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AlendronateThis page contains recent news articles, when available, and an overview of Alendronate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Alendronate (when available) Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women. For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women Mechanism Of Action: The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass. News Articles on Alendronate WEEKEND COLUMNISTS Margaret McCartney - Aug 28, 2009 Alendronate lives in interesting times: a class action has been raised against its manufacturers, Merck, with the complainants asserting that they were not Financial Times Pricey Remedy May Not Be Better - Aug 11, 2009 It costs about 10 times as much as a generic alendronate whose brand name is Fosamax. And studies done so far haven't shown that Boniva is any more Washington Post Atraumatic Bilateral Femur Fracture in Long-Term Bisphosphonate Use - Aug 4, 2009 She had a medical history notable for use of the bisphosphonate alendronate for 16 years before being switched to ibandronate for 1 year before presentation Ortho SuperSite Medicines in Malta 40% more expensive than Europe - Aug 10, 2009 Sufferers are therefore compelled to buy their drugs privately, and so far the only locally available product is Alendronate: patented by Merck, Malta Today A Partial Approval for Amgen's Osteoporosis Drug - Aug 13, 2009 The main treatments now for osteoporosis are drugs called bisphosphonates, like Actonel, Boniva and alendronate, the generic version of Merck's Fosamax. New York Times NASA ISS On-Orbit Status 17 August 2009 - Aug 17, 2009 For Thirsk, the day began with the extended “Bisphosphonatesâ€? biomedical countermeasures experiment for which Bob ingested an Alendronate pill before Space Ref (press release) NASA ISS On-Orbit Status 10 August 2009 - Aug 10, 2009 For Thirsk, the day began with the extended “Bisphosphonatesâ€? biomedical countermeasures experiment for which Bob ingested an Alendronate pill before Space Ref (press release) Osteoporosis Risk in Premenopausal Women - Aug 27, 2009 Effects of the bisphos-phonate, alendronate, on parturition in the rat. Toxicol Appl Pharmacol 1993;121:217-23. Lin JH. Bisphosphonates: a review of their Medscape NASA ISS On-Orbit Status 3 August 2009 - Aug 4, 2009 For FE-4 Thirsk, the day began with the extended “Bisphosphonatesâ€? biomedical countermeasures experiment for which he ingested an Alendronate pill before Space Ref (press release) Insight into the osteoporosis market - Aug 28, 2009 Although between 2007 and 2008 the market declined due to generic penetration of the market leading brand Fosamax (alendronate, Merck & Co), the launch of PRMinds (press release) Fosamax Trial Underway in New York - Aug 11, 2009 Fosamax (alendronate sodium) has been used by more than 20 million people since the FDA approved it in October 1995. Before the medication became available AboutLawsuits.com Endocrine Society calls for Medicare coverage of bone testing for ... - Aug 20, 2009 ...“With the recent availability of a generic preparation of the bisphosphonate alendronate, coverage of BMD testing is likely cost-effective for men as young Endocrine Today China Medicine Announces Second Quarter 2009 Results - Aug 13, 2009 We also obtained exclusive provincial level distribution rights for Alendronate Sodium tablets used for treatment of osteoporosis. PR Newswire (press release) Down to the bone - Aug 7, 2009 The drug's generic name is alendronate, and it belongs to the bisphosphonate class of drugs, sometimes used intravenously for cancer patients but most often The Age Does treatment of new-onset hypertension reduce risk of stroke in ... - Aug 12, 2009 An 83-year-old woman with a known history of osteoporosis presents to your clinic for a yearly evaluation and renewal of her prescription for alendronate Journal of the American Academy of Physician Assistants NASA ISS On-Orbit Status 13 July 2009 - 13 Jul 2009 Two dosing regimens will be tested: (1) an oral dose of 70 mg of Alendronate taken weekly starting 3 weeks prior to flight and then throughout the flight Space Ref (press release) Bone Scans Called Useless Early in Osteoporosis Drug Therapy - Jun 25, 2009 The findings were based on data from the Fracture Intervention Trial, a randomized, placebo-controlled study of alendronate (Fosamax) in 6459 postmenopausal MedPage Today Current Controversies in Bisphosphonate Therapy - Jul 6, 2009 13-15 Tiludronate, alendronate, pamidronate, and risedronate are commonly used on-label in the management of Paget's disease. Ortho SuperSite Bone Mineral Density Monitoring May Not Be Needed Up to 3 Years ... - Jul 2, 2009 The Fracture Intervention Trial was a randomized controlled trial comparing the effects of alendronate vs placebo on BMD after menopause. Medscape Regular BMD monitoring may be unnecessary in some postmenopausal women - Jun 29, 2009 ...