Aktob

This page contains recent news articles, when available, and an overview of Aktob but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Aktob (when available)

Pharmacology and use:
Tobramycin, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections. For the treatment of pseudomonas aeruginosa lung infections

Mechanism Of Action:
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.

News Articles on Tobramycin

Tourism sector seeks to surpass 2007 figures in August  -  Jun 27, 2008
Participating in the Antalya Heading for 10 Millionth Tourist gala, which was organized by the Mediterranean Tourist Hoteliers Association (AKTOB) in Today's Zaman,

Turkish province sees high rental demand  -  Jun 26, 2008
Data from the Mediterranean Tourism Hotels Union (AKTOB) showed that many hotels in the region are fully booked and are likely to remain so over the summer, Ready2invest,

Hotels filled to capacity in only June  -  Jun 23, 2008
...to full hotel occupancy even at the beginning of the summer season, Mediterranean Tourism Hotels Union (AKTOB) Chairman Sururi Çorabatır has said. Today's Zaman,

Hotel chains seek new facilities  -  May 22, 2008
The future of toursim is bright, says the Mediterranean Tourist Hoteliers Association (AKTOB) President Sururi Çorabatır With the growth of the tourism Turkish Daily News (subscription),

Turkish promotional blitz aims to attract Arab travelers  -  May 7, 2008
Mediterranean Tourism Hoteliers Union (AKTOB) President Sururi Çorabatır is happy with the interest in Antalya. “In 2009 the sector will be positioned very Today's Zaman,

Treasury files complaints against luxury hotels  -  Feb 15, 2008
Mediterranean Tourism Hoteliers Union (AKTOB) President Sururi Çorabatır said hotel managers used the beaches to provide comprehensive services to their Turkish Daily News (subscription),

Reducing prices in Antalya hotels to survive winter  -  Jan 18, 2008
We are expecting an increase in 2008,�? Sururi Çorabatır, Mediterranean Tourist Hoteliers Association (AKTOB) president told the Turkish Daily News in an Turkish Daily News (subscription),

Big Brother Antalya city moves into tourism  -  Jan 8, 2008
The Chairman of the Mediterranean Association of Tourist Hoteliers (AKTOB) Osman Ayık, referring to Antalya's reputation in the world, said, “Tourists first Turkish Daily News (subscription),

Arabic Countries Prefer Istanbul For Their Conventions  -  Nov 22, 2007
According to a survey carried out by Mediterranean Tourism Hotels Union (AKTOB), not only the European countries but also Arabic countries prefer Istanbul Turkish Press,

Belek Forests in the sandpit  -  Oct 31, 2007
...say that everything that the tourism sector did was right,�? said Osman Ayık, the chairman of the Union of Mediterranean Hotels and Enterprises (AKTOB). Turkish Daily News (subscription),

IN SHORT...  -  Sep 25, 2007
...(CIS) and Balkan countries has risen," Osman Ayik, chairman of the Mediterranean Touristic Hotels and Entrepreneurs Union (AKTOB), said on Monday. New Anatolian,

Hotels expect high booking in September, October  -  Sep 2, 2007
Mediterranean Hotel Operators Federation’s (AKTOB) President Osman Ayık also said their expectations for September and October were high. Today's Zaman,

Tourism body welcomes tax discount, plans expansion in the CIS, the UK  -  Aug 21, 2007
The Mediterranean Association of Tourist Hoteliers (AKTOB) expects the reduction of the value added tax (VAT), to be adopted in 2008, to boost the Turkish Turkish Daily News (subscription),

Kemer will not become another Bodrum, says mayor  -  Sep 1, 2007
The Mediterranean Association of Tourist Hoteliers (AKTOB) President Osman Ayık noted that after a rapid expansion of tourism facilities in the region, Turkish Daily News (subscription),

Romanians become hope for Turkey  -  Aug 28, 2007
...the Mediterranean Hoteliers Association (AKTOB) chairman, Osman Ayık, says they see the same development in the Ukrainian market and it is now the turn Turkish Daily News (subscription),

Turkey in Brief  -  Aug 26, 2007
AKTOB President Osman Ayık said that the reduced VAT rate is a welcomed development after years of campaigning by the sector. It is also expected to boost Voices Newspaper,

Growth in tourism revives 48 supplier sectors  -  Aug 9, 2007
There is heavy competition among the suppliers of the tourism and hospitality sector, said Mediterranean Association of Touristic Hoteliers (AKTOB) Chairman Turkish Daily News (subscription),

A silent July in holiday resorts due to elections  -  Jul 23, 2007
Turkish Daily News (subscription),Mediterranean Hoteliers Association (AKTOB) President Osman Ayık agreed that there was a drop in the domestic interest rates due to the elections.

