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ActiqThis page contains recent news articles, when available, and an overview of Actiq but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Actiq (when available) Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils. For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy. Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. News Articles on Fentanyl How to Dispose Old Medicine - Apr 14, 2009 They are: Actiq, Daytrana Transdermal Patch, Duragesic Transdermal System, OxyContin Tablets, Avinza Capsules, Baraclude Tablets, Reyataz Capsules, KNDO/KNDU Cephalon Announces Positive Results from a Phase Three Study of ... - Apr 6, 2009 TRISENOX(R) (arsenic trioxide) injection, GABITRIL(R) (tiagabine hydrochloride), NUVIGIL and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). PR Newswire (press release) Cephalon CEO's compensation falls 6.3 percent - Apr 1, 2009 Also, the company settled a series of lawsuits in 2008 alleging it marketed Provigil, Gabitril and the painkiller Actiq for unnapproved indications. Charleston Gazette BUYINS.NET: Market Maker Surveillance Report. Top 6 Winning Stocks ... - 18 Mar 2009 ...and FENTORA, EFFENTORA, ACTIQ, and generic OTFC products, which focus on treating breakthrough cancer pain in opioid-tolerant patients. Trading Markets (press release) Cephalon Announces Positive Results From a Phase Two Study of ... - Mar 17, 2009 TRISENOX(R) (arsenic trioxide) injection, GABITRIL(R) (tiagabine hydrochloride), NUVIGIL and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). PR Newswire (press release) Illegal Drugs: Part Seven - A Personal Journey of Pain ... - Mar 5, 2009 Two of the pain medications that I have been prescribed are Fentanyl Duragesic patches and the brand name Fentanyl Actiq®, of Cephalon, Inc, Salem-News.Com 10-K: CEPHALON INC - Feb 23, 2009 With respect to ACTIQ, its sales have been meaningfully eroded by the launch of FENTORA and by generic OTFC products sold since June 2006 by Barr MarketWatch (press release) States Begin Targeting Drug Company Marketing Practices - Mar 12, 2009 ...to pay $425 million in a federal Medicaid fraud suit involving the same three drugs, the others being tiagibine (Gabitril) and oral fentanyl (Actiq). MedPage Today In Va., it's up to patients to keep an eye on doctors - Mar 8, 2009 There was Actiq, a powerful narcotic approved only to treat severe pain in terminal cancer patients, which is dispensed via a "lollypop" held between the The Virginian-Pilot Jade Goody leaves hospital as she prepares to get married - Feb 19, 2009 She appeared to be sucking on a fentanyl lollipop, a plastic stick which releases the powerful painkilling drug Actiq into the mouth. MorungExpress Cephalon opens bid for Aussie bio-technology firm Arana - Feb 28, 2009 The company's proprietary products in the US include Amrix, Treanda, Fentora, Trisenox, Gabitril, Nuvigil and Actiq. Cephalon's offer will be subject to domain-B Jade Goody gives the thumbs up as she joins her bridesmaids for ... - Feb 19, 2009 Leaving hospital yesterday, Jade was in so much pain she was sucking on a 'lollipop' of the painkilling drug Fentanyl Actiq 600. Daily Mail Cephalon Appoints Sarma P. Duddu as General Manager and Vice ... - 04 Feb 2009 ...in the US that use CIMA drug delivery technology: FENTORA(R) (fentanyl buccal tablet) [C-II] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. PR Newswire (press release), Drugmaker Cephalon linked to indicted Kan. doctor - Feb 3, 2009 In a separate case, Cephalon has admitted it illegally promoted Actiq - a potent, highly addictive painkiller. Actiq is fentanyl in lollipop form. Forbes, Bush administration opened door to controversial off-label ... - Feb 1, 2009 So the company launched a "highly organized" and "concerted plan to maximize revenue by the off-label marketing" of the drugs, Gabitril, Provigil and Actiq, Kansas City Star, Prosecutor: Off-label promos 'must stop' - Jan 29, 2009 Magid lambastes Lilly's "Viva Zyprexa" campaign, and she took Cephalon to task for targeting primary-care docs with the cancer painkiller Actiq. FiercePharma, Oregon gets $2.1 million in Cephalon settlement - Jan 9, 2009 The drugs were Actiq, a highly addictive painkiller; Gabritril, an anti-seizure