Acetaminophen

This page contains recent news articles, when available, and an overview of Acetaminophen but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Acetaminophen (when available)

Pharmacology and use:
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain. For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.

Mechanism Of Action:
Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3′,5′-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. It is now thought that xanthines such as caffeine act as agonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.

News Articles on Caffeine

Spine-health.com Poll Shows Advil, Aleve Most Used for Back Pain ...  -  23 Apr 2008
Tylenol (acetaminophen) was chosen by 11%, and aspirin was selected by 5%. “Other�? accounted for 15% and responses ranged from various prescription drugs to Business Wire (press release),

AHA Statement Takes Aim at Hypertension Resistant to Triple-Drug ...  -  23 Apr 2008
Acetaminophen can also promote mild elevations of BP but to a much lesser extent than NSAIDs. Therefore, acetaminophen is preferred over NSAIDs for pain RMGH Health News,

Taking Common Painkiller (acetaminophen) with Coffee is Extremely ...  -  Apr 21, 2008
...(NaturalNews) Combining caffeine with the active ingredient in Tylenol (acetaminophen) may be extremely dangerous for the liver, according to new research Natural News.com,

Before you pop  -  Apr 21, 2008
BY DAVID BRUCE Almost anyone who has ever suffered an ache or pain has felt the benefits of ibuprofen and acetaminophen. Known by their most popular brand GoErie.com,

Acetaminophen overdoses on the rise  -  Apr 4, 2008
Four days later, the 17-year-old Oklahoma City high school track star died of an acetaminophen overdose. "She was a very smart girl," said Kellie's older Tulsa World,

Painkillers help build muscle in older exercisers  -  Apr 10, 2008
Taking ibuprofen or acetaminophen regularly during resistance training seems to induce chances within the muscle that enhance the metabolic response to Reuters India,

You can overdose on over-the-counter drugs  -  Apr 16, 2008
Street names for DXM include Skittles, Robo and Triple C. Also, it’s commonly mixed with other drugs such as antihistamines and acetaminophen. Inquirer.net,

Acetaminophen is Fifth Leading Cause of Overdose Deaths  -  Mar 24, 2008
The Minnesota Poison Control Center reported over 1700 unintentional acetaminophen overdose calls last year. “It's very readily available and it makes it FOX 9 News,

Over-The-Counter Pain Killers Increase Muscle Mass/strength During ...  -  Apr 6, 2008
ScienceDaily (Apr. 6, 2008) — Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the Science Daily (press release)

Caffeine & acetaminophen could cause liver damage  -  Mar 25, 2008
A recent study shows consuming large amounts of caffeine while taking acetaminophen, or Tylenol, could cause liver damage. In the study, that large amount WWBT,

Have children, no exercise  -  Apr 18, 2008
More is not more effective when it comes to over-the-counter pain relievers with acetaminophen, the active ingredient in Tylenol. Providence Journal,

It's really the 'Freshman 5'  -  Apr 14, 2008
A daily dose of either ibuprofen or acetaminophen appears to boost both muscle mass and strength among elderly men and women who do weight training. Chicago Tribune,

Painkillers Boost Muscle Mass Among Weight-Training Elderly  -  Apr 6, 2008
By Alan Mozes SUNDAY, April 6 (HealthDay News) -- A daily dose of either ibuprofen and acetaminophen appears to boost both muscle mass and strength among U.S. News & World Report,

Cycling Training Tips: Over-the-Counter Strength  -  Apr 17, 2008
By Matt Allyn Taking recommended doses of ibuprofen and acetaminophen boosts strength and muscle growth when paired with a simple strength program, Bicycling

Caraco Pharma Labs Says Patent Claim On Generic Ultracet Held ...  -  Apr 18, 2008
The patent claim relates to Ortho-McNeil's Ultracet, for which Caraco is producing a generic version, Tramadol with Acetaminophen. Ultracet is a combination RTT News,

