Accupril

This page contains recent news articles, when available, and an overview of Accupril but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Accupril (when available)

Pharmacology and use:
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. For the treatment of hypertension and chronic heart failure

Mechanism Of Action:
Quinaprilat competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms. Quinaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

News Articles on Quinapril

Drugs aren't the only treatment for hypertension  -  ‎Aug 14, 2009‎
We also have tried Coreg, Norvasc, Accupril and lisinopril. My reaction to those medications has been severe migraine-like headaches. Los Angeles Times

El conocimiento es poder  -  ‎Aug 14, 2009‎
...presión alta, depresión y trastorno bipolar, con medicamentos como Lipitor, Norvasc, Caduet, Altruline, Geodón, Accuretic y Accupril. Crítica

Pfizer produce medicamentos de amplio uso en el país para ...  -  ‎Aug 12, 2009‎
Accupril (Quinapril) es otro de los medicamentos de importante uso en el país que se produce en las plantas de Pfizer. Es indicado en casos de hipertensión Globovisión

Sun Pharma secures USFDA approval for generic Accupril tablets  -  ‎Jun 19, 2009‎
These quinapril hydrochloride tablets, therapeutically equivalent to Accupril® tablets from Pfizer, are available in four strengths viz. Equity Bulls

Sun Pharma gets US FDA nod for generic Accupril tabs  -  ‎Jun 22, 2009‎
Sun Pharmaceutical Industries Ltd announced that US FDA has granted an approval for its Abbreviated New Drug Application (ANDA) for generic Accupril, pharmabiz.com

Sun Pharma gets USFDA approval for Accupril; stk down  -  ‎Jun 22, 2009‎
The company has got USFDA approval for generic Accupril tablets, reports CNBC-TV18. It was trading with volumes of 8225 shares. On Friday the share closed Moneycontrol.com

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...enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or trandolapril (Mavik). На плувка и дъно

Indian officials lobby for pharma duty cuts; Hospira shares jump ...  -  ‎Jun 22, 2009‎
Report > Meanwhile, Sun Pharmaceutical got the FDA nod to launch a generic version of Pfizer's blood pressure drug Accupril. Report > The European Medicines FiercePharma

Shop around before you buy generic drugs  -  ‎Jun 23, 2009‎
Accupril's generic version costs $84.59 at CVS, but once again at Costco we found the price much cheaper for $17.10. "Even at that one, we are looking at an abc13.com

Indian Market Ends Sharply Lower  -  ‎Jun 22, 2009‎
2.24% even as it received approval from the US Food and Drug Administration for the launch of a generic version of Pfizer's blood pressure drug Accupril. International Business Times UK

Patient in quandary whether to take hormone  -  ‎Apr 18, 2009‎
Brand names of some of these drugs are Lotensin, Capoten, Vasotec, Monopril, Zestril, Univasc, Aceon, Accupril, Altace and Mavik. Cough is one of their side SouthCoastToday.com

Recession is taking a toll on the health of some diabetics  -  ‎Apr 12, 2009‎
...supplies to control type I diabetes is $422.80, including insulin, syringes, lancets, test strips and the drug Accupril, which prevents kidney damage. Fort Worth Star Telegram

The People's Pharmacy  -  ‎Mar 2, 2009‎
His doctor has him on atenolol, reserpine, Accupril, Norvasc and hydrochlorothiazide. Dad is terribly depressed and can barely drag himself out of bed. Seattle Times

Blood pressure medicine can cause hacking cough  -  Dec 22, 2008
Like other blood pressure drugs in this class (Accupril, Altace, benazepril, captopril, enalapril, ramipril and quinapril), lisinopril can cause a hacking Los Angeles Times,

Medicine triggers hallucinations  -  Dec 22, 2008
Like other blood pressure drugs in this class (Accupril, Altace, benazepril, captopril, enalapril, ramipril and quinapril), lisinopril can cause cough as an Online Athens,

Ask Dr. H: Seeking an end to dry mouth  -  Nov 10, 2008
...mouth include: water pills; blood pressure meds called "ACE inhibitors" (Lisinopril, Accupril); antidepressants; decongestant pills; and antihistamines. Philadelphia Inquirer,

There are a number of ways to fight restless legs  14 Sep 2008
ACE inhibitors include Vasotec, enalapril, captopril, Accupril, Altace and Mavik. If you are not sure about your medicine's safety with potassium,SouthCoastToday.com,

Fox News Courts Coveted "Old n' Grouchy" Demographic  Aug 18, 2008
...those blood pressure and ED advertisers. Now, take your Accupril and lie down for a nap; getting worked up like this is liable to throw your hip out again.Jossip,

Throat and Tongue Swelling Can Be Lethal  Aug 17, 2008
Lotensin, captopril, Vasotec, Lisinopril, Prinivil, Monopril, Zestril, Accupril, Altace and Mavik are examples. Other medicines involved in angioedema areRedOrbit,

