Albuterol sulfate

This page contains recent news articles, when available, and an overview of Albuterol sulfate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Albuterol sulfate (when available)

Pharmacology and use:
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific. For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis

Mechanism Of Action:
The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca²⁺-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.

News Articles on Vincristine

FDA Safety Changes: Combivent, Qualaquin, Sucraid  -  ‎Mar 4, 2009‎
On November 10, 2008, the FDA approved safety labeling revisions for ipratropium bromide and albuterol sulfate inhalation aerosol (Combivent; Medscape

10-K: WATSON PHARMACEUTICALS INC  -  ‎Feb 23, 2009‎
...including fentanyl transdermal patch (launched at the end of the third quarter of 2007), albuterol sulfate (launched in the fourth quarter of 2007), MarketWatch (press release)

Economically Disadvantaged Asthma Sufferers Breathe Easier with ...  -  Jan 15, 2009
ProAir ® HFA (albuterol sulfate) Inhalation Aerosol is indicated in patients 4 years of age and older for the treatment or prevention of bronchospasm with WELT ONLINE,

Next Safety Develops an Air-Based Asthma Medication Inhaler That ...  -  Dec 15, 2008
...explains: "The device uses a silicon microfluidic pump to eject droplets of an off-the-shelf FDA-approved solution of albuterol sulfate in water that MarketWatch

Nebulised Formoterol BID Provides Longer Duration of Action Than ...  -  Nov 3, 2008
...lasting than the combination of ipratropium bromide and albuterol sulfate 4 times daily in patients with chronic obstructive pulmonary disease (COPD), DG News

Schering-Plough to appeal decision in Mo. reimbursement case  -  Oct 31, 2008
...for the company and dismissed all claims relating to Schering-Plough's branded pharmaceutical products and Warrick's generic albuterol sulfate solution. Bizjournals.com,

FDA Approvals: ProAir HFA and Nasacort AQ  -  Oct 2, 2008
Describe the appropriate use of albuterol sulfate inhalation solution in asthmatic children. Explain the appropriate use of triamcinolone acetonide nasal Medscape (subscription)

Teva's albuterol inhaler wins new pediatric indication  -  Sep 24, 2008
In clinical studies, ProAir HFA, the albuterol sulfate inhaler, exhibited significant bronchodilator efficacy in pediatric asthmatics aged four to 11 years. Trading Markets (press release),

High Growth Reported for the World Pulmonary Drug Delivery ...  -  Oct 1, 2008
Pulmicort Turbohaler (budesonide), Atrovent (ipratropium bromide), Ventolin (albuterol), Combivent (ipratropium bromide + albuterol sulfate), MarketWatch

DoctorDirectory to Co-market VoSpire ER(R) with DAVA ...  -  Jul 29, 2008
Albuterol sulfate remains a standard of long-lasting oral therapy for patients," said Jay Grobowsky, CEO for DoctorDirectory. VoSpire ER(R) is indicated for IT News Online,

We can go to war, but we can't help our seniors  -  Jul 27, 2008
Every four hours, she has to take a mixture of ipratropium and albuterol sulfate in a small capsule. That is about a teaspoon. Now we are supposed to mix it The Free Lance-Star,

Spring is here, and so are allergies  -  May 14, 2008
Both medications use albuterol sulfate as their active ingredient and individuals who rely on inhalers should be able to make the change without foreseeable Contra Costa Times,

Teva enters drug alliance with UCB in USA  -  Jan 18, 2008
The initial product to be jointly promoted is Teva's ProAirHFA (albuterol sulfate) Inhalation Aerosol, which is the number-one branded hydrofluroalkane Therapeutics Daily (subscription) (press release),

Teva Enters Into US Respiratory Collaboration Deal With UCB  -  Jan 16, 2008
The first product to be jointly promoted by the two companies in the US is Teva's ProAirHFA or albuterol sulfate Inhalation Aerosol. Trading Markets (press release),

Takeda, Dey Pay Alabama $6.75 Million in Medicaid Lawsuit  -  Jan 18, 2008
...and its claim against Dey involved a number of drugs prescribed primarily for pulmonary diseases and asthma, such as albuterol sulfate and ipratropium FDA news (subscription),

Market Report -- In Play (TEVA)  -  Jan 16, 2008
The initial product to be jointly promoted in the US is Teva's ProAir HFA (albuterol sulfate) Inhalation Aerosol. Additionally, the agreement will provide MSN Money

Watson to Sell Generic DuoNeb  -  Jan 10, 2008
Dey’s DuoNeb (ipratropium bromide/albuterol sulfate) inhaled solution is indicated for treating bronchospasm associated with chronic obstructive pulmonary FDA news (subscription),

Teva Specialty Pharmaceuticals and UCB Announce US Respiratory ...  -  Jan 16, 2008
The initial product to be jointly promoted in the US is Teva's ProAir(R)HFA (albuterol sulfate) Inhalation Aerosol. ProAir(R)HFA is the number-one branded PharmaLive.com (press release),

Schering-Plough: Mass Court Finds No Liability For Warrick Unit  -  Nov 5, 2007
...to class plaintiffs, reversing a prior decision of limited liability against Warrick for one form of a generic product, albuterol sulfate solution. CNNMoney.com

Schering-Plough Reports US District Court for District of ...  -  Nov 5, 2007
...but found limited liability against Warrick with respect to one form of a generic product, albuterol sulfate solution, in the years 1998 and 1999. CNNMoney.com

