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AccuprilThis page contains recent news articles, when available, and an overview of Accupril but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Accupril (when available) Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. For the treatment of hypertension and chronic heart failure Mechanism Of Action: Quinaprilat competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms. Quinaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin. News Articles on Quinapril The Winchester Star - Mar 30, 2008 Some of the most common prescriptions were for Accupril for hypertension, Glucophage for Type II diabetes, and Zoloft for depression and anxiety disorders. The Winchester Star, Pfizer - Feb 21, 2008 Tara Croft examined the question in June 2007: With drugs to treat heart disease such as Accupril and Norvasc and cholesterol drug Lipitor, New York-based The Daily Deal (subscription), List of causes for acute hives is long - Feb 18, 2008 ACE inhibitors include Vasotec, enalapril, captopril, Accupril, Altace and Mavik. If you are not sure about your medicine's safety with potassium, Kingston Daily Freeman, One year later, Pfizer emptying Ann Arbor labs - Jan 20, 2008 A year later, the site that created Lipitor - the best-selling prescription drug in history - as well as Accupril, Neurontin, Caduet and Lyrica is on track MLive.com, Common Medications Provide Equal Blood Pressure Control - Nov 1, 2007 ...lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik). Earthtimes, Teva Introduces Quinapril Tablets USP - Oct 4, 2007 This product is AB rated and bioequivalent to Accupril Tablets. Quinapril Tablets are available in 5 mg, 10 mg, 20 mg, and “Our customers count on Teva for PharmaLive.com (press release), BERICHT: Buy Drugs Without Prescription. No Prior Prescription ... - Oct 7, 2007 ...antidepressant medications, antibiotics and more. accupril, buy aciphex, aciphex tablet, aciphex levaquin, rabeprazole sodium aciphex, aciphex uses, Ermelo.org, Buy Drugs Without Prescription. Safe and Secure Ordering. - Oct 3, 2007 ...anxiety, antidepressant medications, antibiotics and more. accupril tablet, aciphex prevacid, aciphex 20mg, aciphex 20, aciphex generic, aciphex uses, LIVE-Wintersport.com, Teva gets FDA approval for generic accupril - Aug 27, 2007 Monday it received final approval from the Food and Drug Administration to market its generic version of Pfizer Inc.'s hypertension treatment Accupril. Ynetnews, Teva says US approves generic form of Accupril - Aug 27, 2007 N: Quote, Profile, Research) Accupril treatment for high blood pressure. The Israel-based drugmaker said all forms of Accupril, including generic products Reuters Teva Pharma Receives FDA Approval Of Generic Accupril Tablets - Aug 27, 2007 The FDA marketing approval for Accupril was granted following the expiration of pediatric exclusivity for US Patent No. 4743450. RTT News, Teva Pharma Wins FDA Approval For Generic Accupril Tablets - Quick ... - Aug 27, 2007 Abbreviated New Drug Application to market its generic version of Pfizer's hypertension treatment Accupril or Quinapril Hydrochloride Tablets, 5 mg, Trading Markets, Teva Announces Approval of Generic Accupril® Tablets - Aug 27, 2007 ...(ANDA) to market its generic version of Pfizer’s hypertension treatment Accupril® (Quinapril Hydrochloride) Tablets, 5 mg, 10 mg, 20 mg and 40 mg. Business Wire (press release), Teva Gets a Two-For - Aug 28, 2007 Yesterday, Teva announced the second consecutive FDA approval, this time for a generic version of Pfizer's (NYSE: PFE) hypertension treatment Accupril. Motley Fool Market Report -- In Play (TEVA) - Aug 27, 2007 Teva Pharm announces approval of generic Accupril tablets Co announces following the expiration of pediatric exclusivity for US Patent No. MSN Money India Aurobindo gets tentative FDA nod for quinapril - Jun 24, 2007 Livemint,He drugs, used in treating hypertension and congestive heart failure, are the generic equivalents of Pfizer Inc.’s Accupril and Accuretic tablets Mumbai: MSU given former Pfizer lab - May 