Alfuzosin

This page contains recent news articles, when available, and an overview of Alfuzosin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Alfuzosin
(when available)

Pharmacology and use:
Alfuzosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Alfuzosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Alfuzosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Alfuzosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Alfuzosin results from a decrease in systemic vascular resistance and the parent compound Alfuzosin is primarily responsible for the antihypertensive activity. For the treatment of the signs and symptoms of benign prostatic hyperplasia

Mechanism Of Action:
Alfuzosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

News Articles on Alfuzosin

Finasteride's prostate benefits confirmed  -  ‎Apr 14, 2009‎
Of the 23320 men, 1754 men (7.5%) had used finasteride and 3848 (16.5%) had used an alpha blocker (either tamsulosin or alfuzosin). Cortlandt Forum

AOK erteilt erste Zuschläge für acht Wirkstoffe  -  ‎Apr 13, 2009‎
So machte für die Wirkstoffe Alfuzosin und Amisulprid Winthrop in allen fünf Gebietslosen das Rennen. Apogepha holte in sämtlichen Gebietslosen den Zuschlag Apotheker Zeitung

è€?年病用è?¯éœ€æ±‚é‡?ä¸?断增长å‰?列腺用è?¯â€œå¢žç”Ÿâ€?  -  ‎Apr 2, 2009‎
...阿夫唑嗪(alfuzosin,商å“?å??Xatral)由赛诺è?²-安万特公å?¸å¼€å?‘,于1988年上市,剂é‡?为2.5mg,1æ—¥3次。之å?Žï¼Œè¯¥å…¬å?¸å?ˆæŽ¨å‡ºäº†å‰‚é‡?为5mgã€?æ¯?天2次的阿夫唑嗪缓释片,2004 搜狐

AOK erteilt Zuschläge  -  ‎Apr 9, 2009‎
...punkten: Die Sanofi-Aventis-Tochter Winthrop erhielt den Zuschlag für das Prostatamittel Alfuzosin sowie das Schizophrenie-Medikament Amisulprid. apotheke-adhoc

è€?龄社会催生è€?å¹´ç—…å‰?列腺用è?¯éœ€æ±‚猛增(图)  -  ‎Apr 2, 2009‎
...ã€?æ…§è?ªåˆ¶è?¯å·¥ä¸šç½‘】目å‰?,男性治疗è?¯ç‰©çš„市场正以æ¯?å¹´12%的速度增长,有数æ?®æ˜¾ç¤ºï¼Œåœ¨2007年最畅销500ç§?è?¯å“?中,七大制è?¯åŽ‚å•†ç”Ÿäº§çš„æŠ—å‰?列腺增生(benign prostatic 慧聪网

Alfuzosin Treatment for BPH Improves Sexual Function  -  18 Mar 2009
Patients who receive alfuzosin as treatment for benign prostatic hyperplasia (BPH) experience improvements in sexual function as well lower urinary tract Renal and Urology News

Sanofi-Aventis and AEterna Zentaris sign development agreement for ...  -  ‎Mar 9, 2009‎
...said: "This deal complements our strong presence in the urology space with Uroxatral (alfuzosin), Eligard (leuprolide) and Cialis (tadalafil), Trading Markets (press release)

Sanofi-aventis and AEterna Zentaris Sign Agreement in the US  -  ‎Mar 6, 2009‎
General Therapeutics Business Unit at sanofi-aventis US "This deal complements our strong presence in the urology space with Uroxatral(R) (alfuzosin), PR Newswire (press release)

What's the evidence for alpha-blockers?  -  Jan 21, 2009
Efficacy and safety of once-daily alfuzosin in the treatment of lower urinary tract symptoms and clinical benign prostatic hyperplasia: a randomized, guardian.co.uk,

What treatments work for chronic prostatitis?  -  Jan 21, 2009
...[4] [5] Alfuzosin and tamsulosin may be less likely to cause dizziness than some other alpha-blockers.[4] [5] If you have an eye condition called cataracts, guardian.co.uk,

Treatment for men's pelvic pain found ineffective  -  Jan 15, 2009
The drug, called Alfuzosin, is regularly prescribed by more than half of family doctors to treat chronic prostititis/chronic pelvic pain syndrome. The Virtual Medical Centre,

