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AcarboseThis page contains recent news articles, when available, and an overview of Acarbose but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Acarbose (when available) Used to reduce blood gluose in patients with type 2 diabetes. Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. Acarbose binds to and inhibits alpha amylase and alpha-gluocside hydrolases. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. For treatment and Management of Diabetes type II (Used in combination therapy as a Second or third line agent) Mechanism Of Action: Acarbose reversibly bind to pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolases. These enzymes inhibit hydrolysis of complex starches to oligosaccharides in the lumen of the small intestine and hydrolysis of oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. News Articles on Acarbose Contradictory Findings Ignite Questions About Blood Glucose ... - Mar 25, 2008 ...sulfonylureas, exanatide, and acarbose. The researchers also said they did not think that hypoglycemia was a factor in the increased death rate. Journal of American Medical Association (subscription), Diabetes trial stops treatment arm in wake of death risk - Feb 17, 2008 ...thiazolidinediones (primarily rosiglitazone), insulins, sulfonylureas, exenatide and acarbose. Given recent concerns about possible cardiovascular risks American Medical News (subscription) What You Should Know About Type 2 Medications - Feb 12, 2008 ...from the liver into the blood; and those that inhibit intestinal carbohydrate metabolism (the a-glucosidase inhibitors like acarbose and miglitol). Diabetes Health (press release), NIH ends diabetes trial on deaths, says medications not responsible - 06 Feb 2008 The medications used included metformin, thiazolidinediones (TZDs, primarily rosiglitazone), insulins, sulfonylureas, exanatide, and acarbose. CNNMoney.com Type 2 Diabetes: Getting the Facts - Oct 30, 2007 Other medications slow the breakdown of carbohydrates (such as acarbose) or make your tissue more sensitive to insulin (such as rosiglitazone), and injected FOX News New IDF guidelines raise importance of post-meal glucose control - Oct 7, 2007 The new guidelines include a specific reference to acarbose (Glucobay®*) as a pharmacological agent with a substantial body of evidence proving that it SpiritIndia, FDA Wants Your Comments on 180-Day Exclusivity Forfeiture - Sep 28, 2007 There is one patent listed for Acarbose Tablets, US Patent No. 4904769, which expires on September 6, 2009. As you probably are aware, for it appears on the Patent Baristas, Bitesize evidence - Treating prediabetes does not affect progression - Sep 24, 2007 After a two-day admission for extensive testing, patients were randomly assigned, concealed allocation uncertain, to receive either placebo or acarbose Pulse, UMaine Researchers Present Blueberry Health Benefits - Aug 16, 2007 ...studies with human volunteers, most recently investigating how blueberry compounds could act like the diabetes management drugs acarbose and miglitol. The University of Maine, Older Is Better: Top Ten Comparison Of Diabetes Drugs Give ... - Jul 26, 2007 Science Daily (press release)The sulfonylureas and acarbose appeared to have no effect on bad cholesterol. And except for metformin and acarbose, drug treatment led to an increase in Older and cheaper pills just fine for diabetes - Jul 16, 2007 Reuters India,The study, funded by the US government's Agency for Healthcare Research and Quality, looked at 10 drugs: acarbose, sold as Precose or Glucobay; Older Diabetes Drugs Effective, Safe - Jul 16, 2007 Forbes,..._Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. _LDL or bad cholesterol drops by about 10 milligrams per Type 2 Diabetes – List of top 10 drugs with Metformin Ranking Highest - Jul 26, 2007 Best Syndication,Sulfonylureas and acarbose did not show to have any effect on bad cholesterol. Drug treatment caused an average weight gain of 2 to 11 pounds except in the Most Diabetes Drugs Provide Similar Glucose Control - Jul 17, 2007 DG NewsNateglinide, acarbose, and miglitol lower HbA1c by about half that much. Combining diabetes