Acyclovir

This page contains recent news articles, when available, and an overview of Acyclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Acyclovir
(when available)

Pharmacology and use:
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox

Mechanism Of Action:
Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts acyclovir to the acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

News Articles on Acyclovir

Sexual roulette and the single mom: genital herpes sores boost ...  -  ‎Aug 28, 2009‎
The anti-herpes drug acyclovir did not reduce the risk of acquiring sexually transmitted HIV when given to men and women infected with herpes simplex Examiner.com

Phase III Trial with BioAlliance's Orofacial Herpes Therapy Shows ...  -  ‎Aug 26, 2009‎
BioAlliance Pharma reported positive preliminary results from a Phase III trial evaluating acyclovir Lauriad®, its mucooadhesive buccal tablet for the Genetic Engineering News (press release)

French and Benelux stocks - Factors to watch on Aug 26  -  ‎Aug 26, 2009‎
The French biotechnology company announced posititive preliminary results of a final stage key clinical trial with herpes treatment Acyclovir Lauriad. Forbes

Why Treated Genital Herpes Boosts HIV Risk  -  ‎Aug 17, 2009‎
The researchers also took biopsies from four of the patients when herpes lesions reappeared and the patients underwent treatment with oral acyclovir. eMaxHealth

Medivir: cold sore treatment faces generic threat  -  ‎Aug 4, 2009‎
The drug is a combination of an anti-inflammatory agent hydrocortisone and acyclovir, an antiviral. The FDA's approval of Lipsovir was based on the outcome Trading Markets (press release)

FDA approves new drug for treatment of cold sores  -  ‎Aug 7, 2009‎
Lipsovir (Medivir AB) is a patented combination of hydrocortisone (an anti-inflammatory agent) and acyclovir (an antiviral) intended for the topical Examiner.com

Herpes healing comes in numbers  -  ‎Aug 3, 2009‎
Treatment: Daily suppression medications like Valtrex, Famvir and Acyclovir can reduce the severity and frequency of outbreaks, or blisters, that can spread News & Observer

VivaGel Demonstrates Anti-HIV and Herpes Activity Following Human ...  -  ‎Aug 4, 2009‎
Starpharma Holdings Limited (ASX:SPL, OTCQX:SPHRY) today announced the results of its clinical trial demonstrating that VivaGel® retains antiviral activity PharmaLive.com (press release)

Federer y Murray disputarán una de las semifinales del Masters de ...  -  ‎Aug 21, 2009‎
...prescribing information buy mg phentermine order phentermine prescription Systemic exposure following topical administration of acyclovir is minimal. La Prensa Gráfica

Confounded by a virus  -  ‎Aug 27, 2009‎
Treatment with antiviral medications, such as acyclovir or famciclovir, is recommended for seven to ten days, along with strong anti-inflammatory drugs Express Buzz

Outcome Announces Commentary, Co-Authored with NICE, on Registries ...  -  ‎Aug 18, 2009‎
Following safety data from the acyclovir (a treatment for infections caused by the herpes viruses) pregnancy registry, the US Food and Drug Administration Business Wire (press release)

Atypical Herpes Zoster Infection Preceded by Sciatica and Foot Drop  -  ‎Aug 17, 2009‎
The patient received treatment with intravenous acyclovir, 10 mg/kg (600 mg), every 8 hours while also receiving 40 mg/d of prednisone. Archives of Dermatology

Modalities to Decrease Stromal Herpes Simplex Keratitis ...  -  ‎Aug 10, 2009‎
All patients continued the use of oral acyclovir or valacyclovir hydrochloride and topical steroids. The frequency and duration of HSK recurrences were Archives of Ophthalmology

FDA blocks Teva from selling vet drugs and warns Apotex  -  ‎Aug 6, 2009‎
Two rejected batches of the antiviral acyclovir may have been shipped to the US, it said. The latest FDA actions follow seizures of medicines and a shutdown Pharmafocus

www.standoutstocks.com: stocks That Standout For August 11th, 2009 ...  -  ‎Aug 11, 2009‎
Existing therapies include acyclovir and drugs chemically related to it. These drugs, nucleoside analogs, act by inhibiting viral DNA synthesis. Trading Markets (press release)

NanoViricides, Inc. Anti-Herpes Drug Candidate Reduces Viral Load ...  -  ‎Aug 10, 2009‎
Existing therapies include acyclovir and drugs chemically related to it. These drugs, nucleoside analogs, act by inhibiting viral DNA synthesis. FOXBusiness

www.standoutstocks.com: Stocks That Standout For August 11th, 2009 ...  -  ‎Aug 11, 2009‎
Existing therapies include acyclovir and drugs chemically related to it. These drugs, nucleoside analogs, act by inhibiting viral DNA synthesis. Trading Markets (press release)

BioAlliance Pharma : le titre reprend son souffle  -  ‎Aug 26, 2009‎
...le groupe a fait part ce matin de résultats préliminaires positifs concernant son essai pivot de phase III dans l'herpès labial avec acyclovir Lauriad. Challenges