drug; and Provigil, a sleep disorder drug. MSNBC Drug maker agrees to settle - Jan 8, 2009 In October, the firm pleaded guilty in Pennsylvania to a misdemeanor charge of misbranding the same three drugs — Actiq, Gabitril and Provigil — and agreed 2TheAdvocate, Cephalon Exercises Option to License Worldwide Rights to ... - Feb 2, 2009 GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(R) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. PR Newswire (press release), 5 patients died on his watch. Now his license is on the line. - Jan 24, 2009 According to a $5 million lawsuit Coogan filed last week , Plotnick put her on a variety of powerful medications, including Actiq , which is approved only The Virginian-Pilot, Off-label drug use poses danger to unsuspecting patients - Jan 15, 2009 Off-label drug use is also legal for controlled substances, the most common being Actiq which is approximately 100 times stronger than morphine and intended The Silhouette, Keeping us safe from drug reps - Jan 27, 2009 One of those drugs, Actiq, is a potent painkiller intended only for cancer patients who are already tolerant of other painkillers and still suffering pain. Philadelphia Inquirer, Cephalon Signs Option Agreement to Acquire Ception Therapeutics - Jan 13, 2009 GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(R) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. PR Newswire (press release), The Big Idea for 2009 as Discussed at JP Morgan - Jan 16, 2009 Products for CNS include Provagil for wakefulness, Gabitril for seizures; in Cancer Treanda for CLL and NHL as well as Actiq for pain in opiate–tolerant Genetic Engineering News (press release), Oregon To Receive $2.1 Million From Drug Company Settlement - Jan 8, 2009 BY ROB MANNING Oregon’s new Attorney General is only in his third day in office, but is already cheering a court victory against a drug company. OPB News, State Reports Misconduct by ‘Rogue’ Supervisor in Its Manhattan ... - Dec 7, 2008 The report said fellow investigators had witnessed Mr. Crisafi on duty sucking on stick lozenges of Actiq, a prescription pain-relieving narcotic. New York Times, Seminole Physician Charged In Fake Prescription Scheme - 21 Nov 2008 Spuza met with the informant and agreed to additionally write prescriptions for another pain drug, Actiq. Those prescriptions would not be filled but would Tampa Tribune, Cephalon: Damn the Torpedoes! We’re Raising Prices! - Nov 18, 2008 Its painkiller, Actiq, recently saw competition from cheap generics. Sales plummeted to $21 million this quarter, down from $45 million a year ago. BNET, Cephalon Inc. Q3 2008 Earnings Conference Call Transcript - Oct 28, 2008 Net sales of rapid onset opioids declined, due primarily to the continued decline in US branded ACTIQ sales and to an increase in the reserve for returns of Seeking Alpha, Cephalon books 3rd-qtr net; settlement cost fades - Oct 28, 2008 The company paid $425 million after the US Department of Justice investigated the way the company sold and marketed three drugs - cancer pain drug Actiq, Forbes, Office of the Maryland Attorney General: Attorney General Gansler ... - Nov 7, 2008 Actiq: Although FDA-approved only to treat opioid-tolerant cancer patients (or those patients for whom morphine-based painkillers are no longer effective), Trading Markets (press release), Pa. Medicaid gets $5.58M from Cephalon settlement - Nov 3, 2008 The drugs involved were pain medication Actiq, Provigil for sleep disorders, and Gabitril for epilepsy. In the settlement, disclosed in September, Philadelphia Inquirer, Cephalon beats economic downturn and raises guidance - Oct 30, 2008 Sales rose by 14% to $489.7 million as Cephalon's central nervous system franchise grew robustly, offsetting the declines of Actiq (fentanyl citrate). Scrip World Pharmaceutical News (subscription), Cephalon Inc Posts Slight Profits for Third Quarter, Raises Full ... - Oct 29, 2008 Sales of Cephalon's flagship sleep disorder drug, Provigil, rose 19 percent to $ 259.2 million dollars for the quarter, while its cancer pain drug, Actiq, Network Médica, Blumenthal wants to revive stop-smoking phone service - Nov 14, 2008 Cephalon recently paid the state $3.8 million to settle allegations that it had illegally marketed three drugs — Actiq, Provigil, and Gabitrol — for uses Journal Inquirer, US recovered $1.34b from settlements of fraud cases - Nov 10, 2008 ...based company marketed three drugs - Actiq, Gabitril, and Provigil - for uses other than those approved by the Food and Drug Administration. Boston Globe (registration), Cephalon Reports Another Strong Quarter - Oct 28, 2008 2008 United States Europe Total Sales: PROVIGIL $241366 $17793 259159 GABITRIL 12176 2337 14513 CNS 253542 20130 273672 ACTIQ 21392 14401 35793 Generic MarketWatch Cephalon Receives FDA Approval for TREANDA to Treat Patients with ... - Oct 31, 2008 GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. MarketWatch AG Announces Recovery of $5.5 Million for PA Medicaid Program in ... - Nov 4, 2008 Inc. Corbett said the settlement resolves that Cephalon engaged in improper off-label marketing for the drugs Actiq, a pain reliever used to treat Gant Daily, Business news in brief - Nov 4, 2008 The drugs involved were pain medication Actiq, Provigil for sleep disorders, and Gabitril for epilepsy. In the settlement, disclosed in September, Philadelphia Inquirer, Cephalon Added to S&P 500 Today - Nov 14, 2008 GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. PR Newswire (press release), Police building case against former nurse in painkiller theft - Nov 8, 2008 In its prescription form, fentanyl is known as Actiq, Duragesic, and Sublimaze. Street names for the drug include Apache, China girl, China white, Colorado Daily, Cephalon Receives FDA Approval for TREANDA to Treat Patients with ... - Nov 3, 2008 GABITRIL ® (tiagabine hydrochloride), NUVIGIL ™ (armodafinil) Tablets [C-IV] and ACTIQ ® (oral transmucosal fentanyl citrate) [C-II]. PR Newswire (press release), Legemiddelanmeldelse - Effentora (fentanyl) – ny formulering mot ... - Nov 20, 2008 Fentanyl mot gjennombruddssmerter har allerede vært brukt i flere år i form av Actiq sugetablett (munnpinne). Fordi Effentora er formulert som en Statens legemiddelverk, Robuster Biotech-Wert schlägt den Markt - Nov 3, 2008 Weitere 29 Prozent der Umsätze stammen bisher aus dem Verkauf von Fentora- und Actiq-Medikamenten. Fentora soll zumindest auf der Verkaufsseite Frankfurter Allgemeine Zeitung, Brand Names/Synonyms: Actiq is also known by the following brand names and/or synonymsActiq; CHEMBANK1683; Dea No. 9801; Duragesic; Duragesic-100; Durogesic; F5886; Fentanest; Fentanil; Fentanil [Dcit]; Fentanila; Fentanila [Inn-Spanish]; Fentanyl; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Fentanylum; Fentanylum [Inn-Latin]; HSDB 3329; Pentanyl; Phentanyl; R 4263; Sentonil; Sublimaze; Sublimaze Preservative Free Drug Category: Actiq is categorized under the following by the FDA: Anesthetics; Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N01AH01; ATC:N02AB03 Dosage Forms: DISC (SUSTAINED-RELEASE); LIQUID; SOLUTION Absorption: Not Available Interactions: Interactions for Fentanyl: Agents Affecting Cytochrome P450 3A4 Isoenzyme System Fentanyl is metabolized mainly via the human cytochrome P450 3A4 isoenzyme system (CYP3A4), therefore potential interactions may occur when DURAGESIC® is given concurrently with agents that affect CYP3A4 activity. Coadminstration with agents that induce 3A4 activity may reduce the efficacy of DURAGESIC®. The concomitant use of transdermal fentanyl with ritonavir or other potent 3A4 inhibitors such as ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may result in an increase in fentanyl plasma concentrations. The concomitant use of other CYP3A4 inhibitors such as diltiazem and erythromycin with transdermal fentanyl may also result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause serious respiratory depression. In this situation, special patient care and observation are appropriate. Central Nervous System Depressants The concomitant use of DURAGESIC® (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death. When such combined therapy is contemplated, the dose of one or both agents should be significantly reduced. MAO Inhibitors DURAGESIC® is not recommended for use in patients who have received MAOI within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics. -->Chemical IUPAC Name: N-(1-phenethyl-4-piperidyl)-N-phenyl-propanamide : |
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