Alphagan

This page contains recent news articles, when available, and an overview of Alphagan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Alphagan
(when available)

Pharmacology and use:
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Mechanism Of Action:
Brimonidine is an alpha adrenergic receptor agonist. It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

News Articles on Brimonidine

Buy alphagan. alphagan on line  -  ‎Jul 1, 2009‎
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Brooke Astor Supported Her Son, The Pharmaceutical Industry  -  ‎Jun 30, 2009‎
According to papers filed in court this week, Astor gobbled down two dozen pills a day, including the medications Bextra, Tenormin, Prevacid, Alphagan, Cityfile

Fitch Revises Allergan's Rating Outlook to Stable; Affirms IDR at 'A-'  -  ‎Mar 31, 2009‎
Management estimates total sales to fall to $4.1 billion to $4.3 billion in 2009, including declines across all medical devices, Botox and the Alphagan FOXBusiness

Experimental and Clinical Evidence for Brimonidine as an Optic ...  -  ‎Apr 13, 2009‎
2-5 Brimonidine tartrate (Alphagan; Allergan, Inc, Irvine, California) is a highly selective 2 -adrenergic agonist that was introduced in 1996. Archives of Ophthalmology

Ask the Pharmacist: Treatment options for glaucoma  -  ‎Mar 4, 2009‎
Newer meds include Iopidine, Trusopt, Azopt and Alphagan P. Depending on which one you take, these drops might cause stinging, enlarged pupils; Sun-Sentinel.com

Inquiry uncaps a multitude of pills  -  ‎Mar 6, 2009‎
Cota’s attorney, Jeffrey Bornstein, said his client admits only to taking Provigil, Alphagan and Synthroid before the accident. Those drugs treat sleepiness The San Francisco Examiner

Allergan Reports Fourth Quarter 2008 Operating Results and ...  -  04 Feb 2009
ALPHAGAN® Franchise product net sales between $350 million and $370 million. LUMIGAN® Franchise product net sales between $410 million and $430 million. PharmaLive.com (press release),

Building a brand after Botox  -  Dec 4, 2008
At the end of 2009, a generic of our glaucoma drug, Alphagan, runs out. But we're prepared for that. Q. How do you stay ahead of the curve? Trading Markets (press release),

Allergan Reports Third Quarter 2008 Operating Results  -  Oct 29, 2008
ALPHAGAN® Franchise product net sales between $390 million and $400 million. â?¢ LUMIGAN® Franchise product net sales between $420 million and $430 million. MarketWatch

Glaucoma and vision 2020  -  Oct 15, 2008
Alpha agonists, like Cannabis sativa derivatives (Canasol - a product unique to Jamaica, and prepared from ganja), and brimonidine (Alphagan) are examples. Jamaica Gleaner,

Pergunte ao candidato  -  Sep 27, 2008
Papa, por várias vezes fui à farmácia no Posto da Aparecida retirar o colírio Alphagan ea senhora que me atendeu me disse que há mais de dois meses não A Tribuna - Santos,

Allergan posts 7% jump in second-quarter profit  -  Jul 30, 2008
Lumigan had sales of $112.5 million, up 19 percent, while Alphagan had sales of $100.7 million, up 30 percent; both drugs relieve eye pressure in glaucoma Forbes,

Allergan reports 20.1% rise in second-quarter product sales  -  Aug 1, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled OSN SuperSite (subscription),

Allergan Reports Second Quarter 2008 Operating Results  -  Jul 30, 2008
ALPHAGAN(R) Franchise product net sales between $380 million and $400 million. -- LUMIGAN(R) Franchise product net sales between $430 million and $450 Genetic Engineering News (press release),

Allergan Inc. Q2 2008 Earnings Call Transcript  -  Jul 30, 2008
We’re delighted that COMBIGAN’s growth has not been at the expense of base ALPHAGAN, as the base continues to grow double digit even in local currency, Seeking Alpha,

