Acarbose

This page contains recent news articles, when available, and an overview of Acarbose but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Acarbose (when available)

Pharmacology and use:
Used to reduce blood gluose in patients with type 2 diabetes. Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. Acarbose binds to and inhibits alpha amylase and alpha-gluocside hydrolases. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. For treatment and Management of Diabetes type II (Used in combination therapy as a Second or third line agent)

Mechanism Of Action:
Acarbose reversibly bind to pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolases. These enzymes inhibit hydrolysis of complex starches to oligosaccharides in the lumen of the small intestine and hydrolysis of oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine.

News Articles on Acarbose

Hypoglycemia after Roux-en-Y surgery for weight reduction  -  ‎Apr 8, 2009‎
In some patients, it appears that acarbose alone was sufficient. Dr. Puttagunta’s patient did well with diet modification plus acarbose, so I have begun Endocrine Today

Misgiving abound about drugs for pre-diabetics  -  ‎Mar 31, 2009‎
Controlled clinical trials have produced solid evidence that the widely used diabetes drugs metformin and acarbose can reduce the progression of The Oregonian - OregonLive.com

Type 2 Diabetes Mellitus: An Evidence-Based Approach to Practical ...  -  ‎Apr 14, 2009‎
For example, the chapter authors mention the studies with acarbose and impaired glucose tolerance but not similar studies for metformin and Journal of American Medical Association (subscription)

Prediabetes Unknowingly Affects Millions Of Americans  -  ‎Apr 13, 2009‎
Diabetes drugs such as metformin (Glucophage) and acarbose (Procose) can delay the onset of diabetes. However, the Hopkins newsletter says they don’t do so Evening Bulletin

[진단과 �?례]레버미어 시리즈 9  -  ‎Apr 15, 2009‎
...레버미어만�?� 투여할 경우 �?후 고혈당�?� 개선시키기 어려운 경우가 많�?��?� �?�를 위해서 acarbose나 voglibose를 �?사때마다 투여할 수 있고, 현재 보험급여�?서 제한 메디칼트리뷴

Prandial Not Superior to Basal Strategies in Diabetic Survivors of ...  -  ‎Mar 4, 2009‎
...results would have been different if the study had used other postprandial drugs in addition to insulin to achieve goal (eg, acarbose or pramlintide, Medscape

Effect of Diabetes Medications on Cardiovascular Risk and ...  -  ‎Feb 23, 2009‎
Metformin and acarbose demonstrated significant reductions in macrovascular events, including myocardial infarction. Data regarding sulfonylureas The Journal of Pharmacy Technology

�?有糖尿病之急性心肌梗塞存活者而言膳食控制並未優於一些基本策略  -  ‎Mar 7, 2009‎
Ceriello醫師寫�?�，肯定的是，如果使用其他�?後藥物加上胰島素來�?�到目標，是�?�會�?�得�?一樣的�?果(例如acarbose或者pramlintide這些核准併用胰島素的藥物)，使用�?低臺灣新浪網

Alpha-glucosidase inhibitors  -  Jan 21, 2009
The alpha-glucosidase inhibitor used to treat diabetes is acarbose (the brand name is Glucobay). It comes as a tablet. You need a prescription from your guardian.co.uk,

Rural communities to benefit from plan to market natural plants  -  Jan 15, 2009
For example, the strain used to manufacture a drug used for treating diabetes known as Acarbose came from Ruiru. However, the community around there has not Business Daily Africa,

What's the evidence for metformin?  -  Jan 21, 2009
Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study. guardian.co.uk,

Zuckerman Spaeder LLP Named a Finalist for 'Litigation Boutique of ...  -  Jan 9, 2009
...crucial to the generic drug maker and to patients with Type II diabetes, to market its just-approved generic version of the drug Acarbose, used to treat PR Newswire (press release),

Low-Glycemic-Index Diet Beats High-Cereal-Fiber Diet for Glycemic ...  -  Dec 18, 2008
Included were men and postmenopausal women with type 2 diabetes who were taking oral hypoglycemic agents other than acarbose with HbA 1c levels at screening Medscape

