Adenosine

This page contains recent news articles, when available, and an overview of Adenosine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Adenosine
(when available)

Pharmacology and use:
Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine is indicated for the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine. For the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome)

Mechanism Of Action:
Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.

News Articles on Adenosine

ESC: Reversible Antiplatelet Promising for ACS  -  30 Aug 2009
...direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 was associated with fewer strokes, heart attacks, and cardiovascular deaths, MedPage Today

Causes of Diabetes  -  30 Aug 2009
The energy pathway is the means by which the body converts sugars from the diet to ATP (adenosine triphosphate). ATP is the fuel molecule used by the body Examiner.com

Nanoflares Light Up Molecules in Live Cells  -  30 Aug 2009
...and his colleagues demonstrated the utility of their nanoflares by developing a real-time assay for intracellular adenosine triphosphate (ATP), Nanotechnology News (press release)

CombinatoRx Gains Adenosine Agonist Rights in Surprise Deal  -  ‎Aug 13, 2009‎
Clinical Data Inc. entered a collaboration and licensing agreement with CombinatoRx Inc. to develop an adenosine A2A agonist BioWorld Online

Blood Not So Simple: Controversial Hemoglobin Substitutes on Life ...  -  ‎Aug 28, 2009‎
..."One of the FDA's recommendations was that these substitutes use adenosine-modified hemoglobin, which is the core of what HemoBioTech does. Scientific American

Rutgers-Camden developing enzyme function database  -  ‎Aug 26, 2009‎
The $201339 grant will allow Palenchar to track and simplify what has been written about some 130 enzymes, including energy-creators adenosine triphosphate Genetic Engineering News (press release)

ADenosine Administration during and after Primary percutaneous ...  -  ‎Aug 9, 2009‎
Earlier small studies had demonstrated that intracoronary adenosine, due to its vasodilatory effect, is associated with improved myocardial perfusion in Cardiosource

HemoBioTech Gains Congressional Recognition of Its Blood ...  -  ‎Aug 17, 2009‎
Cited in the letter is the use of hemoglobin modified with adenosine as a viable blood substitute. Adenosine modified hemoglobin is a fundamental feature of SYS-CON Media

Changes in adenosine triphosphate-stimulated ATP release suggest ...  -  ‎Aug 12, 2009‎
...activity or blocking adenosine triphosphate (ATP)-purinergic receptors can induce changes in purinergic signaling in interstitial cystitis (IC) cells. UroToday

Apyrase treatment prevents ischemia–reperfusion injury in rat lung ...  -  ‎Aug 20, 2009‎
Objective: Endothelial cells express the ectoenzyme ectonucleoside adenosine triphosphate diphosphohydrolase, an apyrase that inhibits vascular inflammation The Journal of Thoracic and Cardiovascular Surgery

U.Va. researchers team up to develop biotech solutions  -  ‎Aug 7, 2009‎
Human beings burn a compound called adenosine triphosphate, or ATP for short. And while power companies struggle to find ways to deal with the byproducts of Staunton News Leader

The impact of caffeine  -  ‎Aug 17, 2009‎
Quitting suddenly also produces a rebound effect, where the body becomes hypersensitive to its own natural sleep-enhancer, adenosine. Sarasota Herald-Tribune

CYP2C19*2 variant linked with diminished platelet response to ...  -  ‎Aug 25, 2009‎
Twelve percent of the found variation in platelet aggregation to adenosine diphosphate was associated with a linkage disequilibrium between the rs12777823 HemOncToday

Can-Fite BioPharma Licenses Potential Inflammatory Disease Rxs ...  -  ‎Aug 5, 2009‎
According to Can-Fite, allosteric modulators are orally available small molecules that enhance the affinity of the natural ligand adenosine to its A3 GenomeWeb Daily News

Clinical Data Inc. Reports Operating Results (10-Q)  -  ‎Aug 10, 2009‎
This increase was due to the interest of $343000 on the notes issued in connection with the Adenosine Therapeutics acquisition and interest on the GuruFocus.com

Parkinson's Disease: When Cells Run Out Of Fuel  -  ‎Aug 24, 2009‎
The relevance of mitochondria to the loss of neurons seems plausible – after all, mitochondria supply the cells with energy in form of adenosine Science Daily (press release)

Why You Should Have a Waterfall in Your Living Room  -  ‎Aug 26, 2009‎
One is the standard unit of energy, adenosine triphosphate (ATP), which is a sugar-phosphate molecule that both plants and animals make and use to power GreenerDesign.com

Two Life Science Companies Manage to Pry Open IPO Window  -  ‎Aug 16, 2009‎
Massachusetts biotech CombinatoRx struck a collaboration and licensing deal with Clinical Data (CLDA) to develop an adenosine A2A agonist compound in a Seeking Alpha