Allergan Reports Second Quarter 2008 Operating Results  -  Jul 30, 2008
ALPHAGAN(R) Franchise product net sales between $380 million and $400 million. -- LUMIGAN(R) Franchise product net sales between $430 million and $450 Centre Daily Times,

Intoxicación por brimonidina en pediatría. Presentación como ...  -  Jul 22, 2008
Lambert J. Allergan; notification of labelling change to the Pediatric Use section of Alphagan. January 12, 1998. COMPLETAR CITA. 4. Enyedi LB, Freedman SF. Anales de Pediatría,

Brimonidine tartrate can successfully reduce halo size and pupil ...  -  Jun 10, 2008
Ji Hoon Lee, MD, and colleagues evaluated the effect of Alphagan (brimonidine tartrate 0.2%, Allergan) on halo and pupil size after administering the drug OSN SuperSite (subscription),

Learn about the World Ophthalmic Pharmaceutical Drugs Market  -  Jun 27, 2008
Ophthalmic Solutions II-70 Alcon's NEVANAC Receives FDA Approval II-71 Fougera Obtains Approval for MetroGel(r) II-71 Allergan's Alphagan P Receives FDA Market Wire (press release)

UPDATE 2-Allergan cites fast eyelash-drug results  -  Jun 4, 2008
The experimental pain drugs are chemically related to another widely used Allergan glaucoma drug, called Alphagan, whose annual sales of about $400 million guardian.co.uk,

Allergan reports 23% rise in first-quarter total product net sales  -  May 8, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled $99.5 OSN SuperSite (subscription),

Allergan, Inc. Q1 2008 Earnings Call Transcript  -  May 8, 2008
It is encouraging that COMBIGAN has provided incremental growth to the base ALPHAGAN business, which continues to grow double digits in the US and Asia Seeking Alpha,

Pilot, Crew Lost in Fog Before Spill  -  Apr 8, 2008
Lipitor for high cholesterol; Alphagan, used to treat glaucoma; the migraine drug Imitrex; and potassium citrate for kidney stones. The Associated Press

Cosco Busan Pilot On Medications, Had DUI Conviction  -  Apr 13, 2008
...drugs or supplements, including the sleep aid Valium, the anti-anxiety drug Lorezepam, the anti-depressant Wellbutrin, and Alphagan for glaucoma. Cunningham Report,

NTSB Blames Pilot’s Medication and Alcohol Use for SF Oil Spill  -  Apr 10, 2008
Lipidor for high cholesterol, Alphagan for glaucoma, Imitrex, a migraine drug, Synthroid for thyroid deficiency and Potassium citrate for kidney stones. eFluxMedia

Drug and alcohol use by Cosco Busan pilot, according to NTSB  -  Apr 9, 2008
...—Alphagan, used to treat glaucoma. Side effects can include tiredness or blurred vision. —Imitrex, a migraine drug. Side effects can include dizziness or San Jose Mercury News,

Allergan 1Q Profit Outlook Falls Short  -  Jan 30, 2008
In 2008, Allergan said sales of its Alphagan eye drops will range from $350 million to $380 million in 2008, while the eye-care product Lumigan will have Houston Chronicle,

Allergan Inc. Updated Company Profile : Outlook, Strategy and ...  -  Jan 8, 2008
2001-06 35 Growth drivers 35 Botox 35 Restasis 37 Lumigan franchise 37 Alphagan franchise 37 Operating revenue and cost analysis, 2001-06 38 Operating Reuters

Botox boosts Allergan, with no end in sight  -  Jan 31, 2008
Sales of eye-care products, including Restasis for dry eye and Lumigan and Alphagan for glaucoma, rose 16 percent to $1.78 billion. OCRegister,

Allergan Q4 Profit Rises As Revenues Grow  -  Jan 30, 2008
Total core medical devices net sales are expected at $870 - $955 million, Alphagan franchise product net sales between $350 million and $380 million. RTT News,

Allergan Reports Fourth Quarter Operating Results  -  Jan 30, 2008
ALPHAGAN(R) Franchise product net sales between $350 million and $380 million. -- LUMIGAN(R) Franchise product net sales between $440 million and $460 Centre Daily Times,