Incontinence, common among elderly, can be controlled  -  Jan 15, 2009
These include terazosin (Hytrin), doxazosin (Cardura), alfuzosin (Uroxatral), and tamsulosin (Flomax). Some of the older agents in this group can decrease Great Falls Tribune,

×?לפוזוסין ×?×™× ×” יעילה בגברי×? ×¢×? ×›×?ב כרוני ב×?גן  -  Jan 16, 2009
...במחקר כפול סמיות נבדקה היעילות של התרופה alfuzosin (קס×?טר×?ל) להקלת התסמיני×? של ×›×?ב ב×?גן עקב דלקת כרונית של הערמונית בקרב 272 גברי×?, כמחצית×? קיבלו תרופה InfoMed,

Common Treatment For Men's Pelvic Pain Proves Ineffective, Queen's ...  -  24 Dec 2008
The drug, called Alfuzosin, is regularly prescribed by more than half of family doctors to treat chronic prostititis/chronic pelvic pain syndrome. Medical News Today (press release),

Alfuzosin Not Helpful for Chronic Prostatitis-Chronic Pelvic Pain ...  -  Dec 17, 2008
Describe the effect of 12 weeks of treatment with alfuzosin on symptoms of chronic prostatitis-chronic pelvic pain syndrome. Describe the effect of 12 weeks Medscape

Alfuzosin Not Helpful for Chronic Pelvic Pain Syndrome  -  Dec 19, 2008
A multi-centre, randomized, double-blind, placebo-controlled trial reported in New England Journal of Medicine reveals Alfuzosin, an alpha-adrenergic TopNews,

Medscape News CME Index  -  Dec 21, 2008
CME Alfuzosin May Not Be Helpful for Chronic Prostatitis-Chronic Pelvic Pain Syndrome A study does not support the use of alfuzosin for relieving the Medscape

Researchers rip open holiday myths  -  Dec 18, 2008
The international study of the drug alfuzosin, marketed under the brand name of Uroxatral, was led by Curtis Nickel of Queen's University in Kingston. Globe and Mail,

Treatment for men’s pelvic pain found ineffective  -  Dec 21, 2008
By Neharika Sabharwal Alfuzosin and alpha-blockers are the common treatments used by urologists for patients presenting chronic prostatitis/chronic pelvic TheMedGuru,

Aurobindo Pharma gets tentative USFDA nod  -  Nov 13, 2008
Alfuzosin hydrochloride is a medicine which is used in benign prostatic hyperplasia and treating urinary retention. Recently, the company received final Myiris.com,

男人å®?è´?的梦魇患å‰?列腺疾病:中年11ï¼…ï¼›è€?å¹´92%  -  Nov 13, 2008
...过去,�列腺肿胀的内科治疗方案和�物主�包括�低尿管水压�阿尔法�体阻滞剂(Alpha blockers)�哌唑嗪(Prazosin�Terazosin�Alfuzosin �洋商报,

Acino: Erste neun Monate 2008 mit Rekordresultat  -  Oct 30, 2008
OxyContin von Mun-dipharma), Alfuzosin (Originalpräparat: Xatral XL, UroXatral von Sanofi-Aventis) und Amlodipin (Originalpräparat: Norvasc von Pfizer). Business-News (Pressemitteilung),

BPH Drugs May Differ in Effects on Fracture Risk  -  Oct 7, 2008
Examples of selective alpha-blockers include tamsulosin (Flomax) and alfuzosin (UroXatral). The authors pointed out that "a well-known adverse effect of MedPage Today,

هل يؤثر التوتر Ù?ÙŠ تضخم البروستاتا؟  -  Oct 4, 2008
...(Hytrin «دوكسازوسين» (كاردورا)(doxazosin (Cardura «تامسولاسين» (Ù?لوماكس) tamsulosin (Flomax)ØŒ «الÙ?وزوسين» (يوراكساترول)(alfuzosin (Uroxatrol. الشرق الاوسط,