Supplement review: Creatine  -  ‎Aug 19, 2009‎
ATP donates its P and becomes adenosine di-phosphate (ADP). However, there is only a limited amount of ATP available to the muscle cells and lasts only a Examiner.com

Drilling for Energy in Mitochondrial Disease  -  ‎Aug 10, 2009‎
It provides a buffer of energy availability that is independent of oxygen availability, and the rate of adenosine 5'-triphosphate (ATP) production as well Archives of Neurology

Wayne State Researchers Get $18M Stimulus Funds  -  ‎Aug 16, 2009‎
This project aims to determine the mechanisms mediating the responses to stimulation of NTS adenosine receptor subtypes and the role of these in modulating WWJ

Intelligent Design 'Evidence' Unproven by Real Science Scientists ...  -  ‎Aug 28, 2009‎
They are the cell's power plants, synthesizing the essential ATP (adenosine-triphosphate) nucleotide, without which nothing in the body can function. Softpedia

Genomic Study Yields Plausible Cause Of Colony Collapse Disorder  -  ‎Aug 24, 2009‎
Ribosomes are the factories in which proteins are made, but Johnson observed that this rRNA contained adenosine-rich sequences not seen in normal ribosomes. Science Daily (press release)

Evolution's Place? 3 (RJS)  -  ‎Aug 27, 2009‎
Many experiments have tested possible mechanisms for the formation of the building blocks of life, adenosine, ribose, amino acids, carbon chains. Beliefnet.com

Sulfonylurea-Induced Insulin Release  -  ‎Aug 25, 2009‎
They act on sulfonylurea receptors, which are the regulatory subunits of adenosine triphosphate (ATP)–sensitive potassium ion (K ATP ) channels and cause Science Now

This Month in Archives of Neurology  -  ‎Aug 10, 2009‎
Sgarbi and colleagues (SEE ARTICLE) report that adenosine triphosphate synthase–deficient cells can be rescued by increasing mitochondrial substrate-level Archives of Neurology

Visualizing the DNA helix with cryoEM  -  ‎Aug 25, 2009‎
Each edge is a 7 nm, 20 base pair duplex, and the edges are connected covalently through single unpaired adenosine nucleotides, making it a rigid, Nanowerk LLC

URS 2009 - Urothelium-derived inhibitory factors and the human ...  -  ‎Aug 24, 2009‎
This urothelium-derived inhibitory factor remains unidentified but is not nitric oxide, a prostaglandin, ATP or adenosine. Whether changes in the release UroToday

Why muscle sugar, D-ribose is taken by athletes & autoimmune ...  -  ‎Aug 22, 2009‎
You should know that ATP stands for adenosine triphosphate. ATP is the "body's basic cellular fuel," according to the book, Reverse Heart Disease Now, Examiner.com

Researchers hail M&M's blue hue  -  ‎Aug 9, 2009‎
The new findings build on earlier research by the same scientists that showed adenosine triphosphate, a chemical that keeps the body's cells alive, Detroit Free Press

HEALTH CARE AND GREEN TEA  -  ‎Aug 25, 2009‎
...you should not drink green tea or take green tea extract without first talking to your health care provider: Adenosine, Antibiotics, Beta-lactam, The Cypress Times

cGMP-dependent protein kinase Ialpha associates with the ...  -  ‎Aug 5, 2009‎
We have shown that neuronal A3 adenosine receptor activation leads to enhanced presynaptic 5-HT transport in vitro and an increased rate of SERT-mediated 7thSpace Interactive (press release)

IG subpoenas Gilead marketing documents; Baxter loses fight for ...  -  ‎Aug 17, 2009‎
CombinatoRx has agreed to pay up to $257 million for the licensing rights to Clinical Data's multiple myeloma treatment, an adenosine A2A agonist dubbed FiercePharma

Wake Up and Smell the Coffee: Caffeine Has Its Benefits  -  ‎Aug 19, 2009‎
It acts as an antagonist of certain adenosine receptors in the brain. By doing so, it acts as if it is a competitive inhibitor. It has also shown to cause Alternative Health Journal

Screening for Asymptomatic Coronary Artery Disease in Patients ...  -  ‎Aug 18, 2009‎
In addition, half of the participants were unable to perform low-level exercise during the adenosine infusion, 22% were using insulin, and 60% had 2 or more Journal of American Medical Association (subscription)

TNF blockers get child cancer warning; DOR drug gets orphan status;  -  ‎Aug 5, 2009‎
...a small molecule activator of AMPK (adenosine monophosphate activated protein kinase) for the treatment of diabetes and metabolic diseases. FierceBiotech

IRadimed Announces 510K Clearance of the New Non-Magnetic MRidium ...  -  ‎Aug 17, 2009‎
...for the MRI - making it an indispensable tool for delivery of critical medications such as Dobutamine, Adenosine, Propofol, and Dexmedetomidine. PR Newswire (press release)