Allergan reports $978.7 million in third-quarter product sales  -  Nov 6, 2007
Specifically, in the third quarter, Alphagan (brimonidine tartrate), Alphagan P (brimonidine tartrate 0.15%) and Combigan (0.2% brimonidine tartrate, OSN SuperSite (subscription),

Combigan Drops Approved for Glaucoma  -  Oct 31, 2007
The drug combines two medications -- Alphagan, approved to treat glaucoma, and timolol, approved to treat high blood pressure. U.S. News & World Report,

Allergan Gets FDA OK for Combigan  -  Oct 31, 2007
It is a combination of Alphagan, already approved for glaucoma, and timolol ophthalmic solution 0.5 percent, a glaucoma treatment. Forbes,

Allergan Receives FDA Approval for Combigan  -  Nov 1, 2007
Combigan is the newest addition to Allergan's glaucoma portfolio, which includes Lumigan (bimatoprost ophthalmic solution) 0.03 percent and Alphagan P FDA news (subscription),

FDA Approves Combigan, New Glaucoma Drug  -  Oct 31, 2007
Allergan's other glaucoma medications already marketed, include Lumigan (bimatoprost) 0.03% and Alphagan P (brimonidine tartrate) 0.1% and 0.5%. MedHeadlines,

Allergan Gets Glaucoma Drug OK  -  Oct 31, 2007
It is a combination of Allergan's Alphagan, already approved for glaucoma, and another medication to reduce pressure. Allergan expects to start selling Orange County Business Journal,

Wednesday's Health Winners & Losers  -  Oct 31, 2007
Allergan also makes Lumigan and Alphagan for glaucoma. Shares were gaining $1.87, or 2.9%, to $67.52. Novavax (NVAX - Cramer's Take - Stockpickr) tacked on TheStreet.com

Allergan Reports Third Quarter Operating Results  -  Nov 6, 2007
ALPHAGAN(R) Franchise product net sales to between $320 million and $330 million. -- BOTOX(R) product net sales to between $1185 million and $1195 million. Genetic Engineering News (press release),

Allergan Says FDA Approves COMBIGAN 0.2%/0.5% For Reduction Of ...  -  Oct 31, 2007
The Irvine, California-based Allergan said COMBIGAN is the newest addition to its glaucoma portfolio, which also includes LUMIGAN 0.03% and ALPHAGAN P 0.1% RTT News,

Allergan, Inc. Receives FDA Approval for COMBIGAN ™ (brimonidine ...  -  Oct 31, 2007
...which also includes LUMIGAN ® (bimatoprost ophthalmic solution) 0.03% and ALPHAGAN ® P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15%. Business Wire (press release),

Transdel Pharmaceuticals, Inc. Completes Merger Transaction ...  -  Oct 1, 2007
While at Allergan he made major contributions to the development and worldwide registration of Alphagan, Lumigan, Restasis, Ketarolac, Avage and BOTOX(TM). Web Services Journal,

Meticulous attention to detail can help prevent or manage surgical ...  -  Aug 28, 2007
Alphagan (brimonidine tartrate, Allergan) can help reduce some pupils with different lighting conditions and will not constrict, he said. OSN SuperSite (subscription),

Allergan reports nearly 24% increase in second quarter product sales  -  Aug 1, 2007
OSN SuperSite (subscription),Alphagan P, Alphagan and Combigan product sales increased 10.3% to $77.4 million, Lumigan product sales increased 15.7% to $94.5 million and Restasis sales

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Allergan sues Apotex over eye drug patents  -  May 23, 2007
Los Angeles Times,Allergan, which had a $127.4-million net loss last year on sales of $3.06 billion, said May 2 that sales of eye products including Alphagan rose 11% to $403

Allergan Could Gain on Inamed Deal, More Botox Uses  -  Apr 15, 2007
Orange County Business Journal,...“When the first generic version of (glaucoma drug) Alphagan received approval in May 2003, the company was able to soften the impact by launching Alphagan P

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Allergan: FDA Seek More Data on Combigan  -  Dec 22, 2006
Houston Chronicle,Combigan is a combination of Alphagan, already FDA approved for glaucoma, and timolol ophthalmic solution 0.5 percent, a blood pressure medication.