Má»™t số Ä‘iá»?u cần biết vá»? bệnh mụn rá»™p sinh dục  -  ‎Aug 26, 2009‎
Dù là bị nhiễm lần đầu hay tái phát thì dùng thuốc chống virut (acyclovir) theo đư�ng toàn thân trong 10 ngày cũng có thể hạn chế được cư�ng độ và th�i gian Tin nhanh

Kinh nghiệm chữa bệnh viêm nang lông  -  ‎Aug 23, 2009‎
Ä?i khám bác sÄ© bảo bị bệnh Zona và cho chữa bằng thuốc Acyclovir. Xin há»?i nguyên nhân và cách Ä‘iá»?u trị bệnh này? Bệnh thá»§y đậu ở trẻ em và bệnh Zona Ä‘á»?u do Nông Nghiệp

护士内科护ç?†å­¦è¾…导:ç—…  -  ‎Aug 19, 2009‎
...对乙型è‚?炎病毒有抑制作用的è?¯ç‰©æœ‰å¹²æ‰°ç´ ï¼ˆinterferonã€?IFN)ã€?阿糖腺苷(Ara-Aã€?vidarabine)ã€?一磷酸阿糖腺苷(Ara-AMP)ã€?阿昔洛韦(无环鸟苷acyclovir)ã€?磷 青年人

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Buy Acyclovir. Acyclovir order online  -  ‎Jun 30, 2009‎
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REBECCA ADLINGTON: Olympic gold? After what she's been through ...  -  ‎Jul 11, 2009‎
Acyclovir, an antiviral drug, is administered to lessen the possibility of brain damage while exhaustive tests are carried out to determine the strain of Daily Mail

Wheeling doctor says he's not responsible for woman's eye problem  -  ‎Jun 17, 2009‎
In addition, he ordered her to take Acyclovir 800 mgm orally five times a day, the suit states. However, Snider says she continued to experience problems West Virginia Record

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I can't help wondering...  -  ‎Jun 25, 2009‎
But her counts have been stable, the IVIGs and Acyclovir have made the world of difference and generally she was being just a typical child. The Dominion Post

Valacyclovir-Induced Psychosis and Manic Symptoms in an Adolescent ...  -  ‎Jun 30, 2009‎
Three medications, acyclovir, valacyclovir, and famciclovir, have been shown to reduce the duration and severity of the disease. Psychosomatics (subscription)

Antiviral Agents May Not Be Helpful for Treatment of Bell's Palsy  -  ‎Jun 18, 2009‎
..."The therapeutic drug choices for the treatment of the idiopathic facial paralysis are (1) corticosteroids, (2) antiviral therapy (acyclovir sodium or Medscape

Quicker cold sore relief?  -  ‎Jun 27, 2009‎
The pills are oral acyclovir (Zovirax), famciclovir (Famvir) and valacyclovir (Valtrex).]The ointments are penciclovir (Denavir) or acyclovir cream. KXXV News Channel 25

Severe drug shortage in Govt. hospitals  -  ‎Jul 4, 2009‎
Gentamicine (used during operations and to treat infections), and Acyclovir (used for chicken pox) are among the essential drugs and vaccines which are Nation on Sunday

Combination Therapy Effective for Previously Untreated Waldenström ...  -  ‎Jun 23, 2009‎
...zoster prophylaxis with either valcyclovir or acyclovir proved effective in all but one patient (who did not fill her prescription for valcyclovir). Cancerpage.com

Is BioAlliance An Attractive Investment?  -  ‎Apr 16, 2009‎
1.) acceptance of US filing for Loramyc® in the United States: Q2 2009. 3.) completion of the first Phase III trial of acyclovir Lauriad in Europe: H2 2009. istockAnalyst.com (press release)

Evaluation of the in vitro skin permeation of antiviral drugs from ...  -  ‎Apr 2, 2009‎
This study evaluates the in vitro skin permeation and penetration of penciclovir and acyclovir from commercialized creams for the treatment of herpes 7thSpace Interactive (press release)

Natural treatments for shingles  -  ‎Apr 9, 2009‎
A double-blind study of 190 people with shingles compared proteolytic enzymes with the conventional drug acyclovir. After 14 days of treatment, Examiner.com

Shingles more painful in elderly  -  ‎Apr 6, 2009‎
We give patients acyclovir, famvir and valacycovir. They are FDA-approved anti-viral drugs that decrease the shedding of the virus, shorten the life span of Baltimore Sun

Excess Sweating  -  ‎Apr 13, 2009‎
These include tricyclic and serotonin reuptake inhibitors, opioid analgesics, acyclovir, and naproxen. It is important to know if there are any triggers eMaxHealth.com

Topic of the week ¿ cold sores  -  ‎Apr 11, 2009‎
Creams containing the antivirals penciclovir or acyclovir are available from chemists. Apply as early as possible, at the first sensation of tingling. Melbourne Herald Sun