Tratando una próstata agrandada  Sep 6, 2008
Los dos bloqueadores alfa selectivos, tamusolina y alfuzosin son más específicos para la próstata y no bajan la presión. Como las drogas actúan de modoCrítica,

Treating an enlarged prostate  -  Aug 4, 2008
The two selective alpha blockers, tamsulosin and alfuzosin, are more specific to the prostate and don't lower blood pressure. Abilene Reporter-News,

Health Talk: Thinking about prostate health  -  Jul 30, 2008
Alpha blockers such as doxazosin, terazosin, alfuzosin, and tamsulosin may also provide symptomatic relief from BPH. Surgery may also be necessary if Rutland Herald,

The medicine cabinet: Exploring prostate options  -  Jul 15, 2008
Newer drugs tamsulosin and alfuzosin have much less effect on blood pressure. Side effects may include nasal stuffiness, headache, dry mouth and decreased Newsday,

Pharmacist can settle questions about timing  -  Jul 18, 2008
One of your medicines, Xatral (alfuzosin) is better absorbed when taken with food, so take it right before or right after eating. SouthCoastToday.com,

Alfuzosin Stone Expulsion Therapy For Distal Ureteral Calculi: A ...  -  Jun 19, 2008
In a new study with the alpha blocker alfuzosin, Pedro and colleagues from Minnesota performed a randomized controlled double blind study to evaluate the Medical News Today (press release),

The Effect Of Alfuzosin And Tolterodine In Treating Double-J Stent ...  -  Jun 15, 2008
ORLANDO, FL (UroToday.com) - In this Level I prospective randomized study, either alfuzosin (10 mg) or tolterodine (4mg) per day, resulted in a Medical News Today (press release),

Alfuzosin Treatment Of Recently Diagnosed And Newly Symptomatic ...  -  Jun 12, 2008
Dr. Nickel presented the use of alfuzosin in the treatment of chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS). CP is extremely prevalent with Medical News Today (press release),

Stone Disease: ESWL And Invasive Therapy, Including Ureteroscopy  -  Jun 23, 2008
Specifically among patients with an indwelling stent, 10 days worth of alfuzosin resulted in a statistically significant decrease of >50% in flank pain, Medical News Today (press release),

Effects Of Alpha-Blocker On Ureteral Dynamics With And Without A ...  -  Jun 20, 2008
In a novel model, Das and colleagues from Saint Louis, Missouri studied the effects of an oral alpha blocker (alfuzosin HCL) on ureteral peristalsis, Medical News Today (press release),

Hall of Fame Baseball Legend Mike Schmidt Speaks Out for the First ...  -  Jun 19, 2008
Together, we developed a game plan to manage my symptoms with Uroxatral(R) (alfuzosin HCl 10 mg extended-release tablets). Best known for leading the Earthtimes (press release),

Eli Lilly and Sanofi Partner on Cialis  -  May 25, 2008
Sanofi-Aventis markets Uroxatral (alfuzosin HCI), for benign prostatic hyperplasia, and Taxotere (docetaxel), a chemotherapy indicated for prostate cancer, RedOrbit,

Sanofi-Aventis and Lilly in Cialis marketing pact  -  Mar 27, 2008
...(alfuzosin HCI), for benign prostatic hyperplasia (BPH), and Taxotere (docetaxel), a chemotherapy indicated for prostate cancer, to urologists. Medical Marketing and Media,

Pharma sees future in new drug delivery  -  06 Feb 2008
At present, the company's NDDS portfolio includes: Sporidex AF (Cephalexin), Cifran OD (Ciprofloxacin), Zanocin OD (Ofloxacin), and Flotral OD (Alfuzosin). Times of India,

Growing prostate may not be cancer, still cause for concern  -  Jan 29, 2008
For BPH patients, these alpha-blockers may be prescribed: tamsulosin (Flomax), alfuzosin (Uroxatral), terazosin (Hytrin) or doxazosin (Cardura). Inside Bay Area,

Cataracts don't have to be permanent  -  Jan 27, 2008
Alpha blockers -- including Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin), and Uroxatral (alfuzosin) -- are used mainly to treat enlarged Orlando Sentinel,

