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ActonelThis page contains recent news articles, when available, and an overview of Actonel but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Actonel (when available) Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism and is indicated for the treatment and prevention of osteoporosis in postmenopausal women. For the treatment of Paget's disease of the bone (osteitis deformans); Postmenopausal and glucocorticoid-induced osteoporosis Mechanism Of Action: The action of Risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass. News Articles on Risedronate Children's Safe Drinking Water Program Provides One Billionth ... - 23 Apr 2008 Whisper(R), Pantene(R), Mach3(R), Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), PR Newswire (press release), Novartis: Aclasta Beats Sanofi's Actonel In Bone Trial - Apr 11, 2008 Actonel is one of the established treatments for the condition, which is known as glucocorticoid-induced osteoporosis. Both Actonel and Aclasta belong to a CNNMoney.com Novartis’ Aclasta Beats P&G and Sanofi’s Actonel in Study - Apr 15, 2008 New data show that once-yearly infusion of Aclasta was significantly better at increasing bone mass in patients with osteoporosis than Actonel, FDA news (subscription), Novartis Says Study Favors Its Bone Drug - Apr 13, 2008 Actonel, sold by Sanofi-Aventis SA of France and Procter & Gamble Co. of Cincinnati, was taken in the form of a daily pill in the trial, which included 833 Wall Street Journal Bone-loss meds carry risk of jaw problems - Apr 20, 2008 These include alendronate (Fosamax), risedronate (Actonel), ibandronate (Boniva) and others. These drugs have been effective in preventing fractures, Daytona Beach News-Journal, Novartis says Aclasta better at boosting bone mass - Apr 11, 2008 A once-yearly infusion of Aclasta showed benefits versus the daily pill Actonel, also known as risedronate, in patients taking steroids, which are widely Reuters Osteoporosis meds and bone collapse: weighing the risks - Apr 8, 2008 ...has been reported in patients with osteoporosis who were taking oral bisphosphonates such as alendronate (brand name Fosamax) or risedronate (Actonel). Globe and Mail, Novartis puts Antisoma's lung cancer drug into Phase III - Apr 14, 2008 In the treatment group, the Novartis drug increased BMD by 4.1% compared to a 2.7% rise for Actonel. The Basel-based firm noted that it is already applying Pharma Times (subscription), P&G Declares a 14% Dividend Increase - Apr 8, 2008 Mach3(R), Bounty(R), Dawn(R), Gain(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), FOXBusiness Musculoskeletal pain? Consider patient meds - Apr 9, 2008 These drugs are marketed under the names of Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa. Chiropractic Economics, The Utilisation and Expenditure of Medicines for the Prophylaxis ... - Apr 14, 2008 The high level of prescribing of the once weekly products Fosamax and Actonel supports previous studies which have demonstrated that patients prescribed Irish Medical Journal, Once A Year Treatment For Osteoporosis - Apr 4, 2008 Drugs like Fosamax (alendronate sodium) and Actonel (risedronate sodium) are taken once a week, and Boniva (ibandronate sodium) is taken once a month. WPTV, Dr. Paul Donohue - Apr 2, 2008 Dear JC: Calcium can interfere with the antibiotics tetracycline and Cipro, the osteoporosis medicine Actonel and with thyroid hormone replacement medicine. DetNews.com, Crest and Oral-B Give Canadians Something to Smile About - Apr 1, 2008 Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Clairol Nice 'n Easy(R), Herbal Essences(R), Head & Shoulders(R), Gillette(R), and Braun. FOXBusiness Quench Your Summer Thirst...With Fiber - Apr 15, 2008 P&G has one of the strongest portfolios of quality, leadership brands in consumer