Allergan Announces FDA Issues Approvable Letter for Combigan ...  -  Dec 22, 2006
PharmaLive.com (press release),COMBIGAN(TM) includes two agents known to reduce IOP - ALPHAGAN(R) (brimonidine tartrate ophthalmic solution 0.2%) and timolol ophthalmic solution 0.5%,

Allergan: FDA Seek More Data on Combigan  -  Dec 22, 2006
Houston Chronicle,Combigan is a combination of Alphagan, already FDA approved for glaucoma, and timolol ophthalmic solution 0.5 percent, a blood pressure medication.

Allergan Announces FDA Issues Approvable Letter for Combigan ...  -  Dec 22, 2006
PharmaLive.com (press release),COMBIGAN(TM) includes two agents known to reduce IOP - ALPHAGAN(R) (brimonidine tartrate ophthalmic solution 0.2%) and timolol ophthalmic solution 0.5%,

Allergen 2Q Net More Than Doubles  Aug 2, 2006
...way. Those eye-care products _ which include Alphagan, Acular and Alocril _ saw sales increase 17 percent to $379.2 million. Botox ... -Houston Chronicle

LASIK Expert Dr. James Salz Provides Strategies in July Issue of ...  Aug 10, 2006
This risk can be minimized with customized wavefront based LASIK and by using postoperative drops such as Alphagan at night to reduce pupil size and thus ... -PR Web

FAMILY DOCTOR: Vommon heart-rate disorder causes momentary out-of ...  Jul 7, 2006
I use Alphagan P eye drops twice daily to prevent glaucoma. I take 20 milligrams of Pravachol, and my cholesterol was 147 when checked last. ... -Canton Repository (subscription)

Medicure Appoints Vice President of Research and Development  Jul 12, 2006
...where he initiated medicinal chemistry programs that led to the discovery and development of Alphagan® and Lumigan® for the treatment of glaucoma. ... -Market Wire

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Brimonidine Helps Soldiers With Poor Night Vision Following ...  May 8, 2006
...who have had visual problems following refractive eye surgery and have treated their eyes with brimonidine ophthalmic solution 0.15% (Alphagan-P), experience ... - DG News

Allergan Reports First Quarter Operating Results; Pharmaceutical ...  May 3, 2006
Total net sales, as reported $615.2 $527.2 $88.0 $92.8 $(4.8) ==== Alphagan P, Alphagan and Combigan $71.0 $66.7 ... - Genetic Engineering News

Brinzolamide 1% Found More Effective Than Brimonidine 0.15% When ...  May 1, 2006
1% (Azopt) to a prostaglandin analog appears to be more effective for reduction of intraocular pressure than adding brimonidine 0.15% (Alphagan P), researchers ... - DG News



Brand Names/Synonyms:
Alphagan is also known by the following brand names and/or synonymsAlphagan; Alphagan P; Brimonidine; Brimonidine Tartrate; Bromoxidine; CHEMBANK1623

Drug Category:
Alphagan is categorized under the following by the FDA: Antihypertensive Agents; EENT Drugs; ATC:S01EA05

Dosage Forms:
0.2% solution

Absorption:
Minimal systemic absorption occurs after ocular insertion.

Interactions:
-->Interactions for Brimonidine:

Although specific drug interaction studies have not been conducted with ALPHAGAN® P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Alpha-agonists, as a class, may reduce pulse and blood pressure. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), anti-hypertensives and/or cardiac glycosides is advised.

Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN® P in humans can lead to resulting interference with the IOP lowering effect. No data on the level of circulating catecholamines after ALPHAGAN® P administration are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.





Chemical IUPAC Name:
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

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