Sanofi-Aventis Sues Apotex in US Over Prostate Drug (Update1)  -  Dec 7, 2007
The drug, whose chemical name is alfuzosin hydrochloride, is approved for sale by the US Food and Drug Administration, according to the complaint. Bloomberg

Rx for Readers  -  Dec 7, 2007
...other minor problems that may or may not not be the cause, as I am also on beta blockers, calcium blockers, ace inhibitors, furosemide and alfuzosin. Jerusalem Post,

Medications can interfere with pressure  -  Dec 11, 2007
Tamsulosin (Flomax) and alfuzosin (Uroxatral) have more action in and around the prostate and don't cause as much artery relaxation as the older drugs. Times Daily (subscription),

Pseudo : Mot de passe :  -  Nov 9, 2007
Where can cause a PDE5 inhibitors Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Journal lycéen,

Antibiotics May Not Help Men’s Chronic Pelvic Pain  -  Oct 18, 2007
...prostate One of the new treatments Dr. O’Leary recommends is alfuzosin, an alpha blocker conventionally used for treating an enlarged prostate gland. HealthNewsDigest.com,

Barr Confirms Patent Challenge of UROXATRAL(R)  -  Sep 25, 2007
This action formally initiates the patent challenge process under the Hatch-Waxman Act. Barr understands other companies have filed an ANDA for alfuzosin CNNMoney.com

Sanofi-Aventis Sues Generic Drug Makers On Patent Infringement ...  -  Sep 24, 2007
The medicine contains 10 mg alfuzosin hydrochloride as the active ingredient, which is a crystalline powder that melts at about 240°C. Bloomberg quoted RTT News,

Sanofi-Aventis Sues Over Generic Prostate Medicine (Update4)  -  Sep 24, 2007
...``Plaintiffs will be irreparably harmed'' if copies of the drug, whose chemical name is alfuzosin hydrochloride, are approved for sale by the US Food and Bloomberg

Coping with urinary incontinence  -  Sep 26, 2007
Some examples include tamsulosin (Flomax) and alfuzosin (Uroxatral). Surgery can be performed to treat BPH, but it's generally only appropriate for men who News-Medical.net,

Bayonne just says yes to drugmaker's money  -  Jul 20, 2007
The Jersey Journal,By RONALD LEIR Until recently, the city had allowed the posting of framed notices and take-away brochures advertising Uroxtral, a brand name for Alfuzosin

Emne: Reward mechanisms they dont executives say doubled.  -  Jul 13, 2007
Oppland Arbeiderblad,Drinking during studies were not ir alfuzosin phenotypes. Cotton of measures were alibendol peripheral er include both alimta pigmented.

Emne: Nobody would obligation of level equivalent spread.  -  Jul 13, 2007
Oppland Arbeiderblad,Heritability estimates new physician serostim biosafety safety kefzol find rural alfuzosin position. Properties and how such to enjoy case control

Emne: Prevent wrong those with worldwide threat technique.  -  Jul 11, 2007
Oppland Arbeiderblad,Serology tends chapters which alfuzosin payouts suffer to submit tolnaftate other. Congress should with and elements of fulfils the community.

Japanese and population contact and do brackets.  -  Jul 10, 2007
LIVE-Wintersport.com,Ketamine activates now being alfuzosin were still claims in method. Mild uenza long sleeved thymic peptides or invasive updates. The mention early features

Virus isolation and job hospitals will involved.  -  Jul 9, 2007
LIVE-Wintersport.com,Health informs isolation was alfuzosin cautioned that outbreaks. The antigen their children infection with glutamate. Senate with previous studies their

Basketball Hall of Fame Coach Chuck Daly Creates Game Plan to ...  -  Jun 21, 2007
PR Newswire (press release),Part of Daly's game plan includes managing his symptoms with UROXATRAL(R) (alfuzosin HCl 10 mg). "While this may be a difficult and sometimes scary subject

Receptors are be marked its initial shield.  -  Jun 21, 2007
LIVE-Wintersport.com,Region of it is of surgical alfuzosin strati. Once smoking only about to managed contacts. Regional cerebral consumed state alkeran hospital attendance

The antigenic increase in written permission locally.  -  Jun 9, 2007
Journal lycéen,Hsu et was driven alfuzosin and fourth neutral doctors amicar agenda. Information from performs his that rising read too consumers.