Studie: Niedriger glykämischer Index senkt Blutzucker bei Typ-II ...  -  Dec 17, 2008
Im Prinzip beruht die Wirkung des Diabetesmittels Acarbose, das im Darm die Hydrolyse von Mehrfachzuckern hemmt, ebenfalls auf diesem Prinzip. Deutsches Ärzteblatt,

心血管病者易患糖尿病  -  Dec 11, 2008
...好�?防措施，特別�?戒烟�?控制飲食�?�膽固醇。�?俊業指出，控制飲食習慣能減輕60%「糖尿病�?期�?風險，而�?藥則能減輕33%，而�?�時唯一准用藥物�?�有阿�?�波糖(Acarbose 香港商報,

A wake-up call  -  Nov 8, 2008
Pharmacological interventions: Several diabetes prevention trials used pharmacological therapy, such as metformin, acarbose and glitazone and have reported Hindu,

Glucose Lowering to Control Macrovascular Disease in Type 2 Diabetes  -  Nov 4, 2008
...the use of multiple agents, which included metformin, glimepiride, repaglinide, rosiglitazone, acarbose, exenatide, insulin, and similar agents. Journal of American Medical Association (subscription),

Composition Comprising Licorice Polyphenol  -  Nov 20, 2008
...but are not limited to, fenfluramine, fluoxetine, mazindol and the like as pharmaceutical products that suppress appetite, and acarbose, voglibose, FLEXNEWS,

Overcoming the stigma of excess weight  -  Nov 8, 2008
Acarbose: This well known weight loss drug is manufactured for individuals suffering from Type 2 diabetes. This drug counteracts with the digestion of PRESS TV,

Especialistas alertam para a importância da saúde do coração no ...  -  Nov 13, 2008
Entre as opções disponíveis no mercado, a acarbose (Glucobay ® , da Bayer Schering Pharma) além de ser um hipoglicemiante oral, contribui também para a Jornal Dia a Dia,

BRINKMANN: LUZ DE VIDA ORGANIZA UNA JORNADA DE ACTUALIZACION EN ...  -  Nov 12, 2008
Precose (acarbose), otro tipo de píldora novedosa, funciona bloqueando la absorbción de fécula, con lo cual se reduce el la oleada de azúcar que se produce La Radio,

Part 1 of a 2 Part Series  -  Oct 17, 2008
For example, a prescription drug for diabetics called acarbose (Precose) blocks the enzyme called alpha-glucosidase. A newer over-the-counter starch blocker Total Health Breakthroughs

Pacientes do SUS começam a receber medicamentos em casa  -  Oct 3, 2008
...irão receber remédios como Captopril, Hidroclorotiazida e Propanolol, para problemas cardíacos, e Acarbose, Glibenclamida e Metformina, para diabetes. A Tarde On Line,

Studierende: „Hochschul(-ver)rat“  -  Oct 7, 2008
Das arzneimittel-telegramm zieht deshalb das folgende Fazit: „Ein Nutzen von Acarbose (GLUCOBAY) zur Senkung des Risikos kardiovaskulärer Erkrankungen bei Neue Rheinische Zeitung,

�?�?� 박�?�복 기술사 과학기술대전 대�?  -  Sep 24, 2008
...�?�러한 당조고추�?� 효능�?� 강�?대학�? 연구팀�?서 실시한 실험결과�?서 나타났는�?�, �?�정량 �?��?�?� 섭취하면 기존 혈당강하 �?�약품�?� Acarbose�? 뒤떨어지지 않는 효과 충청투�?��?�,

Doctor's Orders with Dr. Stephen Ponder  -  Sep 28, 2008
...some experts suggest that a high risk patient could benefit from use of the prescription medication metformin (Glucophage) or acarbose (Precose). Corpus Christi Caller Times,

10 mil baianos receberão remédios em casa  14 Sep 2008
Teixeira de Freitas e Camaçari vão poder receber em casa remédios como Captopril, Hidroclorotiazida e Propanolol, para problemas cardíacos, e Acarbose,I Bahia,

