Allegra

This page contains recent news articles, when available, and an overview of Allegra but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Allegra (when available)

Pharmacology and use:
Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells. For management of Seasonal allergic rhinitis

Mechanism Of Action:
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Fexofenadine exhibits no anticholinergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.

News Articles on Fexofenadine

Child's runnynose shows vbody's defenses  15 Sep 2008
Newer second generation antihistamines like Claritin, Allegra, or Zyrtec usually have little or no sedative effect and therefore are good choices forEvansville Courier & Press,

Herrick appointed to MCOE tech position  15 Sep 2008
Monterey: Monterey High School, James L. Caress; Santa Catalina School, Agnes G. Cho, Allegra G. Krasznekewicz and Katherine L. Robinson; York School,The Salinas Californian,

Teva to Present New Treatment Data at World Congress for Multiple ...  15 Sep 2008
...including that relating to the generic versions of Allegra® , Neurontin®, Lotrel® and Protonix®, the effects of competition on our innovative products,Business Wire (press release),

A New York state of mind  15 Sep 2008
Maybe at London Fashion Week, which continues all week and which has already seen Allegra Hicks cancel her show due to lack of sponsorship,Daily Mail,

Nonfiction Reviews  15 Sep 2008
There’s brilliant and incisive criticism, and artists in their own voices, such as winsome and witty ballerina Allegra Kent on her first performance withPublishers Weekly,

'The Other Side of the Island: A Novel' by Allegra Goodman  Sep 14, 2008
That's the intriguing scenario author Allegra Goodman has envisioned in "The Other Side of the Island," her first science-fiction novel and her first novelLos Angeles Times,

Allegra's Hitch  Sep 3, 2008
ALLEGRA HICKS will no longer showcase her latest collection at this month's London Fashion Week following the withdrawal of support from her catwalkVogue.com,

Fab Flash: Allegra Hicks Pulls Out of London Fashion Week  Sep 3, 2008
Bohemian designer Allegra Hicks has been showing at London Fashion Week since September 2005 and has become quite a regular feature.PopSugar.com,

Study finds juices can cut absorption of some medicines  Sep 9, 2008
Healthy volunteers who took Allegra with grapefruit, apple or orange juice, for example, absorbed only half the amount of the drug, compared with volunteersSeattle Times,

Rod Stoneman Talks The Huston Film School  Sep 11, 2008
Upcoming guests to the school is screenwriter Allegra Huston, daughter of John Huston, who will be Writer in Residence in November; the Scottish film criticThe Irish Film Television Network

Allegra McEvedy live chat: chillies  Sep 10, 2008
According to Allegra Strategies, a research consultancy, the regions in which he is operating have become thirsty for western habits and products,guardian.co.uk,

Poland is cream in the cup for Coffeeheaven  Sep 5, 2008
According to Allegra Strategies, a research consultancy, the regions in which he is operating have become thirsty for western habits and products,Financial Times,

Guardian Daily: Murray denied  Sep 9, 2008
Allegra Stratton gives Belinda Rhodes the details. Labour holds a cabinet meeting in Birmingham in an effort to learn more about how policy made in Londonguardian.co.uk,

Confidence remains buoyant in coffee sector  Sep 11, 2008
The finding comes from a survey of independent coffee-shop operators by Jeffrey Young of Allegra, the specialist research organisation covering the food andCatererSearch,

Theater Grows From a Love of Acting  Sep 5, 2008
Allegra Libonati’s brother, Christian, played Sebastian and ran a summer apprentice program at the theater. Christian Libonati, who just graduated fromNew York Times,

Allergy season continues  Sep 12, 2008
Antihistamines are very effective, said the doctor, pointing to such examples as Claritin, Reactin, Allegra and Aerius. They are all tablets, he said,Times and Transcript,

Local doctor becomes Infectious Disease Society of America fellow  Sep 9, 2008
...by Staff Report/Somerset Reporter Dr. Donald Allegra, a founding partner of ID Care, the largest infectious disease specialty practice in New Jersey,Somerset Reporter,

Juice can wipe out effects of drugs, study finds  Aug 19, 2008
In the study, which was presented at a meeting of the American Chemical Society, researchers gave patients the popular allergy drug Allegra.CTV.ca,

City Hall's latest gimmick is a pair of pedestrian bridges ...  Sep 14, 2008
Does Dr. No think Allegra and Sebastian will decide to visit Calgary? "Billy from Balzac will come to town to laugh at city folk who don't know the value ofCanoe.ca,

The Plight of Musicians in Iraq  Sep 10, 2008
He joins us today along with Allegra Klein, an American violinist who has worked with Iraqi musicians since 2003, to talk about the challenges facingWNYC,

Utility bills sent to wrong city addresses  Sep 11, 2008
The company, Allegra Print and Imaging, runs the file through postal-service software to generate the bills. An error this month meant bills were sent toHelena Independent Record,

