Acyclovir

This page contains recent news articles, when available, and an overview of Acyclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Acyclovir (when available)

Pharmacology and use:
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox

Mechanism Of Action:
Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts acyclovir to the acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

News Articles on Acyclovir

Is BioAlliance An Attractive Investment?  -  ‎Apr 16, 2009‎
1.) acceptance of US filing for Loramyc® in the United States: Q2 2009. 3.) completion of the first Phase III trial of acyclovir Lauriad in Europe: H2 2009. istockAnalyst.com (press release)

Evaluation of the in vitro skin permeation of antiviral drugs from ...  -  ‎Apr 2, 2009‎
This study evaluates the in vitro skin permeation and penetration of penciclovir and acyclovir from commercialized creams for the treatment of herpes 7thSpace Interactive (press release)

Natural treatments for shingles  -  ‎Apr 9, 2009‎
A double-blind study of 190 people with shingles compared proteolytic enzymes with the conventional drug acyclovir. After 14 days of treatment, Examiner.com

Shingles more painful in elderly  -  ‎Apr 6, 2009‎
We give patients acyclovir, famvir and valacycovir. They are FDA-approved anti-viral drugs that decrease the shedding of the virus, shorten the life span of Baltimore Sun

Excess Sweating  -  ‎Apr 13, 2009‎
These include tricyclic and serotonin reuptake inhibitors, opioid analgesics, acyclovir, and naproxen. It is important to know if there are any triggers eMaxHealth.com

Topic of the week ¿ cold sores  -  ‎Apr 11, 2009‎
Creams containing the antivirals penciclovir or acyclovir are available from chemists. Apply as early as possible, at the first sensation of tingling. Melbourne Herald Sun

다제내성 결핵치료제 '오구멘틴정' 급여등재  -  ‎Mar 29, 2009‎
...단순�?�진�? �?�한 �?막염�?� 재발시 기존 항바�?�러스제(acyclovir)로 치료가 잘 �?�지 않고 실명 등 치명�?�?� 결과를 초래할 수 있으므로 팜비어정250mg�?� 투여를 �?�정 Medical Today

Bruk av aciklovir krem under graviditet.  -  ‎Apr 2, 2009‎
Pregnancy outcomes following systemic prenatal acyclovir exposure: Conclusions from the international acyclovir pregnancy registry, 1984-1999. RELIS

�?�아 '발트렉스', 팜비어 제치고 1위 등극  -  ‎Mar 30, 2009‎
...기존 Acyclovir�?� Prodrug으로 기존 Acyclovir�?� 1�?� 4정씩 5회 복용하는�?� 반해 하루 2정 3회 복용하는 간편함으로 환�?�?� 순�?��?�를 높�?��?�다 특히 대�?�?�진환�?�?� 데일리팜

Bệnh thủy đậu: Những đi�?u cần biết  -  ‎Apr 6, 2009‎
Bôi kem acyclovir 5% để giảm ngứa, hạn chế thương tổn và bội nhiễm. - Khi nốt ph�?ng vỡ, bôi thuốc xanh methylen để bớt nhức, làm se nốt, và ngừa bội nhiễm Báo Hoà Bình

Ganciclovir may be used during intravenous acyclovir shortage  -  ‎Feb 27, 2009‎
Manufacturers of acyclovir for injection have experienced a recent increase in demand, resulting in a national shortage of parenteral acyclovir. AAP News (subscription)

Protecting Partners from Herpes  -  ‎Mar 13, 2009‎
Acyclovir, a medication for herpes, can reduce the risk of spreading herpes to partners and reduce the number of outbreaks. Gay.com UK

Abstracts: In Other Archives Journals  -  ‎Mar 16, 2009‎
Whereas the diagnosis of this condition is often straightforward, choosing an appropriate drug (eg, acyclovir, valacyclovir hydrochloride, or famciclovir) Archives of Facial Plastic Surgery

BioAlliance Pharma SA : Full-Year Accounts for 2008  -  ‎Mar 5, 2009‎
...with finalization of the Phase III Loramyc® trial in the United States, the Phase III trial on acyclovir Lauriad® (BA021) and acquisition of Europe-wide Earthtimes (press release)

