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AccutaneThis page contains recent news articles, when available, and an overview of Accutane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Accutane (when available) Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. Mechanism Of Action: Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown. News Articles on Tretinoin Many Teens Share Prescription Drugs: Study - Aug 18, 2009 ...like Oxycontin and Darvocet, followed by antibiotics, acne medications like Accutane, and mood drugs such antidepressants and anti-anxiety medications. ABC News 1 in 5 teens shares prescriptions - Aug 13, 2009 For example, a teen who's taking the acne medication Accutane — which has been linked to birth defects — may give some to a friend who is pregnant but USA Today The Science of Laser Acne Treatment - Aug 27, 2009 One caveat, though: patients who have taken Accutane for acne in the previous six months are not recommended for this type of procedure. 24-7PressRelease.com (press release) Prescription 'Sharing' Among Teens Widespread, Dangerous - Aug 27, 2009 What if a teenager with acne who is taking Accutane — a drug linked to birth defects — gives some to her Bell Gardens Sun 40% Of US Teenagers Share Diverse Prescription Drugs, With ... - Aug 10, 2009 Imagine one teenager who has acne giving some Accutane, a prescription medication, to a friend. The friend is pregnant and does not know it yet. Medical News Today Why College Students Are Using Botox - Aug 13, 2009 The most common previous treatment for refractory acne, Accutane, decreased oil production but produced side effects like liver damage, bleeding in the Grinza Breaking the Vicious Cycle - Aug 17, 2009 From low grade to the motha-fuckin' A-Bomb itself, Accutane. It destroyed my immune system. Years later, I was diagnosed with Crohn's disease, Gamasutra What Is Rosacea? What Causes Rosacea? - Aug 11, 2009 Isotretinoin (Accutane) - this oral medication is sometimes used for severe cases of inflammatory rosacea if other treatments have not worked. Medical News Today Accutane trial set to begin in Madison County - Aug 13, 2009 Madison County Circuit Judge Dave Hylla is set to preside over a medical malpractice trial Monday involving acne medication Accutane. Madison County Record The truth about Michael Jackson's perfect test-tube family - Aug 27, 2009 She said: "He had the powerful drug Accutane in his room. When I read the label it revealed it could damage foetuses. "On top of all the other medication, NOTW Blogs The Sophie Atay Neuroblastoma Appeal - Aug 27, 2009 ...for Sophie would be to have a monoclonal antibody known as 3f8 hopefully, if available, at the same time as she has her Accutane (oral chemotherapy). Rundtownnews.co.uk Community for Hope gets ready to open a Fox Cities affiliate while ... - Aug 23, 2009 ..."He had no depression," Zimmer said of her son, who started taking the acne-prevention drug Accutane a month before his death. His parents blame the drug Oshkosh Northwestern Memo to Michael Bay: Go See 'District 9' - Aug 14, 2009 Despite themselves, the impulse-driven, Accutane-smearing moviegoers who are the lynchpin of this industry respond accordingly to quality. TheWrap Michael created kids like Frankenstein - Aug 22, 2009 She said: "He had the powerful drug Accutane in his room. When I read the label it revealed it could damage foetuses. "On top of all the other medication, News of the World El Niño är tillbaka - Aug 4, 2009 Oral pills like Cialis Viagra and Levitra have helped millions never ending beauty routines one online prescriptions at the lowest laparoscopy if accutane Tidningen Arbetaren Ready to party - Aug 6, 2009 The Hong Kong headquartered critter cheap accutane tablets welfare organization Animals Asia says make you believe that HGH hit the stone floor probably FM Tech Mixed-up media - Aug 12, 2009 By following a regimen you reason why these are the most common complaints men be among men with low when it comes accutane pills to sex root muira puama FM Tech 08-12-09 South Holland Fifefighters Reach Out To Young Cancer Patient - Aug 13, 2009 2007), 100 day isolation, 12 cycles of radiation, 6 months of accutane treatments and many many hospital admissions for Neutropenia and much more. The Shopper Online Hair Removal - Aug 15, 2009 Patients on Accutane should avoid waxing while on medication and for 30 days after completing treatment because skin becomes delicate and the waxing process Vanguard Blood Feud - Aug 12, 2009 But she refused because if the student was taking Accutane his blood could cause a "serious situation" if transmitted to a pregnant woman. New Haven Advocate Pro-Medics Now Stocking New Line of Acne Treatment Products - Aug 7, 2009 Pro-medics now has available for purchase, upon free medical consultation, the oral acne treatment medications Accutane and Aldactone, as well as the Emediawire (press release) Muchos adolescentes comparten sus fármacos de venta bajo receta - Aug 28, 2009 ...como Oxycontin y Darvocet, seguidos de los antibióticos, los remedios para el acné, como Accutane, y los fármacos para regular el estado anÃmico, Buena Salud Many Adolescents Share Prescription Medication Around three ... - Aug 12, 2009 WEDNESDAY, Aug. 12 (HealthDay News) -- One-fifth of US adolescents report sharing prescription medication, and efforts to reduce this practice may be Modern Medicine Usa, Roche cessa la produzione del farmaco anti-acne Accutane - Aug 6, 2009 Hoffman-La Roche ha annunciato che non venderà più il farmaco anti-acne Roaccutan (Accutane negli Stati Uniti), in commercio dal 1982, a causa della RSI news L'IPL, un laser nouvelle génération - Aug 25, 2009 IPL contre l'acné qui détruit la bactérie et réduit donc la prise d'antibiotiques ou d'Accutane, un produit pharmaceutique qui a des effets secondaires. Fugues 一个温顺的洗é?¢ä¹³å?Šä¸€ä¸ªå¥½çš„防晒隔离霜 - Aug 4, 2009 ...å?ªæœ‰å°‘数的皮肤ä¿?å…»å“?è¦?ç»?è¿‡ä¸¥æ ¼çš„åŒ»å¦ä¸´åºŠæ£€éªŒï¼Œæ‰?能获得美国食å“?å’Œè?¯ç‰©æ²»ç?†ç½²ï¼ˆFDA）的批准，例如处方è?¯ç‰©åƒ?治疗é?¢ç–±çš„A酸（Accutane）å?£æœ?剂å?ŠæŸœå?°å°±å?¯ä»¥ä¹°åˆ°çš„防晒 中国医药网 Brand Names/Synonyms: Accutane is also known by the following brand names and/or synonymsAberel; Accutane; Airol; Aknefug; Aknoten; All Trans Retinoic Acid; All Trans-Retinoic Acid; Amnesteem; Avita; Beta-Retinoic Acid; Claravis; Dermairol; Eudyna; Isotretinoin; Lsotretinoin; Panretin; Renova; Retin-A; Retin-a Micro; Retinoate; Retinoic Acid; Retinoic Acid, All Trans Isomer; Retionic Acid; Retisol-A; Solage; Sotret; Stieva-A; Stieva-a Forte; Trans-Retinoic Acid; Tretin M; Tretinoin; Tri-Luma; Vesanoid; Vitamin a Acid; Vitinoin; β-Retinoic Acid Drug Category: Accutane is categorized under the following by the FDA: Keratolytic Agents; Antineoplastic Agents; Cell Stimulants and Proliferants (84:16.00); ATC:D10AD01; ATC:D10AD04; ATC:D10BA01; ATC:L01XX14; ATC:L01XX22 Dosage Forms: CAPSULE; CREAM; GEL; LIQUID Absorption: 1-31% (topical); Interactions: Interactions for Tretinoin: Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA because they may increase irritation with RENOVA. RENOVA should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity. Chemical IUPAC Name: 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid : |
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