Independent.co.uk Web  Sep 12, 2008
I’m the proud owner of an Allegra Hicks throw which covers my somewhat shabby sofa. Like Jacobs and Co., Hicks has tackled the home market with her personalIndependent,

Two Eli productions stand out at New York’s Fringe  Sep 9, 2008
Although the show is unscripted, its creators, Maggie Burrows ’10, Allegra Long ’08 and Celeste Ballard ’08, submitted a “map�? of their vision to the FringeYale Daily News,

Teva Announces Appellate Court Reverses Generic Risperdal(R ...  Sep 13, 2008
...including that relating to the generic versions of Allegra® , Neurontin®, Lotrel® and Protonix®, the effects of competition on our innovative products,WELT ONLINE,

Albany Molecular Research, Inc. Q2 2008 Earnings Call Transcript  Aug 30, 2008
Recurring royalties from Allegra in Q2 2008 were $7.6 million, a decrease of 3% from 2007. AMRI earns royalties from worldwide sales of nonsedatingSeeking Alpha,

'Urban Growth Boundaries' Can't Keep Utah Transit Authority From ...  Sep 8, 2008
We have massive traffic congestion because of our orientation,�? says Mike Allegra, assistant general manager and chief capital development officer for theProgressive Rail Roading,

Students squat over homeless crisis  Aug 20, 2008
University welfare officer Allegra Reinalda said the houses should be used for student accommodation as they could sleep 25, and up to 40 if renovated.The Age,

The NOLA Project wants someone who means 'Business'  Aug 28, 2008
According to NOLA Projecteer AJ Allegra, the job entails assisting in planning, coordination and control of the fiscal affairs of The NOLA Project,The Times-Picayune - NOLA.com,

Dr. Gott: Allergy pills refuse to digest properly  Aug 28, 2008
He prescribed Allegra-D, to be taken twice a day on an empty stomach. I take it diligently, but most times I find the pills still whole in the toilet afterNorthwest Herald,

'Good reads' for young adults  Aug 30, 2008
Then Harleigh forms an unlikely friendship with Allegra, when she literally flies over the walls of Weatherby. Allegra is fascinated by the enormousThe North Bay Nugget,

Wadsworth Open Air Market A Treat For The Senses  Aug 22, 2008
Bring the kids because they can enjoy horse-drawn carriage rides by Allegra Farms and face painting. There will be live music on the patio from theHartford Courant,

Nature Coast: Season preview  Sep 4, 2008
The kicking game took a major hit when Nick Allegra transferred to a school in Atlanta. For now, Gary Myrick will punt and Matt Montano has been brought upTampabay.com,

Industry change an exciting move for local couple  Aug 18, 2008
That may be the case for Joyce and Stephen Morris of Knauertown, whose recent purchase of Allegra Print and Imaging in Lancaster has meant more than justTri County Record,

News Analysis: Buyers look for inspiration in London  Sep 12, 2008
Last week, womenswear label Allegra Hicks was forced to pull out of LFW after its sponsors withdrew support for its catwalk show. The label blamed "economicDrapers online,

The stuff of nightmares for 21st century kids  Sep 9, 2008
By Allegra Goodman My 12-year-old supports Barack Obama, and after the Democratic National Convention I expected euphoria, but he surprised me.International Herald Tribune,

Secrets of Getting More Soy in Your Diet  Sep 5, 2008
Americans know that soy is a healthy protein that can be better for you than other sources high in saturated fat and cholesterol,�? says Allegra Burton,WSET,

City soars  Sep 1, 2008
Of those 10 two - the Allegra apartments on Barkly St and a residential apartment building on the corner of Barkly and Moore streets - reach 10 storeys.Footscray, Yarraville, Braybrook Star,

Doctors: Fruit Juice Could Interfere With Medication  Aug 24, 2008
..."If you were taking an allergy medication, Allegra, and you took it with your fruit juice in the morning it wouldn't work as well," said McGill.WISC,

Leon's not fit for a night out  Sep 3, 2008
Gavyn Davies, former chairman of the BBC, is a major investor and the bafflingly popular Allegra McEvedy, recently appointed MBE, is “development chef�?.This is London,

Stearns family celebrates the golden year of love  Sep 14, 2008
They are loving grandparents to Allegra, Connor, Lauren, Gary, Leah and Tanner. This Golden Anniversary signifies the strength of their marriage and theLaconia Citizen,

Northeast Tarrant school notes  Sep 14, 2008
Sonny & Allegra Nance Elementary kindergarten curriculum night, 5:30 pm Tuesday. J. Lyndal Hughes Elementary WatchDOGS Pizza Party, 6:30 pm Thursday.Fort Worth Star Telegram,

Annie delights - bet your bottom dollar  Aug 31, 2008
The musical will deliver double the star quality, with Bronte Mitchell and Allegra Bonetto sharing the exciting role of the loveable orphan.Ipswich Queensland Times,

