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AcarboseThis page contains recent news articles, when available, and an overview of Acarbose but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Acarbose (when available) Used to reduce blood gluose in patients with type 2 diabetes. Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. Acarbose binds to and inhibits alpha amylase and alpha-gluocside hydrolases. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. For treatment and Management of Diabetes type II (Used in combination therapy as a Second or third line agent) Mechanism Of Action: Acarbose reversibly bind to pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolases. These enzymes inhibit hydrolysis of complex starches to oligosaccharides in the lumen of the small intestine and hydrolysis of oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. News Articles on Acarbose Hypoglycemia after Roux-en-Y surgery for weight reduction - Apr 8, 2009 In some patients, it appears that acarbose alone was sufficient. Dr. Puttagunta’s patient did well with diet modification plus acarbose, so I have begun Endocrine Today Misgiving abound about drugs for pre-diabetics - Mar 31, 2009 Controlled clinical trials have produced solid evidence that the widely used diabetes drugs metformin and acarbose can reduce the progression of The Oregonian - OregonLive.com Type 2 Diabetes Mellitus: An Evidence-Based Approach to Practical ... - Apr 14, 2009 For example, the chapter authors mention the studies with acarbose and impaired glucose tolerance but not similar studies for metformin and Journal of American Medical Association (subscription) Prediabetes Unknowingly Affects Millions Of Americans - Apr 13, 2009 Diabetes drugs such as metformin (Glucophage) and acarbose (Procose) can delay the onset of diabetes. However, the Hopkins newsletter says they don’t do so Evening Bulletin [진단과 ì¦?ë¡€]ë ˆë²„ë¯¸ì–´ 시리즈 9 - Apr 15, 2009 ...ë ˆë²„ë¯¸ì–´ë§Œì?„ íˆ¬ì—¬í• ê²½ìš° ì‹?후 ê³ í˜ˆë‹¹ì?€ ê°œì„ ì‹œí‚¤ê¸° ì–´ë ¤ìš´ 경우가 ë§Žì?€ë?° ì?´ë¥¼ 위해서 acarbose나 voglibose를 ì‹?사때마다 íˆ¬ì—¬í• ìˆ˜ ìžˆê³ , 현재 보험급여ì—?서 ì œí•œ 메디칼트리뷴 Prandial Not Superior to Basal Strategies in Diabetic Survivors of ... - Mar 4, 2009 ...results would have been different if the study had used other postprandial drugs in addition to insulin to achieve goal (eg, acarbose or pramlintide, Medscape Effect of Diabetes Medications on Cardiovascular Risk and ... - Feb 23, 2009 Metformin and acarbose demonstrated significant reductions in macrovascular events, including myocardial infarction. Data regarding sulfonylureas The Journal of Pharmacy Technology å°?æœ‰ç³–å°¿ç—…ä¹‹æ€¥æ€§å¿ƒè‚Œæ¢—å¡žå˜æ´»è€…而言膳食控制並未優於一些基本ç–ç•¥ - Mar 7, 2009 Ceriello醫師寫é?“,肯定的是,如果使用其他é¤?å¾Œè—¥ç‰©åŠ ä¸Šèƒ°å³¶ç´ ä¾†é?”到目標,是å?¦æœƒç?²å¾—ä¸?一樣的çµ?æžœ(例如acarbose或者pramlintideé€™äº›æ ¸å‡†ä½µç”¨èƒ°å³¶ç´ çš„è—¥ç‰©),使用é™?低 臺灣新浪網 Alpha-glucosidase inhibitors - Jan 21, 2009 The alpha-glucosidase inhibitor used to treat diabetes is acarbose (the brand name is Glucobay). It comes as a tablet. You need a prescription from your guardian.co.uk, Rural communities to benefit from plan to market natural plants - Jan 15, 2009 For example, the strain used to manufacture a drug used for treating diabetes known as Acarbose came from Ruiru. However, the community around there has not Business Daily Africa, What's the evidence for metformin? - Jan 21, 2009 Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study. guardian.co.uk, Zuckerman Spaeder LLP Named a Finalist for 'Litigation Boutique of ... - Jan 