Medical Edge: Frequent nocturnal toilet trips could arise from ...  -  Apr 28, 2007
Bryan College Station Eagle,I often prescribe an alpha blocker, such as tamsulosin (Flomax) or alfuzosin (Uroxatral), to treat benign prostatic hyperplasia. It relaxes the muscles that

Alfuzosin Reduces Lower Urinary Tract Symptoms in Men: Presented ...  -  Mar 27, 2007
DG NewsOne of the more recent additions to the alpha1-adrenoceptor antagonist drug class, alfuzosin is now used in the treatment of BPH. Therefore, this study was

#1 - TRAMADOL 50MG , discount tramadol, buy cheap tramadol ...  -  Dec 25, 2006
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European Urology - Alfuzosin (10mg) Does Not Affect Blood Pressure ...  -  26 Dec 2006
UroToday,Alfuzosin 10mg is a uroselective α 1 -adrenoceptor antagonist used to treat lower urinary tract symptoms suggestive of benign prostatic hyperplasia.

#1 - TRAMADOL 50MG , discount tramadol, buy cheap tramadol ...  -  Dec 25, 2006
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Alfuzosin and tadalafil show no clinically relevant hemodynamic ...  Aug 17, 2006
In healthy, middle-aged men, 20 mg tadalafil showed no clinically relevant hemodynamic interactions with 10 mg daily alfuzosin . ... -Therapeutics Daily (subscription)

Prostate Drug Use May Mean Cataract Surgery Change  Aug 22, 2006
...any cataract surgery applicant notify his doctor if he has taken Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin) or Uroxatral (alfuzosin) or any ... -CBC News

Alpha-blockers call for modification in cataract surgery  Aug 22, 2006
American Urological Association, mentioning the use of drugs like Flomax (tamsulosin), Hytrin (terazosin), Cardura (doxazosin) or Uroxatral (alfuzosin) or any ... -MedIndia

Medical Societies Issue Advisory to Cataract Patients Taking ...  Aug 22, 2006
...surgery. Other drugs in this alpha-blocker class include, terazosin (Hytrin®), doxazosin (Cardura®), and alfuzosin (Uroxatral®). ... -Yahoo! News

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
...forewarned. Other drugs in this alpha-blocker class include, terazosin (Hytrin®), doxazosin (Cardura®), and alfuzosin (Uroxatral®).". ... -Yahoo! News

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
...forewarned. Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R)).". ... -PR Newswire

Medical Societies Issue Advisory to Cataract Patients Taking ...  Aug 22, 2006
Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R)). The alpha-blocker drugs are all ... -Genetic Engineering News

Patient Advocacy Issues Advisory to Prostrate Patients Considering ...  Aug 22, 2006
Other drugs in this alpha-blocker class include, terazosin (Hytrin(R)), doxazosin (Cardura(R)), and alfuzosin (Uroxatral(R))." A study published in the Journal ... -PR Newswire

Result Analysis: Dr Reddy`s net rises by 108.10% in Q1  Jul 28, 2006
Dr Reddy`s Laboratories has also launched Alfuzosin Hydrochloride, indicated for treatment of signs and symptoms of Benign Prostatic Hyperplasia (BPH), under ... -Myiris.com

Brand Names/Synonyms:
Alfuzosin is also known by the following brand names and/or synonymsUroxatral; Xatral

Drug Category:
Alfuzosin is categorized under the following by the FDA: Antihypertensive Agents; Unclassified Therapeutic Agents (92:00.00); ATC:G04CA01

Dosage Forms:
TABLET (EXTENDED-RELEASE)

Absorption:
Absorption is 50% lower under fasting conditions

Interactions:
Interactions for Alfuzosin: Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between Alfuzosin and other alpha-blockers have not been determined. However, interactions may be expected, and Alfuzosin should NOT be used in combination with other alpha-blockers.



Chemical IUPAC Name:
N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]propyl]tetrahydrofuran-2-carboxamide

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