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ActonelThis page contains recent news articles, when available, and an overview of Actonel but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Actonel (when available) Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism and is indicated for the treatment and prevention of osteoporosis in postmenopausal women. For the treatment of Paget's disease of the bone (osteitis deformans); Postmenopausal and glucocorticoid-induced osteoporosis Mechanism Of Action: The action of Risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass. News Articles on Risedronate Procter & Gamble announces sale of prescription drug unit … and ... - 30 Aug 2009 Warner gets all of p&g's pharmaceutical products — including the $1 billion selling osteoporosis drug Actonel; co-promotion rights to Enablex (with MedCity News Warner Chilcott Confirms $3.1 Billion Buy Of P&G Drug Unit - Aug 24, 2009 The Ireland -based company, which makes birth-control pills, gains access to P&G drugs Actonel for osteoporosis and colitis treatment Asacol while CNNMoney.com Former P&G exec Napier to head Arbonne - Aug 17, 2009 ...rising to general manager of its North American pharmaceuticals business, where she helped launch the osteoporosis drug Actonel. Bizjournals.com Pricey Remedy May Not Be Better - Aug 11, 2009 ...at preventing bone fractures -- the goal of a drug designed to treat osteoporosis -- than alendronate, risedronate (Actonel) or other bisphosphonates. Washington Post Letters and Comments for August 27, 2009 - Aug 27, 2009 Here's what I found: four pages each for Zostavax, Lyrica, Actonel, Zetia , Caduet and Pristiq, with three pages for Toviaz and Advair Discus, La Grande Observer Reader's Digest files for bankruptcy - Aug 24, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel Minneapolis Star Tribune Glance at P&G sales by sector - Aug 5, 2009 ...cough medicine sales were slow in a mild cold and flu season and heartburn medicine Prilosec OTC and osteoporosis drug Actonel faced more competition. Forbes P& G Takeover? Duane Reade Changes - Aug 24, 2009 They're known for producing women's osteoporosis treatment -- Actonel and overactive bladder treatment Enablex. NO COST OF LIVING ADJUSTMENT: Social myfoxny.com First Fosamax Trial Starts Today - Aug 11, 2009 Other drugs in this class include Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa. Newsinferno.com New CEO Aims to Keep Enhancing Ajinomoto Brand - Aug 23, 2009 ...s Actonel osteoporosis treatment. In the first fiscal quarter ended June 30, Ajinomoto booked a group net profit of 10.69 billion yen ($113.3 million), Wall Street Journal Hip fracture rates have dropped, Canada study finds - Aug 25, 2009 Among them are Merck & Co's Fosamax, Roche Holding AG's Boniva, Novartis AG's Reclast, Procter and Gamble Co's Actonel, Sanofi Aventis' Skelid and Novartis' Reuters Ajinomoto acquires Japanese rights to P&G's osteoporosis drug - Aug 4, 2009 The agreement reportedly allows Ajinomoto to research, develop, manufacture as well as sell the drug, which is to be marketed under the brand name Actonel Trading Markets (press release) Business Highlights - Aug 24, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel The Associated Press Business news in brief - Aug 25, 2009 Warner Chilcott will get products with $2.3 billion in annual sales including Actonel for osteoporosis, Asacol for bowel disorders, and co-promotion rights Philadelphia Inquirer DotW: Back to school, back to work - Aug 28, 2009 ...adds significantly to its sales force while also bolstering its women's products portfolio through the additional of P&G's Actonel and Asacol HD. The IN VIVO Blog A Partial Approval for Amgen's Osteoporosis Drug - Aug 13, 2009 The main treatments now for osteoporosis are drugs called bisphosphonates, like Actonel, Boniva and alendronate, the generic version of Merck's Fosamax. New York Times The good and the not-so-good of osteoporosis drugs - Aug 17, 2009 These include Fosamax, Actonel and Didrocal. The most notable things she remembered from the article were the increased risk of jaw necrosis (death of the North Island Midweek Gov't extends deadline for clunkers paperwork - Aug 24, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel Sacramento Bee Them's the Breaks for Lilly - Aug 19, 2009 GSK) and Roche's Boniva, Merck's (NYSE: MRK) Fosamax, and Procter & Gamble's (NYSE: PG) and sanofi-aventis' (NYSE: SNY) Actonel, to name just a few. Motley Fool Movers roundup: Brocade Communications, Delphi - Aug 25, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel Financial News USA (press release) The Transformation Of Sanofi-Aventis US - Aug 26, 2009 Products like Actonel, Avapro, and Plavix, are founded on partnerships. We're committed to the best science, whether generated through in-house innovation Life Science Leader Magazine Swiffer Dusts Its Way Through Classrooms Across America - Aug 24, 2009 Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), Braun(R) and Fusion(R). PR Newswire (press release) Business Briefs for Aug. 25 - Aug 24, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel Richmond Times Dispatch UK-Business Summary - Aug 24, 2009 P&G's branded drugs, including osteoporosis treatment Actonel and Enablex for overactive bladder, have annual sales of $2.3 billion. Interactive Investor US Session News - Aug 24, 2009 ...rare drugs such as Actonel, Asacol and Enablex, which accordingly permitted the medical corporation shares to rise to their highest level in three years. FXstreet.com The Futures Market Patient Safety: Getting the Name Wrong May be Fatal - Aug 13, 2009 ...likely to confuse drug names that look or sound alike (eg, ephedrine and epinephrine, Taxol and Paxil, vinblastine and vincristine, Actos and Actonel). ADVANCE Procter & Gamble Announces Appointment of Director - Aug 12, 2009 Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), Braun(R) and Fusion(R). PR Newswire (press release) New Bounce(R) Dryer Bar Elevates the Fabric Softener Category to a ... - Aug 11, 2009 Mach3(R), Bounty(R), Dawn(R), Gain(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), PR Newswire (press release) P&G Invites Fans to Enter the '100 Ways to Enjoy Pringles' Sweepstakes - Aug 6, 2009 Pringles(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), PR Newswire (press release) Authentic Febreze Scents Meet Stylish Designs in Brand's First ... - Aug 4, 2009 Whisper(R), Pantene(R), Mach3(R), Bounty(R), Dawn(R), Pringles(R), Folgers(R), Charmin(R), Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), PR Newswire (press release) Stay Cool with Tide Coldwater High-Efficiency - Aug 19, 2009 Bounty(R), Pringles(R), Swiffer(R), Charmin(R), Downy(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Clairol Nice 'n Easy(R), Canada NewsWire (press release) Tide Partners with Children's Retailer Gymboree and Canadian ... - Aug 19, 2009 Charmin(R), Downy(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), and Braun(R). Canada NewsWire (press release) P&G Fiscal Year and Fourth Quarter EPS Exceed Expectations - Aug 5, 2009 Downy(R), Lenor(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), Braun(R) and Fusion(R). PR Newswire (press release) Tuesday Newspaper Review - Irish Business News and International ... - Aug 25, 2009 The move will give Warner global reach, as well as a foothold in the western European pharmaceutical market and access to P&G's osteoporosis drug Actonel FinFacts Ireland Research institute in Akron taps chief - Aug 26, 2009 ...development, market introduction or management of more than 20 drugs, including allergy medication Allegra and osteoporosis drug Actonel, according to a Akron Beacon Journal Garrett Jones of the Pittsburgh Pirates voted winner of the ... - Aug 4, 2009 Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. MLB.com Business Briefs: Company's plan to buy P&G sends stock soaring - Aug 24, 2009 The maker of women's health and dermatology products will get a portfolio with $2.3 billion in annual sales, including blockbuster osteoporosis drug Actonel NewsOK.com From staff and wire reports • August 25, 2009 - Aug 24, 2009 The deal announced Monday with Warner Chilcott PLC will take away $2.3 billion in annual revenues, including the billion-dollar brand Actonel, Jackson Clarion Ledger Notable Mergers and Acquisitions of the Day 8/24: PG/WCRX, CHIC, TIBX - Aug 24, 2009 Actonel(R) (risedronate sodium) for osteoporosis, and the co-promotion rights to Enablex(R) (darifenacin) for the treatment of overactive bladder, StreetInsider.com (subscription) Pampers Diapers Launches New Webb Series "A Parent is Born" to ... - Aug 24, 2009 Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella, Gillette®, and Braun. Emediawire (press release) CA-BUSINESS Summary - Aug 