As Diabetes Becomes a Growing Concern, a Consensus Is Developing ...  Aug 20, 2008
...*The addition of acarbose (manufactured by Bayer and called "Precose" in the United States and "Glucobay" in Europe) slows the absorption of sugars andDiabetes Health (press release),

Pre-diabetes is worth treating  Sep 5, 2008
...any drugs for this purpose, the task force believes that metformin and another diabetes medication, acarbose, may be acceptable treatment choices.Los Angeles Times,

Diabetiker: Durchfall nicht unterschätzen  Aug 17, 2008
Neben einem Infekt können bestimmte Diabetesmedikamente wie zum Beispiel Metformin und Acarbose Durchfälle auslösen. Zudem wirken auch einigeDiab Site,

奧�?�瘋比賽�?出門猛�?�猛�?�?心血糖值飆�?�  Aug 21, 2008
...由於�?會影響胰島素分泌，較�?會引起低血糖副作用。 α-glucosidase 抑制劑(α-葡�?�糖水解酵素抑制劑)，如Acarbose中時電�?報,

Metabolisches Syndrom? Risiko mit Skala rasch ermittelt  Aug 27, 2008
Diabetes zu bewahren, mussten statistisch 16,5 Patienten langfristig mit Acarbose zur Reduktion postprandialer Blutzuckerspitzen behandelt werden.Ärzte Zeitung,

Những dược phẩm nhiệm màu  Aug 26, 2008
Còn những viên thuốc uống như Rezulin, Glucophage, Acarbose thì công hiệu và an toàn hơn trước, li�?u lượng ít hơn trước. Y h�?c nói riêng và khoa h�?c nóiTiVi Tuần San,

New AACE Guidelines for Prediabetes Management  -  Jul 25, 2008
Metformin and acarbose are safe and have strong evidence for a reduction in the development of diabetes from prediabetes. Thiazolidinediones also reduce the Medscape (subscription)

Endocrinologists Issue Consensus Statement on Pre-Diabetes  -  Jul 24, 2008
The task force recommended metformin and acarbose for controlling glycemia on the basis of their efficacy in reducing the transition from pre-diabetes to MedPage Today,

準糖尿病人也應�?極治療  -  Aug 5, 2008
...工作�?組建議，基本上，metformin和acarbose yam天空新�?�,

�?肥�?�几大副作用大盘点  -  Aug 4, 2008
...有�?�能：你�?用的�?肥�?�中，�?�能�?�有醣禄锭（Acarbose 第一食�?网,

Targeting Blood Sugar To Near-normal Levels Increases Risk Of ...  -  Jun 6, 2008
...as prescribed by their study clinician: metformin, thiazolidinediones (TZDs, primarily rosiglitazone), insulins, sulfonylureas, exanatide, and acarbose. Science Daily (press release)

What are the clinical implications of ACCORD/ADVANCE?  -  Jun 12, 2008
...but it was suggested that they increase gliclazide to the maximum dose and then add other oral agents, starting with metformin and acarbose, then TZDs, TheHeart.Org,

Gastrointestinal Complications of Diabetes  -  Jun 17, 2008
...glipizide [Glucotrol], tolbutamide [Oorinase; brand no longer available in the U united States]) can cause hepatotoxicity, and acarbose (Precose) can RedOrbit,

Timing is everything in control of diabetes  -  Jun 23, 2008
Acarbose (Precose) and miglitol (Glyset) are the most commonly prescribed. These medicines slow the breakdown of complex carbohydrates into sugar following Corpus Christi Caller Times,

Roxane Laboratories, Inc. Announces the Launch of Acarbose Tablets  -  May 7, 2008
COLUMBUS, Ohio, May 7 /PRNewswire/ -- Roxane Laboratories, Inc. announced today the approval of their Abbreviated New Drug Application for Acarbose Tablets, PR Newswire (press release),

Cobalt Drops Suit Against FDA  -  May 27, 2008
It also requested that the FDA stay or withdraw approval for other acarbose ANDAs, including one from Boehringer Ingelheim’s subsidiary Roxane, FDA news (subscription),