Turkish Tourism runs toward record  -  Jul 14, 2007
Journal of Turkish Weekly,However for the first time, this year June and July are filled up," said Osman Ayık, Mediterranean Hoteliers Union (AKTOB) President.

Antalya experiences tourism boom  -  02 Jul 2007
Nirvana International,According to figures released by the Mediterranean Tourism Hotels Union (AKTOB), hotels in Antalya were operating at full capacity in June with numbers at

Tourism soars in June, Antalya hotels operating at full capacity  -  Jun 28, 2007
Today's Zaman,The hotels in Antalya are operating at full capacity for the month of June, according to Mediterranean Tourism Hotels Union (AKTOB) head Osman Ayık,

European tourism market brisk  -  Apr 3, 2007
Turkish Daily News (subscription),Mediterranean Hoteliers Union (AKTOB) President Osman Ayık said the European market is more brisk in 2007 than it was in 2006. Speaking to the Anatolia news

THY to conduct market research on direct flights  -  Dec 19, 2006
Turkish Daily News (subscription),Özgen said Mediterranean Touristic Hotels Association (AKTOB) President Osman Ayýk will also participate in the meeting and will support the initiative. ...

Hotel managers seeking reduction in lease terms from landlords  Oct 20, 2006
...at this year's tourism income, 2006 wasn't profitable for managers, said Osman Ayık, head of the Mediterranean Association of Tourism Hoteliers (AKTOB). ... -Turkish Daily News (subscription), Hoteliers optimistic about tourism in 2007  Jul 5, 2006
Mediterranean Hoteliers Union (AKTOB) President Osman Ayık said on Wednesday that 2007 would be a much better year than 2006 for the tourism sector. ... -Turkish Daily News (subscription)

Occupancy rates decline in Antalya hotels  Jun 23, 2006
Mediterranean Union of Touristic Hoteliers (AKTOB) President Osman Ayuk said the occupancy rate in Antalya hotels had fallen to 60 percent since the year's ... -Turkish Daily News (subscription)

NGOs to apply to ECHR against Lara Project  May 10, 2006
The chairman of the Mediterranean Touristic Hoteliers' Union (AKTOB), Osman Ayik, argued that the proposed changes in the controversial bill aren't tourism ... - New Anatolian

Brand Names/Synonyms:
Aktob is also known by the following brand names and/or synonyms3'-Deoxykanamycin B; Aktob; CHEMBANK2411; Distobram; Gernebcin; NF 6; Nebcin; Nebramycin; Nebramycin 6; Nebramycin Factir 6; Nebramycin Factor 6; Nebramycin Vi; Obracin; Obramycin; T4014; TOBRAMYCIN; Tenebrimycin; Tenemycin; Tobi; Tobracin; Tobradex; Tobradistin; Tobramaxin; Tobramitsetin; Tobramycetin; Tobramycin 98%; Tobramycin Base; Tobramycin Sulfate; Tobrasone; Tobrex

Drug Category:
Aktob is categorized under the following by the FDA: Anti-bacterial Agents; Aminoglycosides; ATC:J01GB01; ATC:S01AA12

Dosage Forms:
Ophthalmic Ointment; POWDER FOR SOLUTION; Solution for oral inhalation; Ophthalmic Solution; Oral Solution; IV Solution

Absorption:
Not Available

Interactions:
Interactions for Tobramycin:

In clinical studies of TOBI, patients taking TOBI concomitantly with dornase alfa (PULMOZYME®, Genentech), (beta)-agonists, inhaled corticosteroids, other anti-pseudomonal antibiotics, or parenteral aminoglycosides demonstrated adverse experience profiles similar to the study population as a whole.

Concurrent and/or sequential use of TOBI with other drugs with neurotoxic or ototoxic potential should be avoided. Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. TOBI should not be administered concomitantly with ethacrynic acid, furosemide, urea, or mannitol.

Chemical IUPAC Name:
4-amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxy-tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol

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