medications, evidence shows, often works better at reducing Older diabetes meds just as good - Jul 16, 2007 DetNews.com,Marilynn Marchione / Associated Press Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. Glimepiride, glipizide Old Diabetes Drug Has Advantages - Jul 16, 2007 CBS News,Patients on metformin or the drug acarbose complained of diarrhea and other gastrointestinal problems more than users of other drugs. Common Rheumatoid Arthritis Treatment Shows Potential For Diabetes ... - Jul 12, 2007 Science Daily (press release)...of other drugs studied in clinical trials for diabetes prevention and treatment, including rosiglitazone, hormones, metformin, acarbose and ramipril. Older diabetes drugs may still be the best option - Jul 26, 2007 NewKerala.com,In addition to metformin, the thiazolidinediones and sulfonylureas, drugs included in their analysis were repaglinide (Prandin), miglitol (Glyset), acarbose Diabetes Drugs: Old is Gold - Jul 17, 2007 Earthtimes.orgThe report attested that Glipizide, Glimepiride, Repaglinide, and Glyburide were capable of bringing blood sugar too low, whereas metformin and Acarbose For Type 2 Diabetes, Older Drugs Seem Tried and True - Jul 16, 2007 MedPage Today,They also found that nateglinide (Starlix) and α-glucosidase inhibitors (eg, acarbose) may have slightly less potent effects on HbA1c levels, Emne: Saharan countries clinical and absent or oxidations. - Jul 13, 2007 Oppland Arbeiderblad,Sell for discovery is acarbose and job accolate individual. The chemical booming stock and compares former flight expression. Recombination resulting review Elixir Pharmaceuticals Announces Clinical Data at American ... - Jun 25, 2007 PharmaLive.com (press release),The first study detailed findings from a randomized, double-blind trial comparing Glufast to acarbose in 369 elderly patients (at least 65 years of age) International Diabetes Federation Recommends Acarbose Therapy for ... - May 8, 2007 PharmaLive.com (press release),Acarbose and metformin are the only pharmacotherapies recommended by the IDF.(1) The recommendation for acarbose is supported by the Study to Prevent New Trial Expands Evidence For Glucobay® In Prevention Of ... - Apr 29, 2007 Medical News Today (press release),This new trial, sponsored by Bayer Schering Pharma, will investigate the effects of Bayer's oral antidiabetes drug containing acarbose, Glucobay®, Drug may not be easy solution to diabetes - Apr 27, 2007 London Free Press,The group reviewed evidence on it and two other drugs -- metformin and acarbose -- and recommended lifestyle modification as the first line of approach for Giving drug to prevent diabetes no DREAM solution, researchers say - Apr 26, 2007 Canada.com,The group reviewed evidence on it and two other drugs - metformin and acarbose - for a consensus article published this month in Diabetes Care. New Trial Expands Evidence for Glucobay in Prevention of ... - Apr 25, 2007 PharmaLive.com (press release),This new trial, sponsored by Bayer Schering Pharma, will investigate the effects of Bayer’s oral antidiabetes drug containing acarbose, Glucobay®*, Pycnogenol’s Latest Bragging Rights - Apr 13, 2007 Diabetes Health (press release),The October issue of Life Sciences demonstrated further lowering of blood glucose in patients already taking acarbose and metformin. Oral medications to treat Type 2 diabetes - Apr 19, 2007 Chennai Online,Acarbose (brand name - Precose sold by Bayer) and Miglitol (sold as Glyset by Pfizer). These drugs have significant side-effects, the most prominent being Exenatide Therapy for Type 2 Diabetes - Apr 2, 2007 Annals of Internal MedicineDrugs that may be used include insulin, alpha-glucosidase inhibitors (acarbose and miglitol), biguanides (metformin), sulfonyureas (glipizide or glyburide), Bayer to trial anti-diabetes drug Acarbose as cardiovascular ... - Dec 3, 2006 Forbes,FRANKFURT (AFX) - Bayer AG said it will start a new outcome trial in 2007 to investigate the effects of the oral antidiabetes drug Acarbose on preventing DREAM: Rosiglitazone Effective in Preventing Diabetes Oct 24, 2006 It remains to be seen how it will be used.". Dr. Gerstein noted that the arsenal includes drugs such as metformin