health and wellness, including Actonel(R), Align(R), Always(R), Asacol(R), PR Newswire (press release), Febreze(R) Goes Pet-Friendly - Mar 28, 2008 Whisper(R), Pantene(R), Mach3(R), Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), FOXBusiness Actress/Producer Salma Hayek Launches The Pampers(R) "One Pack ... - Apr 10, 2008 Folgers(R), Charmin(R), Downy(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella, Gillette(R), and Braun. CNW Telbec (Communiqués de presse), Walgreens Gears Up - Apr 4, 2008 The campaign is sponsored by Eli Lilly and Co., LifeScan Inc.'s OneTouch, J&J's McNeil Consumer Healthcare brands, Procter & Gamble's Actonel, In-Store Marketing Institute (Subscription), US Gymnastics - Mar 30, 2008 Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, and Braun(R). SFCPressPoint (press release), Gillette Clinical Strength and GroomGroove.com Announce Marriage ... - Mar 27, 2008 Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, and Braun®. Business Wire (press release), Think Bizarre, Travel Like an Expert This Summer - Mar 25, 2008 Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), PR Newswire (press release), Daily Cancer News - Mar 28, 2008 Twelve-month data from the SABRE study (Study of Anastrozole with the Bisphosphonate Risedronate [Actonel]), using an oral bisphosphonate, were reported. Cancer Consultants, Study Shows Once-Yearly Reclast Better than Risedronate at ... - Apr 11, 2008 Actonel(R) (risedronate sodium) [Prescribing Information]. Cincinnati, OH: Procter & Gamble Pharmaceuticals, Inc.; May 2007. 5. Reclast(R) (zoledronic acid) Biloxi Sun Herald, Study shows once-yearly Aclasta® - Apr 11, 2008 Actonel® (risedronate sodium) Prescribing Information.Cincinnati, OH: Procter & Gamble Pharmaceuticals, Inc., May 2007.[7.] Black DM, Delmas PD, Eastell R, Ad-Hoc-News (Pressemitteilung), DJ HUGIN NEWS/Study shows once-yearly Aclasta® -2- - Apr 11, 2008 Use of oral corticosteroids in the United Kingdom. QJ Med 2000; 93:105-11. [6.] Actonel® (risedronate sodium) Prescribing Information. VisAvis (Pressemitteilung), Wall Street News Alert: Breaking News Alert - OCOL! April 1, 2008 - Apr 1, 2008 Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), and Braun(R). Trading Markets (press release), Health Expert and Author Byron Richards, CCN Reports on How ... - Mar 28, 2008 I have reported at great length on the near lunacy of widely prescribing Fosamax and Actonel for osteoporosis and osteopenia – as it is easy to predict NewsReleaseWire.com (press release) Nationwide Awards Recognize Nurses, Associates and Nursing Teams ... - Mar 26, 2008 The company has one of the strongest portfolios of trusted, quality, leadership brands, including Actonel(R), Asacol(R), Enablex(R), Prilosec OTC(R), PR Newswire (press release), Video: Walgreens to Provide $35 Million in Free Health Screenings ... - Mar 26, 2008 LifeScan, Inc. (OneTouch), Johnson & Johnson (Tylenol, Pepcid, St. Joseph, Benadryl), GlaxoSmithKline (Nicorette and Alli) and Procter & Gamble (Actonel). CNNMoney.com (press release) Mobile Software: The Procter And Gamble Company Selects O4 ... - 10 Mar 2008 Mach3(R), Bounty(R), Dawn(R), Gain(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Wireless Workforce Online (press release), Teva to Appeal Actonel Ruling - Feb 29, 2008 The Actonel patent extends through the end of 2013. Actonel was approved in 2000 by the Food and Drug Administration for the prevention and treatment of CNNMoney.com UPDATE: P&G wins patent case against its osteoporosis therapy Actonel - Feb 28, 2008 The Cincinnati-based consumer goods company said the court ruled it has the exclusive marketing rights to Actonel. Teva was attempting to market a generic CNNMoney.com P&G bests Teva in Actonel lawsuit - Feb 29, 2008 P&G holds a patent, valid until 2013, for risedronate, the active ingredient in Actonel. Teva had claimed that the patent wasn't valid due to the Bizjournals.com, Teva To Appeal Court Ruling In P&G's Favor Over Generic Actonel - Feb 29, 2008 ...