Kidney specialist Adrian Katz, MD, 1932-2009  -  ‎Aug 20, 2009‎
In the late 1960s, he published a series of landmark studies on the enzyme sodium-potassium-activated adenosine triphosphatase, which triggered decades of Media Newswire (press release)

Cardiovascular MR used in workup for myocarditis, various ...  -  ‎Aug 12, 2009‎
According to the registry results, 21% of patients underwent adenosine perfusion and 11% underwent high-dose dobutamine CMR. Cardiology Today

Nutritional Supplement Offers Promising Results for Tired Baby Boomers  -  ‎Aug 25, 2009‎
D-ribose is a naturally occurring five-carbon sugar the body uses as the foundation for adenosine triphosphate (ATP)—the compound that carries energy NPIcenter (press release)

Clinical Data Inc and CombinatoRx team to develop novel B-cell ...  -  ‎Aug 14, 2009‎
Under the agreement Clinical Data has licensed its highly selective adenosine A2A agonist, ATL313, to CombinatoRx. In exchange Clinical Data has the Trading Markets (press release)

DotW: Sideshow  -  ‎Aug 14, 2009‎
CombinatoRx is teaming up with Clinical Data to test the latter's preclinical adenosine A2A agonist, ATL313, in a combination treatment for multiple The IN VIVO Blog

Nonsteroidal Anti-Inflammatory Drugs in Orthopaedics  -  ‎Aug 3, 2009‎
Prostaglandin E2 is the most abundant prostaglandin produced by osteoblasts and was first shown to increase cyclic 3',5' adenosine monophosphate (cAMP) and Journal of Bone and Joint Surgery (subscription)

Researchers affirm efficacy of bitter kola in respiratory diseases  -  ‎Aug 19, 2009‎
Furthermore, they review reported that xanthone causes increase in the level of intracellular cyclic adenosine 3', 5'-monophosphate (cAMP) but not cyclic The Guardian - Nigeria

Chemical Pathology of Homocysteine. IV. Excitotoxicity, Oxidative ...  -  ‎Aug 10, 2009‎
According to the adsorption-induction theory, cytoplasmic calcium influx leads to depletion of cellular adenosine triphosphate (ATP) by reaction with Annals of Clinical & Laboratory Science (subscription)

Prevalence and Risk Factors for Aspirin and Clopidogrel Resistance ...  -  ‎Aug 10, 2009‎
A point-of-care analyzer, VerifyNow (Accumetrics, San Diego, CA), was used to measure adenosine-5-diphosphate and platelet P2YI2 receptor blockage to Annals of Clinical & Laboratory Science (subscription)

Tennis: Ice BathTheory  -  ‎Aug 9, 2009‎
Our food is made of carbohydrates—and it is in the mitochondria that the food is broken down into the ATP (Adenosine Tri-Phosphate)—which is a form of Bleacher Report

Debiopharm Backs Mercury's Preclinical Antidiabetic  -  ‎Aug 4, 2009‎
Debio 0930 is a small molecule activator of AMPK (adenosine monophosphate activated protein kinase). It is being developed to treat type 2 diabetes and Genetic Engineering News (press release)

www.PicksThatMove.com: "Picks that move" Alerts, August 6, 2009 ...  -  ‎Aug 6, 2009‎
...the identification of novel kinase inhibitors that are potent, selective and do not compete with ATP (adenosine triphosphate) for binding to the kinase. TMCnet

The Sandbox: Parent-Child Relationships in EMS  -  ‎Aug 6, 2009‎
The ER doc to whom I brought the first patient said that I was correct to shock the lady with SVT rather than first trying adenosine. EMS1.com - Emergency Medical Service Resources

Brand Names/Synonyms:
Adenosine is also known by the following brand names and/or synonyms2'-Deoxyadenosine; Adenine Deoxy Nucleoside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Adenine Nucleoside; Adenine Riboside; Adenocard; Adenocor; Adenoscan; Adenosin; Adenosine; Adenosine 99%; Adenosine for Biochemistry; Adenosine, Free Base; Adensoine; Adenyldeoxyriboside; Boniton; CCRIS 1782; Da; Deoxyadenosine; Desoxyadenosine; Myocol; Nucleocardyl; Sandesin; Usaf Cb-10

Drug Category:
Adenosine is categorized under the following by the FDA: Vasodilator Agents; Antiarrhythmic Agents; Analgesics; Cardiac drugs; ATC:C01EB10

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Interactions for Adenosine:

Intravenous Adenocard (adenosine) has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile. Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adenocard should be used with caution in the presence of these agents. The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.

The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. Adenosine effects are potentiated by dipyridamole. Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. Carbamazepine has been reported to increase the degree of heart block produced by other agents. As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.





Chemical IUPAC Name:
2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

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