Caraco Pharmaceutical (CPD) Receives Favorable Judgment in Patent Case  -  Apr 18, 2008
Caraco's Tramadol with Acetaminophen product is a generic version of Ortho-McNeil's UltracetÂ®. The Company commenced shipment of Tramadol with StreetInsider.com (subscription),

Problems with low cholesterol pop up  -  Apr 20, 2008
I just started taking half an acetaminophen PM tablet ( 1/4 the adult dose) just before bed. This allows me to sleep through the night. Is this safe? Houston Chronicle,

Pediatricians offer drug-use advice  -  Mar 26, 2008
For fever and mild to moderate pain in children, use acetaminophen or ibuprofen. Acetaminophen is found in such products as Tylenol, Tempra and Panadol. Canada.com,

EB: OTC Painkillers Also Help Grandpa Get Buff  -  Apr 8, 2008
Explain to interested patients that this study found that chronic use of ibuprofen and acetaminophen was associated with greater gains in muscle volume and MedPage Today,

AAN: Some Painkillers Linked to Chronic Migraine  -  Apr 21, 2008
Acetaminophen use was set as the reference for risk of transformed migraine because prior studies have suggested it does not play a role. MedPage Today,

Are COX-Blockers the New Steroids?  -  Apr 8, 2008
The group that took a placebo got bigger, stronger muscles—but those rolling on ibuprofen or acetaminophen did even better, as measured by MRI. Discover Magazine,

Commonly Used Pain Relievers Linked With Increased Risk Of High ...  -  Mar 24, 2008
ISLAMABAD: The commonly used pain medications acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDS), are associated with an increased risk of high Online - International News Network,

Two Drugs Combine for Moderate Fibromyalgia Pain Relief  -  Mar 24, 2008
In 2003, however, a study at an outpatient clinic found that a combination of analgesic drugs, tramadol and acetaminophen, could be a safe and effective way Gather.com,

Phila. Council examines city water  -  Apr 14, 2008
A resident would need to drink eight glasses of water daily for at least 40000 years to acquire a medical dose of acetaminophen, a non-prescription pain Philadelphia Inquirer,

Questcor to Provide Q1 Results  -  Apr 22, 2008
...a unique orally disintegrating tablet formulation of hydrocodone bitartrate and acetaminophen for the treatment of moderate to moderately severe pain. Earthtimes,

And now, testing done for the Chicago Sun-Times has found, it's in ...  -  Apr 21, 2008
The lab tested the water for the presence of 57 chemical compounds, ranging from synthetic hormones and anti-convulsants to Prozac, acetaminophen, Chicago Sun-Times,

Common OTC Pain Relievers Increase Muscle Mass in Weight Training  -  Apr 7, 2008
...a second group taking the manufacturer’s recommended dosage of acetaminophen, commonly marketed as Tylenol; and a third group taking a placebo. MedHeadlines,

Granby man arrested on charges he sold painkillers  -  Apr 11, 2008
25 pills of Lorcet — a moderate prescription drug that is a mixture of acetaminophen and hydrocodone — to someone he thought was a legitimate buyer. Neosho Daily News,

Reading a column will enhance males, keep everyone regular  -  Apr 2, 2008
But when they say that their 500 mg of acetaminophen lowers fevers or relieves pain better than 500 mg of acetaminophen marketed under any other brand, News-Leader.com,

Statistics on generic prescription drugs  -  Apr 7, 2008
In 2007, the top generic drugs, by prescriptions dispensed in the United States, were Acetaminophen and Hydrocodone, Lisinopril, Levothyroxine, Amoxicillin, Press of Atlantic City,

Panadol hoax does the rounds again this year  -  Apr 21, 2008
The active ingredient in Panadol is paracetamol internationally or acetaminophen in the US. It is used for pain relief and reduce fever. GulfNews,