Symptoms and Complications  -  ‎Mar 4, 2009‎
Antiviral medication, such as acyclovir*, may help if taken early in the course of the illness. They are appropriate for high-risk people, including those MyFox Atlanta

Does reperfusion injury still cause significant mortality after ...  -  ‎Mar 11, 2009‎
After completion of ganciclovir, CMV prophylaxis was maintained with acyclovir (800 mg 4 times daily). In the setting of donor CMV + /recipient CMV – The Journal of Thoracic and Cardiovascular Surgery

Depression, cardiac mortality and all-cause mortality  -  ‎Feb 27, 2009‎
...immunosuppressants (such as β-interferon and acyclovir), calcium channel blockers, levodopa, thiazide diuretics and anticonvulsants such as phenytoin. Adv Psychiatric Treat (subscription)

Do away with chickenpox  -  ‎Feb 28, 2009‎
...his siblings and get him to wash his hands frequently. Acyclovir, an antiviral agent, is only effective when given during the early stages of the infection. Malaysia Star

Shingles is a viral infection that shouldn’t be ignored  -  ‎Mar 7, 2009‎
When diagnosed in an early stage antiviral drugs like acyclovir can bring some relief, but not always and these drugs are very expensive. BCLocalNews

Measures to control disease at IDP camps  -  ‎Feb 28, 2009‎
...“We are using the acyclovir vaccine to control the spread of disease.�? Vavuniya Government Agent Mrs. PSM Charles told The Sunday Times that permanent Sunday Times.lk

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Prophylactic Acyclovir Prevents Herpes Zoster Outbreaks During ...  -  Jan 23, 2009
More than 80% received routine prophylactic acyclovir 400 mg daily. The remainder received acyclovir 200 mg daily, valacyclovir 250/500 mg daily or Cancerpage.com,

buy cheap acyclovir online without a prescription  -  Jan 10, 2009
Acyclovir is used for treating chickenpox (varicella) or shingles (herpes zoster) and treating or suppressing genital herpes infections. Denver Post,

What treatments work for cold sores?  -  Jan 21, 2009
Oral acyclovir to suppress frequently recurrent herpes labialis: a double-blind, placebo-controlled trial. Annals of Internal Medicine. 1993; 118: 268-272. guardian.co.uk,

Natural Cold Sore Remedies  -  Jan 26, 2009
Conventional medical care may involve the drug Acyclovir for symptom control. It's important to realize that this drug will not cure the herpes virus, Natural News.com,

What are the symptoms of chickenpox?  -  Jan 21, 2009
Acyclovir for treating varicella in otherwise healthy children and adolescents (Cochrane review). In: The Cochrane Library. Wiley, Chichester, UK. guardian.co.uk,

What will happen to me?  -  Jan 21, 2009
Oral acyclovir to suppress frequently recurrent herpes labialis: a double-blind, placebo-controlled trial. Annals of Internal Medicine. 1993; 118: 268-272. guardian.co.uk,

Sirion Therapeutics New Drug Application for Ganciclovir is ...  -  Jan 26, 2009
The studies found that ganciclovir is as effective as acyclovir and that the tolerability of ganciclovir was superior to acyclovir, particularly with regard PR Newswire (press release),

Dr. Tammy's latest blog entry: A Week in My Life  -  Jan 12, 2009
...trial meaning that it is an already approved medication that is being studied in larger populations.The trial is with a medicine very similar to acyclovir. Baxter Bulletin,

Should We Test for Herpes Simplex Virus During Routine Evaluation ...  -  Jan 29, 2009
...[1] In fact, 2 editorials were published, with slightly different takes on which infants should receive empirical treatment with acyclovir. Medscape

FDA Goes Global to Stop Unsafe Food and Drug Imports  -  Jan 19, 2009
...including formulations of acyclovir, ciprofloxacin, and simvastatin, made at two Ranbaxy Laboratories plants in India, from entering the United States. MedPage Today,

Pharmacies question NAMAF drug list  -  Jan 15, 2009
De Jager gave examples of the common HIV and herpes treatment drugs, Adco-Acyclovir and Cyclivex, manufactured by pharmaceutical companies Adco and APM, Informante,