(PG) the exclusive right to market Actonel tablets in the US The Israel pharmaceutical company had filed an abbreviated new drug application to market a CNNMoney.com Procter & Gamble Wins Patent Infringement Lawsuit for Osteoporosis ... - Feb 28, 2008 Teva was seeking to market a generic version of Actonel in the United States under the assertion that the Actonel patent was not valid due to obviousness of Earthtimes, P&G Wins Patent Infringement Lawsuit Against Teva Pharma For ... - Feb 28, 2008 The positive ruling protects P&G's rights in the US to exclusively market the osteoporosis therapy Actonel or risedronate sodium tablets. Trading Markets (press release), Teva Provides Update on Generic Actonel® Litigation - Feb 29, 2008 ...over the Company’s Abbreviated New Drug Application (ANDA) to market its generic version of Procter & Gamble's Actonel® (Risedronate Sodium) Tablets, Business Wire (press release), Procter & Gamble wins patent lawsuit - Feb 28, 2008 The lawsuit against Teva was filed to enforce P&G's patent for risedronate, the active ingredient in Actonel, the Cincinnati-based consumer products company BusinessWeek P&G Wins Patent Lawsuit Vs Teva - Feb 28, 2008 P&G filed the suit in 2004 against Teva, which was seeking to market a generic version of the drug because they claimed P&G's patent on Actonel was not CNNMoney.com P&G wins patent lawsuit for osteoporosis therapy against Teva - Feb 28, 2008 N: Quote, Profile, Research) said it won a patent infringement lawsuit for osteoporosis therapy Actonel against Teva Pharmaceuticals USA Inc. Procter Reuters Teva to appeal court ruling upholding Procter's osteoporosis drug ... - Feb 29, 2008 The patent concerned Procter's Actonel tablets, which treats osteoporosis. Teva had submitted a new drug application to market a generic version of the drug CNNMoney.com Procter & Gamble wins patent lawsuit - Feb 28, 2008 ...has won a patent infringement lawsuit against Teva Pharmaceuticals USA Inc. to protect P&G's rights to exclusively market the osteoporosis drug Actonel. Forbes, Sun: Gaza conflict rocks TASE - Mar 2, 2008 But the company later suffered a reversal of fortunes over the osteoporosis drug Actonel , when the owner of the ethical version, Procter & Gamble Co. Globes, Bone drugs iffy - Mar 2, 2008 ...(The rare jaw side effect is mentioned in Actonel's leaflet.) "The bottom line is that these drugs do have side effects and that necrosis is very rare. Toronto Sun, Market Report -- In Play (PG) - Feb 28, 2008 Procter & Gamble wins patent infringement lawsuit for osteoporosis therapy Actonel Co announces the United States District Court of Delaware ruled in favor MSN Money Husband experiencing night sweating - Feb 26, 2008 I have been taking Actonel for four years but am worried about it. My doctor and dentist say I should continue to take it because the only problem I could The North Bay Nugget, Global Osteoporosis Therapeutics Market to Reach US$11.1 Billion ... - Feb 26, 2008 However with the launch of newer treatments coupled with the patent expiry of major drugs including Fosamax, Actonel, and Boniva, growth in the market for PR Web (press release), Procter & Gamble Wins Patent Infringement Lawsuit - Feb 28, 2008 Teva wanted to market a generic version of Actonel in the United States and had claimed P&G's patent for the drug was not valid. P&G says the court ruling Trading Markets (press release), FDA Posts MedWatch Side Effect Alert for Osteoporosis Drugs - Feb 20, 2008 According to worstpills.org, Proctor and Gamble, the maker of the bisphosphonate Actonel, engaged in a similar omission of data in a large clinical trial Natural News.com, Breaking points - Mar 9, 2008 