“In this large, placebo-controlled trial of alendronate treatment in postmenopausal women with low BMD and with serial BMD measurements, we found that three Endocrine Today New Report Just Published Stakeholder Insight: Osteoporosis ... - Jun 30, 2009 ...(live-PR.com) - Reportlinker.com announces that a new market research report related to the Pharmaceutical industry is available in its catalogue. Live-PR.com (Pressemitteilung) Management of Osteoporosis Among Home Health and Long-term Care ... - Jun 18, 2009 Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Medscape Ask UT Medicine: More research needed on bone-loss drug - Jun 22, 2009 Q. I've been taking alendronate (Fosamax) for my osteopenia for seven years and my doctor says I should probably be on it for life. San Antonio Express NASA ISS On-Orbit Status 22 June 2009 - Jun 22, 2009 Two dosing regimens will be tested: (1) an oral dose of 70 mg of Alendronate taken weekly starting 3 weeks prior to flight and then throughout the flight Space Ref (press release) Bone density monitoring of no benefit, researchers claim - Jul 1, 2009 In a study of almost 6500 postmenopausal women taking alendronate or placebo, bone density measurements of the hip and spine at baseline, one, two and three Pulse NASA ISS On-Orbit Status 6 July 2009 - Jul 6, 2009 Two dosing regimens will be tested: (1) an oral dose of 70 mg of Alendronate taken weekly starting 3 weeks prior to flight and then throughout the flight Space Ref (press release) NASA ISS On-Orbit Status 29 June 2009 - Jun 29, 2009 Two dosing regimens will be tested: (1) an oral dose of 70 mg of Alendronate taken weekly starting 3 weeks prior to flight and then throughout the flight Space Ref (press release) Drop the densitometry - Jun 24, 2009 ...analysed data from the Fracture Intervention Trial that included more than 6000 postmenopausal women treated with alendronate or placebo for three years Endochrinology Update Top Ten Things That Don't Cause Arthritis - Jul 9, 2009 Other drugs (such as alendronate or phenobarbital) may cause bone or joint pain but not arthritis. Similarly, diuretic drugs (“water pillsâ€?) may increase MSN Health & Fitness Effects of Teriparatide Retreatment in Osteoporotic Men and Women - Jul 7, 2009 Patients and Intervention: Subjects previously participated in a 30-month randomized trial comparing the effects of alendronate (group 1), Journal of Clinical Endocrinology and Metabolism Bone Therapy May Not Always Need Monitoring - Jun 24, 2009 In the study, Australian researchers analyzed data from a large randomized trial that compared the effects of the drug alendronate (a widely used Atlanta Journal Constitution Better access for a treatment to help osteoporosis patients ... - Jun 17, 2009 The CDR recommended that alendronate 70mg/cholecalciferol 5600 IU (vitamin D3) be reimbursed similar to generic alendronate. Furthermore, the Ontario Drug CNW Telbec (Communiqué de presse) Health Check - March 2009 - Jul 6, 2009 In guidelines published last year NICE recommended the drug Alendronate. However, around one in four sufferers cannot tolerate it due to side effects. Linex Legal (subscription) Patient- and Physician-Oriented Web Sites and Drug Surveillance ... - Jun 22, 2009 Drug Administration (FDA) on severe bone, joint, and muscle pain associated with the use of alendronate sodium and risedronate sodium for 1995 to 2002. Archives of Internal Medicine Osteoporosis drug Actonel Once-a-Month listed on PBS - Jun 30, 2009 In two crossover trials where patients trialed both monthly and weekly dosing regimens (monthly ibandronate and weekly alendronate), Medical Devices+Equipment Canada's first and only once-a-month treatment for postmenopausal ... - Jun 24, 2009 R. Effectiveness of bisphosphonates on nonvertebral and hip fractures in the first year of therapy: the risedronate and alendronate (REAL) cohort study. CNW Telbec (Communiqué de presse) 在開始雙磷酸鹽類藥物治療之後三年內å?¯èƒ½ä¸?需è¦?骨質密度監測 - Jul 10, 2009 ...「Fracture Intervention Trialã€?æ˜¯ä¸€é …éš¨æ©ŸæŽ§åˆ¶è©¦é©—ï¼Œæ¯”è¼ƒalendronate與安慰劑å°?æ–¼å?œç¶“後BMD的效果。在1992å¹´5月至1993å¹´5月之間，總共ç´?