9, 2009 ...crucial to the generic drug maker and to patients with Type II diabetes, to market its just-approved generic version of the drug Acarbose, used to treat PR Newswire (press release), Low-Glycemic-Index Diet Beats High-Cereal-Fiber Diet for Glycemic ... - Dec 18, 2008 Included were men and postmenopausal women with type 2 diabetes who were taking oral hypoglycemic agents other than acarbose with HbA 1c levels at screening Medscape Studie: Niedriger glykämischer Index senkt Blutzucker bei Typ-II ... - Dec 17, 2008 Im Prinzip beruht die Wirkung des Diabetesmittels Acarbose, das im Darm die Hydrolyse von Mehrfachzuckern hemmt, ebenfalls auf diesem Prinzip. Deutsches Ärzteblatt, 心血管病者易患糖尿病 - Dec 11, 2008 ...好é ?防措施,特別è¦?戒烟ã€?控制飲食å?Šè†½å›ºé†‡ã€‚å”?ä¿Šæ¥æŒ‡å‡ºï¼ŒæŽ§åˆ¶é£²é£Ÿç¿’慣能減輕60%「糖尿病å‰?期ã€?風險,而æœ?藥則能減輕33%,而ç?¾æ™‚唯一准用藥物å?ªæœ‰é˜¿å?¡æ³¢ç³–(Acarbose é¦™æ¸¯å•†å ±, A wake-up call - Nov 8, 2008 Pharmacological interventions: Several diabetes prevention trials used pharmacological therapy, such as metformin, acarbose and glitazone and have reported Hindu, Glucose Lowering to Control Macrovascular Disease in Type 2 Diabetes - Nov 4, 2008 ...the use of multiple agents, which included metformin, glimepiride, repaglinide, rosiglitazone, acarbose, exenatide, insulin, and similar agents. Journal of American Medical Association (subscription), Composition Comprising Licorice Polyphenol - Nov 20, 2008 ...but are not limited to, fenfluramine, fluoxetine, mazindol and the like as pharmaceutical products that suppress appetite, and acarbose, voglibose, FLEXNEWS, Overcoming the stigma of excess weight - Nov 8, 2008 Acarbose: This well known weight loss drug is manufactured for individuals suffering from Type 2 diabetes. This drug counteracts with the digestion of PRESS TV, Especialistas alertam para a importância da saúde do coração no ... - Nov 13, 2008 Entre as opções disponÃveis no mercado, a acarbose (Glucobay ® , da Bayer Schering Pharma) além de ser um hipoglicemiante oral, contribui também para a Jornal Dia a Dia, BRINKMANN: LUZ DE VIDA ORGANIZA UNA JORNADA DE ACTUALIZACION EN ... - Nov 12, 2008 Precose (acarbose), otro tipo de pÃldora novedosa, funciona bloqueando la absorbción de fécula, con lo cual se reduce el la oleada de azúcar que se produce La Radio, Part 1 of a 2 Part Series - Oct 17, 2008 For example, a prescription drug for diabetics called acarbose (Precose) blocks the enzyme called alpha-glucosidase. A newer over-the-counter starch blocker Total Health Breakthroughs Pacientes do SUS começam a receber medicamentos em casa - Oct 3, 2008 ...irão receber remédios como Captopril, Hidroclorotiazida e Propanolol, para problemas cardÃacos, e Acarbose, Glibenclamida e Metformina, para diabetes. A Tarde On Line, Studierende: „Hochschul(-ver)rat“ - Oct 7, 2008 Das arzneimittel-telegramm zieht deshalb das folgende Fazit: „Ein Nutzen von Acarbose (GLUCOBAY) zur Senkung des Risikos kardiovaskulärer Erkrankungen bei Neue Rheinische Zeitung, ì¦?í?‰ ë°•ë?™ë³µ ê¸°ìˆ ì‚¬ ê³¼í•™ê¸°ìˆ ëŒ€ì „ 대ìƒ? - Sep 24, 2008 ...ì?´ëŸ¬í•œ ë‹¹ì¡°ê³ ì¶”ì?˜ 효능ì?€ ê°•ì›?대학êµ? 연구팀ì—?서 실시한 실험결과ì—?서 나타났는ë?°, ì?¼ì •량 ì?´ìƒ?ì?„ ì„취하면 기존 혈당강하 ì?˜ì•½í’ˆì?¸ Acarboseì—? 뒤떨어지지 않는 효과 ì¶©ì²íˆ¬ë?°ì?´, Doctor's Orders with Dr. Stephen Ponder - Sep 28, 2008 ...some experts suggest that a high risk patient could benefit from use of the prescription medication metformin (Glucophage) or acarbose (Precose). Corpus Christi Caller Times, 10 mil baianos receberão remédios em casa 14 Sep 2008 Teixeira de Freitas e Camaçari vão poder receber em casa remédios como Captopril, Hidroclorotiazida e Propanolol, para problemas cardÃacos, e Acarbose,I Bahia, As Diabetes Becomes a Growing Concern, a Consensus Is Developing ... Aug 20, 2008 ...