ADRIAMYCIN PFS

This page contains recent news articles, when available, and an overview of ADRIAMYCIN PFS but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

ADRIAMYCIN PFS (when available)

Pharmacology and use:
Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific. For the Treatment of Koposi's sarcome connected to AIDS

Mechanism Of Action:
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

News Articles on Doxorubicin

Market Report -- In Play (ABBI) - Aug 8, 2007
...has launched Doxorubicin Hydrochloride Injection, USP 2mg/mL, the generic equivalent of Adriamycin PFS which is owned by Bedford Laboratories, MSN Money

Brand Names/Synonyms:
ADRIAMYCIN PFS is also known by the following brand names and/or synonymsADM; Adriablastin; Adriamycin; Adriamycin Pfs; Adriamycin Rdf; Adriamycin Semiquinone; Adriblastin; Adriblastina; CCRIS 739; Caelyx;; DM2; Doxil; Doxo; Doxorubicin; Doxorubicin Hcl; Doxorubicin Hydrochloride; Doxorubicin [Usan:Ban:Inn]; Doxorubicina [Inn-Spanish]; Doxorubicine [Inn-French]; Doxorubicinum [Inn-Latin]; FI 106; FI-106; HSDB 3070; Rdf Rubex; Rubex

Drug Category:
ADRIAMYCIN PFS is categorized under the following by the FDA: Antibiotics; Antineoplastic Agents; ATC:L01DB01

Dosage Forms:
POWDER FOR SOLUTION

Absorption:
Not Available

Interactions:
-->Interactions for Doxorubicin:

No formal drug interaction studies have been conducted with DOXIL^® . Until specific compatibility data are available, it is not recommended that DOXIL^® be mixed with other drugs. DOXIL^® may interact with drugs known to interact with the conventional formulation of doxorubicin HCl.

Chemical IUPAC Name:
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione

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