5-Flucytosine

This page contains recent news articles, when available, and an overview of 5-Flucytosine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

5-Flucytosine (when available)

Pharmacology and use:
Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; whereupon it is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported. For treatment of (in combination with Amphotericin B) meningitis, endophthalmitis and pylelonephritis

Mechanism Of Action:
Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to monophosphate, a noncompetitive inhibitor of the fungal thymidylate synthetase which interferes with DNA synthesis. Flucytosine interrupts nucleic acid and protein synthesis. The cells of the host do not convert large quantities of flucytosine to fluorouracil, accounting for the selective toxicity of the compound against fungi.

News Articles on 5-Flucytosine

Brand Names/Synonyms:
5-Flucytosine is also known by the following brand names and/or synonymsAncobon; Ancotil; Flucytosin; Flucytosine; Fluocytosine; Fluorcytosine

Drug Category:
5-Flucytosine is categorized under the following by the FDA: Antimetabolites; Antifungals; ATC:D01AE21; ATC:J02AX01

Dosage Forms:
Not Available

Absorption:
Rapidly and completely absorbed, bioavailability is 78-90%

Interactions:
Interactions for 5-Flucytosine: Cytosine arabinoside, a cytostatic agent, has been reported to inactivate the antifungal activity of flucytosine by competitive inhibition. Drugs which impair glomerular filtration may prolong the biological half-life of flucytosine. Drug/Laboratory Test Interactions: Measurement of serum creatinine levels should be determined by the Jaffe reaction, since Ancobon does not interfere with the determination of creatinine values by this method. Most automated equipment for measurement of creatinine makes use of the Jaffe reaction.

Chemical IUPAC Name:
4-amino-5-fluoro-3H-pyrimidin-2-one

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