24, 2009 P&G's branded drugs, including osteoporosis treatment Actonel and Enablex for overactive bladder, have annual sales of $2.3 billion. ReportonBusiness.com CA-BUSINESS Summary - Aug 24, 2009 P&G's branded drugs, including osteoporosis treatment Actonel and Enablex for overactive bladder, have annual sales of $2.3 billion. ReportonBusiness.com Boning Up On Osteoporosis News May Help You Live Longer Says Expert - Aug 15, 2009 Fosamax, approved in the United States in 1995, belongs to the bisphosphonate family of osteoporosis drugs that include Actonel and Boniva. Medical News Today (press release) Warner Chilcott compra unidad medicamentos P&G por 3.100 mln dlr - Aug 24, 2009 Los medicamentos de P&G, como el tratamiento para la osteoporosis Actonel y el fármaco Enablex para vejigas hiperactivas, registran ventas anuales de 2.300 Reuters América Latina P&G verkauft Pharmageschäft an irische Warner Chilcott - Aug 24, 2009 Zur Produktpalette gehören das Osteoporosemittel Actonel und das zur Behandlung von Dickdarmentzündungen eingesetzte Asacol. Außer der Medikamentenpipeline FOCUS Online Warner Chilcott将收è´å®?æ´?处方è?¯ä¸šåŠ¡ - Aug 24, 2009 ...新浪财ç»?讯北京时间周一晚间消æ?¯ï¼Œçˆ±å°”兰制è?¯å•†Warner Chilcott PLC(WCRX)宣布，将以31äº¿ç¾Žå…ƒçš„ä»·æ ¼æ”¶è´å®?æ´?å…¬å?¸(PG)的处方è?¯ä¸šåŠ¡ï¼Œå…¶ä¸åŒ…括骨质ç–?æ?¾ç—‡è?¯ç‰©Actonel， 新浪网 Procter & Gamble cède sa pharmacie pour 3 milliards de dollars - Aug 24, 2009 Vendue environ quatre fois les bénéfices, cette division comprend notamment plusieurs « blockbusters », dont l'Actonel, un traitement destiné à lutter Le Figaro Procter & Gamble не нужны рецепты - Aug 24, 2009 Самым прибыльным из них Ñ?влÑ?етÑ?Ñ? Actonel — женÑ?кий препарат длÑ? лечениÑ? оÑ?теопороза, продажи которого в прошлом году принеÑ?ли P&G Ñ?выше 1 млрд долл. RBC Daily Η Warner Chilcott εξαγοÏ?άζει μονάδα της Procter & Gamble - Aug 24, 2009 Οι ετήσιες πωλήσεις των φαÏ?μάκων της P&G, μεταξÏ? των οποίων συμπεÏ?ιλαμβάνεται το Actonel για τη θεÏ?απεία της οστεοπόÏ?ωσης και το Enablex, ανÎÏ?χονται σε 2,3 Ημερησία Brand Names/Synonyms: Actonel is also known by the following brand names and/or synonymsActonel; Pyridine N-Oxide; Pyridostigmine Bromide; Pyridostigmine Bromine; Risedronate; Risedronate Sodium; Risedronic Acid Drug Category: Actonel is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; Dosage Forms: TABLET Absorption: Rapid absorption (~1 hr) after an oral dose, occurs throughout the upper gastrointestinal tract Interactions: -->Interactions for Risedronate: No specific drug-drug interaction studies were performed. Risedronate is not metabolized and does not induce or inhibit hepatic microsomal drug-metabolizing enzymes (Cytochrome P450). Calcium Supplements/Antacids Co-administration of ACTONEL and calcium, antacids, or oral medications containing divalent cations will interfere with the absorption of ACTONEL. Hormone Replacement Therapy One study of about 500 early postmenopausal women has been conducted to date in which treatment with ACTONEL (5 mg/day) plus estrogen replacement therapy was compared to estrogen replacement therapy alone. Exposure to study drugs was approximately 12 to 18 months and the primary endpoint was change in BMD. If considered appropriate, ACTONEL may be used concomitantly with hormone replacement therapy. Aspirin/Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Of over 5700 patients enrolled in the ACTONEL Phase 3 osteoporosis studies, aspirin use was reported by 31% of patients, 24% of whom were regular users (3 or more days per week). Forty-eight percent of patients reported NSAID use, 21% of whom were regular users. Among regular aspirin or NSAID users, the incidence of upper gastrointestinal adverse experiences in ACTONEL-treated patients (24.5%) was similar to that in placebo-treated patients (24.8%). H2 Blockers and Proton Pump Inhibitors (PPIs) Of over 5700 patients enrolled in the ACTONEL Phase 3 osteoporosis studies, 21% used H2 blockers and/or PPIs. Among these patients, the incidence of upper gastrointestinal adverse experiences in the ACTONEL-treated patients was similar to that in placebo-treated patients. Drug/Laboratory Test Interactions Bisphosphonates are known to interfere with the use of bone-imaging agents. Specific studies with ACTONEL have not been performed. Chemical IUPAC Name: (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonicacid : |
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