다제내성 결핵치료제 '오구멘틴정' 급여등재  -  ‎Mar 29, 2009‎
...단순�진� �한 �막염� 재발시 기존 항바�러스제(acyclovir)로 치료가 잘 �지 않고 실명 등 치명�� 결과를 초래할 수 있으므로 팜비어정250mg� 투여를 �정 Medical Today

Bruk av aciklovir krem under graviditet.  -  ‎Apr 2, 2009‎
Pregnancy outcomes following systemic prenatal acyclovir exposure: Conclusions from the international acyclovir pregnancy registry, 1984-1999. RELIS

ë?™ì•„ '발트렉스', 팜비어 제치고 1위 등극  -  ‎Mar 30, 2009‎
...기존 Acyclovirì?˜ Prodrug으로 기존 Acyclovirì?˜ 1ì?¼ 4정씩 5회 복용하는ë?° 반해 하루 2ì • 3회 복용하는 간편함으로 환ìž?ì?˜ 순ì?‘ë?„를 높ì?¸ë?°ë‹¤ 특히 대ìƒ?í?¬ì§„환ìž?ì?˜ 데일리팜

Bệnh thá»§y đậu: Những Ä‘iá»?u cần biết  -  ‎Apr 6, 2009‎
Bôi kem acyclovir 5% để giảm ngứa, hạn chế thương tổn và bá»™i nhiá»…m. - Khi nốt phá»?ng vỡ, bôi thuốc xanh methylen để bá»›t nhức, làm se nốt, và ngừa bá»™i nhiá»…m Báo Hoà Bình

Ganciclovir may be used during intravenous acyclovir shortage  -  ‎Feb 27, 2009‎
Manufacturers of acyclovir for injection have experienced a recent increase in demand, resulting in a national shortage of parenteral acyclovir. AAP News (subscription)

Protecting Partners from Herpes  -  ‎Mar 13, 2009‎
Acyclovir, a medication for herpes, can reduce the risk of spreading herpes to partners and reduce the number of outbreaks. Gay.com UK

Abstracts: In Other Archives Journals  -  ‎Mar 16, 2009‎
Whereas the diagnosis of this condition is often straightforward, choosing an appropriate drug (eg, acyclovir, valacyclovir hydrochloride, or famciclovir) Archives of Facial Plastic Surgery

BioAlliance Pharma SA : Full-Year Accounts for 2008  -  ‎Mar 5, 2009‎
...with finalization of the Phase III Loramyc® trial in the United States, the Phase III trial on acyclovir Lauriad® (BA021) and acquisition of Europe-wide Earthtimes (press release)

Symptoms and Complications  -  ‎Mar 4, 2009‎
Antiviral medication, such as acyclovir*, may help if taken early in the course of the illness. They are appropriate for high-risk people, including those MyFox Atlanta

Does reperfusion injury still cause significant mortality after ...  -  ‎Mar 11, 2009‎
After completion of ganciclovir, CMV prophylaxis was maintained with acyclovir (800 mg 4 times daily). In the setting of donor CMV + /recipient CMV – The Journal of Thoracic and Cardiovascular Surgery

Depression, cardiac mortality and all-cause mortality  -  ‎Feb 27, 2009‎
...immunosuppressants (such as β-interferon and acyclovir), calcium channel blockers, levodopa, thiazide diuretics and anticonvulsants such as phenytoin. Adv Psychiatric Treat (subscription)

Do away with chickenpox  -  ‎Feb 28, 2009‎
...his siblings and get him to wash his hands frequently. Acyclovir, an antiviral agent, is only effective when given during the early stages of the infection. Malaysia Star

Shingles is a viral infection that shouldn’t be ignored  -  ‎Mar 7, 2009‎
When diagnosed in an early stage antiviral drugs like acyclovir can bring some relief, but not always and these drugs are very expensive. BCLocalNews

Measures to control disease at IDP camps  -  ‎Feb 28, 2009‎
...“We are using the acyclovir vaccine to control the spread of disease.� Vavuniya Government Agent Mrs. PSM Charles told The Sunday Times that permanent Sunday Times.lk

Brand Names/Synonyms:
Acyclovir is also known by the following brand names and/or synonymsAC2; Aciclovier; Aciclovir; Acycloguanosine; Acyclovir; Acyclovir Sodium; Alti-Acyclovir; Avirax; BW-248U; Valtrex; Vipral; Virorax; Wellcome-248u; Zovirax; Zovirax Wellstat Pac; Zovirax Zostab Pac

Drug Category:
Acyclovir is categorized under the following by the FDA: Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB

Dosage Forms:
Intravenous Infusion; Capsules; Tablets; Suspension; Topical Cream; Topical Ointment

Absorption:
Oral _ Bioavailability 10 to 20%

Interactions:
Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced. The clinical effects of this combination have not been studied.



Chemical IUPAC Name:
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

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