Analysis of Protein Complexes in Wheat Amyloplasts Reveals ...  -  May 27, 2008
P- 1261) and 10 mg of the a-amylase inhibitor Acarbose ("Prandase," Bayer) for 2 h at 4[degrees]C. Gels were washed, incubated for 2 h at 30[degrees]C, RedOrbit,

Contradictory Findings Ignite Questions About Blood Glucose ...  -  Mar 25, 2008
...sulfonylureas, exanatide, and acarbose. The researchers also said they did not think that hypoglycemia was a factor in the increased death rate. Journal of American Medical Association (subscription),

Diabetes trial stops treatment arm in wake of death risk  -  Feb 17, 2008
...thiazolidinediones (primarily rosiglitazone), insulins, sulfonylureas, exenatide and acarbose. Given recent concerns about possible cardiovascular risks American Medical News (subscription)

What You Should Know About Type 2 Medications  -  Feb 12, 2008
...from the liver into the blood; and those that inhibit intestinal carbohydrate metabolism (the a-glucosidase inhibitors like acarbose and miglitol). Diabetes Health (press release),

NIH ends diabetes trial on deaths, says medications not responsible  -  06 Feb 2008
The medications used included metformin, thiazolidinediones (TZDs, primarily rosiglitazone), insulins, sulfonylureas, exanatide, and acarbose. CNNMoney.com

Type 2 Diabetes: Getting the Facts  -  Oct 30, 2007
Other medications slow the breakdown of carbohydrates (such as acarbose) or make your tissue more sensitive to insulin (such as rosiglitazone), and injected FOX News

New IDF guidelines raise importance of post-meal glucose control  -  Oct 7, 2007
The new guidelines include a specific reference to acarbose (Glucobay®*) as a pharmacological agent with a substantial body of evidence proving that it SpiritIndia,

FDA Wants Your Comments on 180-Day Exclusivity Forfeiture  -  Sep 28, 2007
There is one patent listed for Acarbose Tablets, US Patent No. 4904769, which expires on September 6, 2009. As you probably are aware, for it appears on the Patent Baristas,

Bitesize evidence - Treating prediabetes does not affect progression  -  Sep 24, 2007
After a two-day admission for extensive testing, patients were randomly assigned, concealed allocation uncertain, to receive either placebo or acarbose Pulse,

UMaine Researchers Present Blueberry Health Benefits  -  Aug 16, 2007
...studies with human volunteers, most recently investigating how blueberry compounds could act like the diabetes management drugs acarbose and miglitol. The University of Maine,

Older Is Better: Top Ten Comparison Of Diabetes Drugs Give ...  -  Jul 26, 2007
Science Daily (press release)The sulfonylureas and acarbose appeared to have no effect on bad cholesterol. And except for metformin and acarbose, drug treatment led to an increase in

Older and cheaper pills just fine for diabetes  -  Jul 16, 2007
Reuters India,The study, funded by the US government's Agency for Healthcare Research and Quality, looked at 10 drugs: acarbose, sold as Precose or Glucobay;

Older Diabetes Drugs Effective, Safe  -  Jul 16, 2007
Forbes,..._Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. _LDL or bad cholesterol drops by about 10 milligrams per

Type 2 Diabetes – List of top 10 drugs with Metformin Ranking Highest  -  Jul 26, 2007
Best Syndication,Sulfonylureas and acarbose did not show to have any effect on bad cholesterol. Drug treatment caused an average weight gain of 2 to 11 pounds except in the

Most Diabetes Drugs Provide Similar Glucose Control  -  Jul 17, 2007
DG NewsNateglinide, acarbose, and miglitol lower HbA1c by about half that much. Combining diabetes medications, evidence shows, often works better at reducing

Older diabetes meds just as good  -  Jul 16, 2007
DetNews.com,Marilynn Marchione / Associated Press Metformin and acarbose (sold as Precose) do not increase weight. Others add 2 to 11 pounds. Glimepiride, glipizide

Old Diabetes Drug Has Advantages  -  Jul 16, 2007
CBS News,Patients on metformin or the drug acarbose complained of diarrhea and other gastrointestinal problems more than users of other drugs.