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BioAlliance Pharma Publishes Its 2009 Financial Calendar  -  Jan 15, 2009
The company is also performing a Phase III trial in labial herpes with acyclovir Lauriad ® (which is based on the same Lauriad® muco-adhesive technology as WELT ONLINE,

What treatments work for Bell's palsy?  -  Jan 21, 2009
Early treatment with prednisolone or acyclovir in Bell's palsy. New England Journal of Medicine. 2007; 357: 1598-607. Engström M, Berg T, guardian.co.uk,

Face the facts when dealing with genital herpes  -  Jan 10, 2009
There are three oral antiviral drugs — acyclovir, valacyclovir and famciclovir — approved for the treatment of genital herpes. Philippine Star,

Herpes Zoster Alert  -  Jan 15, 2009
Acyclovir (Zovirax), the oldest agent, differs from the other drugs in that it must be taken five times a day rather than three. ADVANCE for Physician Assistants,

Your Life: Your Lost Sense Of Smell Is Not To Be Sniffed At  -  Jan 10, 2009
Buy acyclovir cream and use it the next time you feel the affected area tingling. It is not a cure it but will lessen the severity of the outbreak. Glasgow Sunday Mail,

Nueva crema desactiva virus del herpes: estudio EEUU  -  Jan 22, 2009
Acyclovir y drogas relacionadas pueden suspender los síntomas y están disponibles como cremas o píldoras, pero no se ha demostrado que logren prevenir la Buena Salud

Habría forma de prevenir el herpes vaginal  -  Jan 22, 2009
Acyclovir y drogas relacionadas pueden suspender los síntomas y están disponibles como cremas o píldoras, pero no se ha demostrado que logren prevenir la El Mercurio OnLine (Chile),

Lectroject Herpes Device ‘Could Hold The Key’ To Treating HIV  -  Dec 4, 2008
Acyclovir cream enters the body through two electrodes, which are applied either to the wrists or to the top and bottom of the spine, depending on whether WebWire (press release),

Canada: Canada: The IP Year 2008 In Review: Patents (Part 1 of 3)  -  Dec 23, 2008
At issue were two of GSK's Canadian patents, one of which covered amino acid esters of the antiviral compound acyclovir; the other, the selection patent, Mondaq News Alerts (registration),

Cold-sore virus linked to Alzheimer's  -  Dec 6, 2008
The preliminary findings suggest cheap antiviral drugs such as acyclovir or Zovirax, could be used to slow or even prevent Alzheimer's, the Times reported. United Press International

BioAlliance Pharma Adopts the AFEP-MEDEF Guidelines on Executive ...  -  Dec 23, 2008
The company is also performing a Phase III trial in labial herpes with acyclovir Lauriad® (which is based on the same Lauriad® muco-adhesive technology as PharmaLive.com (press release),

Alzheimer's and Autism  -  Dec 16, 2008
Another striking similarity is that the researchers have used acyclovir, an anti-viral drug used by many children with autism as a way to ameliorate some of Age of Autism,

New vaccine policy recommended for older Americans  -  Dec 9, 2008
Acyclovir (Zovirax) has been the mainstay among the antivirals, but it needs to be taken five times a day. Valacyclovir (Valtrex) only needs to be taken Buffalo News,

Herpes treatment options  -  Dec 18, 2008
Herpes treatment options include: Acyclovir (Zovirax): This is the oldest and there is a generic of this medication so it is cheaper. MayoClinic.com

Medivir: Marketing Authorization Application for Lipsovir® now ...  -  Dec 7, 2008
Lipsovir® is a patented combination of hydrocortisone (an anti-inflammatory agent) and acyclovir (an antiviral agent) in a proprietary cream base developed WELT ONLINE,

Bioresearch firm counts on a cure  -  Nov 30, 2008
...“We tried acyclovir; we tried immunoglobulin. Nothing was helping until we got permission to use ST-246,�? he says. Though smallpox has been virtually Crain's New York Business,

Alzheimer : Existing antiviral drugs may help treat Alzheimer’s ...  -  Dec 15, 2008
The new findings are significant in view of the fact that cheap antiviral drugs that can control HSV1 infections, such as acyclovir or Zovirax, Entertainment and Showbiz!,