å…¥6459å??å?œç¶“的低BMD婦女，在 臺灣新浪網 Ostéoporose : elle touche aussi les hommes ! - Jun 25, 2009 Il se trouve que, entre 2001 et 2007, la proportion de seniors ayant eut recours aux trois types de bisphosphonates à l'étude (étidronate, alendronate et CareVox Zoledronic Acid Infusion Effective for Bone Loss Linked With ... - 20 Apr 2009 ..."Guidelines recommend prescription of risedronate or alendronate in many patients given glucocorticoids, who are at increased risk of fracture," the study Medscape NASA ISS On-Orbit Status 13 April 2009 - Apr 13, 2009 The FE-2 also continued the extended “Bisphosphonatesâ€? biomedical countermeasures experiment, today again ingesting an Alendronate pill before breakfast. Space Ref (press release) Link Between Atrial Fibrillation, Bisphosphonates Still Cloudy - Apr 9, 2009 The two case-control studies included in the meta-analysis conflicted: One indicated a significantly increased atrial fibrillation risk with any alendronate MedPage Today NASA ISS On-Orbit Status 30 March 2009 - Mar 30, 2009 In addition, the FE-2 continued the extended “Bisphosphonatesâ€? biomedical countermeasures experiment, today again ingesting an Alendronate pill before Space Ref (press release) Once-a-Year Drug Helps Counter Steroid-Linked Bone Loss - Apr 10, 2009 For example, recent studies have suggested links between long-term use of oral bisphosphonates such as Fosamax (alendronate) to a heightened risk for Forbes What should I consider before having uterus, ovaries removed? - Apr 8, 2009 Some women will need treatment or a preventive strategy using bisphosphonates such as pamidronate (Aredia), ibandronate (Boniva), alendronate (Fosamax) or CNN Smokers’ Lung Treatment May Fail to Fire Up Nycomed Bidders - Apr 8, 2009 In January, it purchased a license to sell an effervescent version of the Alendronate osteoporosis treatment from Florida-based EffRx Inc. Nycomed is Bloomberg Once a year osteoporosis drug 'better at increasing strength of ... - Apr 9, 2009 The study concludes: "Guidelines recommend prescription of risedronate or alendronate in many patients given glucocorticoids, who are at increased risk of Telegraph.co.uk EffRx Signs Expansion of Licensing Deal with Nycomed for Its Novel ... - Mar 30, 2009 ...an expansion of territories in their licensing deal for EffRx’s proprietary drug EX101 (effervescent alendronate), for the treatment of osteoporosis. Business Wire (press release) 抗骨質ç–?鬆見æˆ?績 - Apr 13, 2009 ...å…¶ä¸ä¸€ä»½æ–¼2006年底發表於《美國醫å¸æœƒæœŸåˆŠã€‹ï¼ˆJournal of the American Medical Associationï¼‰çš„ç ”ç©¶å ±å‘ŠæŒ‡å‡ºï¼Œæœ?用「阿侖膦酸ã€?（alendronate，一種雙磷酸鹽å?£ 香港新浪網 Одна прививка в год укреплÑ?ет коÑ?ти - Apr 13, 2009 Ð?апример, недавно обнаружена Ñ?вÑ?зь между препаратов Fosamax (alendronate) и развитием аритмии. Ð’ новом иÑ?Ñ?ледовании ученые Ñ?равнили прием препарата Reclast МЕДСТРИМ.РУ - консультации врачей, новости медицины Bệnh loãng xÆ°Æ¡ng - Apr 5, 2009 Dược phẩm thuá»™c nhóm Biphosphonates etidronate (Didronel), pamidronate (Aredia), alendronate (Fosamax), risedronate (Actonel), zoledronate (Zometa or Người Việt Chứng viêm da & bắp thịt (cÆ¡) - Dermatomyositis - Apr 1, 2009 Bác sÄ© có thể dùng thêm calcium và sinh tố D để giúp duy trì xÆ°Æ¡ng và có thể dùng thêm bisphosphonates, nhÆ° alendronate (Fosamax), risedronate (Actonel). Người Việt Boston هشاشة العظام لدى الرجال.. الوقاية والعلاج - Apr 7, 2009 وأدوية «البيسÙ?وسÙ?انات» التي يتم تناولها عن طريق الÙ?Ù… المتوÙ?رة Øاليا هي alendronate («Ù?وسامكس» Fosamax) Ùˆ risedronate («أكتونيل» Actonel) Ùˆibandronate دنيا الوطن Brand Names/Synonyms: Alendronate is also known by the following brand names and/or synonymsALENDRONIC ACID; Acide Alendronique [Inn-French]; Acido Alendronico [Inn-Spanish]; Acidum Alendronicum [Inn-Latin]; Adronat; Alendronate; Alendronate Sodium; Alendronic Acid; Alendronic Acid [Ban:Inn]; Alendros; Arendal; CHEMBANK1709; Fosamax; MK 217; Onclast Drug Category: Alendronate is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; ATC:M05BA04 Dosage Forms: 10 mg (Rx) Fosamax lactose 40 mg (Rx) Fosamax lactose Absorption: Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast. Interactions: Intravenous ranitidine was shown to double the bioavailability of oral alendronate. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown; no other specific drug interaction studies were performed. Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate. Chemical IUPAC Name: (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid : |
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