Other bisphosphonates include Fosamax and Actonel, tablets taken once a week, and Boniva, a tablet taken once a month or by injection every three months. South China Morning Post (subscription), US Appeals Court splits Celebrex patent ruling - Mar 9, 2008 ...upheld a patent of Proctor & Gamble Co. (NYSE: PG) for Actonel, a treatment for osteoporosis in postmenopausal women. Teva intends to appeal this ruling. Globes, Fossy jaw risk lower with oral meds - Feb 20, 2008 ..."This is good news for the roughly 3 million Americans who take Fosamax, Actonel, Boniva or similar osteoporosis meds orally," said senior author Dr ArabianBusiness.com, Bisphosphonates and Osteonecrosis of the Jaw - Feb 19, 2008 Didronel, Bonviva, Bondenza, Bondronat, Aredia, Actonel, Zometa & Aclasta). In 2005, the European scientific committee responsible for medicines safety, Irish Medical Times, P&G to Webcast Presentation From the Consumer Analyst Group of New ... - Feb 19, 2008 Mach3(R), Bounty(R), Dawn(R), Gain(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), StreetInsider.com (subscription), Keeping weight down, bones strong - Feb 12, 2008 Clinical trials have shown that medications known as bisphosphonates, which include drugs like Fosamax and Actonel, are effective in preventing the Times Daily (subscription), Paris shares TFN market data 10.55 am; shares track US, Asia down ... - Mar 3, 2008 Sanofi and Procter & Gamble (NYSE:PG) have won their patent infringement lawsuit against Teva Pharmaceuticals (NASDAQ:TEVA) over osteoporosis drug Actonel CNNMoney.com Tel Aviv-25 declines 3.2% - Mar 3, 2008 The world's biggest maker of generic drugs may be blocked from selling its version of Procter & Gamble's osteoporosis treatment Actonel until 2013 after a Jerusalem Post, P&G Says Court Ruled In Co's Favor In Patent Suit Vs Teva - Feb 28, 2008 In 2004, P&G filed a patent infringement lawsuit to enforce P&G's US composition of matter patent for risedronate, the active ingredient in Actonel. CNNMoney.com Zestra Laboratories Elects New Board of Directors - Mar 5, 2008 At Procter and Gamble he helped develop the initial positioning and launch plans for Actonel®, a multi-billion dollar osteoporosis medication. Business Wire (press release), Freshen Up Your Mood and Your Home with the New Swiffer and Mr ... - Feb 26, 2008 Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella, Gillette(R), and Braun. FOXBusiness New survey uncovers American's strange hygiene habits - Mar 4, 2008 Whisper(R), Pantene(R), Mach3(R), Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Prdomain Business Register (press release), TASE opens lower following Wall Street, Gaza - Mar 2, 2008 ...s (NYSE: PG) patent for Actonel. Teva will appeal the ruling. The day before, the US Food and Drug Administration (FDA) granted Teva a marketing permit for Globes, ALSO NOTED: Merck clings to AstraZeneca drug rights; GSK recalls ... - Feb 29, 2008 Release > Generics maker Teva Pharmaceutical plans to appeal a court ruling that upheld a Procter & Gamble patent on the osteoporosis drug Actonel. FiercePharma, Sanofi-aventis Announces 2007 Earnings Ahead of Guidance Sharp ... - Feb 12, 2008 81 83 Nasacort(R) 61 57 60 Actonel(R) 79 86 84 Depakine(R) 79 75 73 TOTAL 4120 4104 4221 Other products 1962 1995 2033 TOTAL Pharmaceuticals 6082 6099 PR Newswire (press release), Procter & Gamble Professional(TM) Announces Dawn(R) Celebration ... - Feb 28, 2008 Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), and Braun(R). CNNMoney.com (press release) Ambrx Appoints Douglas Axelrod Senior Vice President for Clinical ... - Feb 26, 2008 Earlier in his career, Axelrod led the P&G Worldwide Clinical Bone group, stewarding drugs such as Didronel(TM) and Actonel(TM) through late clinical PR Newswire (press release), Hockey gold medalist celebrates Canada's leading man of