11, 2007 South Bend Tribune,The research center once employed about 100 Pfizer researchers, who developed drugs including Lipitor, the blood pressure medication Accupril and the In most new patients to treat workers. - May 9, 2007 Journal lycéen,Tolerance to in large Nitrofurantoin the rate Accupril negligence. Examination of widespread use Finasteride damages need earliest days victims. AGS: Centrally Active ACE Inhibitors May Slow Cognitive Decline - May 7, 2007 Psychiatric Times,Agents that don't cross the blood brain barrier are benazapril (Lotensin), enalapril (Vasotec), moexepril (Univasc), and quinapril (Accupril). Inactivated heterologous on whom was later determined. - Apr 19, 2007 LIVE-Wintersport.com,The medication cap was Accupril developed nosocomial Keppra aversive. Americans of the only change in Famotidine editors. An exclusion must then reduction Artificial sweetener accused of causing many illnesses - Apr 9, 2007 DetNews.com,Dear Dr. Donohue: In the causes of cough, you should have mentioned Accupril. It caused mine. Dear JC: The blood-pressure-lowering medicines, ACE inhibitors The antigen sue an via the occasions. - Apr 9, 2007 LIVE-Wintersport.com,Processes involved data collection as shown Accupril holds up assessed. This signal survey whether first in Atrovent for transmiss seed. Health & Fitness briefs - Mar 31, 2007 Bryan College Station Eagle,Accupril (generic name quinapril) for high blood pressure and heart failure. Attention, men older than 45: If you feel yourself getting angry, BUY ALTACE, Altace Online, Altace Cheap - Dec 25, 2006 Indymedia Colombia,Although oral contraceptives have other effects Angiotensin-converting enzyme (ACE) inhibitors Accupril, Aceon, Altace, Capoten, Lotensin, Mavik, Monopril, BUY ALTACE, Altace Online, Altace Cheap - Dec 25, 2006 Indymedia Colombia,Although oral contraceptives have other effects Angiotensin-converting enzyme (ACE) inhibitors Accupril, Aceon, Altace, Capoten, Lotensin, Mavik, Monopril, As Pfizer Changes, Biotech Partners Seem Unaffected - Dec 1, 2006 BioWorld Online,...including decisions made on access and pricing in several large European markets, as well as the loss of US exclusivity on products such as Accupril, Pfizer to Transform In Rapidly Changing Healthcare Environment Oct 19, 2006 The loss of US exclusivity on a number of our major medicines since 2004 (Accupril/Accuretic, Diflucan, Neurontin, Zithromax, and Zoloft), as well as the ... -MSN Money Morris man pleads guilty to Rx thefts Nov 3, 2006 ...and June 9, 2004, he stole more than $13,000 worth of medication from the hospital, including Zithromax, Combivir, Lipitor, Zocor, Accupril, Diovan, Celebrex ... -Dailyrecord.com, Drugmaker announces $10 billion stock buyback for 2007 Oct 19, 2006 ...should be able to more than compensate for losses due to the loss of patent protection for such key products as Zoloft, Zithromax, Accupril and Diflucan. ... -MarketWatch Pfizer Q3 earnings call - tough times ahead Oct 19, 2006 In Q4 2006 and 2007 Pfizer will lose exclusivity on Zoloft, Accupril, Neurontin and Zithromax, all popular drugs. There are some pieces of good news. ... -Blogging Stocks Pfizer Q3 Profit More Than Doubles On Absence Of Charges, Reveals ... Oct 19, 2006 ...growth. However, the company noted that the loss of exclusivity on a number of medicines since 2004 including Accupril. Diflucan ... -Trading Markets, Market Report -- Story Stocks (PFE) Oct 19, 2006 The patent expiration of many of Pfizer's top-selling products, including Accupril/Accuretic, Diflucan, Neurontin, Zithromax, Zoloft, and Bextra, have had a ... -MSN Money Cutting drug prices tests political will Aug 21, 2006 Confiscated were Viagra, a drug for erectile dysfunction; Accupril for hypertension; Lipitor for hyperlipidemia; Dilantin, for convulsion; Norvasc ... -ABS CBN News SC junks Glaxo bid to prosecute Pakistani merchants Aug 21, 2006 Ateeque showed them samples of the medicines he was selling, including Viagra, a drug for erectile dysfunction; Accupril for hypertension; Lipitor for ... -INQ7.net Two IP Law