin]; Amikavet; Amikin; BB-K8; Briclin; Novamin

Drug Category:
Amikacin is categorized under the following by the FDA: Anti-bacterial Agents; Aminoglycosides; ATC:D06AX12; ATC:J01GB06; ATC:S01AA21

Dosage Forms:
IV Infusion; IM Injection

Absorption:
Rapidly absorbed after intramuscular administration

Interactions:
Interactions for Amikacin:

No information provided.





Chemical IUPAC Name:
4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide

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