Home treatments for dental emergencies  -  Apr 21, 2008
However, Dr Abenaim recommends that people can temporarily alleviate the discomfort by taking pain relievers such as paracetamol, aspirin, and acetaminophen DentalPlans.com,

Kinetico Water Systems Can Reduce Pharmaceuticals in Drinking Water  -  Mar 28, 2008
These pharmaceuticals include Acetaminophen, Amoxicillin, Azithromycin, Caffeine, Carbadox, Carbamazepine, Clofibric Acid, Codeine, Cotinine, PR.com (press release),

Cadence Pharmaceuticals, Incorporated Q4 2007 Earnings Call Transcript  -  Apr 17, 2008
Our continued confidence in Acetavance is supported by successful post-operative pain trials of intravenous acetaminophen conducted by our licensor BMS and Seeking Alpha,

warning signals  -  Mar 26, 2008
Pain medicines such as acetaminophen (eg Tylenol) or ibuprofen (eg Advil) do not work the same way as ASA (ie Aspirin) and therefore will not help in the Heart and Stroke Foundation (press release),

Aspirin may be OK, but closely monitor use in cats  -  Apr 20, 2008
Tylenol (acetaminophen) is very dangerous and should never be used for cats." Q: My cat is quite large. He has trouble grooming himself and as a result, Eagle Tribune,

'Cheese' heroin dealer sentenced  -  Apr 19, 2008
Cheese heroin is a combination of black tar heroin and ground-up cold medicine, Tylenol PM, containing acetaminophen and diphenhydramine. Shreveport Times,

Finding the right OTC pain reliever  -  Apr 20, 2008
To start, it's important to understand that over-the-counter pain relievers fall into two categories: Acetaminophen and nonsteroidal anti-inflammatory drugs Utica Observer Dispatch,

Philly Officials to Address H20 Quality  -  Apr 12, 2008
...glasses of water daily for at least 40000 years to acquire a medical dose of acetaminophen, a non-prescription pain reliever found in the city's water. The Associated Press

Study: Chicago Tap Water Contains Trace Chemicals  -  Apr 17, 2008
And Chicago officials say it is, but a Tribune-financed study found tiny amounts of an anti-seizure medication, caffeine, acetaminophen and two chemicals CBS2 Chicago,

Oral Herpes · Fever Blister  -  Mar 30, 2008
Acetaminophen or ibuprofen are usually sufficient to treat any pain that may be associated with cold sores. Cool liquids or ice packs applied to the sore myFOXlubbock.com,

10 Deadliest Drugs  -  Mar 27, 2008
The fifth deadliest drug is another painkiller, this one over-the-counter: acetaminophen (Tylenol). It can cause irreversible and sometimes fatal liver WXii 12.com,

Tension Headache · Sinus Headache  -  Mar 26, 2008
Taking an over-the-counter painkiller such as acetaminophen or ibuprofen, relaxing, resting, correcting poor posture and exercising can all help to relieve MyFox Gulf Coast,

Tribune Media Services  -  Apr 7, 2008
...by putting ice on your knee for 15 to 20 minutes several times a day and taking an over-the-counter pain reliever, such as acetaminophen or ibuprofen. Chicago Tribune,

People's Pharmacy Use Milk of Magnesia for skin conditions  -  Apr 6, 2008
A: The prescription pain reliever Vicodin contains acetaminophen and the narcotic hydrocodone. According to the manufacturer, in sensitive people or at high Houston Chronicle,

New Finding: OptiMSM(R) May Shield Liver from Injury  -  Apr 16, 2008
...“These results suggest that MSM may enhance antioxidant function and assist in detoxification, for ‘insulting’ agents like acetaminophen or alcohol,�? added NPIcenter (press release),

Vitamin Supplements Don't Help You Live Longer, Study  -  Apr 16, 2008
They should be treated in the same way as paracetamol [acetaminophen] with maximum limits on the dosage," said Collins. The Cochrane Library is part of The Medical News Today,