Schering-Plough: artificial prices case highlights an industry ...  -  Nov 6, 2007
...was exonerated of all liability; however, a question mark remained over Warrick's generic respiratory drug albuterol sulfate for the period 1998–99. Pharmaceutical Business Review

Watson Receives FDA Approval for Generic Accuneb(R)  -  Sep 26, 2007
Watson intends to launch its albuterol sulfate inhalation product immediately. Albuterol sulfate is the generic equivalent to Dey, LP's AccuNeb(R) CNNMoney.com

Watson Pharma gets generic AccuNeb OK  -  Sep 26, 2007
The company received 180 days of marketing exclusivity for its albuterol sulfate inhalation solution in 0.021 percent and 0.042 percent base strengths, CNNMoney.com

Genzyme And Bayer Schering Pharma Initiates Phase 3 Trial Of ...  -  Sep 26, 2007
Watson plans to unveil its albuterol sulfate inhalation product immediately and to begin its market exclusivity upon commercial launch. Albuterol sulfate is RTT News,

Watson Pharmaceuticals Inc announces FDA approval for generic Accuneb  -  Sep 27, 2007
Albuterol sulfate is the generic equivalent to Dey LP's AccuNeb Inhalation Solution, which is indicated for the relief of bronchospasm in patients two to 12 Trading Markets,

Watson Pharma Gets FDA Approval To Market Generic Accuneb For ...  -  Sep 26, 2007
The Corona, California-based company had filed with the FDA an Abbreviated New Drug Application for albuterol sulfate inhalation solution in the 0.021% base Trading Markets,

UPDATE 1-Watson gets FDA nod to sell generic asthma inhaler  -  Sep 26, 2007
The company said it intended to launch the inhalation product, albuterol sulfate inhalation solution, immediately and will receive 180 days of marketing Reuters

Laws Of Physics Don't Apply To Ethics  -  Jul 18, 2007
Nebraska StatePaper.com,The price of the generic drug albuterol sulfate was inflated “in a range of 100 percent to 800 percent�? by “Warrick, a subsidiary of Schering-Plough.

Schering-Plough Reports on Favorable Rulings in AWP Case By US ...  -  Jun 27, 2007
PR-GB.com (press release),Although damages claimed against the company for the Warrick albuterol sulfate solution product are quite limited, the company said it is considering

Schering-Plough: Court dismisses claims in suit  -  Jun 21, 2007
MarketWatch...it disagreed with the court's finding of limited liability against Warrick with respect to one form of a generic product, albuterol sulfate solution,

3 Drug Makers Are Convicted in Reimbursement Overcharges  -  Jun 22, 2007
Tuscaloosa News (subscription),Warrick, a subsidiary of Schering-Plough, which is based in Kenilworth, NJ, inflated average wholesale prices for its generic drug albuterol sulfate in a

Drug prices ruled too high  -  Jun 22, 2007
Worcester Telegram,Schering-Plough’s subsidiary Warrick inflated average wholesale prices for its generic drug albuterol sulfate between 100 percent and 800 percent,

The Confusion with Sulfa, Sulfite and Sulfate Allergies  -  May 1, 2007
About - News & Issues,Sulfates are "salts" of various medications, such as albuterol sulfate nebulizer medication used to treat asthma. These medications usually do not contain

Teva Partners with Asthma Foundation and NBA to Go Pro for Asthma ...  -  Apr 2, 2007
American Digital Networks (press release),...provided by IVAX Laboratories' line of respiratory products, including the recently launched ProAir(R) HFA (albuterol sulfate) Inhalation Aerosol.

Allergy & Asthma Network Mothers of Asthmatics Supports FDA's ...  Mar 14, 2006
Albuterol MDIs are now available in several HFA formulations, including Proventil(r) HFA, Ventolin(r) HFA and Albuterol Sulfate HFA. ... - U.S. Newswire

A warning on asthma drugs  Mar 14, 2006
The medications most likely to be mimicked are Albuterol sulfate, manufactured by Nephron Pharmaceuticals and Warrick Pharmaceuticals; Xopenex, a product of ... - Newsday

FDA Approvals: HepaGam B, Xibrom, Proair HFA Mar 1, 2006
...of ocular pain in patients who have undergone cataract extraction; and an expanded indication for chlorofluorocarbon-free albuterol sulfate inhalation aerosol ... - Medscape (subscription)

Brand Names/Synonyms:
Albuterol sulfate is also known by the following brand names and/or synonymsIndole alkaloid; LCR; Leurocristine; Onco TCS; Oncovin; VCR; VIN; Vincasar PFS; Vincrex; Vincristina [DCIT]; Vincristine; Vincristine Sulfate; Vincristine Sulfate PFS; Vincristinum [INN-Latin]; Vincrstine; Vincrystine; Vinkristin; 22-Oxovincaleukoblastine; EINECS 200-318-1; Oncovin (1:1 sulfate salt); Vincaleukoblastine, 22-oxo-; Vincasar (1:1 sulfate salt); Vincrex (1:1 sulfate salt); Z-D-Val-Lys(Z)-OH

Drug Category:
Albuterol sulfate is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01CA02

Dosage Forms:
LIQUID; SOLUTION

Absorption:
Not Available

Interactions:
Interactions for Vincristine: The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. Dosage adjustment should be based on serial blood level monitoring. The contribution of vincristine sulfate to this interaction is not certain. The interaction may result from reduced absorption of phenytoin and an increase in the rate of its metabolism and elimination.

Chemical IUPAC Name:
Not Available

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