Benadryl Tops In Brand Buzz As Hay Fever Season Begins  Aug 18, 2008
Sudafed and Allegra were in the middle of the pack, with 16% and 19% awareness, respectively. New entry Alavert, which has just been offered over theMediaPost Publications,

Community heroes will be honored at luncheon  Aug 28, 2008
The recipients include Detective Greg Gonzales, officer of the year; Officer Vince Allegra, Michael F. Clark award; CSI Becca McConnell, civilian of theSimi Valley Acorn,

DVD review - The Jane Austen Book Club  Aug 20, 2008
Of course, the stellar casting of Maria Bello (Jocelyn), Emily Blunt (Prudie), Kathy Baker (Bernadette), Amy Brenneman (Sylvia), Maggie Grace (Allegra) andTonight,

Some Juices May Hurt Prescriptions' Effectiveness  Aug 20, 2008
The report found that those juices decrease the absorption of the following medications: The allergy drug Allegra, certain antibiotics, such as Cipro andWBZ,

Nibbles: Arsenic linked to diabetes, epilepsy drug helps obese ...  Aug 20, 2008
...levofloxacin (Levaquin), and itraconazole (Sporanox); and even the allergy drug Allegra can be affected by drinking grapefruit, orange or apple juice.CalorieLab Calorie Counter News,

CHARLOTTE T. LYSAGHT  Aug 19, 2008
Surviving are a daughter, Denise Deieso; two brothers, Thaddeus Puszcz and Bernard Puz; three grandchildren, Cara Allegra, Kelly Ann and Meredith Anne;The Jersey Journal - NJ.com,

Tell it to me straight  Aug 31, 2008
By Allegra Goodman BACK TO school sales, first day traffic jams, fresh notebooks, and curriculum nights when parents squeeze themselves into miniatureBoston Globe,

Column: More free cash for seniors  Sep 8, 2008
On August 6, 2008 Judge Allegra from The United States Court of Federal Claims decided differently. In this case, the Nagan Irrevocable Trust purchased lifeSaugus Advertiser,

Brand Names/Synonyms:
Allegra is also known by the following brand names and/or synonymsAllegra; Allegra-D; CHEMBANK1622; Carboxyterfenadine; FEXOFENADINE HYDROCHLORIDE; Fexofenadine; Fexofendine; Terfenadine Acid Metabolite; Terfenadine Carboxylate; Terfenadine-Cooh

Drug Category:
Allegra is categorized under the following by the FDA: Antihistamines; Antihistamines; ATC:R06AX26

Dosage Forms:
Oral tablets and capsules

Absorption:
33%

Interactions:
-->Interactions for Fexofenadine:

Drug Interaction with Erythromycin and Ketoconazole

Fexofenadine has been shown to exhibit minimal (ca. 5%) metabolism. However, coñ administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In 2 separate studies, fexofenadine hydrochloride 120 mg twice daily (240 mg total daily dose) was co-administered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once daily under steady-state conditions to healthy volunteers (n=24, each study). No differences in adverse events or QTc interval were observed when subjects were administered fexofenadine hydrochloride alone or in combination with either erythromycin or ketoconazole. The findings of these studies are summarized in the following table:

Effects on steady-state fexofenadine pharmacokinetics after 7 days of
co-administration with fexofenadine hydrochloride 120 mg every 12 hours
(two times the recommended twice daily dose) in healthy volunteers (n=24)

Concomitant Drug	c_maxSS (Peak plasma concentration)	AUC_ss(0-12h) (Extent of systemic exposure)
Erythromycin (500 mg every 8 hrs)	+82%	+109%
Ketoconazole (400 mg once daily)	+135%	+164%

The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials.

The mechanism of these interactions has been evaluated in in vitro, in situ, and in vivo animal models. These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption. This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. in vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.

Drug Interactions with Antacids

Administration of 120 mg of fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox®) decreased fexofenadine AUC by 41% and c_max by 43%. ALLEGRA should not be taken closely in time with aluminum and magnesium containing antacids.

Interactions with Fruit Juices

Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of fexofenadine. This is based on the results from 3 clinical studies using histamine induced skin wheals and flares coupled with population pharmacokinetic analysis. The size of wheal and flare were significantly larger when fexofenadine hydrochloride was administered with either grapefruit or orange juices compared to water. Based on the literature reports, the same effects may be extrapolated to other fruit juices such as apple juice. The clinical significance of these observations is unknown. In addition, based on the population pharmacokinetics analysis of the combined data from grapefruit and orange juices studies with the data from a bioequivalence study, the bioavailability of fexofenadine was reduced by 36%. Therefore, to maximize the effects of fexofenadine, it is recommended that ALLEGRA should be taken with water.

Chemical IUPAC Name:
2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoicacid

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