House committee begins investigation of FDA drug approvals  -  Jul 23, 2008
...its generic version of Pfizer Inc.'s blood-pressure drug Accupril because Pfizer was likely to win a patent-infringement lawsuit filed against Ranbaxy. JURIST

Q2 2008 GLOBAL SALES AT USD 440 MN (RS 18296 MN), + 11%  -  Jul 29, 2008
The settlement also resolves additional patent litigation between the companies involving the branded drugs Accupril .ie Quinapril Hydrochloride (in the US) Prdomain Business Register (press release),

Take control of your blood pressure  -  Jul 9, 2008
ACE inhibitors, such as quinapril (Accupril), work by inhibiting angiotensin (a hormone) production, thus allowing the arteries to dilate, Bale said. LubbockOnline.com,

Pfizer Rises After Ranbaxy Delays Generic Lipitor (Update1)  -  Jun 18, 2008
The agreement also settles lawsuit over the Viagra impotence drug pending in Ecuador, and one over the blood pressure medicine Accupril pending in New Bloomberg

Siemens, GFI, EADS, Parmalat, Hoechst, Pfizer in Court News  -  Jun 18, 2008
The agreement also settles lawsuit over the Viagra impotence drug pending in Ecuador, and one over the blood pressure medicine Accupril pending in New Bloomberg

Market Report -- In Play (PFE)  -  Jun 18, 2008
The settlement also resolves all patent litigation with Ranbaxy relating to Accupril in the United States and Viagra in Ecuador. Briefing.com is the leading MSN Money

Pfizer and Ranbaxy Settle Lipitor Patent Litigation Worldwide  -  Jun 18, 2008
The settlement also resolves all patent litigation with Ranbaxy relating to Accupril in the United States and Viagra in Ecuador. ag-IP-news Agency,

The Winchester Star  -  Mar 30, 2008
Some of the most common prescriptions were for Accupril for hypertension, Glucophage for Type II diabetes, and Zoloft for depression and anxiety disorders. The Winchester Star,

Pfizer  -  Feb 21, 2008
Tara Croft examined the question in June 2007: With drugs to treat heart disease such as Accupril and Norvasc and cholesterol drug Lipitor, New York-based The Daily Deal (subscription),

List of causes for acute hives is long  -  Feb 18, 2008
ACE inhibitors include Vasotec, enalapril, captopril, Accupril, Altace and Mavik. If you are not sure about your medicine's safety with potassium, Kingston Daily Freeman,

One year later, Pfizer emptying Ann Arbor labs  -  Jan 20, 2008
A year later, the site that created Lipitor - the best-selling prescription drug in history - as well as Accupril, Neurontin, Caduet and Lyrica is on track MLive.com,

Common Medications Provide Equal Blood Pressure Control  -  Nov 1, 2007
...lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik). Earthtimes,

Teva Introduces Quinapril Tablets USP  -  Oct 4, 2007
This product is AB rated and bioequivalent to Accupril Tablets. Quinapril Tablets are available in 5 mg, 10 mg, 20 mg, and “Our customers count on Teva for PharmaLive.com (press release),

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Teva gets FDA approval for generic accupril  -  Aug 27, 2007
Monday it received final approval from the Food and Drug Administration to market its generic version of Pfizer Inc.'s hypertension treatment Accupril. Ynetnews,

Teva says US approves generic form of Accupril  -  Aug 27, 2007
N: Quote, Profile, Research) Accupril treatment for high blood pressure. The Israel-based drugmaker said all forms of Accupril, including generic products Reuters

Teva Pharma Receives FDA Approval Of Generic Accupril Tablets  -  Aug 27, 2007
The FDA marketing approval for Accupril was granted following the expiration of pediatric exclusivity for US Patent No. 4743450. RTT News,

Teva Pharma Wins FDA Approval For Generic Accupril Tablets - Quick ...  -  Aug 27, 2007
Abbreviated New Drug Application to market its generic version of Pfizer's hypertension treatment Accupril or Quinapril Hydrochloride Tablets, 5 mg, Trading Markets,

Teva Announces Approval of Generic Accupril® Tablets  -  Aug 27, 2007
...(ANDA) to market its generic version of Pfizer’s hypertension treatment Accupril® (Quinapril Hydrochloride) Tablets, 5 mg, 10 mg, 20 mg and 40 mg. Business Wire (press release),

Teva Gets a Two-For  -  Aug 28, 2007
Yesterday, Teva announced the second consecutive FDA approval, this time for a generic version of Pfizer's (NYSE: PFE) hypertension treatment Accupril. Motley Fool

Market Report -- In Play (TEVA)  -  Aug 27, 2007
Teva Pharm announces approval of generic Accupril tablets Co announces following the expiration of pediatric exclusivity for US Patent No. MSN Money

India Aurobindo gets tentative FDA nod for quinapril  -  Jun 24, 2007
Livemint,He drugs, used in treating hypertension and congestive heart failure, are the generic equivalents of Pfizer Inc.’s Accupril and Accuretic tablets Mumbai:

MSU given former Pfizer lab  -  May 11, 2007
South Bend Tribune,The research center once employed about 100 Pfizer researchers, who developed drugs including Lipitor, the blood pressure medication Accupril and the

In most new patients to treat workers.  -  May 9, 2007
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AGS: Centrally Active ACE Inhibitors May Slow Cognitive Decline  -  May 7, 2007
Psychiatric Times,Agents that don't cross the blood brain barrier are benazapril (Lotensin), enalapril (Vasotec), moexepril (Univasc), and quinapril (Accupril).

