Alprenolol

This page contains recent news articles, when available, and an overview of Alprenolol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Alprenolol (when available)

Pharmacology and use:
Alprenolol is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Alprenolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Alprenolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Alprenolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, alprenolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action. For the treatment of hypertension, angina, and arrhythmia

Mechanism Of Action:
Alprenolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, alprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.

News Articles on Alprenolol

Two Beta Blockers Found to Also Protect Heart Tissue 15 Sep 2008
Researchers from Duke University Medical Center tested 20 beta blockers and found that two of them -- alprenolol and carvedilol -- could stimulate a pathwayTechJournal South,

Erring on the Side of Hidden Harm: The Granting of Domestic ... - Oct 22, 2007
...alprenolol, which had already been sold for three years in Europe, but not approved for use in the US, could have saved more than 10000 lives a year… American Chronicle,

Brand Names/Synonyms:
Alprenolol is also known by the following brand names and/or synonymsA131; Alfeprol; Alfeprol [Russian]; Alpheprol; Alprenolol; Alprenololum [Inn-Latin]; Apllobal; Aptine; Aptol Duriles; CHEMBANK690; Gubernal; H 56/28; Regletin; Yobir

Drug Category:
Alprenolol is categorized under the following by the FDA: Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; ATC:C07AA01

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
1-(1-methylethylamino)-3-(2-prop-2-enylphenoxy)-propan-2-ol

:

Web health.mongabay.com

Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com lead to other sites. health.mongabay.com does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com responsible for dead or misdirected links.