수술�? 복�?술 6개월후 콘드론 사용가능  -  Dec 16, 2008
...아울러 수�?성 �??렴 �?병�? acyclovir 주사제를 15�?�간 투여하고 다시 경구제로 변경 투여한 사례�? 대해 10�?�간 투여�?� 주사제만�?� 급여로 �?�정하고 �?�후�?� 주사제, 디지틀보사,

Vírus de herpes ligado a Alzheimer  -  Dec 8, 2008
A descoberta, publicada no Journal of Pathology, abre a porta, segundo os próprios cientistas, a um tratamento à base de acyclovir, antiviral utilizado para Diário de Notícias - Lisboa,

Ο ιός του επιχείλιου έ�?πητα ίσως ευθ�?νεται για το Αλτσχάιμε�?!  -  Dec 8, 2008
Φθηνά φά�?μακα όπως τα acyclovir και zovirax μπο�?ο�?ν να ελέγξουν τις μολ�?νσεις από ΗSV1 και είναι α�?κετά ασφαλή ώστε να χο�?ηγο�?νται χω�?ίς συνταγή. Τα �?έα Οnline,

3, 2, 1... ooo ps, mi è spuntato un brufolo!  -  Dec 17, 2008
Febbre del labbro: se sentite che sta arrivando, fatevi prescrivere al più presto la crema all’acyclovir, e applicatela subito, anche 8 volte al giorno, Style.it,

BioAlliance Pharma : Arkéon Finance étudie le plan de réorganisation  -  Dec 5, 2008
Pharmaceutical et plusieurs millions d'Euros résultant d'un accord avec un laboratoire pharmaceutique pour commercialiser l'acyclovir Lauriad en ville. Boursier.com,

BioAlliance Pharma : va devoir réduire la voilure  -  Dec 3, 2008
...lancement de quatre produits : Loramyc aux Etats-Unis, ondansetron RapidFilmTM, ondansétron 0S (Oral Spray) et acyclovir Lauriad", rappelle le groupe. Boursier.com,

A herpeszgyógyszerrel megelőzhető az öregkori elbutulás?  -  Dec 8, 2008
A tudósok ráadásul arra is rámutattak, hogy a herpesz ellen javasolt gyógyszerek (mint az acyclovir) hatásosak lehetnek az öregkori elbutulás megelőzésére Híradó,

�?�医师信箱: 认识颜�?�神�?麻痹  -  Dec 4, 2008
...若�?�现是带状疱疹病毒感染，�?�以并用抗病毒�?�（Acyclovir �?�洋商报,

헤르페스 약으로 치매를 치료한다?  -  Dec 8, 2008
...�?� 연구가 입�?�?� 경우 오래전부터 단순�?�진 치료제로 사용�?�면서 효과와 안전성�?� �?�미 입�?�?� 아시�?�로비르(acyclovir /Zovirax) 같�?� 항바�?�러스제로 치매를 치료할 헬스코리아뉴스,

Camomilla attiva sull'herper genitale  -  Dec 2, 2008
...nei confronti di questo virus riguardano una terapia farmacologica a base di antivirali di sintesi, e per l’esattezza di acyclovir e dei suoi derivati. BenessereBlog.it,

Epilepsy drug shows potential for Alzheimer’s treatment  -  Dec 11, 2008
Neurons passing electrical signalsA drug commonly used to treat epilepsy could help clear the plaques in the brain associated with Alzheimer’s disease, PR-CANADA.net (press release),

Brand Names/Synonyms:
Acyclovir is also known by the following brand names and/or synonymsAC2; Aciclovier; Aciclovir; Acycloguanosine; Acyclovir; Acyclovir Sodium; Alti-Acyclovir; Avirax; BW-248U; Valtrex; Vipral; Virorax; Wellcome-248u; Zovirax; Zovirax Wellstat Pac; Zovirax Zostab Pac

Drug Category:
Acyclovir is categorized under the following by the FDA: Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB

Dosage Forms:
Intravenous Infusion; Capsules; Tablets; Suspension; Topical Cream; Topical Ointment

Absorption:
Oral _ Bioavailability 10 to 20%

Interactions:
Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced. The clinical effects of this combination have not been studied.

Chemical IUPAC Name:
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

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