Inactivated heterologous on whom was later determined.  -  Apr 19, 2007
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DetNews.com,Dear Dr. Donohue: In the causes of cough, you should have mentioned Accupril. It caused mine. Dear JC: The blood-pressure-lowering medicines, ACE inhibitors

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Health & Fitness briefs  -  Mar 31, 2007
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As Pfizer Changes, Biotech Partners Seem Unaffected  -  Dec 1, 2006
BioWorld Online,...including decisions made on access and pricing in several large European markets, as well as the loss of US exclusivity on products such as Accupril,

Pfizer to Transform In Rapidly Changing Healthcare Environment  Oct 19, 2006
The loss of US exclusivity on a number of our major medicines since 2004 (Accupril/Accuretic, Diflucan, Neurontin, Zithromax, and Zoloft), as well as the ... -MSN Money Morris man pleads guilty to Rx thefts  Nov 3, 2006
...and June 9, 2004, he stole more than $13,000 worth of medication from the hospital, including Zithromax, Combivir, Lipitor, Zocor, Accupril, Diovan, Celebrex ... -Dailyrecord.com, Drugmaker announces $10 billion stock buyback for 2007  Oct 19, 2006
...should be able to more than compensate for losses due to the loss of patent protection for such key products as Zoloft, Zithromax, Accupril and Diflucan. ... -MarketWatch Pfizer Q3 earnings call - tough times ahead  Oct 19, 2006
In Q4 2006 and 2007 Pfizer will lose exclusivity on Zoloft, Accupril, Neurontin and Zithromax, all popular drugs. There are some pieces of good news. ... -Blogging Stocks Pfizer Q3 Profit More Than Doubles On Absence Of Charges, Reveals ...  Oct 19, 2006
...growth. However, the company noted that the loss of exclusivity on a number of medicines since 2004 including Accupril. Diflucan ... -Trading Markets, Market Report -- Story Stocks (PFE)  Oct 19, 2006
The patent expiration of many of Pfizer's top-selling products, including Accupril/Accuretic, Diflucan, Neurontin, Zithromax, Zoloft, and Bextra, have had a ... -MSN Money Cutting drug prices tests political will  Aug 21, 2006
Confiscated were Viagra, a drug for erectile dysfunction; Accupril for hypertension; Lipitor for hyperlipidemia; Dilantin, for convulsion; Norvasc ... -ABS CBN News

SC junks Glaxo bid to prosecute Pakistani merchants  Aug 21, 2006
Ateeque showed them samples of the medicines he was selling, including Viagra, a drug for erectile dysfunction; Accupril for hypertension; Lipitor for ... -INQ7.net

Two IP Law Firm Principals, the Only US Patent Law Experts Invited ...  Jul 28, 2006
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Two IP Law Firm Principals, the Only US Patent Law Experts Invited ...  Jul 28, 2006
...on Wednesday, August 9. Fuchs will review and analyze patent enforcement claims and outcomes involving such popular drugs as Zoloft(R), Accupril(R) and Zyprexa ... -PR Newswire

Brand Names/Synonyms:
Accupril is also known by the following brand names and/or synonymsAccupril; Accuprin; Accupro; Acequin; Acuitel; Korec; Quinapril; Quinapril Hcl; Quinapril Hydrochloride; Quinapril Hydrochloride: Accupril; Quinaprilum [Latin]; Quinazil

Drug Category:
Accupril is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA06

Dosage Forms:
Tablets

Absorption:
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.

Interactions:
-->Interactions for Quinapril:

Concomitant diuretic therapy

As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with ACCUPRIL. The possibility of hypotensive effects with ACCUPRIL may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with ACCUPRIL. If it is not possible to discontinue the diuretic, the starting dose of quinapril should be reduced.

Agents increasing serum potassium

Quinapril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of ACCUPRIL with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium.

Tetracycline and other drugs that interact with magnesium

Simultaneous administration of tetracycline with ACCUPRIL reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in ACCUPRIL tablets. This interaction should be considered if coprescribing ACCUPRIL and tetracycline or other drugs that interact with magnesium.

Lithium

Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity.

Other agents

Drug interaction studies of ACCUPRIL with other agents showed:

· Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of ACCUPRIL.

· The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by quinapril coadministration twice-daily.

· ACCUPRIL treatment did not affect the pharmacokinetics of digoxin.

· No pharmacokinetic interaction was observed when single doses of ACCUPRIL and hydrochlorothiazide were administered concomitantly.

· Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of ACCUPRIL resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.

Chemical IUPAC Name:
2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

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