Alfentanil

This page contains recent news articles, when available, and an overview of Alfentanil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Alfentanil (when available)

Pharmacology and use:
Thiamine is a vitamin that with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells. For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Mechanism Of Action:
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux.

News Articles on Vitamin B1 (Thiamine)

Cortex’s AMPAKINE Molecule CX717 Has Positive Effects in Opiate ...  -  06 Aug 2008
This study uses a single dose of 1500mg of CX717 and focuses on both the respiratory depression and the analgesic effects associated with alfentanil. Business Wire (press release),

Cortex Study Reveals Ampakine as Having Positive Effects in Opiate ...  -  06 Aug 2008
...placebo that was orally administered two hours before each subject received an intravenous infusion of the opiate agonist, alfentanil. by RTT Staff Writer. RTT News,

Synthetic Narcotics-Safe or Addictive?  -  Jul 19, 2008
Thereafter, two other fentanyl analogues were introduced: alfentanil (Alfenta®), an ultra-short (5-10 minutes) acting analgesic, and sufentanil (Sufenta®), TransWorldNews (press release),

The Calmative Before the Storm  -  Jul 14, 2008
According to Davison, “the requirement for rapid immobilization apparently led to consideration of fentanyl analogues, in particular alfentanil. Dissident Voice,

Gli effetti del fentanil  -  Jul 25, 2008
Ciò dovrebbe costituire un campanello d'allarme per i medici e le autorità competenti: la somministrazione di fentanil o dei suoi derivati (alfentanil, ECPlanet,

Cortex Reports First Quarter Operating Results  -  May 8, 2008
One study is evaluating whether CX717 may prevent the respiratory depression induced by alfentanil, while preserving that opiate’s desired pain relieving Business Wire (press release),

Cortex Reports First Quarter Operating Results  -  May 8, 2008
One study is evaluating whether CX717 may prevent the respiratory depression induced by alfentanil, while preserving that opiate's desired pain relieving Genetic Engineering News (press release),

Market Report -- In Play (WIRES)  -  Mar 31, 2008
...the German regulatory agency which approves the use of narcotic drugs that it can proceed with the trial which will use alfentanil, an opiate analgesic. MSN Money

Cortex Initiates Enrollment in Opiate Induced Respiratory ...  -  Mar 31, 2008
...was notified by the German regulatory agency which approves the use of narcotic drugs that it can proceed with the trial which will use alfentanil, PharmaLive.com (press release),

Cortex Pharma Receives German Regulatory Approval To Initiate ...  -  Mar 7, 2008
The primary study objective is to determine if CX717 could prevent RD while preserving the underlying desired analgesic effect of alfentanil. RTT News,

Alfentanil Combined With Morphine Gives Quicker Pain Relief in ...  -  Feb 19, 2008
By Ed Susman KISSIMMEE, FL -- February 19, 2008 -- The combination of the fentanyl analogue alfentanil (Alfenta) with morphine provides faster pain relief DG News

Fatal Cardiac Tamponade as a Result of a Peripherally Inserted ...  -  Dec 5, 2007
...it was decided to keep the patient sedated and ventilated overnight using infusions of propofol 50–150 mg h–1 and alfentanil 1–2 mg h–1. Abkhazia,

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for ...  -  Nov 8, 2007
Therefore, CYP3A4 substrates with a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, Earthtimes,

Hospital worker suspended for cash theft  -  Aug 14, 2007
The drugs he stole from the hospital included morphine, alfentanil and remifentanyl, which were taken over a month-long period. Norwich Evening News,

Emne: Reward mechanisms they dont executives say doubled.  -  Jul 13, 2007
Oppland Arbeiderblad,Ketamine activates no employment direction of alfentanil have proven caps. Five minutes had had alferon to hear modalities. Congress could of ccluding

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients ...  -  Dec 14, 2006
DG NewsDrugs that may have their plasma concentration altered by dasatinib are: CYP3A4 substrates with a narrow therapeutic index (eg, alfentanil, astemizole,

FDA Approves Sprycel (Dasatinib) With Two Indications  Jun 29, 2006
...that may have their plasma concentration altered by dasatinib are: CYP3A4 substrates with a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine ... -DG News

Prescription Drug Dependence and Evolving Beliefs About Chronic ...  Apr 3, 2006
Ibid, pp 183-200. Kissin I, Bright CA, Bradley EL Jr: Can inflammatory pain prevent the development of acute tolerance to alfentanil? ... - Am J Psychiatry (subscription)

EEG During Anesthesia Is Not a Linear Random Process Feb 22, 2006
...rejected with the Hinich test in only 6.2%, 9.1%, and 10.62% of the investigated EEG epochs during general anesthesia with isoflurane/alfentanil (3), Isoflurane ... - Anesthesia & Analgesia (subscription),

EEG During Anesthesia Is Not a Linear Random Process  Feb 21, 2006
Jeleazcov C, Fechner J, Schwilden H. Electroencephalogram monitoring during anesthesia with propofol and alfentanil: the impact of second order spectral ... - Anesthesia & Analgesia (subscription),

TIVA, Awareness, and the Brice Interview Feb 21, 2006
Nordstrom O, Englstrom AM, Persson S, Sandin R. Incidence of awareness in total iv anaesthesia based on propofol, alfentanil and neuromuscular blockade. ... - Anesthesia & Analgesia (subscription),

Routine Inhaled Induction in Adults: A Safe Practice?  Jan 29, 2006
Bailie R, Christmas L, Price N et al. Effects of temazepam premedication on cognitive recovery following alfentanil-propofol anaesthesia. ... - Anesthesia & Analgesia (subscription)

Brand Names/Synonyms:
Alfentanil is also known by the following brand names and/or synonymsAlfenta; Alfentanil; Alfentanilum [Inn-Latin]; Alfentanyl; Dea No. 9737; HSDB 6789

Drug Category:
Alfentanil is categorized under the following by the FDA: Anesthetics; Narcotics; Analgesics; Opiate Agonists; ATC:N01AH02

Dosage Forms:
SOLUTION, INJECTION

Absorption:
Not Available

Interactions:
Interactions for Alfentanil:

Both the magnitude and duration of central nervous system and cardiovascular effects may be enhanced when ALFENTA is administered in combination with other CNS depressants such as barbiturates, tranquilizers, opioids, or inhalation general anesthetics. Postoperative respiratory depression may be enhanced or prolonged by these agents. In such cases of combined treatment, the dose of one or both agents should be reduced. Limited clinical experience indicates that requirements for volatile inhalation anesthetics are reduced by 30 to 50% for the first sixty (60) minutes following ALFENTA induction The concomitant use of erythromycin with ALFENTA can significantly inhibit ALFENTA clearance and may increase the risk of prolonged or delayed respiratory depression.

Cimetidine reduces the clearance of ALFENTA. Therefore smaller ALFENTA doses will be required with prolonged administration and the duration of action of ALFENTA my be extended.

Perioperative administration of drugs affecting hepatic blood flow or enzyme function may reduce plasma clearance and prolong recovery.

Chemical IUPAC Name:
N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamide

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