Firm Principals, the Only US Patent Law Experts Invited ... Jul 28, 2006 Fuchs will review and analyze patent enforcement claims and outcomes involving such popular drugs as Zoloft(R), Accupril(R) and Zyprexa(R) while Dr. Yeung will ... -Genetic Engineering News Two IP Law Firm Principals, the Only US Patent Law Experts Invited ... Jul 28, 2006 ...on Wednesday, August 9. Fuchs will review and analyze patent enforcement claims and outcomes involving such popular drugs as Zoloft(R), Accupril(R) and Zyprexa ... -PR Newswire Pfizer Delivers Strong Second-Quarter 2006 Results, Driven By ... Jul 20, 2006 ...quarter 2006 worldwide revenues (excluding the impact of foreign exchange) of products that have lost US exclusivity in 2004-06: Accupril/Accuretic, Diflucan ... -PR Newswire Peterson and Associates, PC Announces Investigation of ACE ... Jul 17, 2006 ACE inhibitor drugs include Vasotec(r), Prinivil(r)/Zestril(r), Monopril(r), Lotensin(r), Altace(r), Aceon(r), Accupril(r), Mavik(r), Univasc(r) and Capoten(r ... -PrimeZone Pfizer To Introduce Generic Version Of Its Antidepressant Zoloft Jun 29, 2006 Greenstone's other products include generic versions of blood-pressure pill Accupril, epilepsy medicine Neurontin and antibiotic Zithromax. ... -Trading Markets Lupin Gets USFDA Approval For Quinapril Tablets Jun 23, 2006 Quinapril is a AB-rated generic equivalent of Pfizer's hypertension drug Accupril and its market is estimated to be about 300 million dollars in the US till ... -MedIndia Lupin gets final approval for Quinapril Tablets Jun 23, 2006 The company`s Quinapril Tablets USP is the AB-rated generic equivalent of Pfizer`s` Accupril` Tablets, a product indicated to treat hypertension. ... -Myiris.com Lupin Receives Final Approval for Quinapril Tablets Jun 26, 2006 Lupin's Quinapril Tablets USP are the AB-rated generic equivalent of Pfizer's' Accupril® Tablets, a product indicated to treat hypertension. ... -Yahoo! News Advisory - Health Canada reminds women not to use ACE inhibitors ... Jun 29, 2006 ACE inhibitors include: - Quinapril HCI (sold under the brand name Accupril) - Ramipril (sold under the brand name Altace) - Captopril (sold under the brand ... -CNW Telbec (Communiqués de presse) Pfizer First-Quarter 2006 Financial Results Reflect Operating and ... Apr 19, 2006 ...quarter 2006 worldwide revenues (excluding the impact of foreign exchange) of products that have lost US exclusivity in 2004-06 -- Accupril/Accuretic, Diflucan ... - International News Service Pfizer's First-Quarter Earnings Rise on Pain, Cholesterol Drugs Apr 19, 2006 ...generic competition. So did sales of the Zithromax antibiotic, the Diflucan anti-infective and the Accupril high blood pressure. (To ... - Bloomberg Pfizer's Earnings Rise on Pain, Cholesterol Drugs (Update2) Apr 19, 2006 ...competition. So did sales of the Zithromax antibiotic, the Diflucan anti-infective and the Accupril high blood pressure drug. (To ... - Bloomberg Good deodorant alternative Mar 15, 2006 ACE inhibitors like Altace (ramipril), Accupril (quinapril), Prinivil (lisinopril) and Vasotec (enalapril) are quite effective and generally well tolerated. ... - Daily Press Alba Therapeutics Announces Creation of Development Advisory Board 06 Mar 2006 ...of Clinical Pharmacology at Parke Davis, he oversaw the exploratory clinical development of drugs such as Neurontin®, Lipitor® and Accupril® and following a ... - Yahoo! News Pfizer 2006 profit view disappoints, stock falls Feb 10, 2006 Fourth-quarter sales of the epilepsy treatment Neurontin plunged 71 percent to $141 million; sales of hypertension drug Accupril fell 74 percent to $44 million ... - Reuters Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ... 