*The addition of acarbose (manufactured by Bayer and called "Precose" in the United States and "Glucobay" in Europe) slows the absorption of sugars andDiabetes Health (press release), Pre-diabetes is worth treating Sep 5, 2008 ...any drugs for this purpose, the task force believes that metformin and another diabetes medication, acarbose, may be acceptable treatment choices.Los Angeles Times, Diabetiker: Durchfall nicht unterschätzen Aug 17, 2008 Neben einem Infekt können bestimmte Diabetesmedikamente wie zum Beispiel Metformin und Acarbose Durchfälle auslösen. Zudem wirken auch einigeDiab Site, 奧é?‹ç˜‹æ¯”è³½ä¸?出門猛å?ƒçŒ›å–?å°?心血糖值飆å?‡ Aug 21, 2008 ...由於ä¸?æœƒå½±éŸ¿èƒ°å³¶ç´ åˆ†æ³Œï¼Œè¼ƒä¸?會引起低血糖副作用。 α-glucosidase 抑制劑(α-è‘¡è?„ç³–æ°´è§£é…µç´ æŠ‘åˆ¶åŠ‘),如Acarbose䏿™‚é›»å?å ±, Metabolisches Syndrom? Risiko mit Skala rasch ermittelt Aug 27, 2008 Diabetes zu bewahren, mussten statistisch 16,5 Patienten langfristig mit Acarbose zur Reduktion postprandialer Blutzuckerspitzen behandelt werden.Ärzte Zeitung, Những dược phẩm nhiệm mà u Aug 26, 2008 Còn những viên thuốc uống như Rezulin, Glucophage, Acarbose thì công hiệu và an toà n hÆ¡n trước, liá»?u lượng Ãt hÆ¡n trước. Y há»?c nói riêng và khoa há»?c nóiTiVi Tuần San, New AACE Guidelines for Prediabetes Management - Jul 25, 2008 Metformin and acarbose are safe and have strong evidence for a reduction in the development of diabetes from prediabetes. Thiazolidinediones also reduce the Medscape (subscription) Endocrinologists Issue Consensus Statement on Pre-Diabetes - Jul 24, 2008 The task force recommended metformin and acarbose for controlling glycemia on the basis of their efficacy in reducing the transition from pre-diabetes to MedPage Today, 準糖尿病人也應ç©?極治療 - Aug 5, 2008 ...工作å°?組建è°ï¼ŒåŸºæœ¬ä¸Šï¼Œmetforminå’Œacarbose yam天空新è?ž, å‡?è‚¥è?¯å‡ 大副作用大盘点 - Aug 4, 2008 ...有å?¯èƒ½ï¼šä½ æœ?用的å‡?è‚¥è?¯ä¸ï¼Œå?¯èƒ½å?«æœ‰é†£ç¦„é”(Acarbose 第一食å“?网, Targeting Blood Sugar To Near-normal Levels Increases Risk Of ... - Jun 6, 2008 ...as prescribed by their study clinician: metformin, thiazolidinediones (TZDs, primarily rosiglitazone), insulins, sulfonylureas, exanatide, and acarbose. Science Daily (press release) What are the clinical implications of ACCORD/ADVANCE? - Jun 12, 2008 ...but it was suggested that they increase gliclazide to the maximum dose and then add other oral agents, starting with metformin and acarbose, then TZDs, TheHeart.Org, Gastrointestinal Complications of Diabetes - Jun 17, 2008 ...glipizide [Glucotrol], tolbutamide [Oorinase; brand no longer available in the U united States]) can cause hepatotoxicity, and acarbose (Precose) can RedOrbit, Timing is everything in control of diabetes - Jun 23, 2008 Acarbose (Precose) and miglitol (Glyset) are the most commonly prescribed. These medicines slow the breakdown of complex carbohydrates into sugar following Corpus Christi Caller Times, Roxane Laboratories, Inc. Announces the Launch of Acarbose Tablets - May 7, 2008 COLUMBUS, Ohio, May 7 /PRNewswire/ -- Roxane Laboratories, Inc. announced today the approval of their Abbreviated New Drug Application for Acarbose Tablets, PR Newswire (press release), Cobalt Drops Suit Against FDA - May 27, 2008 It also requested that the FDA stay or withdraw approval for other acarbose ANDAs, including one from Boehringer Ingelheim’s subsidiary Roxane, FDA news (subscription), Analysis of Protein Complexes in Wheat Amyloplasts Reveals ... - May 27, 2008 P- 1261) and 10 mg of the a-amylase inhibitor Acarbose ("Prandase," Bayer) for 2 h at 4[degrees]C. Gels were washed, incubated for 2 h at 30[degrees]C, RedOrbit, Contradictory Findings Ignite Questions About Blood Glucose ... - Mar 25, 2008 ...sulfonylureas, exanatide, and acarbose. The researchers also said they did not think that hypoglycemia was a factor in the increased death rate. Journal of American Medical Association (subscription), Diabetes trial stops treatment arm in wake of death risk - Feb 17, 2008 ...thiazolidinediones (primarily rosiglitazone), insulins, sulfonylureas, exenatide and acarbose. Given recent concerns about possible cardiovascular risks American Medical News (subscription) What You Should Know About Type 2 Medications - Feb 12, 2008 ...from the liver into the blood; and those that inhibit intestinal carbohydrate metabolism (the a-glucosidase inhibitors like acarbose and miglitol). Diabetes Health (press release), NIH ends diabetes trial on deaths, says medications not responsible - 06 Feb 2008 The medications used included metformin, thiazolidinediones (TZDs, primarily rosiglitazone), insulins, sulfonylureas, exanatide, and acarbose. CNNMoney.com Type 2 Diabetes: Getting the Facts - Oct 30, 2007 Other medications slow the breakdown of carbohydrates (such as acarbose) or make your tissue more sensitive to insulin (such as rosiglitazone), and injected FOX News New IDF guidelines raise importance of post-meal glucose control - Oct 7, 2007 The new guidelines include a specific reference to acarbose (Glucobay®*) as a pharmacological agent with a substantial body of evidence proving that it SpiritIndia, FDA Wants Your Comments on 180-Day Exclusivity Forfeiture - Sep 28, 2007 There is one patent listed for Acarbose Tablets, US Patent No. 4904769, which expires on September 6, 2009. As you probably are aware, for it appears on the Patent Baristas, Bitesize evidence - Treating prediabetes does not affect progression - Sep 24, 2007 After a two-day admission for extensive testing, patients were randomly assigned, concealed allocation uncertain, to receive either placebo or acarbose Pulse, UMaine Researchers Present Blueberry Health Benefits - Aug 16, 2007 ...studies with human volunteers, most recently investigating how blueberry compounds could act like the diabetes management drugs acarbose and miglitol. The University of Maine, Older Is Better: Top Ten Comparison Of Diabetes Drugs Give ... - Jul 26, 2007 Science Daily (press release)The sulfonylureas and acarbose appeared to have no effect on bad cholesterol. And except for metformin and acarbose, drug treatment led to an increase in Older and cheaper pills just fine for diabetes - Jul 16, 2007 Reuters India,The study, funded by the US government's Agency for Healthcare Research and Quality, looked at 10 drugs: acarbose, sold as Precose or Glucobay; Older Diabetes Drugs Effective, Safe - Jul 16, 2007 Forbes,..._Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. _LDL or bad cholesterol drops by about 10 milligrams per Type 2 Diabetes – List of top 10 drugs with Metformin Ranking Highest - Jul 26, 2007 Best Syndication,Sulfonylureas and acarbose did not show to have any effect on bad cholesterol. Drug treatment caused an average weight gain of 2 to 11 pounds except in the Most Diabetes Drugs Provide Similar Glucose Control - Jul 17, 2007 DG NewsNateglinide, acarbose, and miglitol lower HbA1c by about half that much. Combining diabetes