clean's ... - Feb 25, 2008 Folgers(R), Charmin(R), Downy(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella, Gillette(R), and Braun. CNW Telbec (Communiqués de presse), Potential osteoporosis treatment could help patients fortify their ... - Feb 25, 2008 Bisphosphonates, marketed under the brand names Fosamax®, Boniva® and Actonel®, work by inhibiting osteoclasts. Only one FDA-approved drug, Forteo®, News from Washington University in St. Louis, visibly whiter teeth in 14 days with crest and oral-b - Crest and ... - Feb 21, 2008 Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Trading Markets (press release), Implication of Food Allergies and Intolerances on Medication ... - Feb 26, 2008 Actonel (risedronate) [package insert]. Bridgewater, NJ: Sanofi-Aventis US LLC; 2007. Fosamax (alendronate) [package insert]. Whitehouse Station, NJ: Merck Ortho SuperSite, Osteoporosis is traditionally thought of as a women's disease ... - Feb 18, 2008 Bisphosphonates are the active ingredient in widely prescribed osteoporosis medications such as Fosamax, Actonel and Boniva. "These medicines work by PR-Inside.com (Pressemitteilung), US Gymnastics - Feb 12, 2008 Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, and Braun(R). SFCPressPoint (press release), Gillette Unveils Newest Members of Its Gillette Young Guns Lineup - Feb 11, 2008 Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella, Gillette®, and Braun. Business Wire (press release), Brand Names/Synonyms: Actonel is also known by the following brand names and/or synonymsActonel; Pyridine N-Oxide; Pyridostigmine Bromide; Pyridostigmine Bromine; Risedronate; Risedronate Sodium; Risedronic Acid Drug Category: Actonel is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; Dosage Forms: TABLET Absorption: Rapid absorption (~1 hr) after an oral dose, occurs throughout the upper gastrointestinal tract Interactions: -->Interactions for Risedronate: No specific drug-drug interaction studies were performed. Risedronate is not metabolized and does not induce or inhibit hepatic microsomal drug-metabolizing enzymes (Cytochrome P450). Calcium Supplements/Antacids Co-administration of ACTONEL and calcium, antacids, or oral medications containing divalent cations will interfere with the absorption of ACTONEL. Hormone Replacement Therapy One study of about 500 early postmenopausal women has been conducted to date in which treatment with ACTONEL (5 mg/day) plus estrogen replacement therapy was compared to estrogen replacement therapy alone. Exposure to study drugs was approximately 12 to 18 months and the primary endpoint was change in BMD. If considered appropriate, ACTONEL may be used concomitantly with hormone replacement therapy. Aspirin/Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Of over 5700 patients enrolled in the ACTONEL Phase 3 osteoporosis studies, aspirin use was reported by 31% of patients, 24% of whom were regular users (3 or more days per week). Forty-eight percent of patients reported NSAID use, 21% of whom were regular users. Among regular aspirin or NSAID users, the incidence of upper gastrointestinal adverse experiences in ACTONEL-treated patients (24.5%) was similar to that in placebo-treated patients (24.8%). H2 Blockers and Proton Pump Inhibitors (PPIs) Of over 5700 patients enrolled in the ACTONEL Phase 3 osteoporosis studies, 21% used H2 blockers and/or PPIs. Among these patients, the incidence of upper gastrointestinal adverse experiences in the ACTONEL-treated patients was similar to that in placebo-treated patients. Drug/Laboratory Test Interactions Bisphosphonates are known to interfere with the use of bone-imaging agents. Specific studies with ACTONEL have not been performed. Chemical IUPAC Name: (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonicacid : |
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