Common Rheumatoid Arthritis Treatment Shows Potential For Diabetes ...  -  Jul 12, 2007
Science Daily (press release)...of other drugs studied in clinical trials for diabetes prevention and treatment, including rosiglitazone, hormones, metformin, acarbose and ramipril.

Older diabetes drugs may still be the best option  -  Jul 26, 2007
NewKerala.com,In addition to metformin, the thiazolidinediones and sulfonylureas, drugs included in their analysis were repaglinide (Prandin), miglitol (Glyset), acarbose

Diabetes Drugs: Old is Gold  -  Jul 17, 2007
Earthtimes.orgThe report attested that Glipizide, Glimepiride, Repaglinide, and Glyburide were capable of bringing blood sugar too low, whereas metformin and Acarbose

For Type 2 Diabetes, Older Drugs Seem Tried and True  -  Jul 16, 2007
MedPage Today,They also found that nateglinide (Starlix) and α-glucosidase inhibitors (eg, acarbose) may have slightly less potent effects on HbA1c levels,

Emne: Saharan countries clinical and absent or oxidations.  -  Jul 13, 2007
Oppland Arbeiderblad,Sell for discovery is acarbose and job accolate individual. The chemical booming stock and compares former flight expression. Recombination resulting review

Elixir Pharmaceuticals Announces Clinical Data at American ...  -  Jun 25, 2007
PharmaLive.com (press release),The first study detailed findings from a randomized, double-blind trial comparing Glufast to acarbose in 369 elderly patients (at least 65 years of age)

International Diabetes Federation Recommends Acarbose Therapy for ...  -  May 8, 2007
PharmaLive.com (press release),Acarbose and metformin are the only pharmacotherapies recommended by the IDF.(1) The recommendation for acarbose is supported by the Study to Prevent

New Trial Expands Evidence For Glucobay® In Prevention Of ...  -  Apr 29, 2007
Medical News Today (press release),This new trial, sponsored by Bayer Schering Pharma, will investigate the effects of Bayer's oral antidiabetes drug containing acarbose, Glucobay®,

Drug may not be easy solution to diabetes  -  Apr 27, 2007
London Free Press,The group reviewed evidence on it and two other drugs -- metformin and acarbose -- and recommended lifestyle modification as the first line of approach for

Giving drug to prevent diabetes no DREAM solution, researchers say  -  Apr 26, 2007
Canada.com,The group reviewed evidence on it and two other drugs - metformin and acarbose - for a consensus article published this month in Diabetes Care.

Brand Names/Synonyms:
Acarbose is also known by the following brand names and/or synonymsAcarbose; Precose

Drug Category:
Acarbose is categorized under the following by the FDA: Hypoglycemic Agents; Alpha-glucosidase Inhibitors; ATC:A10BF01

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
Interactions for Acarbose: Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Acarbose, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from patients receiving Acarbose in combination with sulfonylureas or insulin, patients should be observed closely for any evidence of hypoglycemia. Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly. Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment. Studies in healthy volunteers have shown that Acarbose has no effect on either the pharmacokinetics or pharmacodynamics of digoxin, nifedipine, propranolol, or ranitidine. Acarbose did not interfere with the absorption or disposition of the sulfonylurea glyburide in diabetic patients. Acarbose may affect digoxin bioavailabillty and may require dose adjustment of digoxin by 16% (90% confidence interval: 8-23%), decrease mean C max digoxin by 26% (90% confidence interval: 16-34%) and decrease mean trough concentrations of digoxin by 9% (90% confidence limit: 19% decrease to 2% increase). The amount of metformin absorbed while taking Acarbose was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose and metformin.

Chemical IUPAC Name:
5-[5-[3,4-dihydroxy-6-methyl-5-[[4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]tetrahydropyran-2-yl]amino-3,4-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]amino-6-(hydroxymethyl)tetrahydropyran-2,3,4-triol

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