5 Home Remedy No-No's  -  Apr 4, 2008
You can also try ibuprofen or acetaminophen to help alleviate pain. Cool tap water can also help, but only in the first minute after you're burned, CBS News,

Choose your over-the-counter weapon for the battle against aches ...  -  Apr 1, 2008
You look in the medicine cabinet in search of relief and the over-the-counter regulars stare back at you: aspirin, ibuprofen, naproxen and acetaminophen, San Diego Union Tribune,

Tokio Marine Capital to buy Japanese drug firm  -  Apr 1, 2008
Showa Yakuhin Kako, whose products include the painkiller acetaminophen, had sales of 8.8 billion yen for the year ended in December. Reuters

Brand Names/Synonyms:
Acetaminophen is also known by the following brand names and/or synonyms4'-Hydroxyacetanilide; 4'-Hydroxyacetanilide, Paracetamol; APAP; Abenol; Abensanil; Acamol; Accu-Tap; Acephen; Aceta; Aceta Elixir; Aceta Tablets; Acetagesic; Acetalgin; Acetaminofen; Acetaminophen; Acetaminophen Uniserts; Actamin; Actamin Extra; Actamin Super; Actimol Chewable Tablets; Actimol Children's Suspension; Actimol Infants' Suspension; Actimol Junior Strength Caplets; Algotropyl; Allay; Alpiny; Alpinyl; Alvedon; Amacodone; Amadil; Aminofen; Aminofen Max; Anacin; Anacin-3; Anacin-3 Extra Strength; Anaflon; Anapap; Anelix; Anexsia; Anexsia 10/660; Anexsia 5/325; Anexsia 7.5/325; Anexsia 7.5/650; Anhiba; Anoquan; Apacet; Apacet Capsules; Apacet Elixir; Apacet Extra Strength Caplets; Apacet Extra Strength Tablets; Apacet Regular Strength Tablets; Apadon; Apamid; Apamide; Apo-Acetaminophen; Arthritis Pain Formula; Aspirin Free Anacin Maximum Strength Caplets; Aspirin Free Anacin Maximum Strength Gel Caplets; Aspirin Free Anacin Maximum Strength Tablets; Aspirin-Free Excedrin Caplets; Atasol Caplets; Atasol Drops; Atasol Forte Caplets; Atasol Forte Tablets; Atasol Oral Solution; Atasol Tablets; Bancap; Bancap Hc; Banesin; Bayer Select Maximum Strength Headache Pain Relief Formula; Bickie-Mol; Bromo Seltzer; Bucet; Butalbital; Butapap; Calpol; Captin; Cetadol; Clixodyne; Co-Gesic; Conacetol; Dafalgan; Dapa; Dapa X-S; Darvocet; Darvocet-N 100; Darvocet-N 50; Datril; Datril Extra-Strength; Dhc Plus; Dimindol; Dirox; Disprol; Dolene Ap-65; Doliprane; Dolprone; Drixoral Plus; Dularin; Duradyne Dhc; Dymadon; Dypap; Elixodyne; Enelfa; Eneril; Esgic; Esgic-Plus; Eu-Med; Excedrin Caplets; Excedrin Extra Strength Caplets; Exdol; Exdol Strong; Febridol; Febrilix; Febrinol; Febro-Gesic; Febrolin; Femcet; Fendon; Feverall; Feverall Junior Strength; Feverall Sprinkle Caps Junior Strength; Fevor; Finimal; Fioricet; Free; G 1; G-1; Gelocatil; Genapap; Genapap Children's Elixir; Genapap Children's Tablets; Genapap Extra Strength Caplets; Genapap Extra Strength Tablets; Genapap Regular Strength Tablets; Genebs; Genebs Extra Strength Caplets; Genebs Regular Strength Tablets; Genebs