and acarbose. Rosiglitazone ... -Medscape (subscription) Diabetic Complications Inevitable? Not So Fast... Sep 13, 2006 Some background on the study - the researchers investigated whether an intervention with acarbose in subjects with early diabetes (fasting plasma glucose ... -The Common Voice Rosiglitazone, but Not Ramipril, Prevents Progression to Diabetes Sep 19, 2006 Also, acarbose and metformin can also prevent progression to diabetes, although their effects are probably less than that of lifestyle interventions. ... -Medscape (subscription) Drug unlikely to slow type 2 diabetes progression Sep 8, 2006 Health) - Treating "postprandial hyperglycemia" -- the spike in blood sugar that occur after meals -- with the drug Precose (also known as acarbose) does not ... -Reuters.uk Drug Can Help Prevent Diabetes, Study Says Sep 18, 2006 ...prescribed to treat diabetes, reduced the risk of developing the disease by 31 percent and another study found that the little-used drug acarbose cut the risk ... -International News Service World News | DREAM comes true for GSK? - 18/09/2006 Sep 18, 2006 Both Merck's Glucophage (metformin) and Bayer's Glucobay (acarbose) have also been shown to reduce the risk of diabetes in patients with impaired glucose ... -Pharma Times (subscription) Not yet diabetic, but bad enough Sep 2, 2006 ...says Prof Chan. Acarbose and pioglitazone are two other medications that could be prescribed for people with pre-diabetes. It seems ... -Malaysia Star Low blood sugar at night still a diabetes problem Jun 30, 2006 On different nights they were assigned to receive no treatment, an uncooked cornstarch bar, a snack, a snack and the drug acarbose, or a dose of terbutaline. ... -Reuters.uk Ranbaxy Q1 Net Flat YoY On Negative Growth In UK And France Apr 20, 2006 ...in India, will provide doctors with an efficacious medicine that is a strong and selective inhibitor as compared to the available 'Alpha-Glycosidase' - Acarbose ... - Trading Markets Ranbaxy Q1, 06, Global Sales At USD 287 MN, Up 14 Per Cent Apr 19, 2006 ...in India, will provide doctors with an efficacious medicine that is a strong and selective inhibitor as compared to the available 'Alpha-Glucosidase' - Acarbose ... - Webbolt Business News Africa suffers 36 cases of biopiracy Mar 31, 2006 ...patent law treaty). — Diabetes Drug produced by a microbe from Kenya: Acarbose is a drug taken by Type II diabetics. The German ... - Public Agenda Looking Back - March 30, 2006 Mar 30, 2006 Acarbose, known by the brand name Prandase, was cleared by Health Canada last November and is just now hitting pharmacy shelves. ... - Brandon Sun Bacteria and ball games keep her busy Mar 17, 2006 Acarbose and voglibose, compounds similar to those Flatt’s team hopes to find, mimic long-chain sugars in the body, where they can stop the breakdown of ... - OSU Daily Barometer Bayer Earns $379m From Diabetes Drug Feb 14, 2006 ...brands in the world. Glucobay, scientifically known as acarbose, is sold by the German pharmaceutical giant Bayer. According to the ... - AllAfrica.com, Ranbaxy Launches Volix (Voglibose) For Treatment Of Diabetes ... Jan 30, 2006 ...will provide Indian doctors with an efficacious medicine which is a strong and selective inhibitor as compared to the available ‘Alpha-Glucosidase' - Acarbose ... - Medical News Today New drug for diabetes Jan 24, 2006 ...drug. Volix (Voglibose) is found to be efficient and selective inhibitor as compared to the available Alpha-Glucosidase - Acarbose. - Andhra Cafe Brand Names/Synonyms: Acarbose is also known by the following brand names and/or synonymsAcarbose; Precose Drug Category: Acarbose is categorized under the following by the FDA: Hypoglycemic Agents; Alpha-glucosidase Inhibitors; ATC:A10BF01 Dosage Forms: TABLET Absorption: Not Available Interactions: Interactions for Acarbose: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin. Chemical IUPAC Name: 5-[5-[3,4-dihydroxy-6-methyl-5-[[4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]tetrahydropyran-2-yl]amino-3,4-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]amino-6-(hydroxymethyl)tetrahydropyran-2,3,4-triol : |
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