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Sales of the Zithromax antibiotic, the Diflucan anti-infective and the Accupril high blood pressure drug also declined. ... - Manufacturer.com Pfizer quarter beats forecasts Jan 19, 2006 Epilepsy treatment Neurontin saw sales slump 71%, hypertension drug Accupril sank 74%, while sales of arthritis treatment Celebrex tumbled 53% following the ... - Life Style Extra Pfizer quarterly profit falls, mauled by generics Jan 19, 2006 They include epilepsy treatment Neurontin, whose fourth-quarter sales plunged 71 percent to $141 million, and hypertension drug Accupril, which fell 74 percent ... - ABC News Heart drug use has increased, but still suboptimal Jan 9, 2006 In 2002, rates of overall and consistent use of angiotensin-converting enzyme (ACE) inhibitors, such as Accupril and Vasotec, in patients with heart failure ... - Reuters.uk Pfizer Fourth-Quarter Net Falls 3 Percent; Lipitor Sales Slow Jan 19, 2006 ...competition. So did sales of the Zithromax antibiotic, the Diflucan anti-infective and the Accupril high blood pressure drug. The ... - Bloomberg Pfizer profit falls, but drugmaker beats forecast Jan 19, 2006 They include epilepsy treatment Neurontin, whose fourth-quarter sales plunged 71 percent to $141 million, hypertension drug Accupril, which fell 74 percent to ... - Reuters India Ranbaxy hit, low US prices pinch Indian drugmakers Jan 17, 2006 November, a US court upheld a ruling blocking sales by Ranbaxy and world-leading generic maker Teva of generic alternatives to Pfizer's Accupril blood pressure ... - Boston Globe Ranbaxy net hit by price pressure, gets new CEO Jan 18, 2006 November also upheld a preliminary district court injunction barring Ranbaxy from selling quinapril tablets - a generic of Pfizer's blood pressure drug Accupril ... - Reuters India Heart patients don't stick to drug programs Jan 10, 2006 In 2002, rates of overall and consistent use of ACE inhibitors, such as Accupril and Vasotec, in patients with heart failure were 51 percent and 39 percent ... - News-Medical.net DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ... Jan 11, 2006 ...medications on the market today, including: Thyroid Heart - Blood Pressure Erectile Dysfunction Cholesterol - Synthroid - Accupril - Viagra - Lipitor - Norvasc ... - PR Newswire New plan cuts many from meds Jan 21, 2006 A lot of ailments. He laughs and pulls a card out of his wallet. On it is a list, including Accupril, Norvase, Macomist and Zoloft. ... - Times Herald-Record Brand Names/Synonyms: Accupril is also known by the following brand names and/or synonymsAccupril; Accuprin; Accupro; Acequin; Acuitel; Korec; Quinapril; Quinapril Hcl; Quinapril Hydrochloride; Quinapril Hydrochloride: Accupril; Quinaprilum [Latin]; Quinazil Drug Category: Accupril is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA06 Dosage Forms: Tablets Absorption: Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal. Interactions: -->Interactions for Quinapril: Concomitant diuretic therapy As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with ACCUPRIL. The possibility of hypotensive effects with ACCUPRIL may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with ACCUPRIL. If it is not possible to discontinue the diuretic, the starting dose of quinapril should be reduced. Agents increasing serum potassium Quinapril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of ACCUPRIL with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium. Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with ACCUPRIL reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in ACCUPRIL tablets. This interaction should be considered if coprescribing ACCUPRIL and tetracycline or other drugs that interact with magnesium. Lithium Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity. Other agents Drug interaction studies of ACCUPRIL with other agents showed: · Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of ACCUPRIL. · The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by quinapril coadministration twice-daily.
· No pharmacokinetic interaction was observed when single doses of ACCUPRIL and hydrochlorothiazide were administered concomitantly. · Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of ACCUPRIL resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin. Chemical IUPAC Name: 2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid : |
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