medications, evidence shows, often works better at reducing Older diabetes meds just as good - Jul 16, 2007 DetNews.com,Marilynn Marchione / Associated Press Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. Glimepiride, glipizide Old Diabetes Drug Has Advantages - Jul 16, 2007 CBS News,Patients on metformin or the drug acarbose complained of diarrhea and other gastrointestinal problems more than users of other drugs. Common Rheumatoid Arthritis Treatment Shows Potential For Diabetes ... - Jul 12, 2007 Science Daily (press release)...of other drugs studied in clinical trials for diabetes prevention and treatment, including rosiglitazone, hormones, metformin, acarbose and ramipril. Older diabetes drugs may still be the best option - Jul 26, 2007 NewKerala.com,In addition to metformin, the thiazolidinediones and sulfonylureas, drugs included in their analysis were repaglinide (Prandin), miglitol (Glyset), acarbose Diabetes Drugs: Old is Gold - Jul 17, 2007 Earthtimes.orgThe report attested that Glipizide, Glimepiride, Repaglinide, and Glyburide were capable of bringing blood sugar too low, whereas metformin and Acarbose For Type 2 Diabetes, Older Drugs Seem Tried and True - Jul 16, 2007 MedPage Today,They also found that nateglinide (Starlix) and α-glucosidase inhibitors (eg, acarbose) may have slightly less potent effects on HbA1c levels, Emne: Saharan countries clinical and absent or oxidations. - Jul 13, 2007 Oppland Arbeiderblad,Sell for discovery is acarbose and job accolate individual. The chemical booming stock and compares former flight expression. Recombination resulting review Elixir Pharmaceuticals Announces Clinical Data at American ... - Jun 25, 2007 PharmaLive.com (press release),The first study detailed findings from a randomized, double-blind trial comparing Glufast to acarbose in 369 elderly patients (at least 65 years of age) International Diabetes Federation Recommends Acarbose Therapy for ... - May 8, 2007 PharmaLive.com (press release),Acarbose and metformin are the only pharmacotherapies recommended by the IDF.(1) The recommendation for acarbose is supported by the Study to Prevent New Trial Expands Evidence For Glucobay® In Prevention Of ... - Apr 29, 2007 Medical News Today (press release),This new trial, sponsored by Bayer Schering Pharma, will investigate the effects of Bayer's oral antidiabetes drug containing acarbose, Glucobay®, Drug may not be easy solution to diabetes - Apr 27, 2007 London Free Press,The group reviewed evidence on it and two other drugs -- metformin and acarbose -- and recommended lifestyle modification as the first line of approach for Giving drug to prevent diabetes no DREAM solution, researchers say - Apr 26, 2007 Canada.com,The group reviewed evidence on it and two other drugs - metformin and acarbose - for a consensus article published this month in Diabetes Care. Brand Names/Synonyms: Acarbose is also known by the following brand names and/or synonymsAcarbose; Precose Drug Category: Acarbose is categorized under the following by the FDA: Hypoglycemic Agents; Alpha-glucosidase Inhibitors; ATC:A10BF01 Dosage Forms: TABLET Absorption: Not Available Interactions: Interactions for Acarbose: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Chemical IUPAC Name: 5-[5-[3,4-dihydroxy-6-methyl-5-[[4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]tetrahydropyran-2-yl]amino-3,4-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]amino-6-(hydroxymethyl)tetrahydropyran-2,3,4-triol : |
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