X-Tra; Hedex; Homoolan; Hy-Phen; Hydrocet; Infants' Feverall; Injectapap; Janupap; Korum; Lestemp; Liquagesic; Liquiprin; Liquiprin Children's Elixir; Liquiprin Infants" Drops; Lonarid; Lorcet-Hd; Lortab; Lyteca; Lyteca Syrup; Meda; Medigesic Plus; Momentum; Multin; Myapap; NAPA; Napafen; Napap; Naprinol; Nealgyl; Nebs; Neopap; Neotrend; Nobedon; Norcet; Norco; O-Acetaminophenol; Oraphen; Oraphen-Pd; Ortensan; Oxycet; Oxycodone 2.5/Apap 500; Oxycodone 5/Apap 500; P-Acetamidophenol; P-Acetaminophenol; P-Hydroxyacetanilide; P-Hydroxyphenolacetamide; Pacemo; Painex; Paldesic; Panadol; Panadol Extra Strength; Panadol Junior Strength Caplets; Panadol Maximum Strength Caplets; Panadol Maximum Strength Tablets; Panaleve; Panasorb; Panets; Panex; Panofen; Papa-Deine #3; Papa-Deine #4; Paracet; Paracetamol; Paracetamol Dc; Paracetamol Ph Eur; Paracetamole; Paracetamolo; Paracetanol; Parapan; Paraspen; Parelan; Parmol; Pasolind; Pasolind N; Pedric; Percocet; Phenaphen; Phenaphen Caplets; Phendon; Phrenilin; Phrenilin Forte; Prompt; Propacet 100; Proval #3; Pyrinazine; Redutemp; Rivalgyl; Robigesic; Rounox; Roxicet; Roxicet 5/500; Roxilox; Salzone; Sedapap; Servigesic; Sk-Apap; Snaplets-Fr; St. Joseph; St. Joseph Fever Reducer; Suppap; Suppap-120; Suppap-325; Suppap-650; Tabalgin; Talacen; Tapanol; Tapanol Extra Strength Caplets; Tapanol Extra Strength Tablets; Tapar; Tavist Allergy/Sinus/Headache; Temlo; Tempanal; Tempra; Tempra Caplets; Tempra Chewable Tablets; Tempra D.S; Tempra Drops; Tempra Syrup; Tencon; Tibinide; Tibizide; Tisin; Tisiodrazida; Tizide; Tralgon; Triad; Triaprin; Tussapap; Tycolet; Tylenol; Tylenol Arthritis Extended Relief; Tylenol Caplets; Tylenol Children's Chewable Tablets; Tylenol Children's Elixir; Tylenol Drops; Tylenol Elixir; Tylenol Extra Strength Adult Liquid Pain Reliever; Tylenol Extra Strength Caplets; Tylenol Extra Strength Gelcaps; Tylenol Extra Strength Tablets; Tylenol Gelcaps; Tylenol Infants Drops; Tylenol Infants" Suspension Drops; Tylenol Junior Strength Caplets; Tylenol Junior Strength Chewable Tablets; Tylenol Regular Strength Caplets; Tylenol Regular Strength Tablets; Tylenol Tablets; Tylox; Tylox-325; Ultracet; Uniserts; Valadol; Valgesic; Valorin; Valorin Extra; Vicodin; Vicodin Es; Vicodin Hp; Wygesic

Drug Category:
Acetaminophen is categorized under the following by the FDA: Analgesics; Antipyretics; ATC:N02BE01

Dosage Forms:
80 mg per mL (OTC) Atasol Drops Panadol Tempra Drops alcohol 10% Tylenol Drops [Generic] 80 mg per 5 mL (OTC) Atasol Oral Solution Panadol sodium Robigesic alcohol 8.5% Tempra Syrup 160 mg per 5 mL (OTC) Tempra Syrup Tylenol Elixir [Generic]

Absorption:
Oral _ Rapid and almost complete

Interactions:
Interactions for Acetaminophen:

No information provided.

Chemical IUPAC Name:
N-(4-hydroxyphenyl)ethanamide

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